These are several minute glandular masses embedded in the lower edge of the thyroid gland. They produce Parathyroid Hormone (PTH), part of the calcium-phosphorus control system. Calcium levels in the blood MUST be within a narrow band of safety. If free calcium drops too low, PTH acts on the kidneys and blocks calcium loss in urine, amplifies calcium absorption into the portal blood (from food and from submucosal storage) and stimulates release of calcium from bone storage. When levels are back up, the hormone backs off. Oddly enough, the thyroid gland secretes its virtual antagonist, calcitonin, which, when calcium levels are too high, stimulates the urine excretion, bone retention and digestive resistance to calcium, and when the blood levels drop, recedes. The body finds calcium levels to be so critical that it has in place TWO separate, mutually antagonistic negative feedback systems,,,like a binary star system. (Be thankful I didn’t bring in the calcium maintenance of minerocortical steroid hormones or vasopressin)
multiple endocrine neoplasia syndromes, designated as type 1 (Wermer’s syndrome), type 2A (Sipple’s syndrome), and type 2B. These involve tumour formation or hyperplasia in various combinations of endocrine glands. Type 1 involves the parathyroid, pituitary, and pancreas, whereas type 2A involves the thyroid medullary cells, the adrenal medulla (*phaeochromocytoma), and the parathyroids. Type 2B is similar to 2A, but patients tend to resemble people with *Marfan’s syndrome and have multiple *neuromas on their mucous membranes. These conditions are inherited as autosomal *dominant characteristics.... mens
the autoimmune destruction of a combination of the thyroid, the adrenals, and the beta cells of the islets of Langerhans, causing type 1 *diabetes mellitus. It is often associated with failure of the ovaries (causing an early menopause), the parathyroids, and the parietal cells of the *gastric glands (causing pernicious anaemia). [M. B. Schmidt (1863–1949), German physician]... schmidt’s syndrome