Bennett.Family: Simaroubaceae.
Habitat: Garhwal, Himachal Pradesh and Kulu.
English: Quassia (substitute for P excelsa Lindtl).Ayurvedic: Bhurangi, Nimbi. (Clerodendrum serratum and its related species represent Bhaargi or Bhaarangi.)Folk: Nimatotaa.Action: Wood—a non-astringent bitter tonic and stomachic, amoe- bicidal, anthelmintic (used as enema), insect repellent. Used as a supporting medicine for temporary relief in cirrhosis of liver.
Many indole alkaloids of beta-car- boline, canthin-6-one and beta-carbo- line dimer type, have been isolated from the wood. These are reported to increase the blood flow rate in the intestine and stomach of rabbit; also exhibited antiviral activity on Herpes simplex virus.Nigaki lactone and methylnigaki- none, isolated from the wood, showed antigastric ulcer activity in rats. The extract of the wood is reported to prevent the secretion of gastric juice in a dose-dependent manner in rats. The extract also showed the same effects on rats having aspirin-induced gastric ulcer.Family: Scrophulariaceae.Habitat: The alpine Himalayas from Kashmir to Sikkim.
English: Picrorhiza.Ayurvedic: Katukaa, Katurohini, Kattarohini, Katuki, Katukikaa, Krishnabhedaa, Kaandaruhaa, Matsyashakalaa, Chakraangi, Shat- parvaa, Arishta, Ashokarohinya, Shakuldaani.Unani: Kutki, Kharbaq-e-Hindi.Siddha/Tamil: Kaduguragini.Action: Root—stomachic, antidiar- rhoeal, cholagogue, hepatoprotec- tive. Used in hepatitis, chronic dysentery, amoebiasis.
Key application: In jaundice, intermittent fever, dyspnoea and skin diseases. (The Ayurvedic Pharmacopoeia ofIndia.)The roots yield a glycosidal bitter principle, kutkin, found to be a mixture of two iridoid glycosides, picro- side I and kutkoside. Also obtained were D-mannitol, kutkiol, kutkisterol and a ketone (identical with apocynin).Kutkin exhibited hepatoprotective activity in CCl4-induced toxic rats.Picroliv, a standardized fraction from the alcoholic extract of the root and rhizome, containing 55-60% of a mixture of picroside I and kutkoside (1:15) showed dose-dependent protective activity on isolated hepatocytes in vitro against thiocetamide-induced hepatic damage in rat and was found to be more potent than Silymarin, a known hepatoprotective agent. Pi- croliv is reported to show protective effect against rifampicin-induced hep- atotoxicity in rats. It also exerts hy- polipidaemic effect in normal, triton- treated and cholesterol-fed rats.Kutkin, picroside I and kutkoside exhibit anti-inflammatory property.The phenolic glycoside, androsin, isolated from the plant, prevents allergen and platelet activating factor- induced bronchial obstruction in guinea-pigs in vitro.Cucurbitacin glycosides, isolated from the root, exhibit liver protective, tumour inhibitory and anti-inflammatory activity.Dosage: Root—1-3 g; 3-6 g as purgative. (CCRAS.)
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