Mammography Health Dictionary

Mammography: From 3 Different Sources


An X-ray procedure for examination of the breast. The breast is gently flattened between an X-ray plate and a plastic cover so that as much tissue as possible can be imaged. The procedure is used to investigate breast lumps, and to screen for breast cancer, because it allows the detection ofbreast tumours too small to be found during a physical examination (see breast self-examination).
Health Source: BMA Medical Dictionary
Author: The British Medical Association
The special technique whereby X-rays are used to show the structure of the breast or any abnormalities in it (see BREASTS; BREASTS, DISEASES OF). It is an e?ective way of distinguishing benign from malignant tumours, and can detect tumours that are not palpable. In a multi-centre study in the USA, called the Breast Cancer Detection Demonstration Project and involving nearly 300,000 women in the 40–49 age group, 35 per cent of the tumours found were detected by mammography alone, 13 per cent by physical examination, and 50 per cent by both methods combined. The optimum frequency of screening is debatable: the American College of Radiologists recommends a baseline mammogram at the age of 40 years, with subsequent mammography at one- to two-year intervals up to the age of 50; thereafter, annual mammography is recommended. In the United Kingdom a less intensive screening programme is in place, with women over 50 being screened every three years. As breast cancer is the commonest malignancy in western women and is increasing in frequency, the importance of screening for this form of cancer is obvious.
Health Source: Medical Dictionary
Author: Health Dictionary
n. the study of the breast by imaging techniques, most commonly X-rays. The breast is usually compressed between radiolucent plates before being exposed to relatively low-energy X-rays to emphasize differences in the soft tissues. Mammography is mainly concerned with the detection and diagnosis of breast cancer.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Breast Screening

A set of investigations aimed at the early detection of breast cancer. It includes self-screening by monthly examination of the breasts, and formal programmes of screening by palpation and mammography in special clinics. In the UK the NHS o?ers regular mammography examinations to all women between 50 and 64 years of age; in 1995–6, 1.1 million women were screened – 76 per cent of those invited. More than 5,500 cancers were detected – 5.3 per 1,000 women screened.... breast screening

Cancer - Breast

Commonest form of cancer in women. Overall mortality remains about 50 per cent at five years. Appears to run in families. Strikes hard unmarried women. Married women who have no children. Those who do not nurse their babies, or who are infertile and have no child before thirty. Eight out of ten chest lumps are benign.

Symptoms. A small lump comes to light while washing, a discharge from the nipple, change in nipple size and colour, irregular contour of the breast surface. Though tissue change is likely to be a cyst, speedy diagnosis and treatment are necessary. Some hospital physicians and surgeons are known to view favourably supportive herbal aids, and do not always think in terms of radical mastectomy. Dr Finlay Ellingwood, Chicago physician (1916) cured a case by injection of one dram Echinacea root extract twice a week into the surrounding tissues.

The condition is believed to be due to a number of causes including suppression of ovulation and oestrogen secretion in pregnant and lactating women. A high fat diet is suspected of interference with the production of oestrogen. Some women are constitutionally disposed to the condition which may be triggered by trauma or emotional shock. Increase in incidence in older women has been linked with excessive sugar consumption. “Consumption overwhelms the pancreas which has to ‘push it out’ to all parts of the body (when broken down by the digestive process) whether they need it or not. The vital organs are rationed according to their requirements of nutrients from the diet. What is left over has to ‘go into store elsewhere’. And the breast is forced to take its share and store it. If it gets too much, for too long, it may rebel!” (Stephen Seely, Department of Bacteriology and Virology, Manchester)

“Women who nurse their babies less than one month are at an increased risk for breast cancer. The longer a woman breast-feeds – no matter what her age – the more the risk decreases. (Marion Tompson, co-founder, The La Leche League, in the American Journal of Epidemiology)

Lactation reduces the risk of pre-menopausal breast cancer. (Newcomb P.A. et al New England Journal of Medicine, 330 1994)

There is currently no treatment to cure metastatic breast cancer. In spite of chemotherapy, surgery and radiotherapy survival rate has not diminished. Herbs not only have a palliative effect but, through their action on hormone function offer a positive contribution towards overcoming the condition. Their activity has been widely recorded in medical literature. Unlike cytotoxic drugs, few have been known to cause alopecia, nausea, vomiting or inflammation of the stomach.

Treatment by a general medical practitioner or oncologist.

Special investigations. Low radiation X-ray mammography to confirm diagnosis. Test for detection of oestrogen receptor protein.

Treatment. Surgery may be necessary. Some patients may opt out from strong personal conviction, choosing a rigid self-disciplined approach – the Gentle Way. Every effort is made to build up the body’s natural defences (immune system).

An older generation of herbalists believed tissue change could follow a bruise on the breast, which should not be neglected but immediately painted with Tincture Arnica or Tincture Bellis perennis.

Vincristine, an alkaloid from Vinca rosea (Catharanthus roseus) is used by the medical profession as an anti-neoplastic and anti-mitotic agent to inhibit cell division.

Of possible therapeutic value. Blue Flag root, Burdock root, Chaparral, Clivers, Comfrey root, Echinacea, Figwort, Gotu Kola, Marshmallow root, Mistletoe, Myrrh, Prickly Ash bark, Red Clover, Thuja, Wild Violet, Yellow Dock.

Tea. Equal parts: Red Clover, Clivers, Gotu Kola, Wild Violet. 1 heaped teaspoon to each cup boiling water; infuse 5-15 minutes. 3 or more cups daily.

Decoctions. Echinacea, Blue Flag root, Queen’s Delight, Yellow Dock.

Tablets/capsules. Blue Flag root, Echinacea, Poke root, Mistletoe.

Formula. Echinacea 2; Gotu Kola 1; Poke root 1; Mistletoe 1; Vinca rosea 1. Mix. Dose: Powders: 500mg (two 00 capsules or one-third teaspoon). Liquid extracts: 1 teaspoon. Tinctures: 2 teaspoons. Thrice daily and at bedtime. According to progress of the disease, increase dosage as tolerated.

Maria Treben’s tea. Parts: Marigold (3), Yarrow 1; Nettles 1. Mix. 2 teaspoons to each cup boiling water. 1 cup as many times daily as tolerated.

William Boericke, M.D. recommends Houseleek. E.H. Ruddock M.D. favours Figwort.

Topical. Treatments believed to be of therapeutic value or for use as a soothing application.

(1) Cold poultice: Comfrey root.

(2) Poultice of fresh Marshmallow root pulped in juicer.

(3) Injection of Extract Greater Celandine (Chelidonium), locally, gained a reputation in the Eclectic school.

(4) The action of Blood root (Sanguinaria) is well known as a paint or injection.

(5) Ragwort poultice: 2oz Ragwort boiled in half a pint potato water for 15 minutes. See: POULTICE.

(6) Popular Russian traditional remedy: Badiaga (Spongilla fluviatilis), fresh water sponge gathered in the autumn; dried plant rubbed to a powder. Poultice.

(7) Maria Treben’s Poultice: Carefully washed fresh Plantain leaves, pulped, and applied direct to the lesion.

(8) If lymph glands are affected, apply Plantain poultice to glands.

(9) Dr Brandini’s treatment. Dr Brandini, Florence, used 4 grains Citric Acid (prepared from lemons) in 1oz (30ml) water for ulcerated cancer of the breast considered incurable. “The woman’s torments were so distressing that neither she nor other patients could get any rest. Applying lint soaked in the solution, relief was instantaneous. Repeated, it was successful.”

(10) Circuta leaves. Simmered till soft and mixed with Slippery Elm bark powder as a poultice morning and night.

(11) Decoction. Simmer gently Yellow Dock roots, fine cut or powdered, 1oz to 1 pint, 20 minutes. Saturate lint or suitable material and apply.

(12) Yellow Dock ointment. Half ounce Lobelia seed, half ounce Yellow Dock root powder. Baste into an ointment base. See: OINTMENT BASE.

(13) Infusion, for use as a wash. Equal parts: Horsetail, Red Clover, Raspberry leaves. 1oz to 1 pint boiling water infuse 15 minutes.

(14) Dr Christopher’s Ointment. Half an ounce White Oak, half an ounce Garden Sage, half an ounce Tormentil, half an ounce Horsetail, half an ounce Lemon Balm. Method: Boil gently half an hour in quart water, strain. Reduce to half a pint by simmering. Add half a pound honey. Bring to boil. Skim off scum. Allow cool. Apply: twice daily on sores.

(15) Dr Finlay Ellingwood. Poke root juice. “Fresh juice from the stems, leaves and roots applied directly to diseased tissue. Exercises a selective action; induces liquefaction and promotes removal, sometimes healing the open wound and encouraging scar formation. Masses of such tissue have been known to be destroyed in a few weeks with only a scar, with no other application but the fresh juice. Produces pain at first, but is otherwise harmless.”

(16) Lesion painted with Mandrake resin. (American Podophyllum)

(17) Dust affected parts with Comfrey powder. Mucilage from Comfrey powder or crushed root with the aid of a little milk. See: COMFREY.

(18) Dr Samuel Thomson’s Cancer Plaster. “Take heads of Red Clover and fill a kettle. Boil in water for one hour. Remove and fill kettle with fresh flower heads. Boil as before in the same liquor. Strain and press heads to express all the liquor. Simmer over a low fire till of the consistency of tar. It must not burn. Spread over a piece of suitable material.”

(19) Wipe affected area with cut Houseleek. (Dr Wm Boericke)

(20) Chinese Herbalism. Take 1-2 Liang pulverised liao-ko-wang (Wickstroemia indica), mix with cold boiled water or rice wine for local compress. Also good for mastitis.

(21) Italian women once used an old traditional remedy – Fenugreek tea.

(22) A clinical trial of Vitamin D provided encouraging results. Patients with locally advanced breast cancer were given a highly active Vitamin D analogue cream to rub on their tumours. “It was effective in one third of the tumours,” said Professor Charles Coombes, clinical oncologist, Charing Cross Hospital, London.

Diet. “A diet rich in cereal products (high in dietary fibre) and green leafy vegetables (antioxidants) would appear to offer women some protection against breast cancer due to the relation between fibre and oestrogen metabolism. Meat-free diet. In a study of 75 adolescent girls, vegetarians were found to have higher levels of a hormone that women suffering from breast cancer often lack. (Cancer Research) Supplements. Daily. Chromium. Selenium (600mcg). Zinc chelate (100mg morning and evening). Beta carotene. “Low levels of Selenium and Vitamins A and E are shown in breast cancer cases.” (British Journal of Cancer 49: 321-324, 1984).

Vitamins A and D inhibit virus penetration in healthy cell walls. Multivitamin combinations should not include Vitamin B12, production of which in the body is much increased in cancerous conditions. Vitamins B-complex and C especially required.

Note: A link between sugar consumption and breast cancer has been reported by some authorities who suggest that countries at the top of the mortality table are the highest also in sugar consumption; the operative factor believed to be insulin.

Screening. Breast screening should be annual from the age of forty.

General. Mothers are encouraged to breast-feed children for the protection it offers against mammary malignancy. (Am.J. Obstet. Gyn. 15/9/1984. 150.)

Avoidance of stress situations by singing, playing an instrument. Adopt relaxation techniques, spiritual healing and purposeful meditation to arouse the immune system; intensive visualisation. Avoid the carcinogens: smoking, alcohol.

Information. Breast Cancer Care. Free Help Line. UK Telephone: 0500 245345. ... cancer - breast

Breast Cancer

A cancerous tumour of the breast. The incidence is raised in women whose menstrual periods began at an early age and whose menopause was late; in those who had no children or had their first child later in life; in those with mothers or sisters who had breast cancer; and in those who are obese. The disease is also more common in countries in which the typical diet contains a lot of fat. One form of breast cancer has a genetic component; 2 genes called BRAC1 and BRAC2 have been identified and appear to be involved in this type of breast cancer.

The first sign of breast cancer may be a painless lump. Other symptoms may include a dark discharge from the nipple, retraction (indentation) of the nipple, and an area of dimpled, creased skin over the lump. In 90 per cent of the cases, only 1 breast is affected. The cancer may be suspected after discovering a lump during breast self-examination or mammography. If a lump is detected, cells will be collected from it by needle aspiration or surgical biopsy. If the lump is cancerous, the treatment given depends on the woman’s age, the size of the tumour, whether or not there are signs of spread to the lymph nodes, and the sensitivity of the tumour cells to hormones, as assessed in the laboratory. A small tumour, with no evidence of having spread outside the breast, is removed surgically. Lymph nodes in the armpit are also commonly removed at the same time. Surgery may be combined with radiotherapy and/or anticancer drugs.

Secondary tumours in other parts of the body are treated with anticancer drugs and hormones. Regular check-ups are required to detect recurrence or the development of a new cancer in the other breast. If the cancer recurs, it can be controlled, in some cases, for years by drugs and/or radiotherapy.... breast cancer

Breast Cyst

A fluid-filled lump that forms within the milk-producing tissue of the breast.

Breast cysts most commonly affect women in their 40s and 50s, especially in the years around the menopause.

A lump can be diagnosed as a cyst by ultrasound scanning, a mammography, or by withdrawing fluid from it with a syringe and needle, which usually results in the lump disappearing.

About half of all women who have a breast cyst will develop future cysts.

Any new breast lump should be seen by a doctor to confirm the diagnosis.... breast cyst

Cancer Screening

Tests to detect early signs of cancer in groups of people who are susceptible to cancer because of their age, occupation, lifestyle, or genetic predisposition. Tests for cancers of the cervix (see cervical smear test), breast (see mammography), bladder, and colon have proven to be effective.... cancer screening

Nipple

The small prominence at the tip of each breast. Women’s nipples contain tiny openings through which milk can pass. The nipple and the areola, a surrounding area of dark skin, both increase in size during pregnancy. Involuntary muscle in the nipple allows it to become erect.

Structural defects of the nipple are rare. An inverted nipple is usually a harmless abnormality of development. Nipple inversion that develops in older women is mostly due to ageing, but mammography may be advisable to rule out the possibility of cancer.

Cracked nipples, common in the last months of pregnancy and during breastfeeding, may lead to infective mastitis. Washing, drying, and moisturizing the nipple daily can help to prevent cracking. Papilloma of the nipple is a noncancerous swelling attached to the skin by a stalk. Paget’s disease of the nipple appears initially as persistent eczema of the nipple and is due to a slow-growing cancer arising in a milk duct. Surgical treatment is required.Discharge from the nipple occurs for various reasons.

A clear, straw-coloured discharge may develop in early pregnancy; a milky discharge may occur after breast-feeding is over.

Galactorrhoea (milk discharge in someone who is not pregnant or breast-feeding) may be caused by a hormone imbalance, or, rarely, a galactocele (a cyst under the areola).

A discharge containing pus indicates a breast abscess.

A bloodstained discharge may be due to a noncancerous breast disorder or cancer.... nipple

Ductal Carcinoma In Situ

(DCIS) the earliest stage of breast cancer, detectable by mammography, which is confined to the lactiferous (milk) ducts of the breast. See carcinoma in situ.... ductal carcinoma in situ

Breasts, Diseases Of

The female breasts may be expected to undergo hormone-controlled enlargement at puberty, and later in pregnancy, and the glandular part of the breast undergoes evolution (shrinkage) after the menopause. The breast can also be affected by many di?erent diseases, with common symptoms being pain, nipple discharge or retraction, and the formation of a lump within the breast.

Benign disease is much more common than cancer, particularly in young women, and includes acute in?ammation of the breast (mastitis); abscess formation; and benign breast lumps, which may be ?broadenosis – di?use lumpiness also called chronic mastitis or ?brocystic disease – in which one or more ?uid-?lled sacs (cysts) develop.

Women who are breast feeding are particularly prone to mastitis, as infection may enter the breast via the nipple. The process may be arrested before a breast abscess forms by prompt treatment with antibiotics. Non-bacterial in?ammation may result from mammary duct ectasia (dilatation), in which abnormal or

blocked ducts may over?ow. Initial treatments should be with antibiotics, but if an abscess does form it should be surgically drained.

Duct ectasia, with or without local mastitis, is the usual benign cause of various nipple complaints, with common symptoms being nipple retraction, discharge and skin change.

Breast lumps form the chief potential danger and may be either solid or cystic. Simple examination may fail to distinguish the two types, but aspiration of a benign cyst usually results in its disappearance. If the ?uid is bloodstained, or if a lump still remains, malignancy is possible, and all solid lumps need histological (tissue examination) or cytological (cell examination) assessment. As well as having their medical and family history taken, any women with a breast lump should undergo triple assessment: a combination of clinical examination, imaging

– mammography for the over-35s and ultrasonagraphy for the under-35s – and ?ne-needle aspiration. The medical history should include details of any previous lumps, family history (up to 10 per cent of breast cancer in western countries is due to genetic disposition), pain, nipple discharge, change in size related to menstrual cycle and parous state, and any drugs being taken by the patient. Breasts should be inspected with the arms up and down, noting position, size, consistency, mobility, ?xity, and local lymphadenopathy (glandular swelling). Nipples should be examined for the presence of inversion or discharge. Skin involvement (peau d’orange) should be noted, and, in particular, how long changes have been present. Fine-needle aspiration and cytological examination of the ?uid are essential with ULTRASOUND, MAMMOGRAPHY and possible BIOPSY being considered, depending on the patient’s age and the extent of clinical suspicion that cancer may be present.

The commonest solid benign lump is a ?broadenoma, particularly in women of childbearing age, and is a painless, mobile lump. If small, it is usually safe to leave it alone, provided that the patient is warned to seek medical advice if its size or character changes or if the lump becomes painful. Fibroadenosis (di?use lumpiness often in the upper, outer quadrant) is a common (benign) lump. Others include periductal mastitis, fat NECROSIS, GALACTOCELE, ABSCESS, and non-breast-tissue lumps – for example, a LIPOMA (fatty tissue) or SEBACEOUS CYST. A woman with breast discharge should have a mammograph, ductograph, or total duct excision until the cause of any underlying duct ectasia is known. Appropriate treatment should then be given.

Malignant disease most commonly – but not exclusively – occurs in post-menopausal women, classically presenting as a slowly growing, painless, ?rm lump. A bloodstained nipple discharge or eczematous skin change may also be suggestive of cancer.

The most commonly used classi?cation of invasive cancers has split them into two types, ductal and lobular, but this is no longer suitable. There are also weaknesses in the tumour node metastases (TNM) system and the International Union Against Cancer (UICC) classi?cation.

The TNM system – which classi?es the lump by size, ?xity and presence of affected axillary glands and wider metastatic spread – is best combined with a pathological classi?cation, when assessing the seriousness of a possibly cancerous lump. Risk factors for cancer include nulliparity (see NULLIPARA), ?rst pregnancy over the age of 30 years, early MENARCHE, late MENOPAUSE and positive family history. The danger should be considered in women who are not breast feeding or with previous breast cancer, and must be carefully excluded if the woman is taking any contraceptive steroids or is on hormone-replacement therapy (see under MENOPAUSE).

Screening programmes involving mammography are well established, the aim being to detect more tumours at an early and curable stage. Pick-up rate is ?ve per 1,000 healthy women over 50 years. Yearly two-view mammograms could reduce mortality by 40 per cent but may cause alarm because there are ten false positive mammograms for each true positive result. In premenopausal women, breasts are denser, making mammograms harder to interpret, and screening appears not to save lives. About a quarter of women with a palpable breast lump turn out to have cancer.

Treatment This remains controversial, and all options should be carefully discussed with the patient and, where appropriate, with her partner. Locally contained disease may be treated by local excision of the lump, but sampling of the glands of the armpit of the same side should be performed to check for additional spread of the disease, and hence the need for CHEMOTHERAPY or RADIOTHERAPY. Depending on the extent of spread, simple mastectomy or modi?ed radical mastectomy (which removes the lymph nodes draining the breast) may be required. Follow-up chemotherapy, for example, with TAMOXIFEN (an oestrogen antagonist), much improves survival (it saves 12 lives over 100 women treated), though it may occasionally cause endometrial carcinoma. Analysis in the mid-1990s of large-scale international studies of breast-cancer treatments showed wide variations in their e?ectiveness. As a result the NHS has encouraged hospitals to set up breast-treatment teams containing all the relevant health professional experts and to use those treatments shown to be most e?ective.

As well as the physical treatments provided, women with suspected or proven breast cancer should be o?ered psychological support because up to 30 per cent of affected women develop an anxiety state or depressive illness within a year of diagnosis. Problems over body image and sexual diffculties occur in and around one-quarter of patients. Breast conservation and reconstructive surgery can improve the physical effects of mastectomy, and women should be advised on the prostheses and specially designed brassieres that are available. Specialist nurses and self-help groups are invaluable in supporting affected women and their partners with the problems caused by breast cancer and its treatment. Breast Cancer Care, British Association of Cancer United Patients (BACUP), Cancerlink, and Cancer Relief Macmillan Fund are among voluntary organisations providing support.... breasts, diseases of

Bipolar Affective Disorder

(BPAD) a severe mental illness affecting about 1% of the population and causing repeated episodes of *depression, *mania, and/or *mixed affective state. Type I BPAD consists equally of depressive and manic episodes, whereas Type II BPAD consists primarily of depressive episodes with occasional phases of *hypomania. Treatment is that of the individual episode. Antidepressants and antipsychotics are used to treat depressive episodes together with mood stabilizers (e.g. *lithium) or antiepileptics. Mood stabilizers are also used to prevent or lessen future episodes. Mania is most commonly treated with benzodiazepines, antipsychotics, and mood stabilizers. ECT may be used for either episode in severe cases. To prevent future episodes many patients need combinations of mood stabilizers with *antidepressant or *antipsychotic medication. Certain types of educational *psychotherapy can be used to prevent relapse as well as to treat the individual episode. Up to 50% of BPAD patients have substance abuse problems, and many suffer from residual mood symptoms between episodes.

BI-RADS (Breast Imaging Reporting and Data System) a standardized system of terminology, report organization, assessment, and classification for mammography and ultrasound or MRI of the breast. BI-RADS reporting enables radiologists to communicate results to the referring physician clearly and consistently, with a final assessment and specific management recommendations.

The success of BI-RADS has inspired several other systems of the same kind: TI-RADS (Thyroid Imaging Reporting and Data System); LI-RADS (Liver Imaging Reporting and Data System); and PI-RADS (Prostate Imaging Reporting and Data System).... bipolar affective disorder

Thermography

n. a technique for measuring and recording the heat produced by different parts of the body by using photographic film sensitive to infrared radiation. The picture produced is called a thermogram. The heat radiated from the body varies in different parts according to the flow of blood through the vessels; thus areas of poor circulation produce less heat. On the other hand a tumour with an abnormally increased blood supply may be revealed on the thermogram as a ‘hot spot’. The technique was formerly used in the diagnosis of tumours of the breast (mammothermography) before the development of more sensitive techniques (see mammography).... thermography

Xeroradiography

n. a type of X-ray imaging in which a picture of the body is recorded on paper rather than on film. A plate of selenium, which rests on a thin layer of aluminium oxide, is charged uniformly by passing it in front of a scorotron. As X-ray photons impinge on this, charges diffuse out in proportion to the energy content of the X-ray. An imprint is formed by the charge distribution on the plate, which attracts toner particles and is transferred to reusable paper plates. Unlike conventional X-ray imaging, xeroradiography does not require photographic developers. The technique does, however, require more radiation exposure. It was widely used in mammography prior to the advent of digital mammography.... xeroradiography



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