Meta Health Dictionary

Meta: From 1 Different Sources


(German / Latin) Form of Margaret, meaning “resembling a pearl / the child of light” / one who is ambitious Metah, Metta, Mettah
Health Source: Medical Dictionary
Author: Health Dictionary

Metabolism

The sum total of changes in an organism in order to achieve a balance (homeostasis). Catabolic burns up, anabolic stores and builds up; the sum of their work is metabolism.... metabolism

Metaplasia

Change of a mature type of cell in a tissue to another mature type of cell usually present in another tissue; e.g., development of squamous epithelium in the trachea among the normal respiratory epithelium = squamous metaplasia.... metaplasia

Metastasis

The spread of cancer cells through the blood, lymphatics or directly and establishment of these newgroups of cells at locations distant from the original cancer.... metastasis

Basal Metabolism

The basic rate of combustion by a person, usually measured after sleep and while resting.... basal metabolism

Meta-analysis

A statistical procedure to combine results from different studies on a similar topic. The combination of results from multiple studies may produce a stronger conclusion than can be provided by any singular study. Meta-analysis is generally most appropriate when there are no definitive studies on a topic and non-definitive studies are in some disagreement.... meta-analysis

Metatarsalgia

Pain affecting the metatarsal region of the foot. It is common in adolescents, and associated with FLAT-FOOT; in adults it may be a manifestation of RHEUMATOID ARTHRITIS. Morton’s metatarsalgia is a form associated usually with the nerve to the second toe cleft, often induced by the compression of tight shoes.... metatarsalgia

Metabolic Disorders

A collection of disorders in which some part of the body’s internal chemistry (see METABOLISM; CATABOLISM) is disrupted. Some of these disorders arise from inherited de?ciencies in which a speci?c ENZYME is absent or abnormal, or does not function properly. Other metabolic disorders occur because of malfunctions in the endocrine system (see ENDOCRINE GLANDS). There may be over- or underproduction of a hormone involved in the control of metabolic activities: a prime example is DIABETES MELLITUS – a disorder of sugar metabolism; others include CUSHING’S SYNDROME; hypothyroidism and hyperthyroidism (see THYROID GLAND, DISEASES OF); and insulinoma (an insulin-producing tumour of the pancreas). The bones can be affected by metabolic disorders such as osteoporosis, osteomalacia (rickets) and Paget’s disease (see under BONE, DISORDERS OF). PORPHYRIAS, HYPERLIPIDAEMIA, HYPERCALCAEMIA and gout are other examples of disordered metabolism.

There are also more than 200 identi?ed disorders described as inborn errors of metabolism. Some cause few problems; others are serious threats to an individual’s life. Individual disorders are, fortunately, rare – probably one child in 10,000 or 100,000; overall these inborn errors affect around one child in 1,000. Examples include GALACTOSAEMIA, PHENYLKETONURIA, porphyrias, TAY SACHS DISEASE and varieties of mucopolysaccharidosis, HOMOCYSTINURIA and hereditary fructose (a type of sugar) intolerance.... metabolic disorders

Metabolites

A by-product, waste product, or endotoxin produced as the result of metabolism, both normal and defensive.... metabolites

Metamyelocyte

An immature granulocyte (white blood cell) usually found in the bone marrow’s blood-making tissue. It can, however, appear in the blood in a range of diseases, including infection.... metamyelocyte

Metaphysis

The extremity of a long bone where it joins the epiphysis (see BONE – Growth of bones).... metaphysis

Metatarsus

Metatarsus is the group name of the ?ve metatarsal bones in the foot. Metatarsus varus is the condition characterised by deviation of the forefoot towards the other foot. It is a common condition in newborn babes and almost always corrects itself spontaneously. Only in the rare cases in which it is due to some deformity of the bones or muscles of the foot is any treatment required.... metatarsus

Metabolite

Any substance involved in a metabolic reaction (a biochemical reaction in the body). The term metabolite is sometimes used to refer only to the products of a metabolic reaction. (See also metabolism.)... metabolite

Drug Metabolism

A process by which the body destroys and excretes drugs, so limiting their duration of action. Phase 1 metabolism consists of transformation by oxidation, reduction, or hydrolysis. In phase 2 this transformed product is conjugated (joined up) with another molecule to produce a water-soluble product which is easier to excrete.... drug metabolism

Metacarpal Bones

The ?ve long bones which occupy the HAND between the carpal bones at the wrist and the phalanges of the ?ngers. The large rounded ‘knuckles’ at the root of the ?ngers are formed by the heads of these bones.... metacarpal bones

Metastatic

See METASTASIS.... metastatic

Metatarsal Bones

The ?ve bones in the foot which correspond to the METACARPAL BONES in the hand, lying between the tarsal bones, at the ankle, and the toes.... metatarsal bones

Metazoa

That division of the animal kingdom which embraces all animals whose cells become differentiated to form tissues. It includes all animals except the protozoa.... metazoa

Metacarpal Bone

One of 5 long, cylindrical bones within the hand. The bones run from the wrist to the base of each digit, with the heads of the bones forming the knuckles.... metacarpal bone

Metatarsal Bone

One of 5 long, cylindrical bones within the foot. The bones make up the central skeleton of the foot and are held in an arch by the surrounding ligaments.... metatarsal bone

Metatarsophalangeal Joint

The joint between each metatarsal bone and its adjoining toe bone (see phalanges). The metatarsophalangeal joint at the base of the big toe is commonly affected by gout and by hallux rigidus.... metatarsophalangeal joint

Heavy Metal Toxicity

Pollution of the blood and tissues by environmental poisons and traces of chemicals is a source of chronic disease. The most common toxic metals are lead, aluminium, cadmium, mercury and arsenic in that order. Copper is also toxic but is essential in small amounts.

Lead disrupts neurotransmitters in the brain and disposes to nervous excitability, aggression and hyperactivity. Aluminium is associated with senile dementia and Alzheimer’s disease, accumulating in the brain. Cadmium induces changes in behaviour with reduced mental ability. Mercury is present in the amalgam used in dental surgery as part-filling for teeth. Arsenical poisoning may occur in food contamination or paints.

An internal chelating or cleansing of tissues of the lungs, urinary system, blood and lymph may be assisted by a combination of relative expectorants, diuretics, hepatics and adaptogens among which are: Barberry, Blue Flag root, Chaparral, Burdock, Echinacea, Red Clover, Yellow Dock. To bind with metals and assist their passage through the intestinal canal to the outside of the body: Irish Moss, Iceland Moss or Slippery Elm. Garlic.

The Medicines Control Agency of the Ministry of Health (UK) has given consideration to the content of heavy metal impurities and rules that a limit of 75 micrograms of total heavy metals shall be the acceptable maximum daily intake.

Licence-holders are required to carry out tests on all incoming material. Some seaweeds may be heavily polluted with mercury, arsenic and radioactive particles as a result of micro-biological contamination. The MCA requires Bladderwrack and other seaweeds to contain minimum levels. ... heavy metal toxicity

Metabolism, Inborn Errors Of

Inherited defects of body chemistry. Inborn errors of metabolism are caused by single gene defects, which lead to abnormal functioning of an enzyme.

Some of these gene defects are harmless, but others are severe enough to result in death or physical or mental handicap. Examples include Tay–Sachs disease, phenylketonuria, Hurler’s syndrome, and Lesch–Nyhan syndrome. Collectively, inborn errors of metabolism affect around 1 child in 5,000.

Symptoms are usually present at or soon after birth. They may include unexplained illness or failure to thrive, developmental delay, floppiness, persistent vomiting, or seizures.

Routine tests are performed on newborn babies for some genetic disorders, such as phenylketonuria.

Treatment is not needed for some inborn errors of metabolism. For others, avoidance of a specific environmental factor may be sufficient. In some cases, the missing enzyme or the protein that it produces can be manufactured using genetic engineering techniques, or a vitamin supplement can help compensate for the defective enzyme. If the enzyme is made in blood cells, a bone marrow transplant may provide a cure.

People with a child or a close relative who is affected may benefit from genetic counselling before planning a pregnancy.... metabolism, inborn errors of

First-pass Metabolism

a process in which a drug administered by mouth is absorbed from the gastrointestinal tract and transported via the portal vein to the liver, where it is metabolized. As a result, in some cases only a small proportion of the active drug reaches the systemic circulation and its intended target tissue. First-pass metabolism can be bypassed by giving the drug via sublingual or buccal routes.... first-pass metabolism

Inborn Error Of Metabolism

any one of a group of inherited conditions in which there is a disturbance in either the structure, synthesis, function, or transport of protein molecules. There are over 1500 inborn errors of metabolism; examples are *phenylketonuria, *homocystinuria, and *hypogammaglobulinaemia.... inborn error of metabolism

Matrix Metalloproteinase

(MMP) any one of a group of zinc-containing proteases capable of digesting the extracellular tissue matrix. These enzymes play an important role in cell division, cell migration, inflammation, neoplastic invasion (*metastasis), and *angiogenesis.... matrix metalloproteinase

Metabolic Syndrome

(insulin resistance syndrome, syndrome X) a very common condition in which impaired glucose tolerance, impaired fasting glucose, or type 2 diabetes (see glucose tolerance test) is combined with central obesity (increased fat within the abdomen), raised blood pressure (*hypertension), and *hyperlipidaemia. It is associated with a risk of premature vascular disease (heart attack and stroke). The principal underlying cause is *insulin resistance, which is genetically determined.... metabolic syndrome

Metacarpal

1. adj. relating to the bones of the hand (*metacarpus). 2. n. any of the bones forming the metacarpus.... metacarpal

Metacarpus

n. the five bones of the hand that connect the *carpus (wrist) to the *phalanges (digits).... metacarpus

Metacentric

n. a chromosome in which the centromere is at or near the centre of the chromosome. —metacentric adj.... metacentric

Metacercaria

n. (pl. metacercariae) a mature form of the *cercaria larva of a fluke. Liver fluke metacercariae are enveloped by thin cysts and develop on various kinds of vegetation.... metacercaria

Metachromasia

(metachromatism) n. 1. the property of a dye of staining certain tissues or cells a colour that is different from that of the stain itself. 2. the variation in colour produced in certain tissue elements that are stained with the same dye. 3. abnormal coloration of a tissue produced by a particular stain. —metachromatic adj.... metachromasia

Metaethics

n. philosophical study of the theoretical foundations of *ethics, as opposed to practical ethics.... metaethics

Metagonimus

n. a genus of small flukes, usually less than 3 mm in length, that are common as parasites of dogs and cats in the Far East, N Siberia, and the Balkan States. Adult flukes of M. yokogawai occasionally infect the human duodenum if undercooked fish (the intermediate host) is eaten. They may cause inflammation and some ulceration of the intestinal lining, which produces a mild diarrhoea. Flukes can be easily removed with tetrachloroethylene.... metagonimus

Metamorphopsia

n. a condition in which objects appear distorted. It is usually due to a disorder of the retina affecting the *macula (the most sensitive part).... metamorphopsia

Metanephrine And Normetanephrine

metabolites of the hormones adrenaline and noradrenaline, respectively. Both hormones are released in excess from a *phaeochromocytoma, and measurement of their metabolites is the most reliable screening test for this rare but potentially lethal condition. The test is best carried out on a complete 24-hour urine collection.... metanephrine and normetanephrine

Metanephros

n. the excretory organ of the fetus, which develops into the kidney and is formed from the rear portion of the *nephrogenic cord. It does not become functional until birth, since urea is transferred across the placenta to the mother.... metanephros

Metaphase

n. the second stage of *mitosis and of each division of *meiosis, in which the chromosomes line up at the centre of the *spindle, with their centromeres attached to the spindle fibres.... metaphase

Metaraminol

n. a *sympathomimetic drug that stimulates alpha receptors and is used as a *vasoconstrictor to treat acute *hypotension.... metaraminol

Metastasize

vb. (of a malignant tumour) to spread by *metastasis.... metastasize

Metastatic Calcification

the calcification of otherwise normal tissues in patients with *hypercalcaemia. Compare dystrophic calcification.... metastatic calcification

Metatarsal

1. adj. relating to the bones of the foot (*metatarsus). 2. n. any of the bones forming the metatarsus.... metatarsal

Metathalamus

n. a part of the *thalamus consisting of two nuclei through which impulses pass from the eyes and ears to be distributed to the cerebral cortex.... metathalamus



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