Peroneal Muscular Atrophy: From 1 Different Sources
A rare, inherited disorder characterized by muscle wasting in the feet and calves and then in the hands and forearms.
The condition, also known as Charcot–Marie– Tooth disease, is caused by degeneration of some peripheral nerves.
It is more common in boys, and usually appears in late childhood or adolescence.
Muscle wasting stops halfway up the arms and legs, making them look like inverted bottles; sensation may be lost.
There is no treatment, but the sufferer rarely becomes totally incapacitated because the disease usually progresses very slowly.
Life expectancy is normal.
Wasting of a tissue or organ... atrophy
See MUSCLES, DISORDERS OF – Myopathy.... muscular dystrophy
A deterioration in the ?bres of the optic nerve (see EYE) resulting in partial or complete loss of vision. It may be caused by damage to the nerve from in?ammation or injury, or the atrophy may be secondary to disease in the eye.... optic atrophy
The name given to structures, such as the muscles, and nerves, on the outer or ?bular side of the leg.... peroneal
The wasting of muscles after prolonged immobility. This can be seen after lengthy immobilisation in a plaster cast, and is particularly severe following paralysis of a limb through nerve injury. (See ATROPHY.)... disuse atrophy
Osteoporosis (see under BONE, DISORDERS OF) in the hand or foot which develops quickly as a result of injury, infection or malignant growth.... sudek’s atrophy
A type of motor neuron disease in which the muscles of the hands, arms, and legs become weak and wasted and twitch involuntarily. The condition eventually spreads to other muscles.... progressive muscular atrophy
a *sex-linked (X-linked) disorder in which affected males develop an increase in muscle size followed by weakness and wasting. It usually starts between the ages of 5 and 15, and 25 years after onset most patients are wheelchair-bound. Although most men become severely disabled, life expectancy is close to normal. The disorder is similar to Duchenne *muscular dystrophy but less severe. [P. E. Becker (20th century), German geneticist]... becker muscular dystrophy
a rare hereditary condition causing night blindness and constricted visual fields, usually developing in the first decade of life. Clinically it is characterized by a progressive atrophy of the choroid and retina.... gyrate atrophy
a rare hereditary disorder, usually affecting young males, that is characterized by loss of central vision due to neuroretinal degeneration. Visual loss in one eye is rapid and usually followed by loss in the second eye. [T. Leber]... leber’s optic atrophy
(MSA) a condition that results from degeneration of cells in the *basal ganglia (resulting in *parkinsonism), the *cerebellum (resulting in *ataxia), the *pyramidal system, and the *autonomic nervous system (resulting in symptoms of autonomic failure, such as postural hypotension).... multiple system atrophy
any aching pain in the muscles and joints. Commonly the symptoms are due to *fibrositis; wear and tear of the joints (*osteoarthritis); or to inflammation of the muscles associated with abnormal immune reactions (*polymyalgia rheumatica). Generalized muscle pain with specific tender points and fatigue is called *fibromyalgia.... muscular rheumatism
(SMA) a hereditary condition in which cells of the spinal cord die and the muscles in the arms and legs become progressively weaker. Eventually the respiratory muscles are affected and death usually results from respiratory infection. Most affected individuals are wheelchair-bound by the age of 20 and few survive beyond the age of 30. The gene responsible has been located: in affected children it is inherited as a double *recessive. There are three forms of the disease, based on severity of the symptoms and the age at which they appear. Type 1 (infantile spinal muscular atrophy) is the most acute and aggressive form of the condition (see Werdnig–Hoffmann disease). Type 2 develops between the ages of 6 months and 2 years and type 3 (Kugelberg–Welander disease), the least severe form, appears between 2 and 17 years of age.... spinal muscular atrophy
see complex regional pain syndrome. [P. H. M. Sudek (1866–1938), German surgeon]... sudek’s atrophy
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