Also known as CELLULITIS. A potentially lethal infection caused by the gram-positive (see GRAM’S STAIN) bacterium Streptococcus pyogenes which has the property of producing dangerous exotoxins. The infection, which starts in the layer of FASCIA under the SKIN, may spread very rapidly, destroying tissue as it spreads. Urgent antibiotic treatment may check the infection, and surgery is sometimes required, but even with treatment patients may die (see STREPTOCOCCUS).