A severe, blistering rash in which the surface layers of the skin peel off, exposing large areas of red raw skin over the body. The condition carries a risk of widespread infection and loss of body fluid and salts.
The most common cause of toxic epidermal necrolysis is an adverse reaction to a drug, particularly a barbiturate, sulphonamide, or penicillin. The condition usually clears up when the drug is discontinued. Intravenous fluid replacement is sometimes necessary.
First described in 1978, this disorder is characterised by high fever, diarrhoea, SHOCK and a rash. It is frequently associated with the use of tampons (see TAMPON), but has occasionally been reported in men. The syndrome may also be linked to the use of contraceptives such as the diaphragm, cap and sponge (see under CONTRACEPTION), and skin wounds or infections may also be a cause. The disease is due to a staphylococcal toxin (see STAPHYLOCOCCUS; TOXINS). Treatment consists of supportive measures to combat shock and eradication of the staphylococcus by ANTIBIOTICS. The design of tampons has been improved. Recurrence of the disorder has been reported and women who have had an episode should stop using tampons and vaginal contraceptives.... toxic shock syndrome
(EGFR) a protein on the surface of cells (see receptor) that binds with epidermal *growth factor and is therefore involved in cell division. EGFR is expressed at increased levels in numerous tumours, particularly of the head and neck, and in colorectal cancer, in which it can be a target for antibody therapy with *cetuximab. *Tyrosine kinase inhibitors acting specifically on the EGFR include gefitinib and erlotinib in lung and pancreatic cancer.... epidermal growth factor receptor
a bacterial disease characterized by fever, shock, and multiple organ failure. It is similar to the *toxic shock syndrome caused by staphylococci, but in these cases the infecting organisms are *Streptococcus Type A bacteria. See also necrotizing fasciitis.... streptococcal toxic shock syndrome
(TEN, Lyell’s syndrome) a severe reaction to medications with a high mortality rate. Medications causing TEN include sulfonamides, anticonvulsants, antiretrovirals, and allopurinol. Widespread separation of the dead epidermal layer from underlying skin occurs, with consequent problems due to skin failure: impaired temperature regulation, infection risk, severe pain, etc. Mucous membranes are commonly affected, including the eyes (sometimes leading to blindness), mouth, and genitalia. Multi-organ failure may occur. Treatments include stopping the offending medication, good supportive nursing (usually in an ITU or HDU setting), antibiotics where appropriate, and intravenous immunoglobulin or ciclosporin.... toxic epidermal necrolysis
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