Peripheral Neuropathy: From 1 Different Sources
(polyneuropathy, peripheral neuritis) any of a group of disorders affecting the sensory and/or motor nerves in the peripheral nervous system. They tend to start distally, in the fingers and toes, and progress proximally. Symptoms include pins and needles, stabbing pains and a numbness on the sensory side, and weakness of the muscles. The most common causes of peripheral neuropathy are diabetes, alcohol, certain drugs, and such infections as HIV; genetic causes of peripheral neuropathy include amyloidosis and *Charcot-Marie-Tooth disease. The diagnosis may be established by neurophysiological tests, blood tests, and occasionally a nerve biopsy.
A disease affecting nerves (see NERVE). It may affect a single nerve (mononeuropathy) or be a generalised disorder (polyneuropathy). Symptoms will depend on whether motor, sensory, or autonomic nerves are affected. Trauma or entrapment of a nerve is a common cause of mononeuropathy, pressure or stretching of a nerve occurring in various situations. Complete recovery in 4–6 weeks is usual. Common causes of polyneuropathy include DIABETES MELLITUS, vitamin B de?ciency (often alcohol-associated) and some viral infections. Genetic and toxic neuropathies are also seen.... neuropathy
See NERVOUS SYSTEM.... peripheral nervous system
The narrowing of the blood vessels in the legs and, less commonly, in the arms. Blood ?ow is restricted, with pain occurring in the affected area. If the blood supply is seriously reduced, GANGRENE of the tissues supplied by the affected vessel(s) may occur and the limb may need to be amputated. The common cause is ATHEROSCLEROSIS which may be brought on by HYPERTENSION, excessively fatty diet, poorly controlled DIABETES MELLITUS or smoking – the latter being the biggest risk factor, with 90 per cent of affected patients having been moderate to heavy smokers. Stopping smoking is essential; adequate exercise and a low-fat diet are important measures. Surgery may be required.... peripheral vascular disease
A condition, such as carpal tunnel syndrome, in which local pressure on a nerve causes muscle pain, numbness, and weakness in the area that the nerve supplies.... entrapment neuropathy
At the edges, especially circulation or nerves. Peripheral functions are usually controlled and modified more by local conditions than systemic (central) controls.... peripheral
In?ammation of the nerves (see NERVE) in the outlying parts of the body. (See NEURITIS.)... peripheral neuritis
These have almost completely replaced BONE MARROW TRANSPLANT, used to treat malignancies such as LEUKAEMIA and LYMPHOMA for the past 20 years. The high doses of CHEMOTHERAPY or RADIOTHERAPY used to treat these diseases destroy the bone marrow which contains stem cells from which all the blood cells derive. In 1989 stem cells were found in the blood during recovery from chemotherapy. By giving growth factors (cytokines), the number of stem cells in the blood increased for about three to four days. In a peripheral-blood stem-cell transplant, these cells can be separated from the peripheral blood, without a general anaesthetic. The cells taken by either method are then frozen and returned intravenously after the chemotherapy or radiotherapy is completed. Once transplanted, the stem cells usually take less than three weeks to repopulate the blood, compared to a month or more for a bone marrow transplant. This means that there is less risk of infection or bleeding during the recovery from the transplant. The whole procedure has a mortality risk of less than 5 per cent – half the risk of a bone marrow transplant.... peripheral-blood stem-cell transplants
The increase of blood into the skin, resulting from the relaxation of the small arterioles that lead into the capillary beads at the edges of the body. This is a gentle way to lessen early high blood pressure, decreasing the difficulty of pushing columns of arterial blood through miles of capillaries.... vasodilation, peripheral
(auditory neuropathy, auditory dyssynchrony) a form of hearing loss characterized by normal cochlear function as measured by *otoacoustic emissions or detection of *cochlear microphonics but abnormal or absent *middle ear reflexes and abnormal *auditory brainstem responses.... auditory neuropathy spectrum disorder
progressive damage to the peripheral nerves seen in some people with long-standing diabetes. It most commonly affects the legs, causing pain or numbness working up from the feet. There is no cure but drugs can sometimes be used to control the discomfort experienced, and good blood glucose control may prevent deterioration over time. See also diabetic holiday foot syndrome.... diabetic neuropathy
(PPN) the delivery of nutrients directly into a peripheral vein (in the arm). Feed solutions must have a low *osmolality (<1200 mOsm/l), and PPN can be given only for a short period (less than four weeks). There is a risk of *phlebitis. See artificial nutrition and hydration; total parenteral nutrition.... peripheral parenteral nutrition
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