Menorrhagia Health Dictionary

A popular name for an excessive blood-stained discharge from the womb (UTERUS). (See MENSTRUATION; MENORRHAGIA.) In the majority of cases, ?ooding is the sign of a miscarriage (see ABORTION).... flooding

A periodic change occurring in (female) human beings and the higher apes, consisting chie?y in a ?ow of blood from the cavity of the womb (UTERUS) and associated with various slight constitutional disturbances. It begins between the ages of 12 and 15, as a rule – although its onset may be delayed until as late as 20, or it may begin as early as ten or 11. Along with its ?rst appearance, the body develops the secondary sex characteristics: for example, enlargement of the BREASTS, and characteristic hair distribution. The duration of each menstrual period varies in di?erent persons from 2– 8 days. It recurs in the great majority of cases with regularity, most commonly at intervals of 28 or 30 days, less often with intervals of 21 or 27 days, and ceasing only during pregnancy and lactation, until the age of 45 or 50 arrives, when it stops altogether – as a rule ceasing early if it has begun early, and vice versa. The ?nal stoppage is known as the MENOPAUSE or the CLIMACTERIC.

Menstruation depends upon a functioning ovary (see OVARIES) and this upon a healthy PITUITARY GLAND. The regular rhythm may depend upon a centre in the HYPOTHALAMUS, which is in close connection with the pituitary. After menstruation, the denuded uterine ENDOMETRIUM is regenerated under the in?uence of the follicular hormone, oestradiol. The epithelium of the endometrium proliferates, and about a fortnight after the beginning of menstruation great development of the endometrial glands takes place under the in?uence of progesterone, the hormone secreted by the CORPUS LUTEUM. These changes are made for the reception of the fertilised OVUM. In the absence of fertilisation the uterine endometrium breaks down in the subsequent menstrual discharge.

Disorders of menstruation In most healthy women, menstruation proceeds regularly for 30 years or more, with the exceptions connected with childbirth. In many women, however, menstruation may be absent, excessive or painful. The term amenorrhoea is applied to the condition of absent menstruation; the terms menorrhagia and metrorrhagia describe excessive menstrual loss – the former if the excess occurs at the regular periods, and the latter if it is irregular. Dysmenorrhoea is the name given to painful menstruation. AMENORRHOEA If menstruation has never occurred, the amenorrhoea is termed primary; if it ceases after having once become established it is known as secondary amenorrhoea. The only value of these terms is that some patients with either chromosomal abnormalities (see CHROMOSOMES) or malformations of the genital tract fall into the primary category. Otherwise, the age of onset of symptoms is more important.

The causes of amenorrhoea are numerous and treatment requires dealing with the primary cause. The commonest cause is pregnancy; psychological stress or eating disorders can cause amenorrhoea, as can poor nutrition or loss of weight by dieting, and any serious underlying disease such as TUBERCULOSIS or MALARIA. The excess secretion of PROLACTIN, whether this is the result of a micro-adenoma of the pituitary gland or whether it is drug induced, will cause amenorrhoea and possibly GALACTORRHOEA as well. Malfunction of the pituitary gland will result in a failure to produce the gonadotrophic hormones (see GONADOTROPHINS) with consequent amenorrhoea. Excessive production of cortisol, as in CUSHING’S SYNDROME, or of androgens (see ANDROGEN) – as in the adreno-genital syndrome or the polycystic ovary syndrome – will result in amenorrhoea. Amenorrhoea occasionally follows use of the oral contraceptive pill and may be associated with both hypothyroidism (see under THYROID GLAND, DISEASES OF) and OBESITY.

Patients should be reassured that amenorrhoea can often be successfully treated and does not necessarily affect their ability to have normal sexual relations and to conceive. When weight loss is the cause of amenorrhoea, restoration of body weight alone can result in spontaneous menstruation (see also EATING DISORDERS – Anorexia nervosa). Patients with raised concentration of serum gonadotrophin hormones have primary ovarian failure, and this is not amenable to treatment. Cyclical oestrogen/progestogen therapy will usually establish withdrawal bleeding. If the amenorrhoea is due to mild pituitary failure, menstruation may return after treatment with clomiphene, a nonsteroidal agent which competes for oestrogen receptors in the hypothalamus. The patients who are most likely to respond to clomiphene are those who have some evidence of endogenous oestrogen and gonadotrophin production. IRREGULAR MENSTRUATION This is a change from the normal monthly cycle of menstruation, the duration of bleeding or the amount of blood lost (see menorrhagia, below). Such changes may be the result of an upset in the balance of oestrogen and progesterone hormones which between them control the cycle. Cycles may be irregular after the MENARCHE and before the menopause. Unsuspected pregnancy may manifest itself as an ‘irregularity’, as can an early miscarriage (see ABORTION). Disorders of the uterus, ovaries or organs in the pelvic cavity can also cause irregular menstruation. Women with the condition should seek medical advice. MENORRHAGIA Abnormal bleeding from the uterus during menstruation. A woman loses on average about 60 ml of blood during her period; in menorrhagia this can rise to 100 ml. Some women have this problem occasionally, some quite frequently and others never. One cause is an imbalance of progesterone and oestrogen hormones which between them control menstruation: the result is an abnormal increase in the lining (endometrium) of the uterus, which increases the amount of ‘bleeding’ tissue. Other causes include ?broids, polyps, pelvic infection or an intrauterine contraceptive device (IUD – see under CONTRACEPTION). Sometimes no physical reason for menorrhagia can be identi?ed.

Treatment of the disorder will depend on how severe the loss of blood is (some women will become anaemic – see ANAEMIA – and require iron-replacement therapy); the woman’s age; the cause of heavy bleeding; and whether or not she wants children. An increase in menstrual bleeding may occur in the months before the menopause, in which case time may produce a cure. Medical or surgical treatments are available. Non-steroidal anti-in?ammatory drugs may help, as may tranexamic acid, which prevents the breakdown of blood clots in the circulation (FIBRINOLYSIS): this drug can be helpful if an IUD is causing bleeding. Hormones such as dydrogesterone (by mouth) may cure the condition, as may an IUD that releases small quantities of a PROGESTOGEN into the lining of the womb.

Traditionally, surgical intervention was either dilatation and curettage of the womb lining (D & C) or removal of the whole uterus (HYSTERECTOMY). Most surgery is now done using minimally invasive techniques. These do not require the abdomen to be cut open, as an ENDOSCOPE is passed via the vagina into the uterus. Using DIATHERMY or a laser, the surgeon then removes the whole lining of the womb. DYSMENORRHOEA This varies from discomfort to serious pain, and sometimes includes vomiting and general malaise. Anaemia is sometimes a cause of painful menstruation as well as of stoppage of this function.

In?ammation of the uterus, ovaries or FALLOPIAN TUBES is a common cause of dysmenorrhoea which comes on for the ?rst time late in life, especially when the trouble follows the birth of a child. In this case the pain exists more or less at all times, but is aggravated at the periods. Treatment with analgesics and remedying the underlying cause is called for.

Many cases of dysmenorrhoea appear with the beginning of menstrual life, and accompany every period. It has been estimated that 5–10 per cent of girls in their late teens or early 20s are severely incapacitated by dysmenorrhoea for several hours each month. Various causes have been suggested for the pain, one being an excessive production of PROSTAGLANDINS. There may be a psychological factor in some sufferers and, whether this is the result of inadequate sex instruction, fear, family, school or work problems, it is important to o?er advice and support, which in itself may resolve the dysmenorrhoea. Symptomatic relief is of value.... menstruation

A drug used in the control of bleeding. It inhibits the activation of PLASMINOGEN and FIBRINOLYSIS, and may be useful when bleeding cannot be stopped – for instance, dental extraction in HAEMOPHILIA. The drug is also useful in MENORRHAGIA.... tranexamic acid

This drug inhibits pituitary gonadotrophin secretion (see PITUITARY GLAND; GONADOTROPHINS) and is used in the treatment of ENDOMETRIOSIS, MENORRHAGIA and GYNAECOMASTIA. The dose is usually of the order of 100 mg twice daily and side-effects may include nausea, dizziness, ?ushing and skeletal muscle pain. It is mildly androgenic (see ANDROGEN).... danazol

Ficus spp.

Moraceae

The genus Ficus constitutes an important group of trees with immense medicinal value. It is a sacred tree of Hindus and Buddhists. Among the varied number of species, the most important ones are the four trees that constitute the group “Nalpamaram”, namely, F. racemosa, F. microcarpa, F. benghalensis and F. religiosa (Athi, Ithi, Peral and Arayal respectively).

1. Ficus racemosa Linn. syn. F. glomerata Roxb.

Eng: Cluster fig, Country fig

San: Udumbarah, Sadaphalah

Hin: Gular, Umar

Ben: Jagya dumur

Mal, Tam,

Kan: Athi

Tel: Udambaramu, Paidi

Gular fig, Cluster fig or Country fig, which is considered sacred, has golden coloured exudate and black bark. It is distributed all over India. Its roots are useful in treating dysentery. The bark is useful as a wash for wounds, highly efficacious in threatened abortions and recommended in uropathy. Powdered leaves mixed with honey are given in vitiated condition of pitta. A decoction of the leaves is a good wash for wounds and ulcers. Tender fruits (figs) are used in vitiated conditions of pitta, diarrhoea, dyspepsia and haemorrhages. The latex is administered in haemorrhoids and diarrhoea (Warrier et al, 1995). The ripe fruits are sweet, cooling and are used in haemoptysis, thirst and vomiting (Nadkarni, 1954; Aiyer et al, 1957; Moos, 1976). Nalpamaradi coconut oil, Candanasava, Valiya Arimedastaila, Dinesavalyadi Kuzhambu, Abhrabhasma, Valiya candanaditaila, etc. are some important preparations using the drug (Sivarajan et al, 1994).

It is a moderate to large-sized spreading laticiferous, deciduous tree without many prominent aerial roots. Leaves are dark green and ovate or elliptic. Fruit receptacles are 2-5cm in diameter, sub- globose or pyriform arranged in large clusters on short leafless branches arising from main trunk or large branches. Figs are smooth or rarely covered with minute soft hairs. When ripe, they are orange, dull reddish or dark crimson. They have a pleasant smell resembling that of cedar apples. The bark is rusty brown with a fairly smooth and soft surface, the thickness varying from 0.5-2cm according to the age of the trunk or bark. Surface is with minute separating flakes of white tissue. Texture is homogeneously leathery (Warrier et al, 1995).

Stem-bark gives gluanol acetate, -sitosterol, leucocyanidin-3-O- -D-glucopyrancoside, leucopelargonidin-3-O- -D-glucopyranoside, leucopelargonidin -3-O- -L-rhamnopyranoside, lupeol, ceryl behenate, lupeol acetate and -amyrin acetate. Stem- bark is hypoglycaemic and anti-protozoal. Gall is CVS active. Bark is tonic and used in rinder pest diseases of cattle. Root is antidysenteric and antidiabetic. Leaf is antibilious. Latex is antidiarrhoeal and used in piles. Bark and syconium is astringent and used in menorrhagia (Husain et al, 1992).

2. Ficus microcarpa Linn. f. syn. F. retusa auct. Non. Linn.

San: Plaksah; Hin,

Ben: Kamarup;

Mal: Ithi, Ithiyal;

Tam: Kallicci, Icci;

Kan: Itti;

Tel: Plaksa

Plaksah is the Ficus species with few branches and many adventitious roots growing downward. It is widely distributed throughout India and in Sri Lanka, S. China, Ryuku Isles and Britain. Plakasah is one of the five ingredients of the group panchvalkala i.e, five barks, the decoction of which is extensively used to clear ulcers and a douche in leucorrhoea in children. This decoction is administered externally and internally with satisfactory results. Plaksah is acclaimed as cooling, astringent, and curative of raktapitta doshas, ulcers, skin diseases, burning sensation, inflammation and oedema. It is found to have good healing property and is used in preparation of oils and ointments for external application in the treatment of ulcers (Aiyer and Kolammal, 1957). The stem-bark is used to prepare Usirasava, Gandhataila, Nalpamaradi taila, Valiya marmagulika, etc. (Sivarajan et al, 1994). The bark and leaves are used in wounds, ulcers, bruises, flatulent colic, hepatopathy, diarrhoea, dysentery, diabetes, hyperdipsia, burning sensation, haemaorrhages, erysipelas, dropsy, ulcerative stomatitis, haemoptysis, psychopathy, leucorrhoea and coporrhagia (Warrier et al,1995) F. microcarpa is a large glabrous evergreen tree with few aerial roots. Leaves are short- petioled, 5-10cm long, 2-6cm wide and apex shortly and bluntly apiculate or slightly emarginate. Main lateral nerves are not very prominent and stipules are lanceolate. Fruit receptacles are sessile and globose occurring in axillary pairs. It is yellowish when ripe without any characteristic smell. Bark is dark grey or brown with a smooth surface except for the lenticels. Outer bark is corky and crustaceous thin and firmly adherent to inner tissue. Inner bark is light and flesh coloured with firbrous texture (Warrier et al, 1995). It is also equated with many other species of the genus. viz. F. Singh and Chunekar, 1972; Kapoor and Mitra, 1979; Sharma, 1983).

The bark contains tannin, wax and saponin. Bark is antibilious. Powdered leaves and bark is found very good in rheumatic headache. The bark and leaves are astringent, refrigerant, acrid and stomachic.

3. Ficus benghalensis Linn.

Eng: Banyan tree; San: Nyagrodhah, Vatah;

Hin: Bat, Bargad;

Ben: Bar, Bot; Mar: Vada; Mal: Peral, Vatavriksham;

Tam: Alamaram, Peral;

Kan: Ala;

Tel: Peddamarri;

Guj: Vad

Banyan tree is a laticiferous tree with reddish fruits, which is wound round by aerial adventitious roots that look like many legs. It is found in the Sub-Himalayan tract and Peninsular India. It is also grawn throughout India. It is widely used in treatment of skin diseases with pitta and rakta predominance. Stem-bark, root -bark, aerial roots, leaves, vegetative buds and milky exudate are used in medicine. It improves complexion, cures erysepelas, burning sensation and vaginal disorders, while an infusion of the bark cures dysentery, diarrhoea, leucorrhoea, menorrhagia, nervous disorders and reduces blood sugar in diabetes. A decoction of the vegetative buds in milk is beneficial in haemorrhages. A paste of the leaves is applied externally to abcesses and wounds to promote suppuration, while that of young aerial roots cure pimples. Young twigs when used as a tooth brush strengthen gum and teeth (Nadkarni, 1954; Aiyer and Kolammal, 1957; Mooss,1976). The drug forms an important constituent of formulations like Nalpamaradi Coconut oil, Saribadyasava, Kumkumadi taila, Khadi ra gulika, Valiyacandanadi taila, Candanasava, etc. (Sivarajan et al, 1994). The aerial roots are useful in obstinate vomiting and leucorrhoea and are used in osteomalacia of the limbs. The buds are useful in diarrhoea and dysentery. The latex is useful in neuralgia, rheumatism, lumbago, bruises, nasitis, ulorrhagia, ulitis, odontopathy, haemorrhoids, gonorrhoea, inflammations, cracks of the sole and skin diseases (Warrier et al, 1995).

It is a very large tree up to 30m in height with widely spreading branches bearing many aerial roots functioning as prop roots. Bark is greenish white. Leaves are simple, alternate, arranged often in clusters at the ends of branches. They are stipulate, 10-20cm long and 5-12.5cm broad, broadly elliptic to ovate, entire, coriaceous, strongly 3-7 ribbed from the base. The fruit receptacles are axillary, sessile, seen in pairs globose, brick red when ripe and enclosing male, female and gall flowers. Fruits are small, crustaceous, achenes, enclosed in the common fleshy receptacles. The young bark is somewhat smooth with longitudinal and transverse row of lenticels. In older bark, the lenticels are numerous and closely spaced; outer bark easily flakes off. The fresh cut surface is pink or flesh coloured and exudes plenty of latex. The inner most part of the bark adjoining the wood is nearly white and fibrous (Warrier et al, 1995).

The bark yields flavanoid compounds A, B and C; A and C are identified as different forms of a leucoanthocyanidin and compound B a leucoanthocyanin. All the 3 were effective as hypoglycaemic agents. Leaves give friedelin, -sitosterol, flavonoids- quercetin-3-galactoside and rutin. Heart wood give tiglic acid ester of taraxasterol. Bark is hypoglycemic, tonic, astringent, antidiarrhoeal and antidiabetic. Latex is antirheumatic. Seed is tonic. Leaf is diaphoretic. Root fibre is antigonorrhoeic. Aerial root is used in debility and anaemic dysentery (Husain et al, 1992).

.4. Ficus religiosa Linn.

Eng:Peepal tree, Sacred fig; San:Pippalah, Asvatthah; Hin:Pippal, Pipli, Pipar; Mal:Arayal

Ben: Asvatha;

Tam: Arasu, Asvattam;

Kan: Aswatha;

Tel: Ravi; Mar: Ashvata, Pimpala

Peepal tree or Sacred fig is a large deciduous tree with few or no aerial roots. It is common throughout India, often planted in the vicinity of the temples. An aqueous extract of the bark has an antibacterial activity against Staphylococcus aureus and Escherichia coli. It is used in the treatment of gonorrhoea, diarrhoea, dysentery, haemorrhoids and gastrohelcosis. A paste of the powdered bark is a good absorbent for inflammatory swellings. It is also good for burns. Leaves and tender shoots have purgative properties and are also recommended for wounds and skin diseases. Fruits are laxative and digestive. The dried fruit pulverized and taken in water cures asthma. Seeds are refrigerant and laxative. The latex is good for neuralgia, inflammations and haemorrhages (Warrier et al, 1995). Decoction of the bark if taken in honey subdues vatarakta (Nadkarni, 1954; Aiyer and Kolammal, 1957; Mooss, 1976; Kurup et al, 1979). The important preparations using the drug are Nalpamaradi taila, Saribadyasava, Candanasava, Karnasulantaka, Valiyamarma gulika etc (Sivarajan et al, 1994). branches bearing long petioled, ovate, cordate shiny leaves. Leaves are bright green, the apex produced into a linear-lanceolate tail about half as long as the main portion of the blade. The receptacles occurring in pairs and are axillary, depressed globose, smooth and purplish when ripe. The bark is grey or ash coloured with thin or membranous flakes and is often covered with crustose lichen patches. The outer bark is not of uniform thickness, the middle bark in sections appear as brownish or light reddish brown. The inner part consists of layers of light yellowish or orange brown granular tissue (Warrier et al, 1995).

Bark gives -sitosterol and its glucoside. Bark is hypoglycaemic. Stem bark is antiprotozoal, anthelmintic and antiviral. Bark is astringent, antigonorrheic, febrifuge, aphrodisiac and antidysenteric. Syconium, leaf and young shoot is purgative (Husain et al, 1992).

Agrotechnology: Ficus species can be cultivated in rocky areas, unused lands, or other wastelands of the farmyard. The plant is vegetatively propagated by stem cuttings. A few species are also seed propagated. Stem cuttings of pencil thickness taken from the branches are to be kept for rooting. Rooted cuttings are to be transplanted to prepared pits. No regular manuring is required. Irrigation is not a must as a plant is hardy. The plant is not attacked by any serious pests or diseases. Bark can be collected after 15 years. Ficus species generally has an economic life span of more than hundred years. Hence bark can be regularly collected from the tree. Root, bark, leaves, fruits and latex form the economic parts (Prasad et al,1995).... ficus

Saraca asoca

Caesalpiniaceae

San:Asoka, Gatasokah;

Hin:Asok, Asoka; Ben:Ashok; Mal:Asokam;

Tam: Asogam;

Kan:Asokada, Aksunkara;

Tel: Asokamu, Vanjalamu

Importance: Ashoka, the sacred tree of Hindus and Buddhists, possesses varied medicinal uses. The bark is useful in dyspepsia, fever, dipsia, burning sensation, visceromegaly, colic, ulcers, menorrhagia, metropathy, leucorrhoea and pimples. The leaf juice mixed with cumin seeds is used for treating stomachalagia. The floweres are considered to be uterine tonic and are used in vitiated conditions of pitta, syphilis, cervical adinitis, hyperdipsia, burning sensation, haemorrhoids, dysentery, scabies in children and inflammation. The well-known Ayurvedic preparations are ”Ashokarishta” and “Ashokaghrita”. Ashokarishta is prescribed in leucorrhoea, haematuria, menorrhagia and other diseases of genitourinary system of females.

Distribution: Ashoka is found almost throughout India, except North-Western India, upto 750m. It is also found in the Andaman Islands.

Botany: Saraca asoca (Roxb.) de Wilde. syn. S. indica auct. non Linn. is a medium sized evergreen tree growing upto 9m height with numerous spreading and drooping glabrous branches. Leaves are pinnate, 30-60cm long having 2-3 pairs of lanceolate leaflets. Flowers are orange or orange yellow, arranged in dense corymbs and very fragrant. Fruits are flat black pods, leathery and compressed with 4-8 seeds/pod. Seeds are ellipsoid oblong and compressed. The bark is dark brown to grey or black with a warty surface. The thickness varies from 5mm to 10mm. The entire cut surface turns reddish on exposure to air. Polyalthia longifolia (Annonaceae) is equated with the name Asoka by some (Kapoor & Mitra, 1979; Chunekar, 1982) and is often used as an adulterant of the genuine Asoka bark or as a substitute (Warrier et al,1996).

Agrotechnology: Asoka grows well in areas with well distributed rainfall and in slightly shady areas. Asoka requires soil rich in organic mater and moisture. The best season of planting is June-July. It is also grown in summer, if irrigation facilities are available. The plant is seed propagated. Seeds are formed usually during February-April. Seeds are collected when they are ripen and fall down and are sown after soaking in water for 12 hours on the prepared beds. Seeds germinate within 20 days. The seeds are then planted in polybags. 2-month-old seedlings from the polybags are used for transplanting. Square shaped pits of 60cm depth are taken at 3m spacing and filled with topsoil, sand and dried cowdung. On this the seedlings are planted. Application of FYM at 10kg/tree/year is highly beneficial. Chemical fertilisers are not usually applied. Irrigation during summer months is essential. No serious pests or diseases are generally noted in this crop. If properly cultivated, Asoka can be cut after 20 years and the bark collected. It is cut at a height of 15cm from the soil level. If given irrigation and fertilisers, the cut wood will sprout again and harvested again after 5 years. This can be continued. When it is difficult to cut the tree, the bark can be peeled off from one side first. When the bark grows and cover that part, the other side can be peeled off. This is also continued (Prasad et al, 1997; Karshakasree, 1998).

Properties and activity: Flowers give -sitosterol, flavonoids and flavone glycosides-quercetin, kaempferol-3-O- -D- glucoside, quercetin-3-O- -D-glucoside. The anthocyanins present are pelargonidin-3, 5-diglucoside and cyanadin-3, 5-diglucoside. Bark yields catechol and sterols-(24)-24-methyl cholest-5-en-3 -ol, (22E, 24)-24-ethylcholesta-5, 22-dien-3 -ol and (24)-24-ethyl cholest-5-en-3 -ol, a wax containing n-alkanes, esters and free primary alcohols. Alcoholic extract and glycoside P2 from stem bark is oxytoxic. Aerial part is CNS active, hypothermic, CNS depressant and diuretic. Stem bark is anticancerous, has spasmodic action on rabbit intestine and cardiotonic action in frog and dog. Seed is antifungal. Stem bark is astringent, antileucorrhoeic, antibilious and uterine sedative. Flower is uterine tonic, antidiabetic and antisyphilitic. Stem bark and flower is antibilious (Husain et al, 1992).... ashoka

A treatment for persistent menorrhagia (heavy menstrual blood loss) that involves endoscopic examination of the uterus (see endoscopy) and removal of the uterus lining, the endometrium, by diathermy or laser.... endometrial ablation

Catharanthus roseus

Apocynaceae

San: Nityakalyani;

Hin: Sadabahar, Baramassi;

Mal: Ushamalari, Nityakalyani

Tel: Billaganeru;

Tam: Sudukattu mallikai; Pun: Rattanjot;

Kan: Kasikanigale, Nitya Mallige

Importance: Periwinkle or Vinca is an erect handsome herbaceous perennial plant which is a chief source of patented cancer and hypotensive drugs. It is one of the very few medicinal plants which has a long history of uses as diuretic, antidysenteric, haemorrhagic and antiseptic. It is known for use in the treatment of diabetes in Jamaica and India. The alkaloids vinblastine and vincristine present in the leaves are recognized as anticancerous drugs. Vinblastine in the form of vinblastin sulphate is available in market under the trade name “VELBE” and Vincristine sulphate as “ONCOVIN” (Eli Lilly). Vinblastine is used in combination with other anticancer agents for the treatment of lymphocytic lymphoma, Hodgkin’s disease, testicular carcinoma and choriocarcinoma. Vincristine is used in acute leukemia, lymphosarcoma and Wilm’s tumour. Its roots are a major source of the alkaloids, raubasine (ajmalicine), reserpine and serpentine used in the preparation of antifibrillic and hypertension-relieving drugs. It is useful in the treatment of choriocarcinoma and Hodgkin’s disease-a cancer affecting lymph glands, spleen and liver. Its leaves are used for curing diabetes, menorrhagia and wasp stings. Root is tonic, stomachic, hypotensive, sedative and tranquilliser (Narayana and Dimri,1990).

Distribution: The plant is a native of Madagascar and hence the name Madagascar Periwinkle. It is distributed in West Indies, Mozambique, South Vi etnam, Sri Lanka , Philippines and Australia. It is well adapted to diverse agroclimatic situations prevalent in India and is commercially cultivated in the states of Tamil Nadu, Karnataka, Gujarat, Madhya Pradesh and Assam. USA, Hungary, West Germany, Italy, Netherlands and UK are the major consumers.

Botany: Catharanthus roseus (Linn.) G.Don.

syn. Vinca rosea Linn. belongs to the family Apocynaceae. It is an erect highly branched lactiferous perennial herb growing up to a height of one metre. Leaves are oblong or ovate, opposite, short-petioled, smooth with entire margin. Flowers are borne on axils in pairs. There are three flower colour types , pink, pink-eyed and white. Calyx with 5 sepal, green, linear, subulate. Corolla tube is cylindrical with 5 petals, rose-purple or white with rose-purple spot in the centre; throat of corolla tube hairy, forming a corona-like structure. The anthers are epipetalous borne on short filaments inside the bulging distal end of corolla tube converging conically above the stigma. Two characteristic secretary systems, namely a column like nectarium on both sides of pistil and a secretory cringulam circling the papillate stigma with a presumed role in pollination - fecundation process are present. Ovary bicarpellary, basally distinct with fused common style and stigma. The dehiscent fruit consists of a pair of follicles each measuring about 25 mm in length and 2.3 mm in diameter, containing up to thirty linearly arranged seeds with a thin black tegumen. On maturity, the follicles split along the length dehiscing the seeds.

Agrotechnology: Periwinkle grows well under tropical and subtropical climate. A well distributed rainfall of 1000 mm or more is ideal. In north India the low winter temperatures adversely affect the crop growth. It can grow on any type of soil ,except those which are highly saline, alkaline or waterlogged. Light soils, rich in humus are preferable for large scale cultivation since harvesting of the roots become easy.

Catharanthus is propagated by seeds. Fresh seeds should be used since they are short-viable. Seeds can be either sown directly in the field or in a nursery and then transplanted. Seed rate is 2.5 kg/ha for direct sowing and the seeds are drilled in rows 45 cm apart or broadcasted. For transplanted crop the seed rate is 500gm/ha. Seeds are sown in nursery and transplanted at 45x 30cm spacing after 60 days when the seedlings attain a height of 15-20cm Nursery is prepared two months in advance so that transplanting coincides with the on set of monsoons. Application of FYM at the rate of 15 t/ha is recommended. An alternate approach is to grow leguminous green manure crops and incorporate the same into the soil at flowering stage. Fertilisers are recommended at 80:40:40 kg N:P2O5:K2O/ha for irrigated crop and 60:30:30 kg/ha for rainfed crop. N is applied in three equal splits at planting and at 45 and 90 days after planting. 4 or 5 irrigations will be needed to optimise yield when rainfall is restricted. Fortnightly irrigations support good crop growth when the crop is grown exclusively as an irrigated crop. Weeding is carried out before each topdressing. Alternatively, use of fluchloraline at 0.75 kg a.i. /ha pre-plant or alachlor at 1.0 kg a.i. per ha as pre-emergence to weeds provides effective control of a wide range of weeds in periwinkle crop. Detopping of plants by 2cm at 50% flowering stage improves root yield and alkaloid contents. No major pests, other than Oleander hawk moth, have been reported in this crop. Fungal diseases like twig blight (top rot or dieback) caused by Phytophthora nicotianae., Pythium debaryanum, P. butleri and P. aphanidermatum; leaf spot due to Alternaria tenuissima, A. alternata, Rhizoctonia solani and Ophiobolus catharanthicola and foot-rot and wilt by Sclerotium rolfsii and Fusarium solani have been reported. However, the damage to the crop is not very serious. Three virus diseases causing different types of mosaic symptoms and a phyllody or little leaf disease due to mycoplasma -like organisms have also been reported; the spread of which could be checked by uprooting and destroying the affected plants.

The crop allows 3-4 clippings of foliage beginning from 6 months. The flowering stage is ideal for collection of roots with high alkaloid content. The crop is cut about 7 cm above the ground and dried for stem, leaf and seed. The field is irrigated, ploughed and roots are collected. The average yields of leaf, stem and root are 3.6, 1.5and 1.5 t/ha, respectively under irrigated conditions and 2.0, 1.0 and 0.75t/ha, respectively under rainfed conditions on air dry basis. The harvested stem and roots loose 80% and 70% of their weight, respectively. The crop comes up well as an undercrop in eucalyptus plantation in north India. In north western India a two year crop sequence of periwinkle-senna-mustard or periwinkle-senna- coriander are recommended for higher net returns and productivity (Krishnan,1995).

Properties and activity: More than 100 alkaloids and related compounds have so far been isolated and characterised from the plant. The alkaloid contents in different parts show large variations as roots 0.14-1.34%, stem 0.074-0.48%, leaves 0.32-1.16%, flowers 0.005-0.84%, fruits 0.40%, seeds 0.18% and pericarp 1.14% (Krishnan et al, 1983). These alkaloids includes monomeric indole alkaloids, 2-acyl indoles, oxindole, -methylene indolines, dihydroindoles, bisindole and others. Dry leaves contain vinblastine (vincaleucoblastine or VLB) 0.00013-0.00063%, and vincristine (leurocristine or LC) 0.0000003-0.0000153% which have anticancerous activity (Virmani et al, 1978). Other alkaloids reported are vincoside, isovincoside (strictosidine), catharanthine, vindolinine, lochrovicine, vincolidine, ajmalicine (raubasine), reserpine, serpentine, leurosine, lochnerine, tetrahydroalstonine, vindoline, pericalline, perivine, periformyline, perividine, carosine, leurosivine, leurosidine and rovidine. The different alkaloids possessed anticancerous, antidiabetic, diuretic, antihypertensive, antimicrobial, antidysenteric, haemorrhagic, antifibrillic, tonic, stomachic, sedative and tranquillising activities.... periwinkle

Linn.

Family: Amaranthaceae.

Habitat: Throughout the tropical and subtropical regions, up to an altitude of 2,100 m, in the southern Andaman Islands.

English: Prickly Chaff Flower.

Ayurvedic: Apaamaarga, Chirchitaa, Shikhari, Shaikharika, Adahshalya, Mayura, Mayuraka, Kharamanjari, Kharapushpaa, Pratyakpushpaa, Aaghaat, Vashira, Kanihi.

Unani: Chirchitaa.

Siddha/Tamil: Naayuruvi.

Folk: Chirchitta, Chichidaa, Latjeeraa.

Action: Astringent, pectoral (ashes of the plant used in asthma and cough), diuretic, hepatoprotective, emmenagogue. Benzene extract of the plant exhibited abortifacient activity. The flowers, ground and mixed with sugar, are given for menorrhagia. Roots—astringent, haemostatic. Seeds—emetic; used for biliousness. Essential oil— antifungal.

Key application: As astringent, emetic. (Indian Herbal Pharmacopoeia.)

Along with other therapeutic applications, The Ayurvedic Pharmacopoeia of India indicates the use of the whole plant in lipid disorders and obesity, the root for its blood-purifying property.

The plant juice and ash are used for treating bleeding piles. An alkaline powder of the plant is used in preparing Kshaarasutra of Ayurvedic medicine, which is recommended for treating fistula-in-ano.

The whole plant contains the alkaloids achyranthine and betaine. Achy- ranthine, a water-soluble alkaloid, is reported to dilate blood vessels, lower blood pressure, decrease heart rate and increase the rate and amplitude of respiration. It also shows spasmodic effects on the rectus muscle of frog, diuretic and purgative action in albino rats.

The presence of ecdysterone and oleanolic acid is also reported in the root.

The ashes of the plant yield large quantities of potash. The seeds yield saponins and oleanolic acid and its ester.

The presence of tannins and glyco- sides is also reported in the plant.

Dosage: Whole plant—20-30 g for decoction. Root—5-10 g. (API Vols. II, III.) Ash—500 mg to 2 g. (CCRAS.)... achyranthes aspera

Nees.

Synonym: A. zeylanica Medic. Justicia adhatoda Linn.

Family: Acanthaceae.

Habitat: Throughout India, up to an altitude of 1,300 m.

English: Malabar Nut, Vasaca.

Ayurvedic: Vaasaa, Vaasaka, Vaasikaa, Simhaasya, Simhaparni, Simhavadanaa, Vaajidanta, Vrisha, Aataruushaka.

Unani: Arusaa.

Siddha/Tamil: Aadaathodai.

Folk: Vasaakaa.

Action: Expectorant (used in bronchial, asthmatic and pulmonary affections), antispasmodic, febrifuge.

Key application: As bronchodilatory, expectorant. (Indian Herbal Pharmacopoeia.) The Ayurvedic Pharmacopoeia of India indicates its use in dyspnoea.

The chief quinazoline alkaloid vas- icine is reported in all parts of the plant, the highest being in inflorescence. It is a bitter bronchodilator, respiratory stimulant, hypotensive, cardiac depressant, uterotonic and aborti- facient. An aqueous solution of va- sicinone hydrochloride, when studied in mice and dogs, was found to potentiate the bronchodilatory activity of aminophylline, also that of isopre- naline. Vasicinone exhibited smooth- muscle-relaxant properties of airways.

Alkaloids present in the plant showed significant protection against allergin-induced bronchial obstruction in guinea pigs.

The leaves are found to activate the digestive enzyme trypsin.

An extract of the leaves showed significant antifungal activity against ringworm.

Adhatoda beddomei C.B. Clarke, found in Kerala, is considered to be more powerful and active than A. vasi- ca. Fresh leaf juice is used in haemoptysis and menorrhagia, also as an antiasthmatic.

Jacobinia tinctoria Henl. is equated with the red-flowered var. of Vaasaa.

Dosage: Leaf—10-20 ml juice. Dried leaves—10-20 g for deoction. Root—3-6 g powder. (API Vols. I, IV)... adhatoda vasica

Kurz.

Synonym: E. viride (Forsk.) Alston. Justica ecbolium Linn.

Family: Acanthaceae.

Habitat: Northeastern Peninsular India.

English: Blue Fox Tail Nail Dye.

Siddha/Tamil: Nilambari.

Action: Plant—used in gout and dysuria; decoction of leaves for stricture. Roots—given in jaundice, menorrhagia and rheumatism.... ecbolium linneanum

Holostemma ada-kodien

Asclepiadaceae

San: Jivanti;

Hin: Chirvel, Charivel;

Mal: Atapathiyan, Atapotiyan, Atakotiyan;

Tam: Palaikkirai;

Tel: Palagurugu; Mar: Dudurli, Shidodi;

Guj: Kharner, Khiravel

Importance: Holostemma is a twining shrub with large flowers. The roots of Holostemma are useful in ophthalmopathy, orchitis, cough, burning sensation, stomachalgia, constipation, fever and tridoshas. The leaves, flowers and fruits are eaten as vegetable. The root is also used in spermatorrhoea. It is used in preparations of Vidaryadiganam, Dhanwandharam thaila, Manasamithravatakam, Balarishta and Anuthaila. It is also useful in eye diseases and it imparts resistance to diseases.

Distribution: The plant occurs in tropical countries. In India, it is found in Himalayas, Dehradun, Konkan, Bombay, Deccan, Karnataka, Kerala and Tamilnadu. It grows over hedges and in open forests especially on the lower slopes of the hills. It is also distributed in Sri Lanka, Burma and W. China.

Botany: Holostemma ada-kodien Schult. syn. Holostemma annulare (Roxb.) K. Schum.

Holostemma rheedii Wall. belongs to the family Asclepiadaceae. It is a laticiferous twining shrub with large conspicuous flowers. Leaves are simple, opposite and cordate. Flowers are purple, arranged in axillary umbellate cymes. Fruits are thick follicles, 9 cm long, cylindrical and bluntly pointed. The roots are long upto 1 m or more, irregularly twisted, thick and cylindrical. When dry it is yellowish brown to brown black in colour with nearly smooth surface bearing white scars and small depressions. A mature root is about 1-2 cm thick when extracted for use (Warrier et al, 1995).

Agrotechnology: Holostemma prefers a tropical climate. The plant is propagated vegetatively by stem cuttings, but mainly by seeds. The seeds are collected from the plant in November-December before being dispersed. Seeds are cleaned, dried and stored for sowing. The stored seeds after soaking in water for 4-5 hours are sown in the seedbeds. About one month old seedlings are then planted in polybags of size 14x10cm which are filled with soil, sand and dried cowdung in 1:1:1 ratio, respectively. Polybags should be kept in shade and irrigated. About 1-1.5 month old seedlings are ready for transplanting. Pits of 30cm cube size are taken at 1-1.2m distance and filled with 10kg dried cowdung and sand. This is covered with surface soil and formed into a mound. Seedlings are transplanted on to the mounds from the polybags carefully. Regular irrigation is to be given till flowering. To aid in trailing, staking is given one month after planting. Flowering and fruiting occurs in November-December. Harvesting can be done at the end of second year when the vines start drying up. Harvesting is done by digging up the tubers. The tubers are cut into pieces of 10cm length and dried in sun before sale (Prasad et al, 1997).

Properties and activity: Holostemma tubers give -amyrin, lupeol and -sitosterol. Alanine, aspartic acid, glycine, serine, threonine and valine were detected chromatographically (Hussain et al, 1992). The root is antidiabetic, antigonorrhoeic, bechic, alterative, tonic, lactative, ophthalmic, emollient, stimulant, aphrodisiac, expectorant and galactagogue.

BLACH MUSALE Curculigo orchioides Amaryllidaceae

San: Musali;

Hin: Kalimusali, Mushali;

Ben: Talamuli;

Mal: Nilappana;

Guj: Musalikand

Tam: Nilapanai;

Tel: Nelatadi Kelangu;

Kan: Neladali

Importance: Musali is a small, geophilous herb, the tuberous rootstock of which is used as a rejuvenating and aphrodisiac drug. It cures morbid vata and pitta, improves complexion and is useful in general debility, deafness, cough, asthma, piles, skin diseases, impotence, jaundice, urinary disorders, leucorrhoea and menorrhagia (Nadkarni, 1954; Aiyer and Kolammal, 1963; Mooss, 1978). Rootstock is the officinal part and it enters into the Ayurvedic formulations like Vidaryadighrta, Vidaryadi lehya, Marmagulika, Musalyadi churna etc. The Pharmacognosy of C. orchioides has been discussed by Aiyer, Kolamma l (1963), Raghunathan, and Mitra (1982). A bibliographical study on C. orchioides has been done by Pandey et al (1983).

Distribution: The plant is found in all districts of India from near sea level to 2300m altitude, especially in rock crevices and laterite soil. It has been recorded to occur in the sub tropical Himalayas from Kumaon eastwards ascending to 1800m, the Khasia hills, Bengal, Asssam, Konkan, Kanara, the western peninsula and Madras extending south as far as a Cape Comerin. It is also distributed in Sri Lanka, Japan, Malaysia and Australia.

Botany: Curculigo orchioides Gaertn. syn. C. malabarica Wight, C. brevifolia Dryand, Hypoxis dulcis Stand belongs to the family Amaryllidaceae. Musali is a small herbaceous plant with cylindrical rootstock. Leaves are simple, sessile, crowded on the short stem with sheathing leaf bases. Flowers are bright yellow. Seeds are black, deeply grooved in wavy lines.

A detailed description of the plant is as follows (Victoria, 1998). Rootstock is straight, cylindrical, tuberous, 5-22cm long, 0.5-0.8 cm thick, brownish surfaces marked with closely spaced prominent transverse wrinkles in the upper or basal half. It bears a few stout lateral roots of 5 or more cm long. Lateral roots are dull white in colour and spongy externally. The fresh cut surfaces of the rootstock has a starch white colour and mucilaginous. A few fibrous roots also occur. Leaves are sessile or short petiolate with sheathing bases, 15-45x1.2-2.5 cm size, linear or linear lanceolate, membranous, glabrouus or sparsely sofly hairy and plicate in bud. The leaf tips when contacts the soil, develops roots and produce adventitious buds. Inflorescence is axillary, scapose racemose, the scape very short and hidden among the bases of leaves underground, clavte, flattened with the pedicels, bracts and the ovary concealed in the leaf sheaths. The lower big flowers on the scape are mostly bisexual and the upper small ones staminate. Flowers are epigynous bright yellow, bisexual or unisxual with lanceolate, memb ranous bract.. Perianth gamophyllous, rotate & six lobed, locate at the top of a slender sterile long extension of the ovary by means of which the perianth is exposed above the ground. Perianth lobes similar, elliptic oblong 1.2-1.6 cm long, 0.2-0.3 cm broad, outer lobes hairy on the back, inner ones sparsely hairy along nerves. Stamens 6 in number, filamentous filiform, short 2mm long, adnate to the base of the perianth lobes, Anthers linear or linear lanceolate, basifixed and sagittate,.Ovary inferior, hidden among the leaves usually below the ground, tricarpellary syncarpous, lanceolate and trilocular with a fairly long slender beak or extension -the stipe. Ovules many in each cell attached by a distinct long funicle. Style short columnar, 2mm with a 3 lobed stigma. Lobes elongate, erect and appressed. Fruit is a capsule about 1.5-2cm long, 8mm broad, oblong, glabrescent with a slender beak and spongy septa. Seeds 1-many, oblong, black, shiny with crustaceous testa grooved deeply in wavy lines.

Properties and activity: Rao and Beri (1951) have identified glucose, mannose, xylose and glucuronic acid from the rootstock of C. orchioides. The rootstock is also reported to contain glycoside, polysaccharides (hemicellulose and other polysaccharides), starch, resin, tannin, mucilage, fat and calcium oxalate. The hexane extract contains an alkaloid-lycorine, sterols including -sitosterols and sapogenin identified as yuccagenin (Rao et al, 1978). The flavone glycoside from the rootstock has been identified as 5,7- dimethoxy glucopyranoside (Yadav et al, 1974; Sharma et al 1975). Mehta et al (1980) have isolated a number of fatty acids from C. orchioides root oil by GLC techniques. They are palmitic, oleic, linolenic linoleic, arachidic and behenic acid. Kubo et al (1983) isolated a new phenolic glycoside namely, curculigoside from the rhizomes and its structure has been elucidated as 5- hydroxy-2-0- -d-glucopyranosyl benzl 1,2,6-dimethoxy benzoate. Yamasaki et al (1994) developed HPLC method for estimating the curculigoside content in curculigo rhizome.

Two new aliphatic hydroxy ketone 27-hydroxy tricontan-6-one (M. P. 84-85o C) and 23- hydroxy tricontan-2-one (M. P. 109-110 o C) were isolated from the rhizome by Misra et al (1984). They also isolated 21-hydroxy tetracontan-20-one and 4-methyl heptade canoic acid from the root stock. Porwal et al (1988) have isolated and identified three new compounds from the rhizome as N- acetyl-N-hydroxy-2-carbamic acid methyl ester, 3-acetyl-5-carbomethoxy-2H-3,4,5,6-tetrahydro-1,2,3,5,6-oxatetrazine and N, N, N’, N’-tetra methyl succinamide. The rhizomes of C. orchioides yielded a new phenolic glycoside corchioside a, characterised as orcinol-3- -D-xylopyranosyl- (1 6)- -D-glucopyranoside and hentriacontanol (Garg et al, 1989).

A new aliphatic compound has been isolated from the rhizomes and characterised as 25- dihydroxy-33-methyl pentatricontan-one (Mehta et al, 1990). Misra et al (1990) isolated a new natural triterpene alcohol-Curculigol charactrised as 24-methy cycloart-7-en-3-beta-20-diol. A novel pentacyclic triterpene has been isolated from the rhizomes of C.orchioides and characterised as 31- methyl-3-oxo-20-ursen-28-oic acid (Metha and Gawarikar,1991). Xu and Xu (1992) and Xu et al (1992 a, b) have isolated 13 cycloartane type. Triterpene glycosides from C. orchioides rhizome and characterised them as curculigo saponin A-M.

The root stock are mucilaginous, sweet, cooling, bitter, emollient, diuretic, aphrodisiac, depurative, alternative, appetiser, carminative, viriligenic, antipyretic and tonic (Sivarajan and Indira, 1994; Warrier et al, 1994).

The uterine stimulant activity of the flavone glycoside extracted from C. orchioides has been studied by Dhawan and Saxena (1958), Sharma et al (1975) and Dhar et al (1979).

The plant extract of C. orchioides showed hypoglycaemic, spasmolytic and anticancer properties (Dhar et al,1968). Phagocytic activity (Kubo et al, 1983) and immunoadjuvant activity (Oru et al, 1982) of phenolic glycosides, curculigoside isolated from the rhizome of the plant have been reported. Porwal and Mehta (1985) discussed the medicinal importance of the plant and its use in indigenous system of medicine as a tonic. Sharma et al (1991) reported the influence of MAK an ayurvedic food supplement constituting C. orchioides against Dimethyl benz anthracene induced mammary tumours in rats. Samanta (1992) reported the modulation of male infertility by Ayurvedic drug, which constitutes C. orchioides. Immunostimulant activity of C. orchioides has been demonstrated by Saxena (1992). Immunological activites of curculigo saponin G were assayed in mice and the results showed that it promoted proliferation of spleen lymphocyctes very significantly and increased the weight of the thymus in vivo in mice (Xu et al,1992).

Pharmacological studies in China, on the alcoholic extract obtained from the plant showed several active effects such as adaptogenic, anti-inflammatory, anticonvulsant, sedative, androgenic and immunopromoting activities (Xu et al, 1992).

Curculigo orchioides is distributed widely throughout the country. The demand of the raw materials and derivatives of the plant for the indigenous drug industries are satisfied mainly from the wild source, depleting the natural population and thus the species have become extinct or endangered. Ansari (1993) have reported C. orchioides as a threatened plant from Madhulia forest of Garakhpur. Augustin and Souza (1995) also considered the plant as an endangered species. As the information on the cultivation of C.orchioides is scanty, it is very necessary to develop suitable agrotechniques for the domestication and large-scale cultivation of the plant.... holostemma

One of the NON-STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS) that is an analgesic (see ANALGESICS) for mild to moderate pain in RHEUMATOID ARTHRITIS, OSTEOARTHRITIS and other musculoskeletal disorders. Also used for DYSMENNORRHOEA and MENORRHAGIA. It must be used with care as it has several side-effects, in particular diarrhoea and occasional haemolytic ANAEMIA. It must not be used in patients with INFLAMMATORY BOWEL DISEASE (IBD).... mefenamic acid

Ailanthus tea was at first used only in Asia, but nowadays, due to its healthy properties, it is consumed worldwide. It can be a natural option in treating diarrhea or diphtheria, but not only. Ailanthus Tea description Ailanthus, or “the tree of life”, is native to Asia and has a long history, being first mentioned in ancient Chinese literature. This tree is said to be an intrusive plant, known for breaking into gardens and cracking walls in the process. It has been used as an ornamental plant, but also as an herbal remedy for a variety of ailments and diseases. Studies revealed that ailanthus bark has bitter, astringent and cooling properties. In traditional Chinese medicine, the bark is associated with the governing meridians of the large intestines, the stomach and the liver. Ailanthus tea is a beverage used mainly in Chinese traditional medicine.  It can either be made of the bark or the flowers of the plant. The bark is acknowledged to “clear heat” and stop bleeding while the flowers are considered to help in the treatment of infectious diseases. Ailanthus Tea brewing To brew Ailanthus tea:

• put the granules into a cup
• put 50-100ml boiling water into the cup and stir it with a spoon
• drink it when it is lukewarm

The dosage is for adults, one sachet each time, twice a day. For children, the dosage should be reduced according to the weight. Ailanthus Tea benefits Ailanthus tea is successfully used in treatingglandular fever. The brew has proved its efficiency in:

• treating diarrhea
• fighting malaria
• fighting asthma
• helping in the treatment of uterine bleeding or menorrhagia
• fighting scarlet fever
• fighting diphtheria
• fighting typhoid fever
• fighting palpitations, asthma and epilepsy

Ailanthus Tea side effects There have been no side effects associated with intaking Ailanthus tea. However, consumers should consult a licensed health care provider before drinking it. Ailanthus tea is benefic in treating a large array of diseases, being an important ingredient in the pharmaceutical industry.... ailanthus tea: a healing tea

Linn.

Synonym: A. gangeticus Linn. A. melancholicus Linn. A. polygamus Linn. Hook. f. in part. A. tristis Linn.

Family: Amaranthaceae.

Habitat: Cultivated throughout India.

English: Chinese Spinach, Garden Amaranth, Fountain Plant.

Ayurvedic: Maarisha-rakta (red var.).

Siddha/Tamil: Arai-keerai, Siru- keerai, Thandu-keerai, Mulakkerai (Tamil).

Folk: Laal Shaak, Laal Marashaa.

Action: Astringent (in menorrhagia, leucorrhoea, dysentery, diarrhoea, haemorrhagic colitis); also used in cough, bronchitis and consumption; externally emollient.

The plant contains amarantin, isoa- marantin, betaine, amino acids, sterols.

Dosage: Leaf, seed, root—10-20 ml juice. (API Vol. III.) Powder—2- 4 g. (CCRAS.)... amaranthus tricolor

Guinea-hen-weed (Petiveria alliacea).

Plant Part Used: Leaf, root, stem.

Dominican Medicinal Uses: The root is traditionally prepared as a tincture in alcohol and taken orally for arthritis, joint and muscle pain. The leaf and/or root is typically prepared as an infusion and taken orally for nausea and stomach ailments, women’s health conditions (dysmenorrhea, menorrhagia, menopausal symptoms, ovarian cysts, labor pains, postpartum recovery, uterine fibroids) and to cleanse the blood. The leaf is also prepared as a poultice and applied topically for skin infections.

Safety: No data on the safety of this plant in humans has been identified in the available literature. Animal studies of the leaf have shown relatively low toxicity, and TRAMIL has approved this herb for particular traditional uses.

Contraindications: Avoid use during pregnancy, lactation and in children under 12 years of age.

Drug Interactions: Concomitant use of this herb with insulin and hypoglycemic drugs may potentiate their effects.

Clinical Data: No human clinical trials have been identified in the available literature.

Laboratory & Preclinical Data: The following biological activities have been demonstrated in laboratory and preclinical studies (using in vitro or animal models): analgesic, antifungal, anti-inflammatory, antinociceptive, chemopreventive, cytotoxic and hypoglycemic.

* See entry for Anamú in “Part 3: Dominican Medicinal Plant Profiles” of this book for more information, including references.... anamú

An operation, usually done under local anaesthetic, in which the lining membrane of the UTERUS (womb) is excised using a type of LASER or DIATHERMY surgery that utilises a hysterescope (a variety of ENDOSCOPE) through which the operator can visualise the inside of the uterus. The operation is done to treat MENORRHAGIA (heavy blood loss during MENSTRUATION) and its introduction has reduced the need to perform HYSTERECTOMY for the condition.... transcervical resection of endometrium (tcre)

Absence or defects of the uterus

Rarely, the UTERUS may be completely absent as a result of abnormal development. In such patients secondary sexual development is normal but MENSTRUATION is absent (primary amennorhoea). The chromosomal make-up of the patient must be checked (see CHROMOSOMES; GENES): in a few cases the genotype is male (testicular feminisation syndrome). No treatment is available, although the woman should be counselled.

The uterus develops as two halves which fuse together. If the fusion is incomplete, a uterine SEPTUM results. Such patients with a double uterus (uterus didelphys) may have fertility problems which can be corrected by surgical removal of the uterine septum. Very rarely there may be two uteri with a double vagina.

The uterus of most women points forwards (anteversion) and bends forwards (ante?exion). However, about 25 per cent of women have a uterus which is pointed backwards (retroversion) and bent backwards (retro?exion). This is a normal variant and very rarely gives rise to any problems. If it does, the attitude of the uterus can be corrected by an operation called a ventrosuspension.

Endometritis The lining of the uterine cavity is called the ENDOMETRIUM. It is this layer that is partially shed cyclically in women of reproductive age giving rise to menstruation. Infection of the endometrium is called endometritis and usually occurs after a pregnancy or in association with the use of an intrauterine contraceptive device (IUCD – see CONTRACEPTION). The symptoms are usually of pain, bleeding and a fever. Treatment is with antibiotics. Unless the FALLOPIAN TUBES are involved and damaged, subsequent fertility is unaffected. Very rarely, the infection is caused by TUBERCULOSIS. Tuberculous endometritis may destroy the endometrium causing permanent amenorrhoea and sterility.

Menstrual disorders are common. Heavy periods (menorrhagia) are often caused by ?broids (see below) or adenomyosis (see below) or by anovulatory cycles. Anovulatory cycles result in the endometrium being subjected to unopposed oestrogen stimulation and occasionally undergoing hyperplasia. Treatment is with cyclical progestogens (see PROGESTOGEN) initially. If this form of treatment fails, endoscopic surgery to remove the endometrium may be successful. The endometrium may be removed using LASER (endometrial laser ablation) or electrocautery (transcervical resection of endometrium). Hysterectomy (see below) will cure the problem if endoscopic surgery fails. Adenomyosis is a condition in which endometrial tissue is found in the muscle layer (myometrium) of the uterus. It usually presents as heavy and painful periods, and occasionally pain during intercourse. Hysterectomy is usually required.

Oligomenorhoea (scanty or infrequent periods) may be caused by a variety of conditions including thyroid disease (see THYROID GLAND, DISEASES OF). It is most commonly associated with usage of the combined oral contraceptive pill. Once serious causes have been eliminated, the patient should be reassured. No treatment is necessary unless conception is desired, in which case the patient may require induction of ovulation.

Primary amenorrhoea means that the patient has never had a period. She should be investigated, although usually it is only due to an inexplicable delay in the onset of periods (delayed menarche) and not to any serious condition. Secondary amenorrhoea is the cessation of periods after menstruation has started. The most common cause is pregnancy. It may be also caused by endocrinological or hormonal problems, tuberculous endometritis, emotional problems and severe weight loss. The treatment of amenorrhoea depends on the cause.

Dysmenorrhoea, or painful periods, is the most common disorder; in most cases the cause is unknown, although the disorder may be due to excessive production of PROSTAGLANDINS.

Irregular menstruation (variations from the woman’s normal menstrual pattern or changes in the duration of bleeding or the amount) can be the result of a disturbance in the balance of OESTROGENS and PROGESTERONE hormone which between them regulate the cycle. For some time after the MENARCHE or before the MENOPAUSE, menstruation may be irregular. If irregularity occurs in a woman whose periods are normally regular, it may be due to unsuspected pregnancy, early miscarriage or to disorders in the uterus, OVARIES or pelvic cavity. The woman should seek medical advice.

Fibroids (leiomyomata) are benign tumours arising from the smooth muscle layer (myometrium) of the uterus. They are found in 80 per cent of women but only a small percentage give rise to any problems and may then require treatment. They may cause heavy periods and occasionally pain. Sometimes they present as a mass arising from the pelvis with pressure symptoms from the bladder or rectum. Although they can be shrunk medically using gonadorelin analogues, which raise the plasma concentrations of LUTEINISING HORMONE and FOLLICLE-STIMULATING HORMONE, this is not a long-term solution. In any case, ?broids only require treatment if they are large or enlarging, or if they cause symptoms. Treatment is either myomectomy (surgical removal) if fertility is to be retained, or a hysterectomy.

Uterine cancers tend to present after the age of 40 with abnormal bleeding (intermenstrual or postmenopausal bleeding). They are usually endometrial carcinomas. Eighty per cent present with early (Stage I) disease. Patients with operable cancers should be treated with total abdominal hysterectomy and bilateral excision of the ovaries and Fallopian tubes. Post-operative RADIOTHERAPY is usually given to those patients with adverse prognostic factors. Pre-operative radiotherapy is still given by some centres, although this practice is now regarded as outdated. PROGESTOGEN treatment may be extremely e?ective in cases of recurrence, but its value remains unproven when used as adjuvant treatment. In 2003 in England and Wales, more than 2,353 women died of uterine cancer.

Disorders of the cervix The cervix (neck of the womb) may produce an excessive discharge due to the presence of a cervical ectopy or ectropion. In both instances columnar epithelium – the layer of secreting cells – which usually lines the cervical canal is exposed on its surface. Asymptomatic patients do not require treatment. If treatment is required, cryocautery – local freezing of tissue – is usually e?ective.

Cervical smears are taken and examined in the laboratory to detect abnormal cells shed from the cervix. Its main purpose is to detect cervical intraepithelial neoplasia (CIN) – the presence of malignant cells in the surface tissue lining the cervix – since up to 40 per cent of women with this condition will develop cervical cancer if the CIN is left untreated. Women with abnormal smears should undergo colposcopy, a painless investigation using a low-powered microscope to inspect the cervix. If CIN is found, treatment consists of simply removing the area of abnormal skin, either using a diathermy loop or laser instrument.

Unfortunately, cervical cancer remains the most common of gynaecological cancers. The most common type is squamous cell carcinoma and around 4,000 new cases (all types) are diagnosed in England and Wales every year. As many as 50 per cent of the women affected may die from the disease within ?ve years. Cervical cancer is staged clinically in four bands according to how far it has extended, and treatment is determined by this staging. Stage I involves only the mucosal lining of the cervix and cone BIOPSY may be the best treatment in young women wanting children. In Stage IV the disease has spread beyond the cervix, uterus and pelvis to the URINARY BLADDER or RECTUM. For most women, radiotherapy or radical Wertheim’s hysterectomy – the latter being preferable for younger women – is the treatment of choice if the cancer is diagnosed early, both resulting in survival rates of ?ve years in 80 per cent of patients. Wertheim’s hysterectomy is a major operation in which the uterus, cervix, upper third of vagina and the tissue surrounding the cervix are removed together with the LYMPH NODES draining the area. The ovaries may be retained if desired. Patients with cervical cancer are treated by radiotherapy, either because they present too late for surgery or because the surgical skill to perform a radical hysterectomy is not available. These operations are best performed by gynaecological oncologists who are gynaecological surgeons specialising in the treatment of gynaecological tumours. The role of CHEMOTHERAPY in cervical and uterine cancer is still being evaluated.

Prolapse of the uterus is a disorder in which the organ drops from its normal situation down into the vagina. First-degree prolapse is a slight displacement of the uterus, second-degree a partial displacement and third-degree when the uterus can be seen outside the VULVA. It may be accompanied by a CYSTOCOELE (the bladder bulges into the front wall of the vagina), urethrocoele (the urethra bulges into the vagina) and rectocoele (the rectal wall bulges into the rear wall of the vagina). Prolapse most commonly occurs in middle-aged women who have had children, but the condition is much less common now than in the past when prenatal and obstetric care was poor, women had more pregnancies and their general health was poor. Treatment is with pelvic exercises, surgical repair of the vagina or hysterectomy. If the woman does not want or is not ?t for surgery, an internal support called a pessary can be ?tted – and changed periodically.

Vertical section of female reproductive tract (viewed from front) showing sites of common gynaecological disorders.

Hysterectomy Many serious conditions of the uterus have traditionally been treated by hysterectomy, or removal of the uterus. It remains a common surgical operation in the UK, but is being superseded in the treatment of some conditions, such as persistent MENORRHAGIA, with endometrial ablation – removal of the lining of the uterus using minimally invasive techniques, usually using an ENDOSCOPE and laser. Hysterectomy is done to treat ?broids, cancer of the uterus and cervix, menorrhagia, ENDOMETRIOSIS and sometimes for severely prolapsed uterus. Total hysterectomy is the usual type of operation: it involves the removal of the uterus and cervix and sometimes the ovaries. After hysterectomy a woman no longer menstruates and cannot become pregnant. If the ovaries have been removed as well and the woman had not reached the menopause, hormone replacement therapy (HRT – see MENOPAUSE) should be considered. Counselling helps the woman to recover from the operation which can be an emotionally challenging event for many.... uterus, diseases of

D. Don.

Family: Caprifoliaceae.

Habitat: The Himalayas from Kashmir to Bhutan at altitudes of 1,200-3,300 m.

Folk: Richh, Richhabi, Khimor (Punjab), Gwiaa, Ghinwaa, Guyaa, Ghenu (Kumaon).

Action: Bark—used in menorrhagia and metrorrhagia.... viburnum cotinifolium

Linn.

Synonym: B. candida Roxb.

Family: Caesalpiniaceae.

Habitat: Punjab, Western Peninsula and Assam. Also cultivated in gardens.

English: Mountain Ebony, Buddhist Bauhinia.

Ayurvedic: Kaanchanaara, Kaan- chanaaraka, Kanchanak, Kaan- chana, Gandhaari, Sonapushpaka, Ashmantaka.

Siddha/Tamil: Sivappumanchori.

Action: Buds—a decoction is given in piles (also used against tumours), haematuria, menorrhagia. Dried buds are used in diarrhoea, dysentery, worm infestation, piles and tumours. Root— carminative, used in dyspepsia and flatulence (a decoction is reported to prevent obesity). Bark—astringent, anthelmintic; used externally in scrofula and skin diseases. Seeds—possess human blood agglutinating activity. Leaf— antifungal.

Along with other therapeutic applications, The Ayurvedic Pharmacopoeia of India indicated the use of the stem bark in lymphadenitis and goitre. (Ka- anchnaar Guggulu is prescribed for glandular swellings and goitre.)

Water-soluble portion of alcoholic extract of the plant showed preventive effect against goitre in rats.

Flowers gave flavonoids, kaempfe- rol-3-galactoside and kaempferol-3- rhamnoglucoside. The stem bark yields hentriacontane, octacosanol and stigmasterol. Stem contains beta-sitos- terol, lupeol and a flavanone glyco- side.

Dosage: Stem bark—20-30 g for decoction. (API Vol. I.)... bauhinia variegata

Wall.

Family: Caprifoliaceae.

Habitat: Khasi hills at altitudes of 900-1,800 m.

Folk: Narwel (Maharashtra).

Action: Leaves—astringent, antispasmodic. Juice used in menorrhagia and as a sedative (a substitute for American Viburnum bark) in uterine disorders, and in post-partum haemorrhage. See Viburnum coriaceum and V. opulus.... viburnum foetidum

 May be caused by a decline in hormone levels. Indicated: Agnus Castus, Black Cohosh.

See: MENORRHAGIA. ... menstruation, prolonged

Bauhinia variegata

Caesalpiniaceae

San: Kancanarah, Kovidarah;

Hin: Kancanar;

Ben: Rakta Kanchan;

Tam: Sigappu-mandarai

Mal: Mandaram, Chuvannamandaram, Malayakatti, Kongu, Kongumandaram;

Tel: Daeva Kanchanamu, Mandara;

Kan: Ullipe, Kanchavala, Kempu Mandara

Importance: In traditional medicine, Bauhinia is extensively used in glandular diseases and as an antidote to poison. The drug is also reported to be useful in dysentery, diarrhoea, piles and worms (Kurup et al, 1979; Sharma et al, 1983). They are useful in vitiated conditions of kapha and pitta, diarrhoea, dysentery, skin diseases, leprosy, intestinal worms, tumours, wounds, ulcers, inflammations, scrofula, protoptosis, haemorrhoids, haemoptysis, cough, menorrhagia and diabetics. Usirasavam and Candanasavam are some of the preparations using the drug. An important Ayurvedic preparation, “Kanchnar Guggal” contains bark of this plant. In Unani system, the flowers are used in “Hab Mussafi Khun”, for skin diseases, the bark is used in “Sufuf Kalan”-an aphrodisiac.

Distribution: The plant is distributed in the Sub-Himalayan tracts from the Indus eastwards and throughout the dry forests of India, ascending to 1300m. It is also cultivated throughout the plains.

Botany: Bauhinia variegata Linn. syn. B.

candida Roxb. belonging to the family Caesalpiniaceae is a moderate sized deciduous tree with vertically cracked grey bark, wood moderately hard, greyish brown with irregular darker patches. Leaves are of 2 leaflets, connate for about two-thirds up. Leaflets are ovate with rounded apex, 10-15cm long, pubescent beneath when young and coriaceous. Flowers are white or pink, the uppermost petal darker and variegated usually appearing before the leaves in short axillary or terminal racemes. Stamens are 5 and stamenodes absent. Fruits are flat dehiscent pods with 10-15 seeds (Warrier et al, 1993).

Other important species of the genus Bauhinia are as follows.

1. B. tomentosa Linn.

It is the yellow or golden flowered one, commonly known as Manja Mandaram. It is found in Africa and Asia. In India it is found wild in dry deciduous forests and often cultivated. The plant is antidysenteric, antidote for snakebite and scorpion sting and also used in liver complaints. The bark is astringent. Root bark is vermifuge. Fruit is diuretic. Seed is tonic, wound healing and aphrodisiac.

2. B. purpurea Linn.

Pink Bauhinia or Camel’s Foot tree is found in South and S. E. Asia. In India, it is found in deciduous forests. Root is carminative and tonic. Bark is astringent and antidiarrhoeal and is used in ulcer and goitre. Flowers are laxative. The experimental studies conducted by Sijoria and Prasad (1979) on animals indicate that B. purpurea is very effective in normalising the thyroid gland.

3. B. racemosa Lam.

The plant is found in Sub-Himalayan tracts, in U.P, West Bengal, Central and South India. The leaf is anticephalalgic and antimalarial. Bark is astringent, antidiarrhoeal. The seeds are antibacterial. Stem-bark is CVS and CNS active, hypothermic and anticancerous.

4. B. malabarica Roxb.

Malabar Mountain Ebony is found in Sub-Himalayan tracts, from Kumaon to West Bengal, ascending to 1350m, Assam, Bihar and South India. The flowers of this plant are antidysenteric.

5. B. retusa Roxb.

The plant is distributed in north-western Himalayas from the Beas eastwards, Himachal Pradesh, U.P., Orissa, M.P. and A.P. The gum of the plant is emmenagogue, diuretic and can be used externally in sores. The seed is hypoglycaemic and hypocholesterolaemic. The aerial part is CVS active and has effect on respiration.

6. B. vahlii W.&A.

Camel’s Foot climber is found in Punjab, Bihar, Assam, Madhy Pradesh, Andra Pradesh and Tamil Nadu. Leaf is demulcent. Seed is tonic and aphrodisiac. Stem is CVS active, antiarrhythmic and spasmolytic.

Agrotechnology: Well drained hilly areas are ideal for the cultivation of Bauhinia. The plant is seed propagated. Seeds are formed in February-March. Seeds are to be collected from the dried pods, soaked in water for 12 hours before sowing in seedbeds. At four-leaved stage they are to be transferred to polybags. Two month old seedlings from polybags are used for field planting. Pits of size 60cm cube are to be taken and filled with 10kg dried cowdung mixed with topsoil and formed into a mound. On these seedlings are to be planted at a distance of 6-7.5m. Irrigation is to be given in the first year. Two weedings and application of organic manure once is required in a year. The plant is not attacked by any serious pests and diseases. The plant flowers on the third year. At the end of tenth year the tree can be cut and wood used for medicinal purposes (Prasad et al, 1997).

Properties and activity: Flowers contain flavanoids-kaempferol-3-galactoside and kaempferol-3- rhamnoglucoside. Stem bark yields hentriacontane, octacosanol and stigmasterol. Stem yields -sitisterol, lupiol and a flavanone glycoside-5, 7-dimethoxy flavanone 4-O- -L- rhamnopyranoside- -D-glucopyranoside. Seeds possess human blood agglutinating activity. Stem bark is hypothermic, CNS active and depressant. Bud, flower, leaf and stembark are antibacterial. Stem possesses juvenoid activity. Bark is alterative, tonic, antileprotic and antirheumatic. Bud is antidysenteric. Root is carminative and antidote for snakebite. Bark, flower and root promote suppuration. Bark and bud are astringent and vermifuge (Husain et al, 1992).... bauhinia

A progestogen drug used primarily in some oral contraceptives. Norethisterone is sometimes prescribed to postpone menstruation. It is also used to treat premenstrual syndrome, menstrual disorders such as menorrhagia, endometriosis, and certain types of breast cancer. It is occasionally given by injection as a long-acting contraceptive. Possible side effects include swollen ankles, weight gain, depression and, rarely, jaundice.... norethisterone

see menorrhagia.... dysfunctional uterine bleeding

(-rrhage) combining form denoting excessive or abnormal flow or discharge from an organ or part. Examples: haemorrhage (excessive bleeding); menorrhagia (excessive menstrual flow).... rrhagia

(Wall.) Engl.

Synonym: B. ciliata Sternb. Saxífraga ligulata Wall.

Family: Saxifragaceae.

Habitat: Temperate Himalaya from Kashmir to Bhutan, between altitudes of 900 and 3,000 m.

Ayurvedic: Paashaanabheda, Ashmaribhedikaa, Ashmaribhit, Ashmghna, Shilaabhit, Shilaabheda. (These synonyms are also equated with Aerva lanata Juss.)

Siddha/Tamil: Padanbethi.

Action: Leaf and root—antiscorbutic, astringent, spasmolytic, antidiarrhoeal. Used in dysuria, spleen enlargement, pulmonary affections as a cough remedy, menorrhagia, urinary tract infections. Alcoholic extract of roots— antilithic. Acetone extract of root- bark—cardiotoxic, CNS depressant and anti-inflammatory; in mild doses diuretic but antidiuretic in higher doses. Anti-inflammatory activity decreases with increasing dosage.

Due to its depressant action on the central nervous system, the drug is used against vertigo, dizziness and headache in moderate or low dosage.

Key application: In lithiasis, dysuria, polyuria. (The Ayurvedic Pharmacopoeia of India; Indian Herbal Pharmacopoeia.)

The rhizome contains an active principle bergenin (0.6%), gallic acid, glucose (5.6%), tannins (14.2-016.3%), mucilage and wax; a C-glycoside and beta-sitosterol.

Bergenin prevented stress-induced erosions in rats and lowered gastric outputs.

(Paashaanabheda indicates that the plant grows between rocks appearing to break them; it does not necessarily mean that it possesses lithotriptic property.)

Dosage: Rhizome—20-30 g for decoction. (API Vol. I)... bergenia ligulata

(Linn.) Moench.

Family: Cruciferae; Brassicaceae.

Habitat: Throughout India as a weed in cultivated areas and waste places, particularly in the temperate regions up to an altitude of 4,200 m.

English: Shepherd's Purse, St. James's Wort.

Folk: Mumiri.

Action: The herb or its juice extracts are employed to check menorrhagia and haemorrhages from renal and genitourinary tract. Also used in diarrhoea and dysentery and as a diuretic.

Key application: In symptom-based treatment of mild menorrhagia and metrorrhagia. (German Commission E.) The British Herbal Pharmacopoeia reported antihaem- orrhagic action.

Aerial parts contain flavonoids, polypeptides, choline, acetylcholine, histamine and tyramine.

The extract of dried or green plant causes strong contraction of the small intestines and uterus of guinea pigs. A quarternary ammonium salt has been isolated from the herb which is reported to be responsible for its pharmacological activity.

Young leaves contain vitamin A (5,000 IU/100 g) and ascorbic acid (91 mg/100 g); among other constituents are hesperidin and rutin, which reduced permeability of blood vessel walls in white mice. A neoplasm inhibitory substance has been identified as fumaric acid. An inhibitory effect of the extracts of the herb on Ehrlich solid tumour in mice was found to be due to the fumaric acid.

Major constituent of the essential oil is camphor.... capsella bursa-pastoris

(L.) G. Don.

Synonym: Vinca rosea L. Lochnera rosea (L.) Reichub.

Family: Apocynaceae.

Habitat: Commonly grown in Indian gardens.

English: Madagascar Periwinkle (Vinca major L. Pich. and Vinca minor Linn. are known as Greater Periwinkle and Lesser Periwinkle respectively).

Folk: Sadaabahaar, Nayantaaraa, Nityakalyaani.

Action: The cytotoxic dimeric alkaloids, present in Madagascar Periwinkle, Catharanthus roseus L. Don, Vincea rosea L., and used for the treatment of certain type of cancer, have not been found in V. major.

Catharanthus roseus (Madagascar Periwinkle) : cytostatic, anti-neoplas- tic, slows down growth of cells by su- pressing immune response. Vinblas- tine and Vincristine are said to prolong remission of leukaemia to more than five years. These chemotherapeutic agents are toxic to the nervous system. Vinblastine is also used for breast cancer and Hodgkin's disease.

Vinca major L. Pich. (Greater Periwinkle): astringent, anti-haemorrha- gic; used for menorrhagia and leu- corrhoea. Contains indole alkaloids including reserpinine and serpentine; tannins.

Vinca minor Linn. (Lesser Periwinkle): astringent; circulatory stimulant. Leaves—stomachic and bitter. Root— hypotensive. Used for gastric catarrh, chronic dyspepsia, flatulence; also for headache, dizziness, behaviours disorders. A homoeopathic tincture is given for internal haemorrhages.... catharanthus roseus

Linn.

Family: Amaranthaceae.

Habitat: Indian gardens, as ornamental.

English: Cock's Comb

Ayurvedic: Jataadhaari.

Folk: Laal Murgaa.

Action: Seeds—demulcent; used for painful micturition, dysentery Flowers—used in menorrhagia and diarrhoea.

The plant contains betanin, and several sterols. The inflorescence contain amarantin, isoamarantin, celosianin and isocelosianin. The seeds contain 10.1-12.8% of protein and yield 7.27.9% of a fatty oil.

Choline esters of hyaluronic acid from the plant, when fed to rats, showed antiulcer and gastro-protective effect.... celosia cristata

Linn.

Family: Menispermaceae.

Habitat: The tropical and subtropical parts of India.

English: Velvet-Leaf Pareira, Pareira Brava.

Ayurvedic: Paathaa, Ambashthaa, Varatiktaaa, Vriki, Aviddhakarni, Piluphalaa, Shreyashi.Bigger var., Raaja Paathaa, is equated with Stephania hernandifolia Walp.)

Unani: Paathaa.

Siddha/Tamil: Paadakkizhangu, Appatta.

Action: Root astringent, an- tispasmodic (used for cramps, painful menstruation), analgesic, antipyretic, diuretic, antilithic and emmenagogue. Prescribed for diarrhoea, dysentery, piles, urogenital affections (cystitis, nephritis, menorrhagia) Root paste is applied topically on scabies and eruptions on the body. Also used for preventing miscarriage.

The Ayurvedic Pharmacopoeia ofIn- dia attributed blood purifying properties to the root and indicated it in lactal disorders.

Hayatine (dl-beberine) is the principal alkaloid of the root. Its derivatives, methiodide and methochloride are reported to be potent neuromus- cular-blocking agents.

Not to be confused with Abuta grandiflora, a South American medicinal plant.

Dosage: Root—3-6 g powder. (API Vol. I.) the plant hastens fracture-healing by reducing the total convalescent period by 33% in experimental rats and dogs; it aids in recovery of the strength of the bones up to 90% in 6 weeks.

Dosage: Stem—10-20 ml juice. (API Vol. III.)... cissampelos pareira

Pers.

Family: Gramineae; Poaceae.

Habitat: Throughout India up to 3,000 m.

English: Bermuda Grass, Bahama Grass, Couch Grass.

Ayurvedic: Duurvaa, Bhaargavi, Shatvalli, Shatparvaa, Tiktaparvaa, Shatviryaa, Sahastravirya, Shitaa, Anantaa, Golomi.

Unani: Duub.

Siddha/Tamil: Arugampallu.

Action: The grass is a reputed as a remedy in epitaxis, haematuria, inflammed tumours, whitlows fleshy excrescences, cuts, wounds, bleeding piles, cystitis, nephritis and in scabies and other skin diseases. It is credited with astringent, diuretic, antidiarrhoeal, anticatarrhal, styptic and antiseptic properties. The Ayurvedic Pharmacopoeia ofIn- dia recommended the dried fibrous root in menorrhagia, metrorrhagia and burning micturation.

Phenolic phytotoxins—ferulic, sy- ringic, p-coumaric, vanillic, p-hydro- xybenzoic and O-hydroxyphenyl acetic acids, are reported from the plant. The leaves contain tricin, flavone C- glycosides and a flavonoid sulphate.

Dosage: Whole plant—10-20 ml juice (API Vol. IV.); root—5-10 ml juice (API Vol. III.)... cynodon dactylon

Stapf.

Synonym: Eragrostis cynosuroides Beauv.

Family: Gramineae; Poaceae.

Habitat: Throughout the plains of India in dry and hot areas and in sandy deserts.

English: Sacrificial Grass (smaller var.)

Ayurvedic: Kusha, Suuchyagra, Yagyabhuushana, Kshurapatra.

Siddha/Tamil: Tharubai.

Action: Root—cooling, diuretic, galactagogue, astringent. Used for urinary calculi, and other diseases of the bladder. Clums—used in menorrhagia, dysentery, diarrhoea and in skin diseases. The Ayurvedic Pharmacopoeia of India recommended the use of the rootstock in dysuria, vaginal discharges and erysipelas.

Dosage: Rootstock—50-100 g for decoction. (API Vol. III.)... desmostachya bipinnata

Pers.

Synonym: D. peregrina (Gaertn.) Gurke D. malabarica (Desr.) Kostel.

Family: Ebenaceae.

Habitat: Throughout India in shady wet places and near streams.

English: Gaub Persimmon, Riber Ebony

Ayurvedic: Tinduka, Tinduki, Sphu- urjaka, Kaalaskandha, Asitkaaraka. Nilasaara.

Unani: Tendu.

Siddha/Tamil: Tumbika, Kattatti.

Action: Fruit and stem bark— astringent. Infusion of fruits—used as gargle in aphthae and sore throat. Fruit juice—used as application for wounds and ulcers. Oil of seeds— given in diarrhoea and dysentery Ether extract of fruit—antibacterial. Bark—astringent and styptic, used in menorrhagia, diarrhoea, dysentery and intermittent fevers.

A paste is applied to boils and tumours. The ethyl acetate extract showed antistress and anti-ulcerogenic activity. It also prevented hepatotoxi- city and leucocytosis in experimental animals.

The bark contains betulinic acid, myricyl alcohol, triterpenoids and sa- ponin. The leaves gave beta-sitosterol, betulin and oleanolic acid. Fruit pulp and seeds contain lupeol, betulin, gallic acid, betulinic acid, hexacosane, hex- acosanol, sitosterol, beta-D-glucoside of sitosterol and a triterpene ketone.

Stem bark—antiprotozoal, antiviral, hypoglycaemic, semen-coagulant. Stems yielded nonadecan-7-ol-one.

Dosage: Bark—50-100 ml decoction. (CCRAS.)... diospyros embryopteris

Roxb. var. cordifolia Hiem.

Habitat: Throughout the greater part of India.

English: Mountain persimmon.

Ayurvedic: Visha-tinduka, Kaaka- tinduka.

Siddha/Tamil: Vakkanai, Vakkanatan.

Folk: Timru.

Action: Various plant parts are used in fever, puerperal fever, neuralgia, pleurisy, pneumonia, menorrhagia, dysurea. Fruits are applied externally to boils.

Bark extract—anti-inflammatory, antipyretic and analgesic. Leaves and seeds—antibacterial.

Diospyrin occurs in the bark and wood. Leaves contain hentriacon- tane, hentriacontanol, beta-sitosterol, alpha-and beta-amyrin, lupeol, taraxe- rol and ursolic acid.

Alcoholic extract of the plant showed CNS depressant and spasmolytic activity and also produced bradycardia and hypertension.... diospyros montana

The condition in which the endometrium (the cells lining the interior of the UTERUS) is found in other parts of the body. The most common site of such misplaced endometrium is the muscle of the uterus. The next most common site is the ovary (see OVARIES), followed by the PERITONEUM lining the PELVIS, but it also occurs anywhere in the bowel. The cause is not known. Endometriosis never occurs before puberty and seldom after the menopause. The main symptoms it produces are MENORRHAGIA, DYSPAREUNIA, painful MENSTRUATION and pelvic pain. Treatment is usually by removal of the affected area, but in some cases satisfactory results are obtained from the administration of a PROGESTOGEN such as NORETHISTERONE, norethynodrel and DANAZOL.... endometriosis

Auct. Non Linn.

Synonym: E. indica Lam.

Family: Euphorbiaceae.

Habitat: Throughout warmer regions of India, up to 1,500 m in the Himalaya.

Ayurvedic: Dugdhikaa.

Action: Plant—used in colic, diarrhoea and dysentery. Leaf— astringent, antidysenteric, antileuc- orrhoeic (also used in menorrhagia).

The plant contains taraxerol, oc- tacosanol, campesterol, stigmasterol, beta-sitosterol, quercetin, quercitrin, ellagic acid, rhamnetin-3-galactoside, rhmnetin-3-rhamnoside and kaempferol.... euphorbia hypericifolia

Linn.

Family: Moraceae.

Habitat: Sub-Himalayan tract and Peninsular India. Planted along roadsides, and in gardens.

English: Banyan tree.

Ayurvedic: Vata, Nyagrodha, Bahupaada, Dhruv.

Unani: Bargad, Darakht-e-Reesh.

Siddha/Tamil: Aalamaram.

Action: Infusion of bark—used in diabetes, dysentery, and in seminal weakness, leucorrhoea, menorrhagia, nervous disorders, erysipelas, burning sensation. Milky juice and seeds—applied topically to sores, ulcers, cracked soles of the feet, rheumatic inflammations. Buds—a decoction in milk is given in haemorrhages. Aerial roots— antiemetic, topically applied to pimples. Leaves—a paste is applied externally to abscesses and wounds for promoting suppuration.

Along with other therapeutic applications, The Ayurvedic Pharmacopoeia of India recommends the aerial root in lipid disorders.

Phytosterolin, isolated from the roots, given orally to fasting rabbits at a dose of 25 mg/kg, produced maximum fall in blood sugar level equivalent to 81% of the tolbutamide standard after 4 h. The root bark showed antidiabetic activity in pituitary diabetes and alloxan-induced diabetes.

The alcoholic extract of the stem bark also exhibited antidiabetic activity on alloxan-induced diabetes in albino rats, and brought down the level of serum cholesterol and blood urea. This activity is attributed to a glucoside, bengalenoside and the flavonoid glycosides, leucocyanidin and leucopelargonidin. Bengalenoside is half as potent as tolbutamide. The leucopelargonidin glycoside is practically nontoxic and may be useful in controlling diabetes with hyperlipi- demia. The leucocyanidin, when combined with a low dose of insulin, not only equalled in response the effects brought about by a double dose of insulin, but also excelled in amelioration of serum cholesterol and triglycerides.

(Additional references: Indian J Physiol Pharmacol, 1975, 19(4), 218220; J Ethnopharmacol, 1989, 26(1), 155; Indian J Physiol Pharmacol, 1994, 38(3), 220-222.)... ficus benghalensis

Linn.

Synonym: F. glomerata Roxb.

Family: Moraceae.

Habitat: Throughout India. Grows wild in forests and hills. Often found around subterranean water streams.

English: Cluster Fig, Country Fig.

Ayurvedic: Udumbara, Sadaaphala, Hema-daudhaka, Jantuphala, Yagyaanga.

Unani: Anjir-e-Aadam, Anjir-e- Ahmak, Gular.

Siddha/Tamil: Atthi.

Action: Astringent and antiseptic; used in threatened abortions, menorrhagia, leucorrhoea, urinary disorders, skin diseases, swellings, boils, haemorrhages. Unripe fruits—astringent, carminative, digestive, stomachic; used in diarrhoea, dyspepsia, dysentery, menorrhagia and haemorrhages. Ripe fruits—antiemetic, also

used in haemoptysis. Root and fruit—hypoglycaemic. Bark— decoction is used in skin diseases, inflammations, boils and ulcers.

The Ayurvedic Pharmacopoeia of India recommends the use of the bark in lipid disorders and obesity.

Leaves and fruit contain gluacol. The fruit also contains beta-sitosterol, lupeol acetate, friedelin, higher hydrocarbons and other phytosterols.

Petroleum ether extract of the stem bark significantly reduced blood sugar level of rats with streptozotocin- induced diabetes. It completely inhibited glucose-6-phosphate dehydrogenase from rat liver. Extracts of fruit and latex did not show any significant effect on blood sugar level of diabetic rats, they inhibited only glucose-6- phosphate but not arginase from rat liver.

An alcoholic extract of the bark has been found to be very effective in reducing blood sugar in alloxan-induced diabetic albino rats. It helped in improving the damaged beta cells of islets of Langerhans, thus exerting permanent blood sugar lowering effect.

The ethanolic extract of seeds also showed hypoglycaemic activity.

Lignin, the main fiber constituent of the fruit, prevented the rise in serum cholesterol levels of some extent. Fresh whole fruits, used as a source of dietary fibre, exhibited more hypoc- holesterolemic activity than pure cellulose.

Dosage: Bark—20-30 g for decoction. (API Vol. I.)... ficus racemosa

Linn.

Family: Moraceae.

Habitat: Sub-Himalayan tracts, West Bengal, Central and South India; planted throughout India as an avenue tree.

English: Peepal, Bot-tree.

Ayurvedic: Ashvattha, Bodhidru, Bodhivrkisha, Sebya, Chalapa- tra, Gajabhaksha, Kshiradruma, Peeppal.

Unani: Peepal.

Siddha/Tamil: Arasu, Ashvatham.

Action: Bark—astringent, antiseptic, alterative, laxative, haemostatic, vaginal disinfectant (used in diabetes, diarrhoea, leucorrhoea, menorrhagia, nervous disorders; also in skin diseases.) Applied externally on unhealthy ulcers and wounds. Leaves and twigs— laxative.

The bark contains beta-sitosteryl-D- glucoside. Vitamin K, n-octacosanol, methyl oleanolate, lanosterol, stigmas- terol, lupen-3-one are reported from the stem bark.

A hypoglycaemic response is reported for beta-sitosterol-D-glucoside obtained from the bark.

Aerial roots are given to women, also used in prescriptions, for inducing conception. The dried fruits are used as a uterine tonic.

The fruits contain 4.9% protein having the essential amino acids, isoleu- cine and phenylalanine. The chloroform extract of fruits exhibited anti- tumour and antibacterial activities in bioassays.

Various plant parts are included in formulations used for menorrha- gia, metrorrhagia, blood dysentery, bleeding piles, haematuria and haemorrhages.

Dosage: Bark, fruit—50-100 ml decoction. (CCRAS.)... ficus religiosa

Linn.

Family: Caesalpiniaceae, Mi- mosaceae

Habitat: Native to tropical America and the West Indies. Grown in Indian gardens.

English: Logwood, Peachwood, Compeachy tree.

Ayurvedic: Pattanga, Patraanga, Bakam (substitute). (Caesalpinia sappan is also equated with Pattanga.)

Unani: Buqqam, Bakam-Hindi.

Action: Astringent. Used for atonic dyspepsia, diarrhoea, summer diarrhoea, dysentery, internal haemorrhages, menorrhagia, leucorrhoea. (It imparts red colour to urine and stool. Incompatible with chalk or lime-water.)

The wood contains about 10% hae- matoxylon, a red-brown phenolic dye, tannins, resin and volatile oil.

Haematoxylin exhibited significant anti-inflammatory activity in the carra- geenan-induced oedema test.

The seed contains crude protein 29.1, pentosan 6.6, and water-soluble gum 3.2%.... haematoxylon campechianum

Linn.

Family: Malvaceae.

Habitat: Native to China; planted in the hedges of gardens.

English: Cotton-Rose, ChineseRose, Confederate Rose.

Ayurvedic: Sthala-Padam, Sthal- Kamal.

Siddha/Tamil: Irratai-vellaichemba- rattam, Sembarattai.

Action: Flower—used in pectoral and pulmonary affections. Leaf and flower—expectorant, bechic, anodyne. Used in menorrhagia, dysuria, swellings, fistulae, wounds and burns.

The flowers contain quercetin, kaempferol, betulinic acid, hexyl stearate, tetratriacontanol, nonacosane, stigmasta-3, 7-dione, stigmasta-4-ene- one and beta-sitosterol. Flowers collected in the morning gave no an- thocyanin; maximum anthocyanin is found in the afternoon.... hibiscus mutabilis

Linn.

Family: Malvaceae.

Habitat: Native of China; grown in gardens throughout India.

English: Rose-of-China, Shoe- flower, Chinese Hibiscus.

Ayurvedic: Japaa, Javaa, Odrapush- pa, Rudrapushpa, Arunaa.

Unani: Gul-e-Gurhal.

Siddha/Tamil: Semparuthi.

Action: Flower—used in impo- tency, bronchial catarrh. Flower and bark—emmenagogue. Leaf— stimulates expulsion of placenta after childbirth; laxative, anodyne. Flower and root—used in menorrhagia.

The plant contains the cyclopro- panoids, methyl sterculate, methyl- 2-hydroxysterculate, 2-hydroxystercu- late, malvalate and beta-sitosterol.

The major anthocyanin in the flower is cyanidin 3-sophoroside. The flower nectar is rich in amino acids, mainly aspartic acid and asparagin. During pollination, the amino acid concentration increases substantially.

Flower powder exhibited anti-inflammatory activity in male albino rats with carrageenan-induced rat paw oedema. The aqueous extract of the plant showed antitumour activity against sarcoma 180 ascites.

An aqueous extract of flowers reduced the duration of oestrus cycle in experimental albino rabbits. The alcoholic extract of flowers showed antiimplantation activity. The benzene extract of flowers, on oral administration, terminated pregnancy in experimental animals.

Flower buds are used in the treatment of vaginal and uterine discharges.

Oral administration of flower extract to rats affected spermatogenesis and endocrine function of testis.

In diabetic patients, a flower bud is given daily up to 10 days or until the level of blood sugar is reduced to tolerable limits.

The white-flowered var. of Japan (cultivated all over India in garden) is equated with Hibiscus syriacus Linn. (Rose of Sharon, Shrubby Althaea). The white flower is an oriental drug used as demulcent and antidiarrhoeal. The bud yields mucilage which consists mainly of partially acetylated acidic polysaccharides. The aqueous extract of the petals causes vasorelaxation of the isolated rat arota via both endo- thelium-dependent and -independent mechanisms. The petals contain anthocyanin pigments.

The cortex and bark exhibit antifun- gal acitivity.

The bark gave canthin-6-one and a fatty acid fraction consisting of lauric, myristic and palmitic acids.

Dosage: Flower—10-20 g paste. (CCRAS.)... hibiscus rosa-sinensis

Phyllanthus emblica

Euphorbiaceae

San: Amalaka, Adiphala

Tel: Amalakam

Hin, Mar: Amla

Kan: Amalaka

Ben: Amlaki

Guj: Ambala

Mal,

Tam: Nelli

Kas: Aonla

Importance: Indian gooseberry or emblic myrobalan is a medium sized tree the fruit of which is used in many Ayurvedic preparations from time immemorial. It is useful in haemorrhage, leucorrhaea, menorrhagia, diarrhoea and dysentery. In combination with iron, it is useful for anaemia, jaundice and dyspepsia. It goes in combination in the preparation of triphala, arishta, rasayan, churna and chyavanaprash. Sanjivani pills made with other ingredients is used in typhoid, snake-bite and cholera. The green fruits are made into pickles and preserves to stimulate appetite. Seed is used in asthma, bronchitis and biliousness. Tender shoots taken with butter milk cures indigestion and diarrhoea. Leaves are also useful in conjunctivitis, inflammation, dyspepsia and dysentery. The bark is useful in gonorrhoea, jaundice, diarrhoea and myalgia. The root bark is astringent and is useful in ulcerative stomatitis and gastrohelcosis. Liquor fermented from fruit is good for indigestion, anaemia, jaundice, heart complaints, cold to the nose and for promoting urination. The dried fruits have good effect on hair hygiene and used as ingredient in shampoo and hair oil. The fruit is a very rich source of Vitamin C (600mg/100g) and is used in preserves as a nutritive tonic in general weakness (Dey, 1980).

Distribution: Indian gooseberry is found through out tropical and subtropical India, Sri Lanka and Malaca. It is abundant in deciduous forests of Madhya Pradesh and Darjeeling, Sikkim and Kashmir. It is also widely cultivated.

Botany: Phyllanthus emblica Linn. syn. Emblica officinalis Gaertn. belongs to Euphorbiaceae family. It is a small to medium sized deciduous tree growing up to 18m in height with thin light grey, bark exfoliating in small thin irregular flakes. Leaves are simple, many subsessile, closely set along the branchlets, distichous light green having the appearance of pinnate leaves. Flowers are greenish yellow in axillary fascicles, unisexual; males numerous on short slender pedicels; females few, subsessile; ovary 3-celled. Fruits are globose, 1-5cm in diameter, fleshy, pale yellow with 6 obscure vertical furrows enclosing 6 trigonous seeds in 2-seeded 3 crustaceous cocci. Two forms Amla are generally distinguished, the wild ones with smaller fruits and the cultivated ones with larger fruits and the latter are called ‘Banarasi’(Warrier et al, 1995).

Agrotechnology: Gooseberry is quite hardy and it prefers a warm dry climate. It needs good sunlight and rainfall. It can be grown in almost all types of soils, except very sandy type. A large fruited variety “Chambakad Large“ was located from the rain shadow region of the Western Ghats for cultivation in Kerala. Amla is usually propagated by seeds and rarely by root suckers and grafts. The seeds are enclosed in a hard seed coat which renders the germination difficult. The seeds can be extracted by keeping fully ripe fruits in the sun for 2-3 days till they split open releasing the seeds. Seeds are soaked in water for 3-4 hours and sown on previously prepared seed beds and irrigated. Excess irrigation and waterlogging are harmful. One month old seedlings can be transplanted to polythene bags and one year old seedlings can be planted in the main field with the onset of monsoon. Pits of size 50 cm3 are dug at 6-8m spacing and filled with a mixture of top soil and well rotten FYM and planting is done. Amla can also be planted as a windbreak around an orchard. Irrigation and weeding are required during the first year. Application of organic manure and mulching every year are highly beneficial. Chemical fertilisers are not usually applied. No serious pests or diseases are generally noted in this crop. Planted seedlings will commence bearing from the 10th year, while grafts after 3-4 years. The vegetative growth of the tree continues from April to July. Along with the new growth in the spring, flowering also commences. Fruits will mature by December-February. Fruit yield ranges from 30-50kg/tree/year when full grown (KAU,1993).

Properties and activity: Amla fruit is a rich natural source of vitamin C. It also contains cytokinin like substances identified as zeatin, zeatin riboside and zeatin nucleotide. The seeds yield 16% fixed oil, brownish yellow in colour. The plant contains tannins like glucogallia, corilagin, chebulagic acid and 3,6-digalloyl glucose. Root yields ellagic acid, lupeol, quercetin and - sitosterol (Thakur et al, 1989).

The fruit is diuretic, laxative, carminative, stomachic, astringent, antidiarrhoeal, antihaemorrhagic and antianaemic.... indian gooseberry

Linn.

Synonym: I. paniculata R. Br. Burm. I. mauritiana Jacq.

Family: Convolvulaceae.

Habitat: Tropical India in moist regions.

English: Milky Yam.

Ayurvedic: Kshira-vidaari, Kshir- valli, Payasvini, Swaadukandaa, Ikshukandaa, Gajavaajipriyaa, Kan- dapalaasha, Bhuumikuushmaanda.

Siddha: Paalmudukkan kizhangu.

Folk: Bilaaikanda. Bhuin Kakhaaru (Orissa).

Action: Cholagogue, galactagogue, alterative, demulcent, purgative. Resin from root—uses similar to Jalap. Flour of raw rhizome is given in enlargement of liver and spleen, also for menorrhagia, debility and fat accumulation.

Rhizomes gave taraxerol acetate and beta-sitosterol. Fresh leaves contain 6.3 mg/100 g of carotene.

Vidaari is equated with Pueraria tuberosa DC. (Fabaceae). Dry pieces of Dioscorea pentaphylla Linn. are sold as Vidaari Kanda.

Dosage: Tuber—3-6 g powder. (CCRAS.)... ipomoea digitata

Ruiz & Pav.

Family: Krameriaceae.

Habitat: Peru, Bolivia. Reported to be imported into India.

English: Peruvian Rhatany, Krameria.

Action: Astringent, styptic, antidiarrhoeal, vulnerary. Used for menorrhagia; topically for wounds, haemorrhoids and chilblains; as a lozenge, gargle or mouthwash for gingivitis and pharyngitis.

Key application: For topical treatment of mild inflammations of oral and pharyngeal mucosa. (German Commission E.)

The astringency of the drug is due to condensed tannins composed of pro- cyanidins and propelargondins.

In India, the roots of Hemidesmus indicus are sometimes used as a substitute for Rhatany.... krameria triandra

Linn.

Family: Labiatae; Lamiaceae.

Habitat: West Himalayas from Kashmir to Kumaon.

English: White Dead Nettle, Archangel.

Action: Haemostatic (particularly on the uterus), astringent, diuretic, anti-inflammatory, antispasmodic, expectorant. Used for menorrhagia, leucorrhoea, cystitis, prostatitis, bleeding piles, diarrhoea, irritable bowel and respiratory catarrh.

Key application: Internally, for catarrh of the upper respiratory passages; externally, for mild, superficial inflammation of the skin. (German Commission E.) Flowers have been recommended for teas and other galenical preparations for internal applications, rinses, baths and moist compresses. As astringent. (The British Herbal Pharmacopoeia.)

The herb contains iridoid monoterpenes; triterpene saponins; caffeic acid derivatives; flavonoids based on kaem- pferol; tannins (mainly catechins). The plant also gave a carbocyclic iridoid, caryoptoside; besides lambalbide, al- bosides A and B (iridoid monoter- penes).... lamium album

Gaertn.

Nelumbium speciosum

Family: Nymphaeaceae.

Habitat: Throughout warmer parts of India, up to 1,800 m.

English: East Indian Lotus, Sacred Lotus.

Ayurvedic: Kamala, Padma, Nalina, Aravinda, Jalaja, Raajeeva, Pushkara, Ambuja, Abja, Pankaja. Pundarika (whitish), kokanada (red), Indivara (Bluish).

Unani: Used as a substitute for Nilofar.

Siddha/Tamil: Thaamarai, Ambel.

Action: Filament—astringent and haemostatic. Prescribed for bleeding piles and menorrhagia. Flowers—a decoction is given in cholera, fever, strangury, palpitation of heart. Rhizomes—given in piles, chronic dyspepsia and dysentery; applied externally to cutaneous eruptions, scabies and ringworm. Rhizome-arrowroot— given to children in diarrhoea and dysentery. Root—astringent, diuretic, antiemetic, cooling. Used for dysentery, dyspepsia, piles, skin affections and for its anticoagulant properties.

The Ayurvedic Pharmacopoeia ofIn- dia recommends dried rhizomes, with roots attached at nodes, in syncope and vertigo.

Flowers yielded quercetin, luteolin and their glycosides and kaempferol glycosides. Leaves gave quercetin, iso- quercitrin and leucoanthocyanidin.

Isoquinoline alkaloid, nuciferin, is neuroleptic. Active agents in the leaves are the alkaloids, nelumbin and roe- merin.

Dosage: Dried flower—12-24 g for decoction (API, Vol. II); rhizomes— 5-10 m powder; 10-20 ml juice (API, Vol. III). Seed—3-6 g powder; flower—10-20 ml juice. (CCRAS.)... nelumbo nucifera

A malignant growth in the tissues of the uterus. Cancer of the uterus mainly affects the cervix (see cervix, cancer of) and endometrium. In rare cases, the uterine muscle is affected by a type of cancer called a leiomyosarcoma. The term uterine cancer usually refers to cancer of the endometrium.

Risk factors for endometrial cancer include anything that may raise oestrogen levels in the body, such as obesity, a history of failure to ovulate, or taking oestrogen hormones long term if these are not balanced with progestogen drugs. It is also more common in women who have had few or no children.

Before the menopause, the first symptom of cancer of the uterus may be menorrhagia or bleeding between periods or after sexual intercourse; after the menopause, it is usually a bloodstained vaginal discharge. Diagnosis is made by hysteroscopy or biopsy.

Very early endometrial cancer is usually treated by hysterectomy and removal of the fallopian tubes and ovaries.

If the cancer has spread, radiotherapy and anticancer drug treatment may also be used.... uterus, cancer of

(intrauterine system) a hormonal contraceptive device consisting of a plastic T-shaped frame that is inserted into the uterus. It carries a progestogen (*levonorgestrel) in a sleeve around its stem and has two fine threads attached to its base, by which it can be removed. It provides a long-term method of contraception that is also reversible. The IUS is also used in the treatment of menorrhagia and benign *endometrial hyperplasia as it acts by thinning the endometrium. A newer version delivers a smaller amount of levonorgestrel and is suitable for young women who have not been pregnant; it is not licensed for menorrhagia or for use after the menopause.... ius

Matricaria recutica

FAMILY: Asteraceae (Compositae)

SYNONYMS: M. chamomilla, camomile, blue chamomile, matricaria, Hungarian chamomile, sweet false chamomile, single chamomile, chamomile blue (oil).

GENERAL DESCRIPTION: An annual, strongly aromatic herb, up to 60 cms tall with a hairless, erect, branching stem. It has delicate feathery leaves and simple daisy-like white flowers on single stems. In appearance it is very similar to the corn chamomile (Anthemis arvensis) but can be distinguished from it because the latter is scentless.

DISTRIBUTION: Native to Europe and north and west Asia; naturalized in North America and Australia. It is cultivated extensively, especially in Hungary and eastern Europe, where the oil is produced. It is no longer grown in Germany, despite the herbal name.

OTHER SPECIES: There are many varieties of chamomile, such as the pineapple weed (Chamaemelium suaveolens) and the Roman chamomile (C. nobile), both of which are used to produce an essential oil.

HERBAL/FOLK TRADITION: This herb has a long-standing medicinal tradition, especially in Europe for ‘all states of tension and the visceral symptoms that can arise therefrom, such as nervous dyspepsia and nervous bowel, tension headaches, and sleeplessness; especially useful for all children’s conditions, calming without depressing …’.

An excellent skin care remedy, it has many of the same qualities as Roman chamomile, except that its anti-inflammatory properties are greater due to the higher percentage of azulene.

ACTIONS: Analgesic, anti-allergenic, anti inflammatory, antiphlogistic, antispasmodic, bactericidal, carlminative, cicatrisant, cholagogue, digestive, emmenagogue, febrifuge, fungicidal, hepatic, nerve sedative, stimulant of leucocyte production, stomachic, sudorific, vermifuge, vulnerary.

EXTRACTION: Essential oil by steam distillation from the flower heads (up to 1.9 per cent yield). An absolute is also produced in small quantities, which is a deeper blue colour and has greater tenacity and fixative properties.

CHARACTERISTICS: An inky-blue viscous liquid with a strong, sweetish warm-herbaceous odour. It blends well with geranium, lavender, patchouli, rose, benzoin, neroli, bergamot, marjoram, lemon, ylang ylang, jasmine, clary sage and labdanum.

PRINCIPAL CONSTITUENTS: Chamazulene, farnesene, bisabolol oxide, en-yndicycloether, among others. (NB The chamazulene is not present in the fresh flower but is only produced during the process of distillation.)

SAFETY DATA: Non-toxic, non-irritant; causes dermatitis in some individuals.

AROMATHERAPY/HOME: USE

Skin Care: Acne, allergies, boils, burns, cuts, chilblains, dermatitis, earache, eczema, hair care, inflammations, insect bites, rashes, sensitive skin, teething pain, toothache, wounds.

Circulation Muscles And Joints: Arthritis, inflamed joints, muscular pain, neuralgia, rheumatism, sprains.

Digestive System: Dyspepsia, colic, indigestion, nausea.

Genito-Urinary System: Dysmenorrhoea, menopausal problems, menorrhagia.

Nervous System: Headache, insomnia, nervous tension, migraine and stress-related complaints.

OTHER USES: Used in pharmaceutical antiseptic ointments and in carminative, antispasmodic and tonic preparations. Extensively used in cosmetics, soaps, detergents, high-class perfumes and hair and bath products. Used as a flavour ingredient in most major food categories, including alcoholic and soft drinks.... chamomile, german

Linn.

Family: Oleaceae; Nyctanthaceae.

Habitat: Outer Himalaya, Assam, West Bengal; cultivated in many parts of India.

English: Tree of Sorrow, Night Jasmine, Coral Jasmine.

Ayurvedic: Paarijaata, Shephaali, Shephaalikaa, Mandaara.

Unani: Harasingaar.

Siddha: Pavazha mattigai.

Action: Leaves—bitter tonic, chola- gogue, febrifuge, anti-inflammatory, antispasmodic, hypotensive, respiratory stimulant. Used for fevers, rheumatism, obstinate sciatica.

The leaves and seeds contain iri- doid glycosides; other constituents reported from the leaves are mannitol, beta-amyrin, beta-sitosterol, hentria- contane, benzoic acid, astragalin, nico- tiflorin, oleanolic acid, nyctanthic acid, friedelin and lupeol. The seeds contain a polysaccharide glucomannan.

All parts of the plant are used for allergic disorders. Alcoholic extract of the plant was found to inhibit passive cutaneous anaphylaxis (PCA) in experimental animals. The inhibition was comparable to standard drugs used for allergy and bronchial asthma.

Ethanolic extract of the leaves, flowers and seeds demonstrated strong stimulation of antigen specific and non-specific immunity in mice.

The 50% ethanolic extracts of the leaves, flowers, seeds and roots were found effective in treating caecal amoe- biasis caused by Entamoeba histolytica in rats. But the extracts did not exhibit direct amoebicidal activity in vitro against trophozoites of the parasite.

The iridoid glucosides showed an- tileishmanial activity both in vivo and in vitro.

Dosage: Leaf—10-20 ml juice. (CCRAS.)

Seeds—used in diabetes, also in cutaneous diseases. Filaments— astringent and cooling; prescribed for bleeding piles and menorrhagia. Plant—toxic on the nervous system.

The flowers contain flavonoids including quercetin, kaempferol, api- genin. Cardiac glucoside, nymphalin, showed sedative action in small doses.

The petroleum ether extract of the plant of Nymphaea species, given at a dose of 300 mg/kg i.p. prevented necrosis of the liver tissue and promoted, to some extent, liver regeneration in CCl4-induced toxicity.

Dosage: Dried flowers—3-6 g (API, Vol. III); seed—3-6 g. powder (CCRAS.).... nyctanthes arbor-tristis

Oöphoritis (infection of the ovaries) rarely occurs alone, except in viral infections such as mumps. Usually it is associated with infection of the FALLOPIAN TUBES (SALPINGITIS). It may occur as a complication of a miscarriage, a therapeutic abortion, or the birth of a baby. Cases not associated with pregnancy typically result from sexual activity: the most common organisms involved are Chlamydia, E. coli, and Neisseria gonorrhoea. Cervical swabs should be sent for culture and analgesics given, together with the appropriate antibiotics.

Failure of OVULATION is the cause of INFERTILITY in around a third of couples seeking help with conception. It may also lead to menstrual problems (see MENSTRUATION), such as an irregular menstrual cycle or MENORRHAGIA. An uncommon cause of failure of ovulation is POLYCYSTIC OVARY SYNDROME, often associated with acne, hirsutism, and obesity. Treatment depends on the symptoms. Early ovarian failure is the cause of premature MENOPAUSE. Treatment consists of hormone replacement therapy using a combination of oestrogen and progestogen.

Ovarian cysts (for example, follicular cysts) result from ovulation. They may be symptomless but sometimes cause abdominal pain, pain during intercourse or disturbances in menstruation. Twisting or rupture can cause severe pain, pyrexia (fever) and nausea, and explorative surgery – endoscopic laparotomy – may be needed to establish a diagnosis (symptoms of ECTOPIC PREGNANCY are similar). The ovary may have to be removed. Simple cysts often disappear of their own accord but a large cyst can cause pressure on surrounding structures and therefore should be surgically removed.

In young women the most common benign tumour is a dermoid cyst, while in older women, ?broma (see under UTERUS, DISEASES OF) is more common. All benign tumours should be removed surgically in order to be sure they are not malignant.

Malignant tumours may be primary (arising in the ovary) or secondary (metastases from a cancer developing in another organ). Treatment depends upon the site and type of the primary tumour.

Around 5,000 women a year are diagnosed as having ovarian cancer in England and Wales. Unfortunately it is not readily detected in its early stages; around 85 per cent of women do not see a doctor until after the tumour has spread. Early tumours present with symptoms similar to benign tumours, while late ones present with abdominal distension, pain and vague gastrointestinal symptoms. The disease is most common in menopausal women. Earlier diagnosis and treatment can be achieved by ULTRASOUND screening. Treatment is surgical, aimed at totally removing the tumour mass. Nowadays RADIOTHERAPY is only used for palliation. CHEMOTHERAPY is often given to patients with ovarian metastases, or who have residual disease after surgery. The most active cytotoxic agent is the taxane, PACLITAXEL – especially when it is combined with cisplatin.... ovaries, diseases of

Nees.

Family: Acanthaceae.

Habitat: The sub-tropical Himalayas, Upper Gangetic Plain, Bihar, North Bengal and Assam.

Folk: Dieng-soh kajut (Meghalaya), Chuhai (Bihar), Titaaphul (Assam).

Action: Whole plant—used like Adhatoda vasica in whooping cough and menorrhagia. Fruits and leaves—burnt and prescribed for fevers. The leaves are reported to contain diterpene lactone, phlogantholide A and its glucoside.

A related species, P. jenkinsii C. B. Clarke, found in Assam, is also known as Titaaphul. A decoction of leaves is given for diseases of spleen and liver and for fevers.... phlogacanthus thyrsiflorus

R. Br.

Family: Labiatae; Lamiaceae.

Habitat: Throughout the plains of India, up to 1,500 m in the hills.

Ayurvedic: Samudrashosha, Kammarkasa.

Folk: Bhuu-Tulasi.

Action: Plant—diuretic, an- thelmintic, astringent, demulcent. Leaves—used for toothache. Seeds—mucilaginous, used for diarrhoea, leucorrhoea, menorrhagia and haemorrhoids.

The plant contains flavones—nepe- tin and hispidulin and their gluco- sides. Flowers also contain nepetin. Sitosterol and oleanolic acid are also present. The seeds yield secoisolari- ciresinol diester.... salvia plebeia

Linn.

Family: Umbelliferae.

Habitat: Europe, including Britain. The Himalayas from Kashmir to Bhutan, Assam, Western Ghats and Palni hills in South India.

English: Wood Sanicle.

Action: Plant—astringent, alterative, vulnerary. Used in leucorrhoea, menorrhagia, bleeding piles; also in diarrhoea and dysentery. The herb is also employed as an ingredient of an ointment used for septic ulcers.

The herb contains saponins based on saniculogenins; allantoin; chlorogenic and rosmarinic acids. The flowers contain 3.1 and fruits 1.1% rosmarinic acid. The leaves contain 0.6% chlorogenic acid. The roots contain 23.1, leaves 12.8, flowers 6.0 and fruits 5.2% surcose. Rhizome contains chlorogeni acid 1.2 and sucrose 13.9%.... sanicula europaea

(Roxb.) De Wilde.

Synonym: S. indica auct. non L.

Family: Caesalpiniaceae.

Habitat: Throughout India, except Northwestern India, up to 750 m.

English: Ashoka tree.

Ayurvedic: Ashoka, Ashoku, Hempushpa, Taamrapallava, Pindapushpa, Gandhapushpa. (Polyalthia longifolia Benth. & Hook. f., an ornamental roadside tree, is wrongly called Ashoka.)

Unani: Ashoka.

Siddha/Tamil: Asogam.

Action: Bark—uterine tonic (imparts healthy tone to uterus), used for suppressed menses, leucorrhoea, menstrual pain, menorrhagia, complaints of menopause. Also used for dyspepsia, biliousness, colic, burning sensation. Flowers—pounded and mixed with water, used in haemorrhagic dysentery, bleeding piles and retention of urine.

The Ayurvedic Pharmacopoeia ofln- dia recommends the bark in metro- hhagia, menorrhagia, chronic lymphadenitis and inflammations.

The flowers contain fatty acids and gallic acid; apigenin-7-O-beta- D-glucoside, cyanidin-3,5-diglucoside, kaempferol 3-O-beta-D-glucoside, pe- largonidin-3,5-diglucoside, quercetin and its 3-O-beta-D-glucoside and sitos- terol.

The bark yields alkanes, esters and primary alcohols. It gave n-octacosa- nol, tannin (6%), catechin, (+)-cate- chol, (-)-epicatechin, (-)-epicatechol, leucocyanidin, leucopelargonidin, pro- cyanidin derivatives, methyl-and eth- ylcholesterol derivatives.

Quercetin and its 3-O-rhamnoside, kaempferol-3-O-alpha-L-rhamnoside, amyrin, ceryl alcohol and beta-sitos- terol have been isolated from leaves and stems.

Alcoholic extract of the bark is reported to be active against a wide range of bacteria. The aqueous extract has been found to enhance the life span of mice infected with Ehrlich ascites carcinoma by 24%.

Pure phenolic glucoside (P2), isolated from stem bark, exhibited highly potent oxytocic activity on different mammals and was similar in nature to pitocin and ergometrine.

Dosage: Dried stem bark—20-30 g for decoction. (API, Vol. I.)... saraca asoca

(Linn.) Merrill.

Synonym: S. aegyptiaca Pers.

Family: Papilionaceae; Fabaceae.

Habitat: Cultivated and wild throughout India.

English: Common Sesban.

Ayurvedic: Jayantikaa, Jayanti, Jayaa, Jwaalaamukhi, Suukshma-muulaa, Suukshma-patraa, Keshruuhaa, Balaamotaa.

Siddha/Tamil: Sembai, Karum- sembai (leaf).

Folk: Jainta.

Action: Seed and bark—astringent, emmenagogue. Used in menorrhagia, spleen enlargement and diarrhoea. Leaves—anti- inflammatory. Bark—juice applied to cutaneous eruptions. Unsaponifi- able matter of fixed oil from seeds— cardiac depressant, antibacterial.

The Ayurvedic Pharmacopoeia ofIn- dia recommends the use of the leaf in dysuria.

The pods and leaves contain cholesterol, campesterol and beta-sitosterol. Flowers contain cyanidin and delphini- din glucosides. Pollen and pollen tubes contain alpha-ketoglutaric, oxaloacetic and pyruvic acids.

Dosage: Leaf—3-6 g powder. (API, Vol. II.)... sesbania sesban

Roxb.

Synonym: S. beddomei C. B. Clarke S. candolleana Brand.

Family: Symplocaceae.

Habitat: Throughout North and eastern India, extending southwards to Peninsular India.

English: Lodh tree, Sapphire Berry

Ayurvedic: Lodhra, Rodhra, Shaavara., Sthulavalkal, Trita, Pattikaa Lodhra, Shaabara Lodhra.

Unani: Lodh Pathaani.

Siddha/Tamil: Vellilethi, Velli- lothram.

Action: Bark—used as specific remedy for uterine complaints, vaginal diseases and menstrual disorders; menorrhagia, leucorrhoea (The Ayurvedic Pharmacopoeia of India); also used in diarrhoea, dysentery, vaginal ulcers, inflammatory affections and liver disorders.

The bark gave colloturine, harman (loturine) and loturidine. Stem bark gave proanthocyanidin-3-monogluco- furanosides of 7-O-methyl-and 4'-O- methyl-leucopelargonidin. Betulinic, oleanolic, acetyl oleanolic and ellagic acids are reported from the plant.

Glycosides, isolated from the ethanolic extract of the stem bark, are highly astringent and are reported to be responsible for the medicinal properties of the bark.

The bark extracts have been reported to reduce the frequency and intensity of the contractions in vitro of both pregnant and non-pregnant uteri of animals. A fraction from the bark, besides showing action on uteri, was spasmogenic on various parts of the gastrointestinal tract and could be antagonized by atropine.

The bark extracts were found to inhibit the growth of E. coli, Micrococcus pyogenes var. aureus, and enteric and dysenteric groups of organisms.

Dosage: Stem bark—3-5 g powder; 20-30 g for decoction. (API, Vol. I.)

S. laurina Wall., synonym S. spica- ta Roxb. (North and East Idia, Western and Eastern Ghats); S. ramosis- sima Wall. (the temperate Himalayas from Garhwal to Bhutan); S. sumuntia Buch.-Ham. (Nepal to Bhutan) are also equated with Lodhra.

The powdered bark is used in folk medicine for biliousness, haemorrhages, diarrhoea, dysentery and genitourinary diseases.

Symplocos theaefolia Buch-Ham. ex D. Don (the Eastern Himalayas from Nepal to Bhutan and in the Khasi Hills at altitudes between 1,200 and 2,500 m) is known as Kharanl in Nepal and Dieng-pei or Dieng-twe-pe in khasi.

The ethanolic extract of leaves showed hypoglycaemic activity in rats and anticancer activity against Friend- virus-leukaemia (solid) in mice. The extract of the leaves and of stems showed activity against human epider- moid carcinoma of the nasopharynx in tissue-culture.

The Wealth of India equated S. laurina with Lodh Bholica (Bengal) and S. sumuntia with Pathaani Lodh.

The wood of Symplocos phyllocalyx C. B. Clarke is known as Chandan and Laal-chandan. It should not be confused with Santalum album or Ptero- carpus santalinus.... symplocos racemosa

Linden (Tilia species).

Plant Part Used: Flower and attached leaf bract.

Dominican Medicinal Uses: Flower and leaf bract: infusion, orally, for relief from anxiety, insomnia, nervousness, stress; women’s health: menorrhagia, uterine fibroids, menopausal hot flashes. Given to children.

Safety: Considered relatively safe; no adverse effects known; if taken in excess or for a long time, may be harmful to the heart.

Laboratory & Preclinical Data: In vivo: antinociceptive, anti-inflammatory (leaf flavonoids); anxiolytic (flower extract).

In vitro: antigenotoxic, antioxidant, GABAa receptor inhibition (water plant extract), iron-absorption promoting (flower extract).

* See entry for Tilo in “Part 3: Dominican Medicinal Plant Profiles” of this book for more information, including references.... tilo

(Linn.) Pich.

Synonym: V pubescens Urv.

Family: Apocynaceae.

Habitat: Native to Europe. Found in the Himalayas, West Bengal and Palni Hills.

English: Green Periwinkle, Greater Periwinkle.

Action: Astringent, antihaemor- rhagic, hypotensive. Used to treat menorrhagia and leucorrhoea.

The herb contains indole alkaloids; majdine, isomajdine, majoridine, aku- ammine, akuammigine, carpanaubine, irvine, reserpine, serpentine, sarpagi- ne, tetrahydroalstonine, vincamajine and vincamajoreine; and tannins.

The cytotoxic dimeric alkaloids present in Vinca rosea L., used in the treatment of certain types of cancer, have not been found in Vinca major.... vinca major

Less. non-Rich.

Synonym: W chinensis Merrill.

Family: Compositae; Asteraceae.

Habitat: Bengal, Assam, Konkan, and Tamil Nadu.

Ayurvedic: Bhringaraaja (yellow- flowered var.), Pitabhringi, Pitabhringa-raaja, Avanti, Ke- sharaaja, Kesharaaga.

Siddha/Tamil: Manjal karisaalai, Potralai kaiyan tagarai, Patalai Kaiantakerai.

Action: Leaves—bechic; used in alopecia, juice used for dyeing hair and for promoting hair growth. Plant—deobstruent; used in menorrhagia and abdominal swellings, as a tonic for hepatic and splenic enlargement.

See Eclipta alba.

The expressed juice of the herb contained an oil-soluble black dye 11.2; tannin 220; saponin 500 (contradictory reports) and phytosterol 3.75 mg/100 g among other constituents. The leaves contain isoflavonoids.

The bisdesmosidic oleanolic acid saponins have been isolated from the fresh leaves. Significant hepatoprotec- tive activity has been found in the pro- saponin from ginsenoside Ro (chiku- setsusaponinV); and in coumestans, wedelolactone and demethyl wedelo- lactone, isolated from the methanol extract of the herb.

Wedelolactone has also been found to be a potent and selective 5-lipoxy- genase-inhibitor, the process being an oxygen radical scavenger mechanism.

Wedelolactone (0.05%), isolated from the leaves, is analogous in structure to coumestrol, an estrogen from Melilotus sp. (clover).

Family: Rubiaceae.

Habitat: Sub-Himalayan region, West Bengal, Madhya Pradesh, Andhra Pradesh and Maharashtra.

Ayurvedic: Tilaka.

Folk: Tiliyaa (Bihar), Tilki, Mimri (Bengal).

Action: Bark—administered in urinary affections.... wedelia calendulaceae

Lam.

Siddha/Tamil: Charai Kattu Ilandai, Kottaimaram, Todari.

Folk: Churnaa, Sekaraa (Bihar); Torana (Gujarat).

Action: Bark—astringent, an- tidiarrhoeal. Flowers—used in prescriptions for menorrhagia. Stem and fruit—hypotensive.

The bark contains vanillic acid, be- tulin, betulinic acid, kaempferol, quer- cetin, myricetin, apigenin and apige- nin-7-O-glucoside. The bark also contains several N-formyl cyclopeptide alkaloids.

The triterpene saponins isolated from the bark showed CNS depressant, tranquilizing and analgesic activity in albino rats and produced no hepato- toxicity. The cyclopeptide alkaloids of the plant show antibacterial as well as antifungal activity.... ziziphus rugosa

Kurz.

Synonym: W. floribunda Salisb.

Family: Lythraceae.

Habitat: Throughout North India, rather scarce in South India.

English: Fire-flame Bush, Shiran- jitea.

Ayurvedic: Dhaataki, Dhaatri, Kun- jaraa, Taamrapushpi, Bahupushpi, Vahnijwaalaa.

Siddha/Tamil: Velakkai.

Action: Dried flower—purifies blood, heals ulcers, astringent, prescribed in haemetemesis, erysipelas, dysentery, diarrhoea, menorrhagia, leucorrhoea. Flowers are used in alcohol-based tonics for fermentation (a yeast strain, saccharomyces cerevisiae, has been isolated). Bark—uterine sedative.

The Ayurvedic Pharmacopoeia ofIn- dia recommends the flower in acute diarrhoea, haemorrhages, ulcerations and erysipelas.

The dried flowers are powdered and sprinkled over ulcers and wounds. The flowers also enter into an ointment used on pustules of smallpox.

In small doses the plant stimulates, while in large doses depresses the central nervous system.

The flowers and leaves gave polyphe- nols—ellagic acid, polystachoside and myricetin-3-galactoside. Flowers also gave anthocyanins—pelargonidin- 3,5-diglucoside and cyanidin-3,5-di- glucoside; octacosanol, chrysopha- nol-8-O-beta-D-glucopyranoside and beta-sitosterol. Hecogenin, mesoinos- itol and flavone glycosides—quercetin- 3-rhamnoside, naringenin-7-glucoside and kaempferol, have been reported from flowers.

The bark contains C-glucoside, ber- genin.

The flowers, leaves and bark contain tannins—24.1, 12-20 and 20-27% respectively. Dimeric hydrolyzable tannins—woodfordins A, B and C, and trimeric tannins woodfordin D and oenothein A and B have been isoalt- ed from dried flowers. A new tannin monomer, isoschimawalin A and five oligomers—woodfordin E, F, G, H and I, have also been isoalted.

Oenothein A and B exhibited remarkable host-mediated antitumour activity. Woodfordin C and D also showed antitumour activity. Woodfordin C showed inhibitory activity toward DNA topoisomerase II.

Dosage: Flower—3-6 g powder. (API, Vol. I.)

English: Pala Indigo Plant.

Ayurvedic: Shveta Kutaja. (white- flowered), Punkutaja, Indrayava (seeds).

Unani: Inderjao Shireen.

Siddha/Tamil: Irum-paalai, Nila- paalai.

Action: Bark—antidysenteric. Also used in piles and skin diseases. Seeds—antidysenteric, astringent, febrifuge, anthelmintic. Bark and seeds—prescribed in flatulence and bilious affections.

Pods, without seeds, contain the cycloartanes, cycloartenone and cy- cloeucalenol along with alpha- and beta-amyrin, beta-sitosterol, ursolic acid, oleanolic acid and the terpene, wrightial. The leaves contain beta- amyrin. Stem bark gave beta-amyrin, beta-sitosterol and lupeol.

The seeds, leaves and roots have been shown to contain an indigo- yielding glucoside.

The flowers gave 3-O-rhamnogluco- side which exhibited significant anti- inflammatory activity in carrageenan- induced hind paw oedema.

The bark is commonly used as an adulterant of Kurchi Bark (obtained from Holarrhena antidysenterica).... woodfordia fruticosa

Water horehound. Gipsywort. German: Gemeiner Wolfstrapp. French: Lycope. Italian: Licopo. Lycopus europaeus and Lycopus virginicus. Properties of both plants are the same. Dried herb. Action: “cardio-active diuretic, increasing force of myocardial contraction and reducing heart rate” BHP (1983). Palpitation, peripheral vasoconstrictor, antitussive, hypoglycaemic, sedative, anti-haemorrhagic, thyrostatic, narcotic (mild).

Mild contraceptive containing lithospermum acid which blocks gonadotropic hormones of the anterior pituitary (Rudolf F. Weiss MD)

Uses: To reduce rapid heart beat from over-active thyroid. Reduces high pulse rate in thyrotoxicosis with heart involvement. Raises blood sugar levels in diabetes. Internal haemorrhages, bleeding from the lungs, menorrhagia. High blood pressure.

Combinations. With Lily of the Valley (Bugleweed 2; Lily 1) for heart cases. With Elecampane (equal parts) for cough of tuberculosis. With Valerian 1 for thyrotoxicosis.

Preparations: Thrice daily.

Tea: 1 heaped teaspoon to each cup boiling water; infuse 10 minutes. Dose: half-1 cup. Tincture BHP (1983) 1 part to 5 parts 45 per cent alcohol. Dose: 2-6ml in water. ... bugleweed

Conclusion of menstruation at the end of reproductive life – between the years 45-50 – and lasting about 4 years. Ovulation fails, hormonal activity wanes. Intervals between periods longer. Periods may stop gradually or suddenly and become scantier.

Symptoms. Not all present at once. Hot flushes, weight gain, depression, urinary frequency, headaches, backache, painful breasts, vaginal discomfort, cannot sleep or concentrate and gets irritable. Cries easily. Poor sexual response.

The hot sweats must not be misdiagnosed. They may be due to an over-worked thyroid gland which requires Kelp, Bugleweed. Palpitations may be due to tachycardia – see: CARDIO-VASCULAR AGENTS: Hawthorn, Lily of the Valley, Motherwort, etc. Tiredness often points to anaemia – see: ANAEMIA.

Oestrogen deficiency predisposes to osteoporosis (weakening and softening of the bones), height loss. Increased flow, or spotting, after an interval of 6 months should be investigated. Excessive blood loss may be due to fibroids.

Alternatives. Herbs to enable women to adjust naturally to the menopause are many and varied. In general use: Agnus Castus (ovarian hormone precurser), Black Haw (Uterine relaxant), Broom (gentle diuretic and heart restorative), Clivers, Goldenseal, Helonias (ovarian hormone precurser), Lady’s Mantle, Life root, Lime flowers, Marjoram, Motherwort, Nettles, Oats (nutrient), Parsley tea, Pennyroyal, Raspberry leaves, Skullcap (tension), St John’s Wort (anxiety), Valerian (nervous excitability).

For menopausal flooding, see: MENORRHAGIA.

Hot flushes: see entry.

With circulatory disorders, add Rosemary.

Alternative formulae. Teas. (1) Motherwort and Raspberry leaves. (2) Lady’s Mantle, Lime flowers, Yarrow. (3) Raspberry leaves, Broom, Clivers. Place 1 heaped teaspoon in each cup boiling water; infuse 15 minutes; 1 cup thrice daily. (4) Sage tea. (Chinese traditional)

Vitamin E. Hot flushes and circulatory distress.

Evening Primrose oil capsules.

Formula. Agnus Castus 2; Black Haw 1; Valerian half. Dose: Liquid Extracts: 1 teaspoon. Tinctures: 2 teaspoons. Powders: 500mg (two 00 capsules or one-third teaspoon). Thrice daily.

Diet. Infrequency of hot flushes and other menopausal symptoms in Japanese women are believed to be related to their Soya-rich diet, Soya containing isoflavonoids which are similar to human oestrogen. Avoid coffee. Reduce tea, Cola drinks, Alcohol.

Vitamins. The condition makes heavy demands upon the vitamin reserves. C, 1g morning and evening. E, 500iu morning and evening. B-complex, B6.

Minerals. Calcium helps reduce risk of fracture, particularly in menopausal women who may increase their intake to 800mg daily – calcium citrate malate being more effective than the carbonate. Dried milk powder contains high percentage of Calcium. ... menopause

An abnormality in the monthly cycle of menstrual bleeding. Menstrual disorders may be a sign of a problem in the pelvic area, such as fibroids, endometriosis, or pelvic inflammatory disease, but the cause is often unknown.

Dysmenorrhoea (painful periods) is the most common type of menstrual disorder. Other types of menstrual disorder are amenorrhoea (absence of menstruation), polymenorrhoea (too frequent menstruation), oligomenorrhoea (infrequent periods or scanty blood loss), and menorrhagia (excessive bleeding).

Some women have extreme variations in the length of menstrual cycles or menstrual periods, or in the amount of blood lost (see menstruation, irregular).... menstruation, disorders of

An abnormal, fluid-filled swelling in an ovary. Ovarian cysts are common and, in most cases, noncancerous. The most common type, a follicular cyst, is one in which the egg-producing follicle enlarges and fills with fluid. Cysts may also occur in the corpus luteum, a mass of tissue that forms from the follicle after ovulation. Other types include dermoid cysts and cancerous cysts (see ovary, cancer of).

Ovarian cysts are often symptomless, but some cause abdominal discomfort, pain during intercourse, or irregularities of menstruation such as amenorrhoea, menorrhagia, or dysmenorrhoea. Severe abdominal pain, nausea, and fever may develop if twisting or rupture of a cyst occurs. This condition requires surgery.An ovarian cyst may be discovered during a routine pelvic examination and its position and size confirmed by ultrasound or laparoscopy. In many cases, simple ovarian cysts – thin-walled or fluid-filled cysts – resolve themselves. However, complex cysts (such as dermoid cysts) usually require surgical removal. If an ovarian cyst is particularly large, the ovary may need to be removed (see oophorectomy).... ovarian cyst

Cupressus sempervirens

FAMILY: Cupressaceae

SYNONYMS: Italian cypress, Mediterranean cypress.

GENERAL DESCRIPTION: A tall evergreen tree with slender branches and a statuesque conical shape. It bears small flowers and round, brownish-grey cones or nuts.

DISTRIBUTION: Native to the eastern Mediterranean; now grows wild in France, Italy, Corsica, Sardinia, Sicily, Spain, Portugal, North Africa, England and, to a lesser degree, the Balkan countries. Cultivation and distillation usually take place in France, also Spain and Morocco.

OTHER SPECIES: There are many other species of cypress found throughout the world which are used to produce an essential oil, such as C. lusitanica found in Kenya. With regard to oil quality, however, C. sempervirens is considered superior.

HERBAL/FOLK TRADITION: It was highly valued as a medicine and as an incense by ancient civilizations and it is still used as a purification incense by the Tibetans. It benefits the urinary system and is considered useful where there is excessive loss of fluid, such as heavy perspiration or menstrual loss and diarrhoea: ‘The cones are … very drying and binding, good to stop fluxes of all kinds.’.

The Chinese consider the nuts very nutritious, beneficial for the liver and respiratory system and to check profuse perspiration.

ACTIONS: Antirheumatic, antiseptic, antispasmodic, astringent, deodorant, diuretic, hepatic, styptic, sudorific, tonic, vasoconstrictive.

EXTRACTION: Essential oil by steam distillation from the needles and twigs. An oil from the cones is available occasionally. (A concrete and absolute are also produced in small quantities.)

CHARACTERISTICS: A pale yellow to greenish-olive mobile liquid with a smoky, sweet-balsamic tenacious odour. It blends well with cedarwood, pine, lavender, mandarin, clary sage, lemon, cardamon, Moroccan chamomile, ambrette seed, labdanum, juniper, benzoin, bergamot, orange, marjoram and sandalwood.

PRINCIPAL CONSTITUENTS: Pinene, camphene, sylvestrene, cymene, sabinol, among others.

SAFETY DATA: Non-toxic, non-irritant and non-sensitizing.

AROMATHERAPY/HOME: USE

Skin Care: Haemorrhoids, oily and overhydrated skin, excessive perspiration, insect repellent, pyorrhoea (bleeding of the gums), varicose veins, wounds.

Circulation Muscles And Joints: Cellulitis, muscular cramp, oedema, poor circulation, rheumatism.

Respiratory System: Asthma, bronchitis, spasmodic coughing.

Genito-urinary system: Dysmenorrhoea, menopausal problems, menorrhagia.

Nervous System: Nervous tension and stress-related conditions.

OTHER USES: Employed in some pharmaceutical products; used as a fragrance component in colognes, after-shaves and perfumes.... cypress

Pelargonium graveolens

FAMILY: Geraniaceae

SYNONYMS: Rose geranium, pelargonium.

GENERAL DESCRIPTION: A perennial hairy shrub up to 1 metre high with pointed leaves, serrated at the edges and small pink flowers. The whole plant is aromatic.

DISTRIBUTION: Native to South Africa; widely cultivated in Russia, Egypt, Congo, Japan, Central America and Europe (Spain, Italy and France). With regard to essential oil production, there are three main regions: Reunion (Bourbon), Egypt and Russia (also China).

OTHER SPECIES: There are over 700 varieties of cultivated geranium and pelargonium, many of which are grown for ornamental purposes. There are several oil-producing species such as P. odorantissimum and P. radens, but P. graveolens is the main one commercially cultivated for its oil. Geranium Bourbon (P. Roseum) has a superior fragrance to other species, having a rich rosy-fruity scent due to the higher levels of linalook and iso-methone content. See also Botanical Classification section.

HERBAL/FOLK TRADITION: The British plant herb robert (Geranium robertianum) and the American cranesbill (G. maculatum) are the most widely used types in herbal medicine today, having been used since antiquity. They have many properties in common with the rose geranium, being used for conditions such as dysentery, haemorrhoids, inflammations, metrorrhagia and menorrhagia (excessive blood loss during menstruation). The root and herb of cranesbill is specifically indicated in the British Herbal Pharmacopoeia for diarrhoea and peptic ulcer.

ACTIONS: Antidepressant, antihaemorrhagic, anti-inflammatory, antiseptic, astringent, cicatrisant, deodorant, diuretic, fungicidal, haemostatic, stimulant (adrenal cortex), styptic, tonic, vermifuge, vulnerary.

EXTRACTION: Essential oil by steam distillation from the leaves, stalks and flowers. An absolute and concrete are also produced in Morocco.

CHARACTERISTICS: The Bourbon oil is a greenish-olive liquid with a green, rosy-sweet, minty scent. The Bourbon oil is generally preferred in perfumery work; it blends well with lavender, patchouli, clove, rose, sandalwood, jasmine, juniper, neroli, bergamot and other citrus oils.

PRINCIPAL CONSTITUENTS: Citronellol, geraniol, linalol, isomenthone, menthane, phellandrene, sabinene, limonene, among others. Constituents vary according to type and source.

SAFETY DATA: Non-toxic, non-irritant, generally non-sensitizing; possible contact dermatitis in hypersensitive individuals, especially with the Bourbon type.

AROMATHERAPY/HOME: USE

Skin Care: Acne, bruises, broken capillaries, burns, congested skin, cuts, dermatitis, eczema, haemorrhoids, lice, oily complexion, mature skin, mosquito repellent, ringworm, ulcers, wounds.

Circulation Muscles And Joints: Cellulitis, engorgement of breasts, oedema, poor circulation.

Respiratory System: Sore throat, tonsillitis.

Genito-Urinary And Endocrine Systems: Adrenocortical glands and menopausal problems, PMT.

Nervous System: Nervous tension, neuralgia and stress-related conditions.

OTHER USES: Used as a fragrance component in all kinds of cosmetic products: soaps, creams, perfumes, etc. Extensively employed as a flavouring agent in most major food categories, alcoholic and soft drinks.... geranium

Rosa centifolia

FAMILY: Rosaceae

SYNONYMS: Rose maroc, French rose, Provence rose, hundred-leaved rose, Moroccan otto of rose (oil), French otto of rose (oil), rose de mai (absolute or concrete).

GENERAL DESCRIPTION: The rose which is generally used for oil production is strictly a hybrid between R. centifolia, a pink rose, and R. gallica, a dark red rose. This variety, known as rose de mai, grows to a height of 2.5 metres and produces an abundance of flowers with large pink or rosy-purple petals. There are two subspecies – one is more spiny than the other.

DISTRIBUTION: The birthplace of the cultivated rose is believed to be ancient Persia; now cultivated mainly in Morocco, Tunisia, Italy, France, Yugoslavia and China. The concrete, absolute and oil are mainly produced in Morocco; the absolute in France, Italy and China.

OTHER SPECIES: There are over 10,000 types of cultivated rose! There are several subspecies of R. centifolia, depending on the country of origin. Other therapeutic species are the red rose or apothecary rose (R. gallica) of traditional Western medicine, the oriental or tea rose (R. indica), the Chinese or Japanese rose (R. rugosa) and the Turkish or Bulgarian rose (R. damascena) which is also extensively cultivated for its oil. Recently rosehip seed oil from R. rubiginosa has been found to be a very effective skin treatment; it promotes tissue regeneration and is good for scars, burns and wrinkles. The wild rose (Eubatus rubus) is now also being used to produce a rare absolute with a rich, spicy-earthy fragrance. See also entry on damask rose and the Botanical Classification section.

HERBAL/FOLK TRADITION: The healing virtues of the rose have been known since antiquity and although roses are rarely used in herbal practice nowadays, up to the Middle Ages they played an essential part in the materia medica, and still

fulfil an important role in Eastern medicine. They were used for a wide range of disorders, including digestive and menstrual problems, headaches and nervous tension, liver congestion, poor circulation, fever (plague), eye infections and skin complaints. ‘The symbolism connected with the rose is perhaps one of the richest and most complex associated with any plant ... traditionally associated with Venus, the Goddess of love and beauty, and in our materialistic age the Goddess is certainly alive and well in the cosmetics industry for rose oil (mainly synthetic) is found as a component in 46% of men’s perfumes and 98% of women’s fragrances.’.

The French or Moroccan rose possesses narcotic properties and has the reputation for being aphrodisiac (more so than the Bulgarian type), possibly due to the high percentage of phenyl ethanol in the former. For further distinctions between the different properties of rose types, see damask rose.

ACTIONS: Antidepressant, antiphlogistic, antiseptic, antispasmodic, anti-tubercular agent, antiviral, aphrodisiac, astringent, bactericidal, choleretic, cicitrisant, depurative, emmenagogue, haemostatic, hepatic, laxative, regulator of appetite, sedative (nervous), stomachic, tonic (heart, liver, stomach, uterus).

EXTRACTION: 1. Essential oil or otto by water or steam distillation from the fresh petals. (Rose water is produced as a byproduct of this process.) 2. Concrete and absolute by solvent extraction from the fresh petals. (A rose leaf absolute is also produced in small quantities in France.)

CHARACTERISTICS: 1. The oil is a pale yellow liquid with a deep, sweet, rosy-floral, tenacious odour. 2. The absolute is a reddish orange viscous liquid with a deep, rich, sweet, rosy-spicy, honeylike fragrance. It blends well with jasmine, cassie, mimosa, neroli, geranium, bergamot, lavender, clary sage, sandalwood, guaiacwood, patchouli, benzoin, chamomile, Peru balsam, clove and palmarosa.

PRINCIPAL CONSTITUENTS: It has over 300 constituents, some in minute traces. Mainly citronellol (18–22 per cent), phenyl ethanol (63 per cent), geraniol and nerol (10–15 per cent), stearopten (8 per cent), farnesol (0.2–2 per cent), among others.

SAFETY DATA: Non-toxic, non-irritant, non-sensitizing.

AROMATHERAPY/HOME: USE

Skin care: Broken capillaries, conjunctivitis (rose water), dry skin, eczema, herpes, mature and sensitive complexions, wrinkles.

Circulation muscles and joints: Palpitations, poor circulation.

Respiratory system: Asthma, coughs, hay fever.

Digestive system: Cholecystitis, liver congestion, nausea.

Genito-urinary system: Irregular menstruation, leucorrhoea, menorrhagia, uterine disorders.

Nervous system: Depression, impotence, insomnia, frigidity, headache, nervous tension and stress-related complaints – ‘But the rose procures us one thing above all: a feeling of well being, even of happiness, and the individual under its influence will develop an amiable tolerance.’.

OTHER USES: Rose water is used as a household cosmetic and culinary article (especially in Persian cookery). The concrete, absolute and oil are employed extensively in soaps, cosmetics, toiletries and perfumes of all types – floral, oriental, chypres, etc. Some flavouring uses, especially fruit products and tobacco.... rose, cabbage

Amenorrhoea/lack of menstruation (M,B):

French basil, carrot seed, celery seed, cinnamon leaf, dill, sweet fennel, hops, hyssop, juniper, laurel, lovage, sweet marjoram, myrrh, parsley, rose (cabbage & damask), sage (clary & Spanish), tarragon, yarrow.

Dysmenorrhoea/cramp, painful or difficult menstruation (M,C,B):

Melissa, French basil, carrot seed, chamomile (German & Roman), cypress, frankincense, hops, jasmine, juniper, lavandin, lavender (spike & true), lovage, sweet marjoram, rose (cabbage & damask), rosemary, sage (clary & Spanish), tarragon, yarrow.

Cystitis (C,B,D):

Canadian balsam, copaiba balsam, bergamot, cedarwood (Atlas, Texas & Virginian), celery seed, chamomile (German & Roman), cubebs, eucalyptus blue gum, frankincense, juniper, lavandin, lavender (spike & true), lovage, mastic, niaouli, parsley, Scotch pine, sandalwood, tea tree, thyme, turpentine, yarrow.

Frigidity (M,S,B,V):

Cassie, cinnamon leaf, jasmine, neroli, nutmeg, parsley, patchouli, black pepper, cabbage rose, rosewood, clary sage, sandalwood, ylang ylang.

Lack of nursing milk (M):

Celery seed, dill, sweet fennel, hops.

Labour pain & childbirth aid (M,C,B):

Cinnamon leaf, jasmine, true lavender, nutmeg, parsley, rose (cabbage & damask), clary sage.

Leucorrhoea/white discharge from the vagina (B,D):

Bergamot, cedarwood (Atlas, Texas & Virginian), cinnamon leaf, cubebs, eucalyptus blue gum, frankincense, hyssop, lavandin, lavender (spike & true), sweet marjoram, mastic, myrrh, rosemary, clary sage, sandalwood, tea tree, turpentine.

Menopausal problems (M,B,V):

Cypress, sweet fennel, geranium, jasmine, rose (cabbage & damask).

Menorrhagia/excessive menstruation (M,B):

Chamomile (German & Roman), cypress, rose (cabbage & damask).

Premenstrual tension/PMT (M,B,V):

Carrot seed, chamomile (German & Roman), geranium, true lavender, sweet marjoram, neroli, tarragon.

Pruritis/itching (D):

Bergamot, Atlas cedarwood, juniper, lavender, myrrh, tea tree.

Sexual overactivity (M,B):

Hops, sweet marjoram.

Thrush/candida (B,D):

Bergamot, geranium, myrrh, tea tree.

Urethritis (B,D):

Bergamot, cubebs, mastic, tea tree, turpentine.

Immune System

Chickenpox (C,S,B):

Bergamot, chamomile (German & Roman), eucalyptus (blue gum & lemon), true lavender, tea tree.

Colds/’flu (M,B,V,I):

Angelica, star anise, aniseed, copaiba balsam, Peru balsam, French basil, West Indian bay, bergamot, borneol, cabreuva, cajeput, camphor (white), caraway, cinnamon leaf, citronella, clove bud, coriander, eucalyptus (blue gum, lemon & peppermint), silver fir, frankincense, ginger, grapefruit, immortelle, juniper, laurel, lemon, lime, sweet marjoram, mastic, mint (peppermint & spearmint), myrtle, niaouli, orange (bitter & sweet), pine (longleaf & Scotch), rosemary, rosewood, Spanish sage, hemlock spruce, tea tree, thyme, turpentine, yarrow.

Fever (C,B):

French basil, bergamot, borneol, camphor (white), eucalyptus (blue gum, lemon & peppermint), silver fir, ginger, immortelle, juniper, lemon, lemongrass, lime, mint (peppermint & spearmint), myrtle, niaouli, rosemary, rosewood, Spanish sage, hemlock spruce, tea tree, thyme, yarrow.

Measles (S,B,I,V):

Bergamot, eucalyptus blue gum, lavender (spike & true), tea tree.... genito-urinary and endocrine systems