Nonsteroidal Anti-inflammatory Drugs: From 1 Different Sources
A group of drugs, also known as NSAIDs that produce analgesia (pain relief) and reduce inflammation in joints and soft tissues such as muscles and ligaments.
Nonsteroidal anti-inflammatory drugs are widely used to relieve symptoms caused by types of arthritis, such as rheumatoid arthritis, osteoarthritis, and gout. They do not cure or halt the progress of disease. NSAIDs are also used in the treatment of back pain, menstrual pain, headaches, pain after minor surgery, and soft tissue injuries.
The drugs reduce pain and inflammation by blocking the production of prostaglandins (chemicals that cause inflammation and trigger transmission of pain signals to the brain).
NSAIDs may cause a wide range of side effects, the most important of which are nausea, indigestion, bleeding from the stomach, and, sometimes, peptic ulcer.
A group of drugs used to treat high blood pressure (HYPERTENSION). Untreated hypertension leads to STROKE, heart attacks and heart failure. The high incidence of hypertension in western countries has led to intensive research to discover antihypertensive drugs, and many have been marketed. The drugs may work by reducing the power of the heartbeat, by dilating the blood vessels or by increasing the excretion of salts and water in the urine (diuresis). Antihypertensive treatment has greatly improved the prognosis of patients with high blood pressure by cutting the frequency of heart and renal failure (see KIDNEYS, DISEASES OF), stroke, and coronary thrombosis (see HEART, DISEASES OF). Drugs used for treatment can be classi?ed as follows: diuretics; vasodilator antihypertensives; centrally acting antihypertensives; adrenergic neurone-blocking drugs; alpha-adrenoreceptorblocking drugs; drugs affecting the renin-angiotensin system; ganglion-blocking drugs; and tyrosine hydroxylase inhibitors. The drugs prescribed depend on many factors, including the type of hypertension being treated. Treatment can be di?cult because of the need to balance the e?ectiveness of a drug in reducing blood pressure against its side-effects.... antihypertensive drugs
(PID) Also called salpingitis, the term is applied to infections of the fallopian tubes that follow or are concurrent with uterine and cervical infections. Gonorrhea and Chlamydia are the most common organisms, and the infection is usually begun through sexual contact, although metabolic imbalances, subtler systemic infections like a slow virus, the local insult of herpes or candidiasis, the sequela of medication or recreational drugs, birth control pills, even an IUD...all can alter the vaginal flora and induce inflammation sufficient to allow an endogenous organism to start the infection. PID after birth, on the other hand, is usually the result of staph or strep infections infecting injured membranes.... pelvic inflammatory disease
ARRHYTHMIA is a variation in the normal rhythm of the heartbeat. Management of the condition requires accurate diagnosis of the type, and ELECTROCARDIOGRAPHY is vital in this process (see HEART, DISEASES OF). Drug treatment is usually part of the management, and antiarrhythmic drugs can be divided clinically into those that act on supraventricular arrhythmias, those that act on both supraventricular and ventricular arrythmias, and those that act on ventricular arrythmias. Respective examples are VERAPAMIL, DISOPYRAMIDE and LIDOCAINE. This large group of drugs can also be classi?ed according to their effects on the electrical reactions of active myocardial cells. The many drugs available are described in the British National Formulary.... antiarrhythmic drugs
A group of drugs, which include ANTIBIOTICS, used to treat infections caused by BACTERIA. Drugs include CEPHALOSPORINS and cephamycins, TETRACYCLINES, AMINOGLYCOSIDES, MACROLIDES, and antituberculous compounds.... antibacterial drugs
See NEUROLEPTICS.... antipsychotic drugs
Chemicals used to kill cancerous cells. Most cytotoxic drugs also kill normal cells. There is a delicate balance between killing enough cancer cells and not so many normal cells.... cytotoxic drugs
See CONTROLLED DRUGS.... dangerous drugs
A group of chemical substances produced illegally whose properties and effects are similar to those of drugs of abuse. They may be derived from narcotic ANALGESICS, AMPHETAMINES or HALLUCINOGENS. Ecstasy is a widely used designer drug and has caused deaths among teenagers. Designer drugs are potentially dangerous, especially if taken with alcohol.... designer drugs
These widely used drugs include a range of different preparations which relieve DEPRESSION. All the antidepressants available at the time of writing are more or less equally e?ective. In studies where patients agree to take either antidepressants or identical dummy PLACEBO pills (without knowing which), at least two-thirds of those who receive antidepressants feel much better within three months, while fewer than one-third of those on placebos recover naturally in the same period. In general these drugs are useful for severe and moderate depression including postnatal illness; they are not e?ective in milder forms of depression although they may be tried for a short time if other therapies have failed.
The most widely prescribed type of antidepressants are the tricyclics, so-called because their molecular structure includes three rings. The other commonly used types are named after the actions they have on chemicals in the brain: the SELECTIVE SEROTONIN-REUPTAKE INHIBITORS (SSRIS) and the MONOAMINE OXIDASE INHIBITORS (MAOIS) – see also below. All types of antidepressant work in similar ways. Tricyclic antidepressants have cured depression in millions of people, but they can cause unpleasant side-effects, particularly in the ?rst couple of weeks. These include SEDATION, dry mouth, excessive sweating, CONSTIPATION, urinary problems, and impotence (inability to get an erection). Up to half of all people prescribed tricyclic drugs cannot tolerate the side-effects and stop treatment before their depression is properly treated. More seriously, tricyclics can upset the rhythm of the heart in susceptible people and should never be given in the presence of heart disease.
The SSRIs are newer, coming into wide use in the late 1980s. They increase the levels in the brain of the chemical messenger SEROTONIN, which is thought to be depleted in depression. Indeed, the SSRIs are as e?ective as tricyclics and, although they can cause nausea and excessive sweating at ?rst, they generally have fewer side-effects. Their main disadvantage, however, is that they cost much more than the most commonly used tricyclic, amitriptyline. On the other hand, they are more acceptable to many patients and they cause fewer drop-outs from treatment – up to a quarter rather than a half. The money saved by completed, successful treatment may outweigh the prescribing costs. SSRIs have been reported as associated with an increased risk of suicide.
Another group of antidepressants, the MAOIs, have been in use since the late 1950s.
They are stimulants, rather than sedatives, and are particularly helpful for people who are physically and mentally slowed by depression. They work well but have one big disadvantage – a dangerous interaction with certain foods and other drugs, causing a sudden and very dangerous increase in blood pressure. People taking them must carry an information card explaining the risk and listing the things that they should avoid. Because of this risk, MAOIs are not used much now, except when other treatments have failed. A new MAOI, moclobemide, which is less likely to interact and so cause high blood pressure, is now available.
LITHIUM CARBONATE is a powerful antidepressant used for intractable depression. It should be used under specialist supervision as the gap between an e?ective dose and a toxic one is narrow.
St John’s Wort is a popular herbal remedy which may be e?ective, but which is handicapped by di?erences of strength between di?erent preparations or batches. It can interact with a number of conventional drugs and so needs to be used cautiously and with advice.
In general, antidepressants work by restoring the balance of chemicals in the brain. Improved sleep and reduced anxiety are usually the ?rst signs of improvement, particularly among people taking the more sedative tricyclic drugs. Improvement in other symptoms follow, with the mood starting to lift after about two weeks of treatment. Most people feel well by three months, although a few residual symptoms, such as slowness in the mornings, may take longer to clear up. People taking antidepressants usually want to stop them as soon as they feel better; however, the risk of relapse is high for up to a year and most doctors recommend continuing the drugs for around 4–6 months after recovery, with gradual reduction of the dose after that.
Withdrawal reactions may occur including nausea, vomiting, headache, giddiness, panic or anxiety and restlessness. The drugs should be withdrawn gradually over about a month or longer (up to six months in those who have been on maintenance treatment).
A wide range of antidepressant drugs is described in the British National Formulary. Examples include:
Tricyclics: amitryptyline, imipramine, doxepin.
MAOIs: phenelzine, isocarboxazid.
SSRIs: citalopram, ?uoxetine, paraxtene. (Antidepressant drugs not in these three
groups include ?upenthixol, mertazapine and venlafaxine.)... antidepressant drugs
A group of drugs, also known as thrombolytics, with the ability to break down the protein FIBRIN, the prime constituent of blood clots (see THROMBUS; THROMBOSIS). They are used to disperse blood clots that have formed in the vessels of the circulatory system. The group includes STREPTOKINASE, alteplase and reteplase. The drugs work by activating PLASMINOGEN to form PLASMIN which degrades ?brin and breaks up the blood clot (see COAGULATION).... fibrinolytic drugs
Drugs used to treat hyperthyroidism, in which the thyroid gland is overactive. They may be used as the sole treatment or before thyroid surgery. Carbimazole and propylthiouracil interfere with the production of thyroid hormone by the gland.... antithyroid drugs
A collective term for chronic disorders affecting the small and/or large intestine that cause abdominal pain, bleeding, and diarrhoea. Crohn’s disease and ulcerative colitis are the most common types of inflammatory bowel disease.... inflammatory bowel disease
1. adj. describing a drug that reduces *inflammation. The various groups of anti-inflammatory drugs act against one or more of the mediators that initiate or maintain inflammation. Some groups suppress only certain aspects of the inflammatory response. The main groups of anti-inflammatory drugs are the *antihistamines, the glucocorticoids (see corticosteroid), and the nonsteroidal anti-inflammatory drugs (see NSAID). 2. n. an anti-inflammatory drug.... anti-inflammatory
Pre?x meaning against.... anti
See ANALGESICS; NON-STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS).... anti-inflammatory drugs
Any of the therapeutic substances considered indispensable for the rational care of the vast majority of diseases in a given population.... essential drugs
These drugs reduce the amount of low-density LIPOPROTEINS, which transport CHOLESTEROL and triglycerides (see TRIGLYCERIDE) in the blood, or raise the concentration of high-density lipoproteins. The aim is to reduce the progression of ATHEROSCLEROSIS and therefore help prevent coronary heart disease (see HEART, DISEASES OF). These drugs should be combined with reducing other risk factors for raised lipid concentrations, such as a high-fat diet, smoking and obesity. Lipid-regulating drugs include STATINS, ?brates, anion-exchange resins, and NICOTINIC ACID, which may be used singly or in combination under careful medical supervision (see HYPERLIPIDAEMIA).... lipid-regulating drugs
All those medications requiring written notification from a doctor to a pharmacist before they can be dispensed.... prescription drugs
Drugs, such as CANNABIS and LYSERGIC ACID DIETHYLAMIDE (LSD), that expand consciousness and perception. (See DEPENDENCE.)... psychedelic drugs
A group of drugs used to treat type-2 diabetes (see under DIABETES MELLITUS) which work by suppressing the activity of RESISTIN, a recently discovered hormone that acts against INSULIN. Resistin links obesity to type-2 diabetes which has long been known to be associated with overweight subjects.... thiazolidinedione drugs
Herbs that check any tendency to miscarriage. They should be prescribed by a practitioner and may include: Raspberry leaves, Cramp bark, Lobelia, etc. See: ABORTION. ... anti-abortives
Herbs that relieve the symptoms of asthma. According to the case the remedy may be an expectorant, antispasmodic, bronchodilator or a combination of each. A large group including:– Belladonna, Black Haw bark, Comfrey, Ephedra, Elecampane, Euphorbia, Evening Primrose, Gelsemium, Irish Moss, Lobelia, Mullein, Senega, Storax, Stramonium, Wild Cherry bark and Wild Yam are all of practitioner use. ... anti-asthmatics
In the United Kingdom, controlled drugs are those preparations referred to under the Misuse of Drugs Act 1971. The Act prohibits activities related to the manufacture, supply and possession of these drugs, and they are classi?ed into three groups which determine the penalties for o?ences involving their misuse. For example, class A includes COCAINE, DIAMORPHINE, MORPHINE, LSD (see LYSERGIC ACID DIETHYLAMIDE and PETHIDINE HYDROCHLORIDE. Class B includes AMPHETAMINES, BARBITURATES and CODEINE. Class C includes drugs related to amphetamines such as diethylpropion and chlorphentermine, meprobamate and most BENZODIAZEPINES and CANNABIS.
The Misuse of Drugs Regulations 1985 de?ne the classes of person authorised to supply and possess controlled drugs, and lay down the conditions under which these activities may be carried out. In the Regulations, drugs are divided into ?ve schedules specifying the requirements for supply, possession, prescribing and record-keeping. Schedule I contains drugs which are not used as medicines. Schedules II and III contain drugs which are subject to the prescription requirements of the Act (see below). They are distinguished in the British National Formulary (BNF) by the symbol CD and they include morphine, diamorphine (heroin), other opioid analgesics, barbiturates, amphetamines, cocaine and diethylpropion. Schedules IV and V contain drugs such as the benzodiazepines which are subject to minimal control. A full list of the drugs in each schedule can be found in the BNF.
Prescriptions for drugs in schedules II and III must be signed and dated by the prescriber, who must give his or her address. The prescription must be in the prescriber’s own handwriting and provide the name and address of the patient and the total quantity of the preparation in both words and ?gures. The pharmacist is not allowed to dispense a controlled drug unless all the information required by law is given on the prescription.
Until 1997 the Misuse of Drugs (Noti?cation and Supply of Addicts) Regulations 1973 governed the noti?cation of addicts. This was required in respect of the following commonly used drugs: cocaine, dextromoramide, diamorphine, dipipanone, hydrocodeine, hydromorphone, levorphanol, methadone, morphine, opium, oxycodone, pethidine, phenazocine and piritranide.
In 1997 the Misuse of Drugs (Supply to Addicts) Regulations 1997 revoked the 1973 requirement for noti?cation. Doctors are now expected to report (on a standard form) cases of drug misuse to their local Drug Misuse Database (DMD). Noti?cation by the doctor should be made when a patient ?rst presents with a drug problem or when he or she visits again after a gap of six months or more. All types of misuse should be reported: this includes opioids, benzodiazepines and central nervous system stimulants. The data in the DMD are anonymised, which means that doctors cannot check on possible multiple prescribing for drug addicts.
The 1997 Regulations restrict the prescribing of diamorphine (heroin), Diconal® (a morphine-based drug) or cocaine to medical practitioners holding a special licence issued by the Home Secretary.
Fuller details about the prescription of controlled drugs are in the British National Formulary, updated twice a year, and available on the Internet (see www.bnf.org).... controlled drugs
Remedies that inhibit release of acetylcholine as a neuro-transmitter. Given for anti-depressant therapy. May have side-effects of dry mouth, drowsiness, blurred vision. Administered by a qualified practitioner. Two chief remedies: Belladonna (atropa) and Henbane (hyoscyamus). They reduce acid secretion but are sometimes given with Comfrey and other tissue builders to promote healing. Anti-cholinergics decrease secretion of gastric juices by their control of the vagus nerve. ... anti-cholingergics
Usually refers to children with fevers. Herbs for a febrile seizure, or for prevention and reduction of epileptic fits. Usually given orally, but where this is not possible a rectal injection or a suppository (such as Valerian) may be used. Another term for ‘antispasmodics’. ... anti-convulsants
CROHN’S DISEASE and ULCERATIVE COLITIS are chronic in?ammatory diseases characterised by relapsing and remitting episodes over many years. The diseases are similar and are both classi?ed as IBD, but a signi?cant distinction is that Crohn’s disease can affect any part of the GASTROINTESTINAL TRACT from mouth to anus, whereas ulcerative colitis affects only the COLON. The incidence of IBD varies widely between countries, being rare in the developing world but much more common in westernised nations, where the incidence of Crohn’s disease is around 5–7 per 100,000 (and rising) and that of ulcerative colitis at a broadly stable 10 per 100,000. It is common for both disorders to develop in young adults, but there is a second spike of incidence in people in their 70s. Details about the two disorders are given under the individual entries elsewhere in the dictionary. In?ammatory bowel disease should not be confused with IRRITABLE BOWEL SYNDROME (IBS) which has some of the same symptoms of IBD but a di?erent cause and outcome.... inflammatory bowel disease (ibd)
See also MEDICINES. Government legislation covers the manufacture, sale and prescription of drugs in the UK. As well as stating which drugs may be sold over the counter (OTC) without a doctor’s or dentist’s prescription, and those which can be obtained only with such a prescription, government regulations determine the extent of availability of many substances which are liable to be abused – see Misuse of Drugs Act 1971 (below). The Misuse of Drugs Regulations 1985 de?ne those individuals who in their professional capacity are authorised to supply and possess controlled drugs: see the schedules of drugs listed below under the 1985 regulations.
Misuse of Drugs Act 1971 This legislation forbids activities relating to the manufacture, sale and possession of particular (controlled) drugs. These are classi?ed into three grades according to their dangers if misused. Any o?ences concerning class A drugs, potentially the most damaging when abused, carry the toughest penalties, while classes B and C attract lesser penalties if abused.
Class A includes: cocaine, dextromoramide, diamorphine (heroin), lysergic acid (LSD), methadone, morphine, opium, pethidine, phencyclidine acid and injectable preparations of class B drugs.
Class B includes: oral amphetamines, barbiturates, codeine, glutethimide, marijuana (cannabis), pentazocine and pholcodine.
Class C includes: drugs related to the amphetamines, anabolic and androgenic steroids, many benzodiazepines, buprenorphine, diethyl propion, human chorionic gonadotrophin (HCG), mazindol, meprobamate, pemoline, phenbuterol, and somatropin.
Misuse of Drugs Regulations 1985 These regulations de?ne those people who are authorised in their professional capacity to supply and possess controlled drugs. They also describe the requirements for legally undertaking these activities, such as storage of the drugs and limits on their prescription.
Drugs are divided into ?ve schedules and some examples follow.
I: Almost all are prohibited except in accordance with Home O?ce authority: marijuana (cannabis), LSD.
II: High potential for abuse but have
accepted medical uses: amphetamines, cocaine.
III: Lower potential for abuse: barbiturates, meprobamate, temazepam.
IV: Lower potential for abuse than I to III. Minimal control: benzodiazepines.
V: Low potential for abuse: generally compound preparations containing small amounts of opioids: kaolin and morphine (antidiarrhoeal medicine), codeine linctus (cough suppressant).
(See also CONTROLLED DRUGS.)... misuse of drugs
These act by inhibiting the formation of PROSTAGLANDINS which are mediators of INFLAMMATION. They act both as ANALGESICS to relieve pain, and as inhibitors of in?ammation. Aspirin is a classic example of such a compound. Newer compounds have been synthesised with the aim of producing fewer and less severe side-effects. They are sometimes preferred to aspirin for the treatment of conditions such as RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, sprains, strains and sports injuries. Their main side-effects are gastrointestinal: gastric ulcers and gastric haemorrhage may result (see STOMACH, DISEASES OF). This is because prostaglandins are necessary for the production of the mucous protective coat in the stomach and, when the production of prostaglandin is inhibited, the protection of the stomach is compromised. NSAIDs should therefore be used with caution in patients with DYSPEPSIA and gastric ulceration. The various nonsteroidal anti-in?ammatory drugs di?er little from each other in e?cacy, although there is considerable variation in patient response. Ibuprofen is one of the ?rst choices in this group of drugs as it combines good e?cacy with a low incidence of side-effects and administration is only required twice daily. Other drugs in this series include diclofenac, fenbufen, fenclofenac, fenoprofen, feprazone, ?urbiprofen, indomethacin, indoprofen, ketoprofen, ketorolac, naproxen, piroxicam, sulindac, tiaprofenic acid and tolmetin.... non-steroidal anti-inflammatory drugs (nsaids)
Herbs with an ability to arrest diarrhoea or soothe an irritable bowel. According to degree, an astringent may have a similar effect. A large group including:– Avens, Bistort, Catnep, Cinnamon, Hemlock Spruce, Holy Thistle, Kola nuts, Matico, Orris root, Rhatany root. ... anti-diarrhoeals
See: CARMINATIVES. ... anti-flatulents
Remedies that arrest fungal growth on the skin or mucous membrane. See: ANTI- FUNGAL. ... anti-mycotics
Herbs that arrest or inhibit vomiting and nausea. Black Horehound. ... anti-nauseants
Herbs that prevent formation or destroy tumour cells. Some reported in the literature to arrest the spread of malignancy. A neoplasm is a new growth and may be malignant or non- malignant. Bayberry (intestinal), Bryonia (lung), Clivers (Genito-urinary tract), Comfrey (general), Condurango (gastric), Dandelion (liver), Echinacea, Greater Celandine (epithelial), Mandrake (face and skin), Mistletoe, Myrrh, Plantain (throat), Poke root (breast), Queen’s Delight, Red Clover (epithelial and breast), Rosebay Willowherb (gastric), Vinca rosea (leukaemia), Thuja (womb), Wild Violet (breast and womb), Yellow Dock. ... anti-neoplastics
This group of drugs is one of three main types of drugs used to treat DEPRESSION, and was the ?rst to be introduced (in the 1950s). Tricyclic drugs work by blocking the re-uptake of the neurotransmitters SEROTONIN and NORADRENALINE (see NEUROTRANSMITTER), thus increasing the amount of the neurotransmitters at the nerve cell’s receptors. In people with depression, fewer neurotransmitters than normal are released, resulting in a slowing of neural activities. The drugs have a sedative e?ect, which can be useful for depressives with sleep problems, and an antimuscarinic action which can cause dry mouth and constipation (see ANTIMUSCARINE). Overdosage can produce COMA, ?ts (see SEIZURE) and irregular heart rhythm (ARRHYTHMIA). They are sometimes used for treating bed-wetting. (See also ANTIDEPRESSANT DRUGS.)... tricyclic antidepressant drugs
Agents that reduce the production of mucus. Angelica, Avens, Bayberry, Bistort, Blood root, Cayenne, Chamomile (German), Coltsfoot, Comfrey, Elderflowers, Elecampane, Eyebright, Fenugreek, Garlic, Ginger, Goldenseal, Gotu Kola, Ground Ivy, Hyssop, Iceland Moss, Irish Moss, Juniper, Liquorice, Marsh Cudweed, Marshmallow, Mountain Grape, Mouse Ear, Mullein, Myrrh, Parsley, Plantain, Poke root, Senega, Skunk Cabbage, White Horehound, Wild Cherry bark, Wild Indigo, Witch Hazel, Yarrow. Successful treatment of catarrh is often dependent upon efficient kidney, skin and bowel function which may require also, diuretics, alteratives and laxatives. ... anti-catarrhals
A group of powerful astringents clinical experience has shown to be effective in arresting mild to moderate internal bleeding.
Digestive tract: Marigold, Comfrey, Bur-Marigold, Matico, Shepherd’s Purse, Holy Thistle, American Cranesbill, Goldenseal.
Anal/Rectal: Pilewort, Plantain, Matico, Rhatany root, Witch Hazel.
Mouth: Tormentil.
Nose-bleeds: Nettles.
Uterus. Shepherd’s Purse, Ladies Mantle, Greater Periwinkle, Beth root, Avens, Goldenseal. Urinary system. Bistort, Plantain, Marigold, Stone root, Horsetail, Bur-Marigold.
Lungs. Bugleweed, Elecampane, Lungwort.
Colon. Greater Burnet, Matico, Comfrey, Bistort, Wild Yam, Holy Thistle, Avens, Tormentil. Capillary haemorrhage. Buckwheat. ... anti-haemorrhagics
Herbs that stimulate the body’s immune system to withstand infection. Alternatives to anti-bacterial substances obtained from micro-organisms as penicillin, streptomycin etc. Those from herbs do not destroy beneficial bacteria normally present in the intestines, neither does the body get used to them.
Some essential oils are natural antibiotics. Others: Blue Flag root, Buchu, Chaparral, Butterbur, Echinacea, Feverfew, Garlic, Goldenseal, Holy Thistle, Horse Radish (Vogel), Juniper berries, Myrrh, Nasturtium, Poke root, Red Clover, Watercress (Vogel), Wild Indigo, Wild Thyme.
Vitamin C is a powerful antibiotic (1-2g daily).
ANTI-INFLAMMATORIES. A group of agents known to reduce inflammation. Action is not to suppress but to enable tissue to return to normal on the strength of its own resources. Some members of the group are helpful for chronic conditions such as polyarthritis and rheumatism caused by a sub-acute inflammation going on quietly over a long time. Others work by blocking prostaglandin synthesis. General. Chamomile (German, Roman), Cowslip root, Fennel, Feverfew, Heartsease, Mistletoe, Turmeric, Yellow Dock.
Specific. Bistort (bowel). Comfrey (bones). Devil’s Claw (muscles). St John’s Wort (nerve tissue). Lignum vitae (rheumatic joints). Poke root (lymph vessels). Eyebright (conjunctivitis: topical as an eye lotion). Horsechestnut (anus). Bogbean (liver and gall bladder).
Steroid-like action. Ginseng, Black Cohosh, Black Haw, Liquorice, Wild Yam.
Aspirin-like action. Birch, Black Willow bark, Meadowsweet, White Poplar bark, White Willow bark, Wintergreen.
Some types of inflammation may be reduced by herbs that stimulate the eliminatory organs – lungs, bowel, skin and kidneys. A timely enema may reduce a high temperature with inflammation, to expel toxins and unload an over-loaded bowel; (Dandelion root, Parsley root, Sarsaparilla).
ANTI-INFLAMMATION FORMULA. (Biostrath). Drops containing cultures combined with extracts derived from medicinal plants possessing known therapeutic properties: Arnica, Bryony, Balm, Chamomile, Horseradish, Marigold, Hypericum, Echinacea.
Indications: colic, inflammation of the alimentary tract. ... anti-infectives
Remedies that inhibit the action of protozoa, a class of single-celled microscopic animals. Ipecacuanha, Peruvian bark. ... anti-protozoals
Agents to relieve intense itching. Chamomile, Chickweed, Clivers, Cucumber, Goldenseal, Marigold, Sarsaparilla, Peppermint, St John’s Wort. ... anti-pruritics
Another term for FEBRIFUGE. ... anti-pyretic
Herbs that may relieve discomforts of rheumatism and arthritis. Bearberry, Black Cohosh, Blue Cohosh, Black Willow, Bladderwrack, Blue Flag root, Bogbean, Boneset, Burdock, Calluna (Heather flowers), Cayenne, Celery seed, Chickweed, Couchgrass, Cowslip (Biostrath), Dandelion, Devil’s Claw, Guaiacum, Juniper, Lavender, Meadowsweet, Mountain Grape, Nettles, Parsley root, Poke root, Prickly Ash, Sarsaparilla, Pipsissewa, White Poplar, Wild Yam, Wintergreen, Wood Sage, Willow (Biostrath), Wormwood, Yarrow, Yellow Dock. ... anti-rheumatics
Plant medicines that destroy or inhibit growth of disease-causing bacteria or other micro-organisms. Aniseed, Barberry, Bayberry, Bearberry, Benzoin, Blood root, Buchu, Camphor, Caraway oil, Catechu, Cayenne, Cinnamon, Clove, Cornsilk, Coriander, Echinacea, Elecampane, Eucalyptus, Fennel seed, Garlic, Gentian, Goldenseal, Guaiacum, Heather flowers (Calluna), Hemlock Spruce bark, Juniper, Kava Kava, Kino, Labrador tea, Lavender, Liquorice, Lovage root, Mandrake, Marigold, Marjoram, Meadowsweet, Mountain Grape, Myrrh, Nasturtium, Olive, Orthosiphon, Parsley root, Peppermint, Peruvian balsam, Plantain, Propolis, Rosemary, Rue, Sage, St John’s Wort, Southernwood, Thuja, Thyme, Turmeric, White Pond Lily, Wild Indigo, Wood Sage, Wormwood, Yarrow. ... anti-microbials
Agents that relieve or cure scurvy. Bogbean, Burdock, Chickweed, Clivers, Cubebs, Blue Flag root, Lemon juice, Sorrel, Nettles, Sarsaparilla, Yellow Parilla, Yellow Dock, Watercress. ... anti-scorbutics
An agent that tends to reduce glandular inflammation and swelling, and inhibits onset of tuberculosis of the lymphatics. See: LYMPHATICS. ... anti-scrofulous
Agents for relief of muscular cramp, spasm or mild pain. To reduce spasm of smooth muscle. The key remedy is Cramp bark but all have their specific uses.
They may be general (Black Haw, Cramp bark), or those that exert their influence upon specific structures: Hyssop (lungs), Cloves (mucous membranes), Wild Thyme (bronchi), Figwort (anus).
Others in common use: Asafoetida, Balm, Betony, Black Haw (muscles generally, also womb), Black Cohosh, Blue Cohosh, Butterburr, Blood root (externally), Cayenne, German Chamomile (stomach), Dong Quai (ovaries), Eucalyptus, Hops (stomach), Ladyslipper, Liquorice, Lime Blossom, Lobelia, Mistletoe, Motherwort (heart), Nutmeg (angina), Passion Flower, Skullcap, Skunk Cabbage, Thyme, Valerian, Vervain, Wild Cherry (respiratory), Wild Carrot (kidneys and bladder), Wild Lettuce, Wild Yam. Devil’s Claw (muscles).
Anti-Spasmodic Drops (Heath and Heather). Cramp, neuralgia, etc. Tincture Myrrh 6 per cent; Tincture Capsic 15 per cent; with 45 per cent ethanol extractive from Scutellaria (Skullcap) 10 per cent; Lobelia 1.25 per cent; Fennel 2.5 per cent; American Valerian 5 per cent. Dose: 10-30 drops according to age.
John Christopher: 2oz crushed Lobelia seeds; half an ounce Lobelia herb; 1 teaspoon Cayenne; macerated in 1 pint cider 8 days. 1-2 teaspoon when necessary.
Combination: powders. Equal parts: Skullcap, Valerian, Lobelia, Black Cohosh. Myrrh quarter part. Mix. Sift. Quarter of a teaspoon in water, honey etc as necessary.
Formula. Powders. Cramp Bark 2; Skullcap 1; Cloves half; Cayenne Pepper quarter. Mix. Dose: 500mg (two 00 capsules or one-third teaspoon thrice daily. (Indian Herbology of North America, Alma R. Hutchens) ... anti-spasmodics
Agents that have anti-bacterial action on most strains of staphylococcus. For treatment of pus-forming lesions, necrotic tissue and for after-surgery infections.
Angostura, Balm, Barberry, Bayberry, Bearberry, Benzoin, Bistort, Blood root, Black Cohosh, Black Currant, Buchu, Bugleweed (Lycopus virginicus and Lycopus europaeus), Butternut (Juglans cinerea), Camphor, Catechu, Cola, Cornsilk, Elecampane, Eucalyptus, Fringe Tree, Goldenseal, Guaiacum, Holy Thistle, Hops, Jaborandi, Jalap, Jambul, Juniper, Kino, Ladysmantle, Labrador tea, Lavender, Liquorice, Male fern, Mandrake, Marjoram, Meadowsweet, Mountain Grape, Myrtle (common), Oleander, Olive, Orthosiphon, Pennyroyal, Peony (common), Pine (Hemlock spruce), Pulsatilla, Rhus toxicodendron, Sage, St John’s Wort, Senna, Sumach, Sumbul, Sundew, Thuja, Turmeric, Unicorn root true, Walnut (juglans regia), Wild Indigo. Propolis, a resin foraged by bees for the exclusion of draughts in the hive has proved to be an effective anti-staphylococcal. ... anti-staphylococcals
See: ANTI-NEOPLASTICS. ... anti-tumours
To reduce cough severity, ease expectoration and clear the lungs. Over a hundred medicinal plants are listed from which the following are a small selection: Angelica, Balm of Gilead, Coltsfoot, Comfrey, Cowslip, Elecampane, Fenugreek, Garlic, Grindelia Hyssop, Linseed, Liquorice, Marshmallow, Irish Moss, Mousear, Mullein, Pleurisy root, Senega, Sweet Chestnut leaves, Sundew, Violet leaves, Thyme (Garden or Wild), White Horehound, Slippery Elm bark, Marsh Cudweed,. ... anti-tussives
A group of vasodilator drugs used to treat heart failure, hypertension, and diabetic nephropathy. (angiotensin converting enzyme) inhibitors are often prescribed with other drugs such as diuretic drugs or betablocker drugs. Possible side effects include nausea, loss of taste, headache, dizziness, and dry cough.... ace inhibitor drugs
A group of drugs used to treat hypertension (high blood pressure) and urinary symptoms due to enlargement of the prostate gland. Alpha-blockers are also used to treat urinary retention caused by an enlarged prostate gland (see prostate, enlarged). Side effects of the drugs may include dizziness and fatigue due to a sudden drop in blood pressure, nausea, dry mouth, and drowsiness.... alpha-blocker drugs
A type of antibiotic drug. Aminoglycoside drugs are given by injection and are generally reserved for the treatment of serious infections because their use can damage the inner ear or kidneys. Important examples are gentamicin and streptomycin, which are also used topically for eye and ear infections.... aminoglycoside drugs
See amfetamine drugs.... amphetamine drugs
Drugs that stimulate breathing. Replaced by ventilation, they are seldom used now.... analeptic drugs
Natural or synthetic androgen hormones used as drugs; one of the most important is testosterone. These drugs are used in the treatment of male hypogonadism (underactivity of the testes) to stimulate the development of sexual characteristics.
Androgen drugs are occasionally used to treat certain types of breast cancer. They have been widely used by sportsmen wishing to increase muscle bulk and strength, a practice that is dangerous to health (see steroids, anabolic).
Adverse effects include fluid retention, weight gain, increased blood cholesterol, and, rarely, liver damage. When taken by women, the drugs can cause male characteristics, such as facial hair, to develop.
androgen hormones A group of hormones that stimulate the development of male sexual characteristics.
Androgens are produced by specialized cells in the testes in males and in the adrenal glands in both sexes. The ovaries secrete very small quantities of androgens until the menopause. The most active androgen is testosterone, which is produced in the testes. The production of androgens by the testes is controlled by certain pituitary hormones, called gonadotrophins. Adrenal androgens are controlled by ACTH, another pituitary hormone.
Androgens stimulate male secondary sexual characteristics at puberty, such as the growth of facial hair and deepening of the voice. They have an anabolic effect (they raise the rate of protein synthesis and lower the rate at which it is broken down). This increases muscle bulk and accelerates growth. At the end of puberty, androgens cause the long bones to stop growing. They stimulate sebum secretion, which, if excessive, causes acne. In early adult life, androgens promote male-pattern baldness.
Androgen deficiency may occur if the testes are diseased or if the pituitary gland fails to secrete gonadotrophins. Typical effects include decreased body and facial hair, a high-pitched voice, underdevelopment of the genitalia, and poor muscle development.
Overproduction of androgens may be the result of adrenal disorders (see adrenal tumours; adrenal hyperplasia, congenital), of testicular tumours (see testis, cancer of), or, rarely, of androgensecreting ovarian tumours (see ovary, cancer of).
In men, excess androgens accentuate male characteristics; in boys, they cause premature sexual development.
In women, excess androgens cause virilization, the development of masculine features such as an increase in body hair, deepening of the voice, clitoral enlargement, and amenorrhoea.... androgen drugs
A group of drugs that are used to eradicate worm infestations. Possible side effects include nausea, abdominal pain, rash, headache, and dizziness.... anthelmintic drugs
Drugs that are used to treat or prevent allergic reactions (see allergy). There are several groups, including corticosteroids, antihistamines, leukotriene receptor antagonists, and sodium cromoglicate.... antiallergy drugs
A group of drugs used to relieve the symptoms of anxiety. Benzodiazepine drugs and beta-blocker drugs are the 2 main types, although antidepressant drugs may occasionally be used. Benzodiazepine drugs promote mental and physical relaxation; they can also be used to treat insomnia, but their use for this purpose is avoided because they are addictive. Beta-blockers reduce only the physical symptoms of anxiety, such as shaking and palpitations, and are not addictive.... antianxiety drugs
Drugs that reduce inflammation. The main groups of these drugs are nonsteroidal antiinflammatory drugs and corticosteroid drugs. (See also analgesic drugs.)... anti-inflammatory drugs
Drugs used to treat malaria. One antimalarial drug, chloroquine, is also used to treat arthritis.... antimalarial drugs
Drugs that reduce the tendency of platelets to stick together to form blood clots when blood flow in the arteries is disrupted. This action reduces the risk of thromboembolism, which can cause potentially fatal disorders such as a myocardial infarction or stroke. Aspirin and dipyridamole are commonly used antiplatelet drugs. Others, such as ticlopidine, are used specifically to protect against clots forming in the coronary arteries of people with angina.... antiplatelet drugs
Drugs that reduce fever. Examples of antipyretic drugs include paracetamol, aspirin, and other non-steroidal anti-inflammatory drugs.... antipyretic drugs
Drugs that are used to slow or halt the spread of viruses in people with HIV infection and AIDS. There are 3 main groups: reverse transcriptase inhibitors, protease inhibitors, and non-nucleoside reverse transcriptase inhibitors. Drugs from different groups are often used in combination. Antiretroviral drugs can have a range of side effects, including nausea, vomiting, diarrhoea, tiredness, and a range of effects on blood chemistry, particularly involving fats.... antiretroviral drugs
A group of drugs that relax spasm in smooth muscle in the wall of the intestine or bladder. These drugs are used to treat irritable bowel syndrome and irritable bladder. Possible side effects include dry mouth, blurred vision, and difficulty in passing urine. (See also anticholinergic drugs.)... antispasmodic drugs
Drugs that suppress or relieve a cough (see cough remedies).... antitussive drugs
A group of sedative drugs that work by depressing activity within the brain. They include thiopental and phenobarbital. In the past, barbiturates were widely used as antianxiety drugs and sleeping drugs but have been largely replaced by benzodiazepine drugs and other nonbarbiturates. Barbiturates are now strictly controlled because they are habit-forming and widely abused. An overdose can be fatal, particularly in combination with alcohol, which dangerously increases the depressant effect on the brain (including suppression of the respiratory centre). However, phenobarbital is still commonly used as an anticonvulsant drug in the treatment of epilepsy. Thiopental is very short acting and is used to induce anaesthesia (see anaesthesia, general).... barbiturate drugs
See bisphosphonate drugs.... biphosphonate drugs
A group of non-steroidal anti-inflammatory drugs (NSAIDs) that cause less stomach irritation as a side effect than other NSAIDs. Examples of -2 inhibitors include celecoxib and rofecoxib.... cox-2 inhibitor drugs
A group of drugs used to treat bleeding disorders and to control bleeding. Haemostatic preparations that help blood clotting are given to people who have deficiencies of natural clotting factors. For example, factor VIII is used to treat haemophilia. Drugs that prevent the breakdown of fibrin in clots, such as tranexamic acid, can also improve haemostasis.... haemostatic drugs
Drugs that induce sleep (see sleeping drugs).... hypnotic drugs
A group of drugs that increase the efficiency of the body’s immune system. Immunostimulant drugs include vaccines, interferon and aldesleukin (interleukin-2). Interferon is used to treat persistent viral infections, such as hepatitis C, and some types of multiple sclerosis. Aldesleukin is used in the treatment of some types of cancer.... immunostimulant drugs
Drugs used in the treatment of glaucoma to reduce pressure in the eye. Used topically, miotic drugs cause the pupil to contract, which opens up the drainage channels and drains fluid from the front of the eye. Side effects include headache, particularly over the eye, and blurred vision. Common miotics include carbachol and pilocarpine. (See also mydriatic drugs.)... miotic drugs
Drugs that make sputum (phlegm) less sticky and easier to cough up. An example is acetylcysteine.... mucolytic drugs
A group of drugs used to treat uveitis and to dilate the pupil during examination of the inside of the eye and for surgery. Mydriatics work by relaxing the circular muscles of the iris, causing the pupil to dilate. Common mydriatic drugs include tropicamide, cyclopentolate, homatropine, and phenylephrine. (See also cycloplegia; miotic drugs.)... mydriatic drugs
See opioid analgesic drugs.... narcotic drugs
Drugs that have been developed to treat rare conditions but are not manufactured generally.... orphan drugs
A group of drugs similar to progesterone hormone. The drugs are used in oral contraceptives, are prescribed to treat menstrual problems (see menstruation, disorders of), and are included in hormone replacement therapy (HRT). Progestogen drugs are also used to treat premenstrual syndrome, endometriosis, and hypogonadism, and are sometimes used as anticancer drugs. Adverse effects include weight gain, oedema, headache, dizziness, rash, irregular periods, breast tenderness, and ovarian cysts.... progestogen drugs
Drugs that have an effect on the mind, including hallucinogenic drugs, sedative drugs, sleeping drugs, tranquillizer drugs, and antipsychotic drugs.... psychotropic drugs
A group of drugs used to produce sedation. Sedative drugs include sleeping drugs, antianxiety drugs, antipsychotic drugs, and some antidepressant drugs. A sedative drug is often included in a premedication.... sedative drugs
A group of drugs including corticosteroid drugs and anabolic steroids (see steroids, anabolic).... steroid drugs
A group of antibacterial drugs that has largely been superseded by more effective and less toxic alternatives.... sulphonamide drugs
Drugs that have a sedative effect. Tranquillizers are divided into 2 types: major tranquillizers (see antipsychotic drugs) and minor tranquillizers (see antianxiety drugs).... tranquillizer drugs
n. any one of a group of drugs that inhibit the action of testosterone on the prostate gland by blocking androgen receptors, competing for binding sites, or decreasing androgen production. They are therefore used in the treatment of prostate cancer, which is an androgen-dependent tumour. Anti-androgens include *abiraterone acetate, *bicalutamide, *cyproterone, *finasteride, and *flutamide.... anti-androgen
adj. describing a group of drugs used to correct irregularities in the heartbeat (see arrhythmia). They include *adenosine, *amiodarone, *verapamil, *disopyramide, *flecainide, and *lidocaine.... anti-arrhythmic
(anti-D Ig) a preparation of anti-D, a *rhesus factor antibody formed by Rh-negative individuals following exposure to Rh-positive blood (usually by exchange between fetal and maternal blood in Rh-negative women who carry a Rh-positive fetus). Anti-D Ig is administered (by intramuscular injection) to Rh-negative women within 72 hours of giving birth to a Rh-positive child (or following miscarriage or abortion) to prevent the risk of *haemolytic disease of the newborn in a subsequent child. It rapidly destroys any remaining Rh-positive cells, which could otherwise stimulate antibody production affecting the next pregnancy. Anti-D is also available as antenatal prophylaxis to all Rh-negative pregnant women.... anti-d immunoglobulin
see Müllerian duct.... anti-müllerian hormone
(oestrogen-receptor antagonist) n. one of a group of drugs that oppose the action of oestrogen by binding to *oestrogen receptors in the body’s tissues. The most important of these drugs is currently *tamoxifen, which is used in the treatment of breast cancers dependent on oestrogen. Because they stimulate the production of pituitary *gonadotrophins, some anti-oestrogens (e.g. *clomifene, tamoxifen) are used to induce or stimulate ovulation in infertility treatment. Side-effects of anti-oestrogens include hot flushes, itching of the vulva, nausea, vomiting, fluid retention, and sometimes vaginal bleeding.... anti-oestrogen
see cytokine inhibitor.... anti-tnf drugs
an agent that inhibits the action of *vascular endothelial growth factor (VEGF). See angiogenesis inhibitor.... anti-vegf
see NSAID.... nonsteroidal anti-inflammatory drug
(in the UK) an Act of Parliament restricting the use of dangerous drugs. These controlled drugs are divided into three classes: class A drugs (e.g. heroin, morphine and other potent opioid analgesics, cocaine, LSD) cause the most harm when misused; class B drugs include amphetamines, barbiturates, and cannabis, and class C drugs include most benzodiazepines and anabolic steroids. The Act specifies certain requirements for writing prescriptions for these drugs. The Misuse of Drugs (Supply to Addicts) Regulations 1997 and the Misuse of Drugs Regulations 2001 lay down who may supply controlled drugs and the rules governing their supply, prescription, etc.... misuse of drugs act 1971
see shock.... systemic inflammatory response
an agent which combats anaemia. Anti-arthritic: an agent which combats arthritis. Antibilious: an agent which helps remove excess bile from the body.... anti-anaemic
an agent which reduces the incidence and severity of nausea or vomiting.... anti-emetic
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