A viral infection that causes a rash and joint inflammation. Many children have no symptoms, but some have a bright red rash on the cheeks, a mild fever, and sometimes mild joint inflammation. Symptoms are more severe in adults; they include a rash on the palms and soles of the feet and severe inflammation in the knee, wrist, and hand joints. A diagnosis is made from the symptoms and a blood test. The infection usually clears up within 2 weeks without treatment.