Monocyte Health Dictionary

This is a mature form of what is released from the marrow as a monocyte. A macrophage lives long, can digest much detritus, and is able to wear particles of odd food on its outer membrane. This allows T-cell and B-cell Iymphocytes to taste the particle (an epitope) and form an antibody response. Further, these macrophages, traveling as monocytes, will take up permanent residence in many tissues, providing them with immunity. They line the spleen, form the cleansing Kupffer cells in the liver, make up the “dust cells” that protect the lungs, protect the synovial fluids of the joints, and form the microglial cells that provide protection to the brain and nerve tissues. On and on, the macrophages clean up messes and acting as the intermediates between innate and acquired immunity.... macrophage

(Linn. f.) Willd.

Family: Mimosaceae.

Habitat: Drier regions of India, particularly Punjab, Madhya Pradesh, Uttar Pradesh, Bihar, Andhra Pradesh, Orissa and Rajasthan.

English: Cutch tree, Catechu.

Ayurvedic: Khadira, Kadara, Somavalka, Gaayatri, Dantdhaavan, Kantaki, Raktasaara (heartwood extract).

Unani: Khair, Kaat, Katthaa (heartwood extract).

Siddha/Tamil: Karunkaali (bark), Kalippakku, Kadiram. Katthakkaambu, Kaasukkatti (heartwood extract).

Action: Cutch from wood— powerful astringent (in urinary and vaginal discharge), antidiarrhoeal, haemostatic; used for treating excessive mucous discharges, haemorrhages, relaxed conditions of gums, throat and mouth, stomatitis, irritable bowel; also used as an antileprotic drug.

Along with other therapeutic applications, The Ayurvedic Pharmacopoeia of India indicates the use of dried pieces of heartwood in inflammations, skin diseases and urinary disorders, recommends its use as a blood purifier, in diseases caused by lipid disorders.

Cutch (the concentrated extract) contains tannins 2-20%, catechin 2533%, phlobatannins including cate- chutannic acid 20-50%; flavonoids including quercetin, quercitrin, fisetin; gums, resins, pigments. The gum from A. catechu is a good substitute for Gum arabic.

Seed extract—hypoglycaemic to normal albino rats, but not effective in diabetic rats. The saline extract of seeds shows leuco-agglutinating activity against leukaemic cells. It agglutinates white cells from patients with different types of leukaemia. The activity is inhibited by simple sugars. Root extract shows antibacterial and fungi- cidal activity.

The heartwood contains a hepato- protective principle—cyanidanol.

Astringent and antibacterial properties of catechu result from its high tannin content.

Gambrine in pale catechu shows hy- potensive effects.

Fisetin in black catechu and (+)- catechin in black and pale catechu may protect against liver damage; (+)- catechin is also thought to protect against experimentally induced ulcers in animals; (+)-catechin (cianidanol) is associated with fatal anaemia. Methyl- catechin, one of the major metabolites of (+)-catechin, inhibits the binding of monocytes to vascular endothelial cells; thus, the catechin found in catechu may reduce atherosclerosis. (Natural Medicines Comprehensive Database, 2007.)

Dosage: Heartwood—20-30 g for decoction. (API Vol. I.)... acacia catechu

These are a group of white blood cells that have many and well-pigmented granules, and derive from the bone marrow myeloblasts. The granules are sources of digestive, immunologic, and inflammatory proteins. The classic granulocytes are neutrophils, eosinophils, and basophils, but one should also include mast cells. Also, macrophages, which start out as agranulocytic monocytes but get lots of granules when they grow up.... granulocytes

The scienti?c name for white blood cells. Leucocytes contain no HAEMOGLOBIN so are colourless, and have a well-formed NUCLEUS. Healthy people have around 8,000 leucocytes per cubic millimetre of blood. There are three main classes of white cells: granulocytes, lymphocytes and monocytes.

Granulocytes Also known as polymorphonuclear leucocytes (‘polys’), these normally constitute 70 per cent of the white blood cells. They are divided into three groups according to the staining reactions of these granules: neutrophils, which stain with neutral dyes and constitute 65–70 per cent of all the white blood cells; eosinophils, which stain with acid dyes (e.g. eosin) and constitute 3–4 per cent of the total white blood cells; and basophils, which stain with basic dyes (e.g. methylene blue) and constitute about 0·5 per cent of the total white blood cells.

Lymphocytes constitute 25–30 per cent of the white blood cells. They have a clear, non-granular cytoplasm and a relatively large nucleus which is only slightly indented. They are divided into two groups: small lymphocytes, which are slightly larger than erythrocytes (about 8 micrometres in diameter); and large lymphocytes, which are about 12 micrometres in diameter.

Monocytes Motile phagocytic cells that circulate in the blood and migrate into the tissues, where they develop into various forms of MACROPHAGE such as tissue macrophages and KUPFFER CELLS.

Site of origin The granulocytes are formed in the red BONE MARROW. The lymphocytes are formed predominantly in LYMPHOID TISSUE. There is some controversy as to the site of origin of monocytes: some say they arise from lymphocytes, whilst others contend that they are derived from histiocytes – i.e. the RETICULO-ENDOTHELIAL SYSTEM.

Function The leucocytes constitute one of the most important of the defence mechanisms against infection. This applies particularly to the neutrophil leucocytes (see LEUCOCYTOSIS). (See also ABSCESS; BLOOD – Composition; INFLAMMATION; PHAGOCYTOSIS; WOUNDS.)... leucocytes

Cells – including monocytes (a variety of LEUCOCYTES) in the blood and macrophages (see MACROPHAGE) in the tissues – that envelop and digest BACTERIA cells, cell debris and other small particles. Phagocytes are an essential part of the body’s defence mechanisms.... phagocyte

A process by which BACTERIA and other foreign particles in the body are ingested by monocytes in the blood and macrophages in the tissues (see under PHAGOCYTE) that envelop and digest bacteria, cells, cell debris and other small particles. Phagocytes are an essential part of the body’s defence mechanisms.... phagocytosis

White Blood Cells, including those of innate immunity, including basophils, neutrophils, eosinophils, monocytes, macrophages (and others) and those of acquired immunity, the various types of lymphocytes. Also called leukocytes.... wbc

(blood corpuscle) any of the cells that are present in the blood in health or disease. The cells may be subclassified into three major categories, namely red cells (*erythrocytes); white cells (*leucocytes), which include granulocytes, lymphocytes, and monocytes; and *platelets (see illustration). The blood cells account for approximately 40% of the total volume of the blood in health; red cells comprise the vast majority.... blood cell

Fever, or PYREXIA, is the abnormal rise in body TEMPERATURE that frequently accompanies disease in general.

Causes The cause of fever is the release of fever-producing proteins (pyrogens) by phagocytic cells called monocytes and macrophages, in response to a variety of infectious, immunological and neoplastic stimuli. The lymphocytes (see LYMPHOCYTE) play a part in fever production because they recognise the antigen and release substances called lymphokines which promote the production of endogenous pyrogen. The pyrogen then acts on the thermoregulatory centre in the HYPOTHALAMUS and this results in an increase in heat generation and a reduction in heat loss, resulting in a rise in body temperature.

The average temperature of the body in health ranges from 36·9 to 37·5 °C (98·4 to 99·5 °F). It is liable to slight variations from such causes as the ingestion of food, the amount of exercise, the menstrual cycle, and the temperature of the surrounding atmosphere. There are, moreover, certain appreciable daily variations, the lowest temperature being between the hours of 01.00 and 07.00 hours, and the highest between 16.00 and 21.00 hours, with tri?ing ?uctuations during these periods.

The development and maintenance of heat within the body depends upon the metabolic oxidation consequent on the changes continually taking place in the processes of nutrition. In health, this constant tissue disintegration is exactly counterbalanced by the consumption of food, whilst the uniform normal temperature is maintained by the adjustment of the heat developed, and of the processes of exhalation and cooling which take place, especially from the lungs and skin. During a fever this balance breaks down, the tissue waste being greatly in excess of the food supply. The body wastes rapidly, the loss to the system being chie?y in the form of nitrogen compounds (e.g. urea). In the early stage of fever a patient excretes about three times the amount of urea that he or she would excrete on the same diet when in health.

Fever is measured by how high the temperature rises above normal. At 41.1 °C (106 °F) the patient is in a dangerous state of hyperpyrexia (abnormally high temperature). If this persists for very long, the patient usually dies.

The body’s temperature will also rise if exposed for too long to a high ambient temperature. (See HEAT STROKE.)

Symptoms The onset of a fever is usually marked by a RIGOR, or shivering. The skin feels hot and dry, and the raised temperature will often be found to show daily variations – namely, an evening rise and a morning fall.

There is a relative increase in the pulse and breathing rates. The tongue is dry and furred; the thirst is intense, while the appetite is gone; the urine is scanty, of high speci?c gravity and containing a large quantity of solid matter, particularly urea. The patient will have a headache and sometimes nausea, and children may develop convulsions (see FEBRILE CONVULSION).

The fever falls by the occurrence of a CRISIS – that is, a sudden termination of the symptoms – or by a more gradual subsidence of the temperature, technically termed a lysis. If death ensues, this is due to failure of the vital centres in the brain or of the heart, as a result of either the infection or hyperpyrexia.

Treatment Fever is a symptom, and the correct treatment is therefore that of the underlying condition. Occasionally, however, it is also necessary to reduce the temperature by more direct methods: physical cooling by, for example, tepid sponging, and the use of antipyretic drugs such as aspirin or paracetamol.... fever

Cells, also called blood corpuscles, present in blood for most or part of their lifespan. They include red blood cells, which make up about 45 per cent by volume of normal blood, white blood cells, and platelets. Blood cells are made in the bone marrow by a series of divisions from stem cells.

Red blood cells (also known as RBCs, red blood corpuscles, or erythrocytes) transport oxygen from the lungs to the tissues (see respiration). Each is packed with haemoglobin, enzymes, minerals, and sugars. Abnormalities can occur in the rate at which RBCs are either produced or destroyed, in their numbers, and in their shape, size, and haemoglobin content, causing forms of

anaemia and polycythaemia (see blood, disorders of).

White blood cells (also called WBCs, white blood corpuscles, or leukocytes) protect the body against infection and fight infection when it occurs. The 3 main types of are granulocytes (also called polymorphonuclear leukocytes), monocytes, and lymphocytes. Granulocytes are further classified as neutrophils, eosinophils, or basophils, and each type of granulocyte has a role in either fighting infection or in inflammatory or allergic reactions. Monocytes and lymphocytes also play an important part in the immune system. Lymphocytes are usually formed in the lymph nodes. One type, a T-lymphocyte, is responsible for the delayed hypersensitivity reactions

White (see allergy) and Red blood blood cell is also involved in cell (neutrophil) protection against cancer. T-lymphocytes manufacture chemicals, known as lymphokines, which affect the function of other cells. In addition, the T-cells moderate the activity of B-lymphocytes, which form the antibodies that can prevent a second attack of certain infectious diseases. Platelets (also known as thrombocytes), are the smallest blood cells and are important in blood clotting.

The numbers, shapes, and appearance of the various types of blood cell are of great value in the diagnosis of disease (see blood count; blood film).... blood cells

n. an iron-storage compound found mainly in the cells of the *macrophage– *monocyte system in the marrow, in the *Kupffer cells of the liver, and in the spleen. It contains around 30% iron by weight.... haemosiderin

(white blood cell) n. any blood cell that contains a nucleus. In health there are three major subdivisions: *granulocytes, *lymphocytes and *monocytes, which are part of the immune system, being involved in protecting the body against foreign substances and in antibody production. In disease, a variety of other types may appear in the blood, most notably immature forms of the normal red or white blood cells.... leucocyte

an infectious disease, caused by the Epstein-Barr virus, that affects the lymph nodes in the neck, armpits, and groin. In the western world it mainly affects adolescents and young adults; in developing countries young children are most affected. After an incubation period of 5–7 days, symptoms commence with swelling and tenderness of the lymph nodes, fever, headache, a sore throat, lethargy, and loss of appetite. In some cases the liver is affected, causing *hepatitis, or the spleen is enlarged. Glandular fever is diagnosed by the presence of large numbers of *monocytes in the blood. Complications are rare but symptoms may persist for weeks before recovery. Medical name: infectious mononucleosis.... glandular fever

n. (pl. granulomata or granulomas) a localized collection of cells, usually produced in response to an infectious process, that is characterized by the presence of aggregates of epithelioid *histiocytes; giant cells, monocytes, or lymphocytes may also be present. The types of cells comprising a granuloma (of which there may be many or few) and their arrangement can assist in diagnosing the cause of the response; this is important in the diagnosis of tuberculosis, sarcoidosis, Crohn’s disease, and the presence of certain foreign bodies (e.g. starch, talc). Other conditions giving rise to granulomata include syphilis, leprosy, and coccidioidomycosis, and a granuloma may also occur around the apex of a tooth root as a result of inflammation or infection of its pulp. —granulomatous adj.... granuloma

n. any of a group of malignant diseases in which the bone marrow and other blood-forming organs produce increased numbers of certain types of white blood cells (*leucocytes). Overproduction of these white cells, which are immature or abnormal forms, suppresses the production of normal white cells, red cells, and platelets. This leads to increased susceptibility to infection (due to *neutropenia), *anaemia, and bleeding (due to *thrombocytopenia). Other symptoms include enlargement of the spleen, liver, and lymph nodes.

Leukaemias are classified into acute or chronic varieties depending on the rate of progression of the disease. They are also classified according to the type of white cell that is proliferating abnormally; for example acute lymphoblastic leukaemia (see lymphoblast), chronic lymphocytic leukaemia (see lymphocyte), acute myeloblastic leukaemia (see myeloblast), hairy-cell leukaemia (see hairy cell), and monocytic leukaemia (see monocyte). (See also myeloid leukaemia.) Leukaemias can be treated with *cytotoxic drugs or *monoclonal antibodies, which suppress the production of the abnormal cells, or occasionally with radiotherapy.... leukaemia

n. the earliest identifiable cell that gives rise to a *monocyte. It is probably identical with the *myeloblast and matures via an intermediate stage (promonocyte). It is normally found in the blood-forming tissue of the *bone marrow but may appear in the blood in certain diseases, most notably in acute monoblastic *leukaemia.... monoblast

n. an increase in the number of *monocytes in the blood. It occurs in a variety of diseases, including monocytic *leukaemia and infections due to some bacteria and protozoa.... monocytosis

n. the condition in which the blood contains an abnormally high number of mononuclear leucocytes (*monocytes and *lymphocytes). See glandular fever.... mononucleosis

(RES) a community of cells – *phagocytes – spread throughout the body. It includes *macrophages and *monocytes. The RES is concerned with defence against microbial infection and with the removal of worn-out blood cells from the bloodstream. See also spleen.... reticuloendothelial system

(TNF) either of two proteins, TNF-? or TNF-?, that function as *cytokines. Produced by macrophages, monocytes, T lymphocytes, and various other cells, they mediate many responses, including inflammation, and have a marked action against tumour cells. Anti-TNF drugs (see cytokine inhibitor) are used in the treatment of several disorders, especially rheumatoid arthritis and ankylosing spondylitis.... tumour necrosis factor