An increase of fibrous tissue within the bone marrow (also known as myelofibrosis), in which the marrow’s ability to produce blood cells is impaired. Myelosclerosis may be primary (occurring with no obvious cause) or secondary (resulting from another bone marrow disease).
The main symptoms of myelosclerosis are those of anaemia. Enlargement of the spleen, night sweats, loss of appetite, and weight loss also commonly occur. In secondary myelosclerosis, the underlying disease may cause other symptoms. Treatment of primary myelosclerosis includes blood transfusions to relieve symptoms. A few patients may develop acute leukaemia. Treatment of secondary myelosclerosis depends on the underlying cause.
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