adj. liable to cause damage to the kidneys. Nephrotoxic drugs include *aminoglycoside antibiotics, sulphonamides, and gold compounds. —nephrotoxicity n.
Habitat: Uttar Pradesh, Bengal, Madhya Pradesh and western peninsular India.
English: Bracteated Birthwort.Ayurvedic: Kitamaari, Dhumrapa- traa, Naakuli.Unani: Kiraamaar.Siddha/Tamil: Aadutheendaappaalai, Kattusuragam.Action: Oxytocic, abortifacient, emmenagogue.
Leaves and fruit contain ceryl alcohol, aristolochic acid and beta-sitos- terol. Aristolochic acid is insecticidal, poisonous, nephrotoxic. Leaf juice— vermifuge. Seeds—strong purgative. Products containing aristolochic acid are banned in the U.S., Canada, Great Britain, European countries and Japan.The seed compounds, aristolochic acid and magnoflorine, induce contractions in the isolated uterus of pregnant rat and stimulate the isolated ileum of guinea pig. They also activate the muscarinic and serotoner- gic receptors in a variety of organs. Magnoflorine decreases arterial blood pressure in rabbits, and induces hypothermia in mice.See also A. longa.... aristolochia bracteolataHabitat: Native to Mediterranean region; found in Kashmir, Assam and the Nilgiris, also grown in hedges.
English: Great Reed, Spanish- Bamboo-Reed, Giant-Bamboo- Reed.Ayurvedic: Nala, Potgala, Shuunya- madhya, Dhamana.Siddha/Tamil: Korukkai.Action: Rhizome—sudorific, emollient, diuretic, antilactant, antidropsical; uterine stimulant (stimulates menstrual discharge), hypotensive.
The rhizome yields indole-3-alkyl- amine bases, including bufotenidine and dehydro-bufontenine. The leaves yield sterols and triterpenoids.Bufotenidine possesses antiacetyl- choline properties, histamine release activity and is a uterine stimulant. Alkaloids from the flowers produced cu- rarimetic effect of the non-polarizing type.Dosage: Root—50-100 ml decoction. (CCRAS.) 4.5%) with methyl eugenol (an important constituent of A. europaeum), and also aristolochic acid. (Aristolochic acid is carcinogenic and nephrotoxic.) Asarum sp. are not used as a substitute for ginger.... arundo donaxCytotoxic drugs are used either singly or in combination, when an enhanced response is the aim. Chemotherapy of cancer is a complex process and should be supervised by an oncologist in co-operation with physicians, surgeons, radiotherapists and radiologists as appropriate.
The cytotoxic drugs include:
(1) The alkylating agents which act by damaging DNA, thus interfering with cell reproduction. Cyclophosphamide, ifosfamide, chlorambucil, kelphalan, busulphan, thiotepa and mustine are examples of alkylating agents.
(2) There are a number of cytotoxic antibiotics used in the treatment of cancer – doxorubicin, bleomycin, dactinomycin, mithramycin and amsacrine are examples. They are used primarily in the treatment of acute leukaemia and lymphomas.
(3) Antimetabolites – these drugs combine irreversibly with vital enzyme systems of the cell and hence prevent normal cell division. Methotrexate, cytarabine, ?uorouracil, mercaptopurine and azathioprine are examples.
(4) Another group of cytotoxic drugs are the vinca alkaloids such as vincristine, vinblastine and vindesima.
(5) Platinum compounds such as carboplatin, cisplatin and oxaliplatin are e?ective. All of them are given intravenously, but the latter two tend to have more unpleasant side-effects. Carboplatin and cisplatin are useful in the treatment of solid tumours. Carboplatin, a derivative of cisplatin, is given intravenously in ovarian cancer and in small-cell lung cancer. Better tolerated than cisplatin, the drug causes less nausea and vomiting, nephrotoxicity, neurotoxicity and ototoxicity. Where platinum-containing therapy has failed, intravenous treatment with paclitaxel may be tried. With only a limited success rate, it is relatively toxic and should be carefully supervised; responses, however, are sometimes prolonged.
Also of increasing importance in treating cancer are interferons. These are naturally occurring proteins with complex effects on immunity and cell function. Although toxic, with numerous adverse effects, they have shown some anti-tumour e?ect against certain lymphomas and solid tumours.... cytotoxic
Habitat: Native to tropical Southeast Asia; distributed throughout India; also planted in public parks.
English: Emblic, Indian gooseberry.Ayurvedic: Aaamalaki, Aaamalaka, Dhaatri, Kaayasthaa, Amoghaa, Amritaphala, Amla, Aaamalaa, Dhaatriphala, Vayasyaa, Vrshya, Shiva, Hattha.Unani: Aamalaa, Amlaj.Siddha/Tamil: Nellikkaai, Nelli.Action: Fruit—antianaemic, anabolic, antiemetic, bechic, astringent, antihaemorrhagic, antidiarrhoeal, diuretic, antidiabetic, carminative, antioxidant. Used in jaundice, dyspepsia, bacillary dysentery, eye trouble and as a gastrointestinal tonic. Juice with turmeric powder and honey is prescribed in diabetes insipidus. Seed—antibilious, antiasthmatic. Used in bronchitis. Bark—astringent. Leaf—juice is given in vomiting.
A decoction of powdered pericarp is prescribed for paptic ulcer.Key application: As an antacid. (Indian Herbal Pharmacopoeia.).The fruit is an important source of vitamin C, minerals and amino acids. The edible fruit tissue contains protein concentration threefold and vitamin C (ascorbic acid) concentration 160-fold than those of apple. The fruit also contains considerably higher concentration of most minerals and amino acids than apple.The fruit gave cytokinine-like substances identified as zeatin, zeatin ribo- side and zeatin nucleotide; suspension culture gave phyllembin. Phyllem- bin exhibits CNS depressant and spasmolytic activity, potentiates action of adrenaline and hypnotic action of Nembutal.The leaves contain gallic acid (10.8 mg/g dry basis), besides ascorbic and music acid. The methanol extract of the leaves is found to be effective in rat paw inflammation.The bark contains tannin identified as mixed type of proanthocyanidin.The fruit contains superoxide dis- mutase 482.14 units/g fresh weight and exhibits antisenescent (anti-aging) activity. Fruit, juice, its sediment and residue are antioxidant due to gallic acid. EtOH (50%) extract—antiviral.Aqueous extract of the fruit increases cardiac glycogen level and decreases serum GOT, GPT and LDH in rats having induced myocardial necrosis.Preliminary evidence suggests that the fruit and its juice may lower serum cholesterol, LDL, triglycerides and phospholipids without affecting HDL levels and may have positive effect on atherosclerosis. (Eur J clin Nutr, 42, 1988, 939-944; PhytotherRes, 14, 2000, 592-595.)An aqueous extract of the fruit has been reported to provide protection against radiation-induced chromosomal damage in both pre-and postirradiation treatment. The fruit is reported to enhance natural killer cell activity and antibody dependent cellular cytotoxicity in mice bearing Dalton's lymphoma ascites tumour. The extract of the fruit and ascorbic acid prevented hepatotoxic and nephrotoxic effects induced by lead and aluminium. The toxicity could be counteracted to a great extent by the fruit extract than by an amount of ascorbic acid alone equivalent to that contained in fruits. (The fruit can be used as a dietary supplement to counteract prolonged exposure to metals in population in industrial areas.)The fruits are reported to activate trypsin (proteolytic enzyme) activity.The fruits can be used as coagulant in the treatment of water and can purify low turbidity water.The fruits can be consumed safely all round the year.Dosage: Fresh fruit—10-20 g; pulp juice—5-10 ml. (API Vol. I.)... emblica officinalisFAMILY: Cupressaceae
SYNONYM: Common juniper.
GENERAL DESCRIPTION: An evergreen shrub or tree up to 6 metres high, with bluish green narrow stiff needles. It has small flowers and little round berries, which are green in the first year, turning black in the second and third.
DISTRIBUTION: Native to the northern hemisphere: Scandinavia, Siberia, Canada, northern Europe and northern Asia. The oil is mainly produced in Italy, France, Yugoslavia, Austria, Czechoslovakia, Spain, Germany and Canada.
OTHER SPECIES: In Yugoslavia an oil is produced from the fruit and twigs of J. smerka, less rich and sweet than that of common juniper. There are various other species of juniper such as J. oxycedrus which produces cade oil, J. virginiana which produces the so-called Virginian cedarwood oil, and J. sabina which produces savin oil. See also Botanical Classification section.
HERBAL/FOLK TRADITION: The needles and berries have a long traditional history of use. It is used medicinally for urinary infections such as cystitis and urethritis; for respiratory problems such as bronchitis, colic and coughs; as well as gastro-intestinal infections and worms. It helps expel the build-up of uric acid in the joints, and is employed in gout, rheumatism and arthritis. Current in the British Herbal Pharmacopoeia for rheumatic pain and cystitis.
ACTIONS: Antirheumatic, antiseptic, antispasmodic, antitoxic, aphrodisiac, astringent, carminative, cicatrisant, depurative, diuretic, emmenagogue, nervine, parasiticide, rubefacient, sedative, stomachic, sudorific, tonic, vulnerary.
EXTRACTION: Essential oil by steam distillation from 1. the berries (sometimes fermented first as a by-product of juniper – brandy manufacture – the oil is considered an inferior product), and 2. the needles and wood. A resinoid, concrete and absolute are also produced on a small scale.
CHARACTERISTICS: 1. A water-white or pale yellow mobile liquid with a sweet, fresh, woody-balsamic odour. It blends well with vetiver, sandalwood, cedarwood, mastic, oakmoss, galbanum, elemi, cypress, clary sage, pine, lavender, lavandin, labdanum, fir needle, rosemary, benzoin, balsam tolu, geranium and citrus oils. 2. A water-white or pale yellow mobile liquid with a sweet-balsamic, fresh, turpentine-like odour.
PRINCIPAL CONSTITUENTS: Mainly monoterpenes: pinene, myrcene, sabinene with limonene, cymene, terpinene, thujene and camphene, among others.
SAFETY DATA: Non-sensitizing, may be slightly irritating, generally non-toxic. However, it stimulates the uterine muscle (an abortifacient) and must not be used during pregnancy. Neither should it be used by those with kidney disease due to its nephrotoxic effect. The wood oil is usually adulterated with turpentine oil. It is best to use only juniper berry oil, in moderation.
AROMATHERAPY/HOME: USE
Skin care: Acne, dermatitis, eczema, hair loss, haemorrhoids, oily complexions, as a skin toner, wounds.
Circulation muscles and joints: Accumulation of toxins, arteriosclerosis, cellulitis, gout, obesity, rheumatism.
Immune system: Colds, ’flu, infections.
Genito-urinary system: Amenorrhoea, cystitis, dysmenorrhoea, leucorrhoea.
Nervous system: Anxiety, nervous tension and stress-related conditions.
OTHER USES: Berries and extracts are used in diuretic and laxative preparations; also veterinary preventatives of ticks and fleas. Employed as a fragrance component in soaps, detergents, cosmetics and perfumes, especially spicy fragrances and aftershaves. Extensively used in many food products but especially alcoholic and soft drinks: the berries are used to flavour gin.... juniper
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