Mutagen Health Dictionary

A change occurring in the genetic material (DNA) in the CHROMOSOMES of a cell. It is caused by a fault in the replication of a cell’s genetic material when it divides to form two daughter cells. Mutations may occur in somatic cells which may result in a local growth of the new type of cells. These may be destroyed by the body’s defence mechanism or they may develop into a tumour. If mutation occurs in a germ cell or gamete – the organism’s sex cells – the outcome may be a changed inherited characteristic in succeeding generations. Mutations occur rarely, but a small steady number are caused by background radiation in the environment. They are also caused by mutagens (see MUTAGEN). (See also GENETIC DISORDERS.)... mutation

DC.

Synonym: A. officinarum Hayne

Family: Compositae; Asteraceae.

Habitat: Native to the Mediterranean region; cultivated in Algeria.

English: Spanish, Pellitory, Pyrethrum Root.

Ayurvedic: Aakaarakarabha, Aakallaka, Aakulakrit, Agragraahi.

Unani: Aaqarqarhaa.

Siddha/Tamil: Akkiraakaaram.

Action: Stimulant, cordial, rubefa- cient.A gargle of infusion is prescribed for relaxed vulva. Root— used for toothache, rheumatic and neuralgic affections and rhinitis. Roots, along with the root of Witha- nia somnífera and Vitis vinifera, are used in epilepsy.

Along with other therapeutic applications, Ayurvedic Pharmacopoeia of India indicates the use of the root in sciatica, paralysis, hemiplegia and amenorrhoea.

The root contains anacycline, isobu- tylamide, inulin and a trace ofessential oil.

The local anaesthetic activity of the alcoholic (2%) extract of the root was found to be comparable to that of xy- locaine hydrochloride (2%) in dental patients.

Use of the drug in patients with insulin-dependent diabetes mellitus reduces the dose of insulin. It decreased the plasma glucose and serum cholesterol levels after oral administration for 3-6 weeks. (The plant is mixed with Helleborus nigar in a ratio of 1:3.) The plant extract inhibited tobacco-induced mutagenesis by 47.5% at a concentration of 1 mg/plate.

Dosage: Root—500 mg to 1 g powder. (CCRAS.)... anacyclus pyrethrum

Anise, anise burnet-saxifrage (Pimpinella anisum).

Plant Part Used: Fruit (seed).

Dominican Medicinal Uses: The seeds are traditionally prepared as a decoction and taken orally for colic (in children and adults), common cold, empacho, flatulence, flu, gastrointestinal disorders, headache, indigestion, nervous tension, pasmo and stress.

Safety: The seeds are generally regarded as safe for human consumption in moderation and widely used as a culinary spice. Caution is advised if this herbal remedy is combined with anís de estrella due to potential contamination with a toxic look-alike (see entry for “Anís de estrella”).

Contraindications: Studies show conflicting recommendations regarding safety of internal use during pregnancy and lactation. Use of this herb in combination with anís de estrella is contraindicated in children (due to potential for contamination with the toxic look-alike Illicium anisatum (see “Anís de estrella”); however, anís chiquito is considered safe for children when used appropriately.

Drug interactions: Anticoagulants, NSAIDS, antiplatelet drugs, warfarin: Avoid use of anís chiquito if taking any of these medications due to potential risk of excessive bleeding as a result of interaction with coumarin derivatives.

Clinical Data: No clinical trials of the oral use of this herb have been identified in the available literature. One open clinical trial has evaluated the pediculicidal effects of anise oil in combination with other ingredients.

Laboratory & Preclinical Data: The following biological activities of this plant have been investigated in laboratory studies using in vitro or animal models: anticonvulsant, antidiuretic, antiflatulent, antifungal, antimicrobial, antispasmodic, estrogenic, expectorant, hypotensive, liver regeneration, muscle stimulant and mutagenic.

* See entry for Anís chiquito in “Part 3: Dominican Medicinal Plant Profiles” of this book for more information, including references.... anís chiquito

Linn. f.

Habitat: Native to China; now grown in Himachal Pradesh, Kumaon, the Nilgiris and West Bengal for edible fruits.

English: Japanese Persimmon.

Ayurvedic: Tinduka (var.).

Action: Hypotensive, hepatopro- tective, antidote to poisons and bacterial toxins. Calyx and peduncle of fruit—used in the treatment of cough and dyspnoea. Roasted seeds—used as a substitute for coffee.

The fruit, in addition to sugars, glucose, fructose, ascorbic acid, citric acid, contains (% of fresh weight) 0.20-1.41 tannins, 0.21-10.07 total pectins, 0.67 pentosans and 0.16-0.25 polyphenols. The fruit also contains 2.4 mg/100 g carotenoids; carotene expressed as vitamin A 2200-2600 IU. The carote- noids identified in the pulp include cryptoxanthine, zeaxanthin, antherax- anthin, lycopene and beta-carotene. (Many carotenoids originally present in the fruit decompose during ripening.

The fruit pulp is an antidote to bacterial toxins and is used in the preparation of a vaccine for pertussis.

Condensed tannins from the fruits effectively inhibited 2-nitrofluorene mutagen.

The immature leaves contain a ster- oidal saponin, lignin and phenolic compounds. Eugenol and dihydroac- tinidiolide are reported from fresh leaves.

The leaves are reported to exhibit hepatoprotective activity. Leaves also contain hypotensive principles. Astra- galin and isoquercitrin have been isolated from leaves.... diospyros kaki

n. a substance that can either reduce the spontaneous production of mutations or prevent or reverse the action of a *mutagen.... antimutagen

n. any substance, agent, or process that induces the formation of developmental abnormalities in a fetus. Known teratogens include such drugs as *thalidomide and alcohol; such infections as German measles and cytomegalovirus; and also irradiation with X-rays and other ionizing radiation. Compare mutagen. —teratogenic adj.... teratogen

Nutritional Profile Energy value (calories per serving): Low Protein: Moderate Fat: Low Saturated fat: Low Cholesterol: None Carbohydrates: High Fiber: Moderate Sodium: High Major vitamin contribution: Folate Major mineral contribution: Potassium, phosphorus

About the Nutrients in This Food Celery has moderate amounts of dietary fiber and small amounts of the B vitamin folate. One-half cup diced raw celery has one gram dietary fiber and 17 mcg folate (4 percent of the R DA).

The Most Nutritious Way to Serve This Food Fresh, filled with cheese to add protein.

Diets That May Restrict or Exclude This Food Low-fiber diet Low-sodium diet

Buying This Food Look for: Crisp, medium-size pale green celery with fresh leaves. Darker stalks have more vitamin A but are likely to be stringy. Avoid: Wilted or yellowed stalks. Wilted stalks have lost moisture and are low in vitamins A and C. Yellowed stalks are no longer fresh; their chlorophyll pigments have faded enough to let the yellow carotenes show through. Avoid bruised or rotten celery. Celery cells contain chemicals called furocoumarins (pso- ralens) that may turn carcinogenic when the cell membranes are damaged and the furocou- marins are exposed to light. Bruised or rotting celery may contain up to a hundred times the psoralens in fresh celery.

Storing This Food Handle celery carefully to avoid damaging the stalks and releasing furocoumarins. Refrigerate celery in plastic bags or in the vegetable crisper to keep them moist and crisp. They will stay fresh for about a week.

Preparing This Food R inse celery under cold running water to remove all sand and dirt. Cut off the leaves, blanch them, dry them thoroughly, and rub them through a sieve or food mill. The dry powder can be used to season salt or frozen for later use in soups or stews.

What Happens When You Cook This Food When you cook celery the green flesh will soften as the pectin inside its cells dissolves in water, but the virtually indestructible cellulose and lignin “strings” on the ribs will stay stiff. If you don’t like the strings, pull them off before you cook the celery. Cooking also changes the color of celery. Chlorophyll, the pigment that makes green vegetables green, is very sensitive to acids. When you heat celery, the chlorophyll in its stalks reacts chemically with acids in the celery or in the cooking water to form pheophytin, which is brown. The pheophytin will turn the celery olive-drab or, if the stalks have a lot of yellow carotene, bronze. You can prevent this natural chemical reaction and keep the celery green by cooking it so quickly that there is no time for the chlorophyll to react with the acids, or by cooking it in lots of water (which will dilute the acids), or by cooking it with the lid off the pot so that the volatile acids can float off into the air.

Adverse Effects Associated with This Food Contact dermatitis. Celery contains limonene, an essential oil known to cause contact der- matitis in sensitive individuals. (Limonene is also found in dill, caraway seeds, and the peel of lemon and limes.) Photosensitivity. The furocoumarins (psoralens) released by damaged or moldy celery are photosensitizers as well as potential mutagens and carcinogens. Constant contact with these chemicals can make skin very sensitive to light, a problem most common among food work- ers who handle large amounts of celery without wearing gloves. Nitrate/nitrite poisoning. Like beets, eggplant, lettuce, radish, spinach, and collard and turnip greens, celery contains nitrates that convert naturally into nitrites in your stomach and then react with the amino acids in proteins to form nitrosamines. Although some nitro- samines are known or suspected carcinogens, this natural chemical conversion presents no known problems for a healthy adult. However, when these nitrate-rich vegetables are cooked and left to stand at room temperature, bacterial enzyme action (and perhaps some enzymes in the plants) convert the nitrates to nitrites at a much faster rate than normal. These higher-nitrite foods may be hazardous for infants; several cases of “spinach poison- ing” have been reported among children who ate cooked spinach that had been left standing at room temperature.... celery

Linn.

Family: Malvaceae.

Habitat: Native to the West Indies; now cultivated in Uttar Pradesh, Andhra Pradesh, West Bengal, Bihar, Punjab, Assam and Tamil Nadu.

English: Roselle, Jamaican Sorrel, Natal Sorrel, Red Sorrel.

Ayurvedic: Ambashtthaki.

Siddha/Tamil: Sivappu Kashmakki, Pulichai-keerai, Gogu, Seemai Kaseru.

Folk: Laal-ambaadi, Patavaa, Patsan.

Action: Digestive, choleretic, antibilious, laxative, diuretic, hypotensive, antiscorbutic. Used as a cardiac and nervine tonic for disorders of circulation, also for calcified arteries.

Key application: Flowers—used for loss of appetite, for colds, catarrhs of the upper respiratory tract and stomach, for disorders of circulation. (Included among unapproved herbs by German Commission E.)

The seeds contain sterols, including 3.2% ergosterol; leaves contain sitosterol-beta-D-galactoside. Flowers contain myricetin, kaempferol and quercetin, but did not contain free mutagenic flavonol aglycons.

The aqueous extract of flower buds has been reported to decrease blood pressure, cause relaxation of rat uterus. Succulent sepals and leaves—hypoten- sive, antimicrobial and anthelmintic.

Oil and unsapanofiable matter—antibacterial, antifungal.

Dosage: Root—5-10 g. (API Vol. III.)... hibiscus sabdariffa

Linn.

Family: Solanaceae.

Habitat: Punjab, Rajasthan, Gujarat and Maharashtra.

Unani: Chirchataa, Chirchitaa, Chirchitta.

Folk: Kheechar Chirchataa.

Action: Immunostimulatory, antiproliferatory, antiageing; antioxidant.

The leaves and flowers contain free quercetin (1.28 and 1.58 mg/g dry weight, respectively), and bound kaem- pferol. Total alkaloid percentage is nearly the same in shoots (1.26%) and fruits (1.24%) but lower in cal- li (0.83%) and roots (0.67%). Fruits had highest atropine content (0.95%) and shoots the highest hyoscyamine content (0.33%).

Flavonoids are active against E. coli, Staphylococcus aureus and Candida albicans (quercetin does not show activity against Candida albicans).

The polysaccharide extract from fruits showed antiageing, immunos- timulatory and antiproliferatory activities. The polysaccharide acts as an an- tioxidant and prevented CCl4-induced increases in lipid peroxidases in liver. It can also protect against genetic damage from mutagenic and genotoxic compounds. This activity leads to its potential use in preventing the adverse effects of chemotherapeutic agents.

The fruit contain beta-carotene (8 mg/100 g dry weight), also free amino acids (1.0-2.6%); major amino acid is proline.

The dried fruit and root bark reduce cholesterol level by preventing its absorption in gastrointestinal tract. A constituent of the root bark, kuko- amine exhibits cholesterol lowering, antihypertensive and hypoglycaemic effects. Hepatoprotective activity is attributed to a cerebroside constituent found in the fruit. (Natural Medicines Comprehensive Database, 2007.)

The fruit and root bark is contraindi- cated in bleeding disorders and hypoglycemia. (Sharon M. Herr.)... lycium barbarum

Roxb.

Synonym: P. pilosa Linn.

Family: Portulacaceae.

Habitat: Peninsular India, near sea-coasts.

Ayurvedic: Bichhuu-buuti.

Folk: Jangali Gaajar (Gujarat), Sanjivani (Bihar).

Action: Leaves—an infusion is given internally in dysuria; externally applied to erysipelas. The herb shows diuretic, calculolythic, analgesic and antipyretic properties.

The aerial parts contain diterpe- noids, pilosanone A and B. leucorrhoea, dysmenorrhoea, arthritis, cramps, kidney stones, bleeding piles; as a mouth wash in pyrrhoea, gingivitis and sore throat.

Key application: In mild dismenor- rhoeal disorders; as a support for treatment of milder, nonspecific, acute diarrhoea and in light inflammation of the oral and pharyngeal mucosa. (German Commission E.)

The plant gave anthocyanins—cy- anidin and delphinidin. Aerial parts gave tannins (2-10%). The plant also gave choline, betaine, histidine, an essential oil and vitamin E.

The maximum amounts of tannins occur in the root stock (up to 17.5% on dry basis). The ethanolic and aqueous extract of the herb (1 : 5) contain 0.3 to 0.8% of tannin. The tannin fraction exhibited anti-mutagenic effect.

Potentilla fruticosa HK. (temperate Himalaya) is also used like Silverweed.

The flowers and young shoots contain flavonoids, quercetin, terniflorin, tribuloside and (-)-catechin. The plant also contains stigmasterol, beta-sitos- terol and campesterol; (-)-epicatechol gallate, (±)-catechol, (-)-epicatechol, (-)-epigallocatechol and (-)-epigallo- catechol gallate have been isolated from aerial parts.... portulaca tuberosa

Linn.

Synonym: R. munjesta Roxb.

Family: Rubiaceae.

Habitat: Throughout India, ascending to an altitude of 3,700 m.

English: Indian Madder, Bengal Madder.

Ayurvedic: Manjishthaa, Vikasaa, Samangaa, Yojanavalli, Kaalameshi- ka, Raktaangi, Raktayashtikaa, Arunaa, Gandira, Jingi.

Unani: Manjeeth.

Siddha/Tamil: Manjitti.

Action: Roots and dried stem— blood purifier, astringent, diuretic, emmenagogue, deobstruent, antidysenteric, antiseptic, alterative.

The Ayurvedic Pharmacopoeia ofIn- dia recommends the use of the dried stem in blood, skin and urinogenital disorders; dysentery; piles, ulcers, inflammations; erysipelas, skin diseases and rheumatism. (Roots, leaves and seeds of R. cordifolia, R. tinctorum and allied species are used in amenorrhoea, liver diseases, gall and spleen complaints.) (Mutagenic and carcinogenic aspects of the drug are under investigation.)

It is reported that after oral administration of the root decoction, the urine and bones of the patient show a red tinge.

The roots are rich in anthraquinones and their glycosides (around 20), the important ones include purpurin (tri- hydroxy anthraquinone), munjistin (xanthopurpurin-2-carboxylic acid); besides xanthopurpurin, peudopur- purin (purpurin-3-carboxylic acid), free alizarin as well as its glucoside.

Whole plant yielded pentacylic tri- terpenic acids—rubicoumaric and ru- bifolic acids.

Antitumour cyclic hexapeptides have been isolated from the root (while lucidin is thought to be carcinogenic).

The root extracts of R. sikkimensis Kurz, known as Naaga-Madder (Nepal eastwards to Assam, Nagaland and Ma- nipur); are very similar to those of R. cordifolia.

Dosage: Stem—2-4 g. (API, Vol. III.)... rubia cordifolia

A. Br.

Synonym: S. papilionacea (Burm. f.) Boiss.

Family: Scrophulariaceae.

Habitat: The arid regions of Gujarat and in Rajasthan.

Ayurvedic: Nepaal-Nimba.

Folk: Saannipaat (Maharashtra).

Action: Broken pieces of dried fruits, stems and leaves—used in enteric fever. Leaf—antidiabetic. Fruit, leaf, stem—diuretic.

An alkaloid, schweinfurthin, a hydrocarbon and an unsaturated ketone were reported from the leaves. Recently, two macrocylic alkaloids, 11- epi-ephedradine and schweinine, have been isolated from the whole plant, along with (-)-ephedradine A. Experimentally, 11-epi-ephedradine A was mutagenic to Salmonella typhimurium.... schweinfurthia sphaerocarpa