Neural tube defects Health Dictionary

Neural Tube Defects: From 2 Different Sources


Congenital abnormalities resulting from the failure of the NEURAL TUBE to form normally. The resulting conditions include SPINA BIFIDA, MENINGOCELE and defects in the bones of the SKULL.
Health Source: Medical Dictionary
Author: Health Dictionary
a group of congenital abnormalities caused by failure of the *neural tube to form normally. In *spina bifida the bony arches of the spine, which protect the spinal cord and its coverings (the meninges), fail to close. More severe defects of fusion of these bones will result in increasingly serious neurological conditions. A meningocele is the protrusion of the meninges through the gap in the spine, the skin covering being vestigial. There is a constant risk of damage to the meninges, with resulting infection. Urgent surgical treatment to protect the meninges is therefore required. In a meningomyelocele (myelomeningocele, myelocele) the spinal cord and the nerve roots are exposed, often adhering to the fine membrane that overlies them. There is a constant risk of infection and this condition is accompanied by paralysis and numbness of the legs and urinary incontinence. *Hydrocephalus and an *Arnold–Chiari malformation are usually present. A failure of fusion at the cranial end of the neural tube (cranium bifidum) gives rise to comparable disorders. The bone defect is most often in the occipital region of the skull but it may occur in the frontal or basal regions. A protrusion of the meninges alone is known as a cranial meningocele. The terms meningoencephalocele, encephalocele, and cephalocele are used for the protrusion of brain tissue through the skull defect. This is accompanied by severe mental and physical disorders.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Nasogastric Tube

A small-bore plastic or rubber tube passed into the stomach through the nose, pharynx and then the oesophagus. It is used either to aspirate gas and liquid from the stomach or to pass food or drugs into it.... nasogastric tube

Birth Defects

See CONGENITAL.... birth defects

Neural Tube

The structure in the EMBRYO from which the BRAIN and SPINAL CORD develop.... neural tube

Test-tube Baby

See EMBRYO TRANSFER.... test-tube baby

Eustachian Tube

The passage that runs from the middle ear into the back of the nose, just above the soft palate. The tube acts as a drainage channel from the middle ear and maintains hearing by opening periodically to regulate air pressure. The lower end of the tube opens during swallowing and yawning, allowing air to flow up to the middle ear, equalizing the air pressure on both sides of the eardrum.

When a viral infection such as a cold causes blockage of the eustachian tube, equalization cannot occur, resulting in severe pain and temporary impairment of hearing. A person with a blocked eustachian tube who is subjected to rapid pressure changes may suffer from barotrauma. Glue ear or chronic otitis media may occur if the tube is blocked, preventing adequate drainage from the middle ear. These conditions, which often result in partial hearing loss are more common in children. This is partly because their adenoids are larger and more likely to cause a blockage if they become infected and partly because children’s eustachhian tubes are shorter than those of adults.... eustachian tube

Fallopian Tube

One of the 2 tubes that extend from the uterus to the ovary. The fallopian tube transports eggs and sperm and is where fertilization takes place.

The tube opens into the uterus at one end, and the other end, which is divided into fimbriae (finger-like projections), lies close to the ovary. The tube has muscular walls lined by cells with cilia (hair-like projections). The fimbriae take up the egg after it is expelled from the ovary. The beating cilia and muscular contractions propel the egg towards the uterus. After intercourse, sperm swim up the fallopian tube from the uterus. The lining of the tube and its secretions sustain the egg and sperm, encouraging fertilization, and nourish the egg until it reaches the uterus.

Salpingitis is inflammation of the fallopian tube, usually the result of a sexually transmitted bacterial infection, that can lead to infertility.

An ectopic pregnancy (development of an embryo outside the uterus) most commonly occurs in the fallopian tube.... fallopian tube

Ryle’s Tube

See NASOGASTRIC TUBE.... ryle’s tube

Stomach Tube

A soft rubber or plastic tube with rounded end, and usually about 75 cm (30 inches) in length, which is used for washing out the stomach when it contains some poisonous material. (See GASTRIC LAVAGE.) A narrower tube, 90 cm (36 inches) in length, is used to obtain a sample of gastric juice for examination. Such a tube can also be allowed to pass out of the stomach into the duodenum so that the contents of the upper part of the small intestine are similarly obtained for analysis.... stomach tube

Test-tube

A tube of thin glass closed at one end, which is used for observing chemical reactions or for bacterial culture.... test-tube

Endotracheal Tube

A tube that is passed into the trachea through the nose or mouth that enables delivery of oxygen during artificial ventilation or of anaesthetic gases (see anaesthesia) during surgery. An inflatable cuff around the lower end of the endotracheal tube prevents secretions or stomach contents from entering the lungs.... endotracheal tube

Limb Defects

Incomplete development of one or more limbs at birth.

Limb defects are rare and may be inherited or form part of a syndrome.

In a condition called phocomelia, hands, feet, or tiny finger- or toe-buds are attached to limb stumps or grow directly from the trunk.

The sedative drug thalidomide, when taken by pregnant women, is known to have caused phocomelia in fetuses.... limb defects

T-tube Cholangiography

An imaging technique performed to check that there are no gallstones left in the bile duct after a cholecystectomy.

A T-shaped rubber tube is inserted into the bile duct during the surgery.

A week or so later, contrast medium is inserted into the tube and X-rays are taken.... t-tube cholangiography

Fallopian Tube Recanalization

(FTR) an *interventional radiology technique to open up blocked Fallopian tubes as a treatment for infertility. This usually follows a *hysterosalphingogram.... fallopian tube recanalization

Neural Arch

see vertebra.... neural arch

Neural Crest

the two bands of ectodermal tissue that flank the *neural plate of the early embryo. Cells of the neural crest migrate throughout the embryo and develop into sensory nerve cells and peripheral nerve cells of the autonomic nervous system.... neural crest

Neural Plate

the strip of ectoderm lying along the central axis of the early embryo that forms the *neural tube and subsequently the central nervous system.... neural plate

Neural Spine

the spinous process situated on the neural arch of a *vertebra.... neural spine

Photomultiplier Tube

an electronic device that magnifies the light emitted from a *scintillator by accelerating electrons in a high-voltage field. The resulting signal can be used to display the scintillations on a TV screen. Such devices are commonly used in *gamma cameras.... photomultiplier tube

Neural Tube Defect

A developmental failure affecting the spinal cord or brain of the embryo. The most serious defect is anencephaly (total lack of a brain), which is fatal. More common is spina bifida, in which the vertebrae do not form a complete ring around the spinal cord. Spina bifida can occur anywhere on the spine, but it is most common in the lower back.

There are different forms of spina bifida. In spina bifida occulta, the only defect is a failure of the fusion of the bony arches behind the spinal cord, which may not cause any problems. When the bone defect is more extensive, there may be a meningocele, a protrusion of the meninges, or a myelomeningocele, a malformation of the spinal cord. Myelomeningocele is likely to cause severe handicap, with paralysis of the legs, loss of sensation in the lower body, hydrocephalus, and paralysis of the anus and bladder, causing incontinence. Associated problems include cerebral palsy, epilepsy, and mental handicap.

Surgery is usually performed a few days after birth. In mild cases, the defect can usually be corrected, but in myelomeningocele, some handicap will remain.

Genetic factors play a part in neural tube defects, which show multifactorial inheritance. Couples who have had an affected child or who have a family history of neural tube defects should seek genetic counselling. The risk of a neural tube defect occurring can be substantially reduced if the mother takes folic acid supplements for a month before conception and during the early part of the pregnancy.

Ultrasound scanning and amniocentesis allow accurate antenatal testing for neural tube defects.... neural tube defect

Ryle’s Tube

a flexible *nasogastric tube that enables aspiration of gastric secretions and evacuation of intestinal gas. [J. A. Ryle (1889–1950), British physician]

s... ryle’s tube

Tube

n. (in anatomy) a long hollow cylindrical structure, e.g. a *Fallopian tube.... tube



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