Hook.
Synonym: M. pruriens Baker non DC.
Family: Papilionaceae; Fabaceae.
Habitat: Throughotu India, including Andaman and Nicobar Islands.
English: Cowhage, Horse-eye Bean.
Ayurvedic: Aatmaguptaa, Kapikac- chuu, Rshabhi, Adhigandhaa, Ajadaaa, Kacchuraa, Laan- guli, Rshyaproktaa, Svaguptaa, Shyaamguptaa, Markati, Kanduraa, Kevaanch, Shuukashimbi.
Unani: Konchh.
Siddha/Tamil: Poonaikkaali.
Action: Seed—astringent, nervine tonic, local stimulant, used in impotence, spermatorrhoea, urinary troubles, leucorrhoea, traditionally used for male virility. Also used in depressive neurosis. Hair on fruit— vermifuge, mild vesicant; used for diseases of liver and gallbladder. Leaf—applied to ulcers. Pod— anthelmintic. Root and fruit—spasmolytic, hypoglycaemic. Root— CNS active.
The Ayurvedic Pharmacopoeia ofIn- dia recommends the seed in impotence and paralysis agitans; the root in vaginal laxity.The seeds contain the alkaloids, mu- cunine, mucunadine, mucunadinine, prurieninine, pruriendine and nicotine, besides beta-sitosterol, gluthione, lecithin, vernolic and gallic acids. They contain a number of bioactive substances including tryptamine, alky- lamines, steroids, flavonoids, cou- marins and cardenolides. L-DOPA is present in the seed as well as in the stem, leaves and roots.Major constituents of the hairs on the pod are amines such as 5-hydroxy- tryptamine (serotonin), and a proteolytic enzyme mucuanain. (Serotonin was present only in pods.)Prurieninine slowed down heart rate, lowered blood pressure and stimulated intestinal peristalsis in experiments carried out on frogs. The spas- molysis of smooth muscles was caused by indole bases.Seed diet produced hypoglycaemic effect in normal rats, however, such diet had insignificant effect on alloxan- treated rats.There is some evidence that Cow- hage might be useful for chlorproma- zine-induced hyperprolactinemia in men. (Natural Medicines Comprehensive Database, 2007.) (Males with hy- perprolactinemia frequently face im- potency.) (Cured seeds are used in Indian medicine for male sexual dysfunction.)Mucuna cochinchinensis Cheval.; synonym M. nivea (Roxb.) DC.; Sti- zolobium niveum Kuntze (cultivated in Bengal and Bihar for edible pods and seeds) is known as Lyon Bean (Khamach in Bengal). The pod yielded L-DOPA (0.06%).
Dosage: Cured seed—3-6 g (API, Vol. III); root—3-6 g powder for decoction (API, Vol. IV.)... mucuna prurita