Parathyroid Hormone-related Protein: From 1 Different Sources
(PTH-RP) a protein that is secreted by certain malignant tumours and is the main cause of malignant *hypercalcaemia. PTH-RP, which has effects similar to *parathyroid hormone, stimulates generalized bone resorption and excessive calcium reabsorption in the kidney tubules. It is most commonly produced by lung tumours, squamous-cell carcinomas of other organs, melanomas, and tumours of the breast, liver, pancreas, bladder, and prostate.
A chemical produced in the body by endocrine glands and carried in the blood to other organs where the hormone causes processes to change in the target organ. A chemical messenger.... hormone
The presence of protein in the urine, sometimes a symptom of kidney compromise. See ALBUMINURIA... proteinuria
A hormone produced by the anterior PITUITARY GLAND which stimulates the formation of follicles in the ovary each menstrual cycle (see OVARIES; MENSTRUATION) and of spermatocytes in the testis (see TESTICLE). It is under hypothalamic control (see HYPOTHALAMUS) and in the female there is feedback inhibition by oestrogens from the developing follicle.... follicle-stimulating hormone
(LH) This is a sugar-bearing protein manufactured by the anterior pituitary. Like a lot of the pituitary hormones, it surges on and off, since constant secretion would overload and deaden receptors. In women, it builds up after menses, stimulating the release of estrogen from the ovaries. Estrogen in turn stimulates the hypothalamus to increase its stimulation of LH from the pituitary, until, a day or two before ovulation, they produce a guitar-amp feedback, and the cells that produce LH start to surge follicle-stimulating hormone (FSH). The egg pops, being replaced by the corpus luteum, which produces progesterone for the next eleven to twelve days. Progesterone inhibits and lowers LH levels, as well as inhibiting levels of estrogen already being produced by the young follicles that will produce next month’s egg. In men, LH is responsible for stimulation of testosterone, although FSH and the testes hormone inhibin are responsible for both the production of sperm and controlling testosterone.... luteinizing hormone
Molecular constituent of all cells comprising amino acid building blocks.... protein
Within a few years medical scientists have introduced into the domestic scene a steroid which has changed the whole course of female history. HRT has solved some basic medical problems by making good the loss of oestrogen in a woman’s body when menstruation is finished and her body learns to adjust.
A lack of oestrogen induces hot flushes, night sweats, thinning of the bones (osteoporosis) with possible fractures, and a wide range of physical and emotional disorders.
HRT also prevents the increased frequency of coronary disease which may follow the menopause. With oestrogen only, HRT appears to increase the incidence of cancer of the uterine body. Use of oestrogen and progestogen avoids this.
HRT is available as a tablet, transdermal patch, implant or topical cream. Most women notice temporary improvement in their appearance and hot flushes as long as treatment is continued. HRT is not prescribed by the herbal practitioner. Soya and Hops are a mild alternative.
Side-effects of such treatment include blood pressure rise, weight gain and periods probably continue with a monthly bleed. Elderly women taking HRT for osteoporosis may develop bleeding problems, the risk of blood clot and gall bladder diseases.
Helonias has proved a useful alternative, effective in eliminating excess fluids, reducing hot flushes, and relieving that bloated feeling, thus helping the older woman to live a normal life.
Damiana. 1 heaped teaspoon leaves to each cup boiling water; infuse 5-10 minutes; strain. 1 cup 2-3 times daily for 3-6 weeks.
Sarsaparilla. 1oz (30g) root in 1 pint (500ml) water; simmer gently 20 minutes; strain. 1 cup 2-3 times daily for 3-6 weeks.
Supplementation. Daily. Vitamin E, 400iu. Vitamin B-complex (high potency). Evening Primrose oil capsules, 500mg morning and evening. Dolomite, for Calcium and Magnesium, 2 tablets morning and evening.
Note: An extensive study of breast cancer risks with HRT revealed a positive link between the risk of cancer and length of use. Risk of the disease increased with all types of women using HRT with every year of use. Pre-menstrual women were more than twice at risk. It would appear that oestrogens cannot be taken without risk. (Centre for Disease Control, Atlanta, USA) See: OESTROGENS. ... hormone replacement therapy (hrt)
A variety of chronic symptoms and physical findings that occur in some persons who are infected with HIV, but do not meet the Centres for Disease Control’s definition of AIDS. Symptoms may include chronic swollen glands, recurrent fevers, unintentional weight loss, chronic diarrhoea, lethargy, minor alterations of the immune system (less severe than those that occur in AIDS), and oral thrush. ARC may or may not develop into AIDS.... aids-related complex
(LH-RH) The same substance as Follicle-Stimulating-Hormone Releasing Hormone (FSH-RH), both of which are actually Gonadotrophin-Releasing Hormone (GnRH or GRH). Confused? Imagine being an endocrinologist 20 years ago. These (This) are (is) a peptide secreted into the little portal system that drains from the hypothalamus to the pituitary. If it is surged hourly and not too strongly, the pituitary secretes LH and the ovaries secrete estrogen. If it is surged hourly and strongly, the estrogens rise drastically, the pituitary secretes FSH, you pop an egg, start the corpus luteum and begin progesterone secretion. The surge is now slowed to every four or five hours, not too strongly, and the pituitary secretes LH every four or five hours...and the ovaries make progesterone. The same hypothalamic hormone triggers different pituitary responses based on AMPLITUDE and FREQUENCY.... luteinizing-hormone releasing hormone
See ACTH.... adrenocorticotrophic hormone
See ADH.... antidiuretic hormone
A protein produced in the body in response to inflammation.... c-reactive protein
ACTH is the commonly used abbreviation for CORTICOTROPIN.... acth (adrenocorticotrophic hormone)
See also CORTICOTROPIN. A hormone which is released into the body during stress. Made and stored in the anterior PITUITARY GLAND, ACTH regulates the production of corticosteroid hormones from the ADRENAL GLANDS, and is vital for the growth and maintenance of the adrenal cortical cells. Its production is in part controlled by the amount of HYDROCORTISONE in the blood and also by the HYPOTHALAMUS. ACTH participates in the FEEDBACK MECHANISM of hormone production and actions involving particularly the hypothalamus and pituitary gland. The hormone is used to test adrenal function and treat conditions such as ASTHMA. (See also CUSHING’S SYNDROME.)... adrenocorticotrophic hormone (acth)
A protein produced in the gut and liver of the FETUS. Abnormality in the fetus, such as neural tube defect, may result in raised levels of alphafeto protein in the maternal blood. In DOWN’S (DOWN) SYNDROME, levels may be abnormally low. In either case, screening of the pregnancy should be carried out, including AMNIOCENTESIS to check the amount of alpha-feto protein in the amniotic ?uid. The protein may also be produced in some abnormal tissues in the adult – in patients with liver cancer, for example.... alpha-feto protein
See VASOPRESSIN.... antidiuretic hormone (adh)
A system used for payment under prospective payment systems. It classifies treatments by diagnosis, measuring the relative complexity of a hospital procedure and accounting for the resources used in the procedure. The system accounts for principal diagnosis, secondary diagnosis, surgical procedures, age, sex and presence of complications.... diagnosis-related group
1 Represents classes of hospital patients with similar clinical characteristics. DRGs form a clinical grouping system which describes hospital discharges according to medical condition. 2 A system used for payment under prospective payment systems. It classifies treatments by diagnosis, measuring the relative complexity of a hospital procedure and accounting for the resources used in the procedure. The system accounts for principal diagnosis, secondary diagnosis, surgical procedures, age, sex and presence of complications.... diagnosis-related group (drg)
See OESTRADIOL.... follicular hormone
Individual outcome measure that extends beyond traditional measures of mortality and morbidity to include such dimensions as physiology, function, social activity, cognition, emotion, sleep and rest, energy and vitality, health perception and general life satisfaction (some of these are also known as health status, functional status or quality-of-life measures).... health-related quality-of-life (hrql) measure
See under MENOPAUSE.... hormone replacement therapy(hrt)
A list of diagnoses and identifying codes used by medical practitioners and other health care providers. The coding and terminology provide a uniform language that permits consistent communication on claim forms. Data from earlier time periods were coded using the appropriate revision of the ICD for that time period. Changes in classification of causes of death in successive revisions of the ICD may introduce discontinuities in cause of death statistics over time.... international statistical classification of diseases and related health problems, tenth revision (icd-10)
A hormone secreted by the anterior PITUITARY GLAND which stimulates OVULATION, maturation of the CORPUS LUTEUM, and the synthesis of progesterone by the ovary (see OVARIES) and testosterone by the testis (see TESTICLE).... luteinising hormone
A natural hormone released by the HYPOTHALAMUS gland in the BRAIN. It stimulates the release of GONADOTROPHINS from the PITUITARY GLAND; these control the production of the sex hormones (see ANDROGEN; OESTROGENS).... luteinising hormone-releasing hormone (lhrh)
Reagent used by intradermal administration in the Mantoux (tuberculin) test for TB.... purified protein derivative (ppd)
These are fats similar to, and usually synthesized from, cholesterol, starting with Acetyl-CoA, moving through squalene, past lanosterol, into cholesterol, and, in the gonads and adrenal cortex, back to a number of steroid hormones. Nearly all of the classic hormones are proteins or smaller peptides; they don’t get inside a cell (the membrane keeps them out); instead, they bind to, and initiate, cell changes from the outside. The exceptions are the thyroxines (from the thyroid) and the steroid hormones. They move into the cell, bind with receptors, and initiate changes in the way a cell regenerates itself or synthesizes new compounds. Because the steroid hormones stimulate cell growth, either by changing the internal structure or increasing the rate of proliferation, they are often called anabolic steroids. Estrogen, an ovarian steroid, when secreted into the bloodstream, will be bound within a short time by internal receptors inside those cells that need estrogen for their growth; the unused portion is partially broken down, mostly in the liver, and partially stored in a less active form by adipose tissue. Since luteinizing hormone from the pituitary is surged in pulses an hour apart, the estrogen is also surged from the reacting ovaries, and by the time more estrogen is available, the binding cells need more; their program of synthesis has run out and needs to be started again. Of course, most steroid hormone reactions are less measured than this, but you get the idea.... steroid hormone
A hormone (see HORMONES) produced and released by the HYPOTHALAMUS which stimulates the release of THYROTROPHINSTIMULATING HORMONE (TSH) by the PITUITARY GLAND.... thyrotrophin-releasing hormone (trh)
A hormone (see HORMONES) manufactured and released by the anterior part of the PITUITARY GLAND which stimulates the THYROID GLAND to manufacture and release thyroid hormones (THYROXINE and TRI-IODOTHYRONINE).... thyrotrophin-stimulating hormone (tsh)
A form of arthritis running concurrently with a bowel disorder arising from intestinal irritation. Acute Crohn’s disease or colitis may be related. Joint stiffness and inflammation subside on disappearance of the bowel condition.
Chronic bowel conditions are frequently responsible for heavy drainage of vitamins and minerals via excessive stool. Calcium may be pillaged from the bones to make up blood calcium levels which, if prolonged, may lead to rigid spine.
Treatment. Treatment of arthritis would be secondary, the primary object being to normalise the bowel. Alternatives:–
Teas or decoctions. Comfrey leaves, Calamus, Chamomile, Avens, Agrimony, Marshmallow root, Meadowsweet, Slippery Elm bark, Wild Yam.
Tea. Formula. Equal parts: Agrimony, Balm, Chamomile. 1 heaped teaspoon to each cup boiling water; infuse 5-10 minutes; 1 cup freely.
Fenugreek seeds. Decoction. 1 cup freely.
Tablets/capsules. Calamus, Fenugreek, Goldenseal, Wild Yam.
Formula. Fenugreek 2; Wild Yam 1; Goldenseal quarter; Ginger quarter. Mix. Dose: Powders: 500mg (two 00 capsules or one-third teaspoon). Liquid extracts: 1 teaspoon. Tinctures: 2 teaspoons.
Bamboo powder. Two 320mg capsules thrice daily. (Dr Max Rombi)
Biostrath Willow Formula.
Diet. Slippery Elm food. Vitamin B12. Low fat. Cider vinegar.
Supportive: high enemas. Natural lifestyle. Outlook good. ... arthritis – bowel related
A drug that blocks the action of a hormone.... hormone antagonist
Proteins present in blood plasma, including albumin, blood clotting proteins, and immunoglobulins.... plasma proteins
Large molecules consisting of hundreds or thousands of amino acids linked into long chains. Proteins may also contain sugars (glycoproteins) and lipids (lipoproteins). There are 2 main types of proteins. Fibrous proteins are insoluble and form the structural basis of many body tissues. Globular proteins are soluble and include all enzymes, many hormones, and some blood proteins, such as haemoglobin.... proteins
The formation of protein molecules through the joining of amino acids.... protein synthesis
(AMD, ARMD) see macular degeneration.... age-related macular degeneration
see Müllerian duct.... anti-müllerian hormone
any one of a variety of conditions involving the *pleura, but not the lungs (see asbestosis), in subjects exposed to asbestos. These include the formation of pleural plaques, diffuse pleural thickening, and pleural effusions (see oedema).... asbestos-related pleural disease
a protein of low molecular weight found in the urine of patients with multiple *myeloma and rarely in patients with *lymphoma, *leukaemia, and *Hodgkin’s disease. [H. Bence-Jones (1814–73), British physician]... bence-jones protein
(CRH) a peptide hypothalamic hormone (of 41 amino acids) stimulating the release of *ACTH (adrenocorticotrophic hormone) from the anterior pituitary. Its own release is suppressed by a *negative feedback loop involving cortisol, and its action is increased by antidiuretic hormone (see vasopressin) and *angiotensin II. It can be administered intravenously as part of the CRH test, during which blood is analysed at 15-minute intervals for one hour for the ACTH response, which is excessive in cases of primary adrenal failure and suppressed in cases of anterior *hypopituitarism.... corticotrophin-releasing hormone
a hormone produced by cells that do not usually produce it. Some tumour cells secrete hormones; for example, small-cell lung cancer cells secrete antidiuretic hormone and cause *hyponatraemia.... ectopic hormone
(GnRH, gonadorelin) a peptide hormone produced in the hypothalamus and transported via the bloodstream to the pituitary gland, where it controls the synthesis and release of pituitary *gonadotrophins. It may be used to test the ability of the pituitary to produce gonadotrophins. *Gonadorelin analogues are used to treat endometriosis, fibroids, some types of infertility, and prostate cancer.... gonadotrophin-releasing hormone
a family of plasma proteins whose function is to bind free hormone molecules to varying degrees and thus reduce their function. Alterations in levels of the binding globulins, for example during pregnancy or ill health, can result in variations in assays of hormone levels in individuals. Examples include thyroid-binding globulin, sex-hormone-binding globulin, and corticosteroid-binding globulin.... hormone-binding globulins
see luteinizing hormone.... interstitial-cell-stimulating hormone
see prolactin.... lactogenic hormone
(luteotrophin) see prolactin.... luteotrophic hormone
(MSH) a peptide hormone produced and secreted by the anterior pituitary gland. In humans it stimulates production and dispersal of melanin in the melanocytes. Alpha-melanocyte-stimulating hormone (?-MSH), which is released by neurons in the hypothalamus, suppresses appetite and regulates energy balance. It also stimulates sexual activity and is involved in regulation of heart rate and blood pressure.... melanocyte-stimulating hormone
an enzyme that catalyses the transfer of a phosphate group from ATP to a specific amino acid residue of an intracellular protein (usually serine, threonine, or tyrosine), thereby affecting the biological activity of the protein. Protein kinase inhibitors are drugs that block the action of protein kinases in tumour cells and are used in the treatment of cancer. They include *sorafenib, *sunitinib, and *temsirolimus. See also tyrosine kinase inhibitor.... protein kinase
(in *nuclear medicine) a scan that can help to localize the site of a parathyroid adenoma before surgical removal, to treat primary *hyperparathyroidism. The tracer is technetium-99m-labelled sestamibi (a small protein), which is selectively absorbed by overactive parathyroid glands.... sestamibi parathyroid scan
any steroid hormone, produced mainly by the ovaries or testes, that is responsible for controlling sexual development and reproductive function. *Oestrogens and *progesterone are the female sex hormones; *androgens are the male sex hormones.... sex hormone
(SIADH) a condition of inappropriately high plasma levels of ADH (see vasopressin) with associated water retention, dilutional *hyponatraemia, and the production of highly concentrated urine. Renal, adrenal, thyroid, and hepatic function are normal, as is the volume of circulating blood (euvolaemia). It is caused by a variety of pathological conditions, usually intrathoracic and intracerebral, and also by a number of drugs, including antidepressants, chemotherapy agents, and some of the older antidiabetic agents. The treatment involves fluid restriction, treatment (or removal) of the underlying cause (or drug), and, in severe cases, administration of *demeclocycline to reduce the effects of ADH on the kidney. Very rarely, hypertonic saline is given.... syndrome of inappropriate secretion of antidiuretic hormone
an iodine-containing substance, synthesized and secreted by the thyroid gland, that is essential for normal metabolic processes and mental and physical development. There are two thyroid hormones, *triiodothyronine and *thyroxine, which are formed from *thyroglobulin. Lack of these hormones gives rise to *cretinism in infants and *myxoedema in adults. Excessive production of thyroid hormones gives rise to *thyrotoxicosis.... thyroid hormone
(TSH, thyrotrophin) a hormone, synthesized and secreted by the anterior pituitary gland under the control of *thyrotrophin-releasing hormone, that stimulates activity of the thyroid gland. Raised levels of TSH are found in primary *hypothyroidism. Normal or low TSH levels in the presence of a low serum thyroxine are found in secondary hypothyroidism and the *euthyroid sick syndrome.... thyroid-stimulating hormone
(TRH) a hormone from the hypothalamus (in the brain) that acts on the anterior pituitary gland to stimulate the release of *thyroid-stimulating hormone. A preparation of TRH (protirelin) may be given by intravenous injection to test thyroid gland function and to estimate reserves of thyroid-stimulating hormone in the pituitary.... thyrotrophin-releasing hormone
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