Pituitary apoplexy Health Dictionary

Pituitary Apoplexy: From 1 Different Sources


acute intrapituitary haemorrhage, usually into an existing tumour, presenting as severe headache and collapse. It is a medical emergency. Due to the sudden expansion in size of the gland with the haemorrhage, it is accompanied by lesions of the cranial nerves running close to the pituitary gland, causing paralysis of the muscles of the orbit and occasionally the face. Anterior pituitary insufficiency usually results, but posterior pituitary function survives. Surprisingly, pituitary function usually recovers.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Apoplexy

A sudden loss of consciousness... apoplexy

Pituitary Gland

Also known as the pituitary body and the hypophysis, this is an ovoid structure, weighing around 0·5 gram in the adult. It is attached to the base of the BRAIN, and lies in the depression in the base of the skull known as the sella turcica. The anterior part is called the adenohypophysis and the posterior part the neurohy-P pophysis. The gland is connected to the HYPOTHALAMUS of the brain by a stalk known as the hypophyseal or pituitary stalk.

The pituitary gland is the most important ductless, or endocrine, gland in the body. (See

ENDOCRINE GLANDS.) It exerts overall control of the endocrine system through the media of a series of hormones which it produces. The adenohypophysis produces trophic hormones (that is, they work by stimulating or inhibiting other endocrine glands) and have therefore been given names ending with ‘trophic’ or ‘trophin’. The thyrotrophic hormone, or thyroid-stimulating hormone (TSH), exerts a powerful in?uence over the activity of the THYROID GLAND. The ADRENOCORTICOTROPHIC HORMONE (ACTH) stimulates the cortex of the adrenal glands. GROWTH HORMONE, also known as somatotrophin (SMH), controls the growth of the body. There are also two gonadotrophic hormones which play a vital part in the control of the gonads: these are the follicle-stimulating hormone (FSH), and the luteinising hormone (LH) which is also known as the interstitial-cell-stimulating hormone (ICSH) – see GONADOTROPHINS. The lactogenic hormone, also known as prolactin, mammotrophin and luteotrophin, induces lactation.

The neurohypophysis produces two hormones. One is oxytocin, which is widely used because of its stimulating e?ect on contraction of the UTERUS. The other is VASOPRESSIN, or the antidiuretic hormone (ADH), which acts on the renal tubules and the collecting tubules (see KIDNEYS) to increase the amount of water that they normally absorb.... pituitary gland

Pituitary

An endocrine gland somewhat behind the eyes and suspended from the front of the brain. The front section, the anterior pituitary, makes and secretes a number of controlling hormones that affect the rate of oxidation; the preference for fats, sugars, or proteins for fuel; the rate of growth and repair in the bones, connective tissue, muscles, and skin; the ebb and flow of steroid hormones from both the gonads and adrenal cortices. It does this through both negative and positive feedback. The hypothalamus controls these functions, secreting its own hormones into a little portal system that feeds into the pituitary, telling the latter what and how much to do. The hypothalamus itself synthesizes the nerve hormones that are stored in the posterior pituitary, which is responsible for squirting them into the blood when the brain directs it to. These neurohormones act quickly, like adrenalin, to constrict blood vessels, limit diuresis in the kidneys, and trigger the complex responses of sexual excitation, milk let­down in nursing, and muscle stimulus in the uterus (birthing, orgasm, and menstrual contractions), prostate, and nipples.... pituitary

Pituitary-linked Disorders

ACROMEGALY or gigantism is the result of the overactivity of, or tumour formation of cells in, the adenohypophysis which produces GROWTH HORMONE (see also PITUITARY GLAND). If this overactivity occurs after growth has ceased, acromegaly arises, in which there is gross overgrowth of the ears, nose, jaws, and hands and feet. DWARFISM may be due to lack of growth hormone.

DIABETES INSIPIDUS, a condition characterised by the passing of a large volume of URINE every day, is due to lack of the antidiuretic hormone (see VASOPRESSIN). Enhanced production of the ADRENOCORTICOTROPHIC HORMONE (ACTH) leads to CUSHING’S SYNDROME. Excessive production of PROLACTIN by micro or macro adenomas (benign tumours) leads to hyperprolactinaemia and consequent AMENORRHOEA and GALACTORRHOEA. Some adenomas do not produce any hormone but cause effects by damaging the pituitary cells and inhibiting their hormone production.

The most sensitive cells to extrinsic pressure are the gonadotrophin-producing cells and the growth-hormone producing cells, so that if the tumour occurs in childhood, growth hormone will be suppressed and growth will slow. Gonadotrophin hormone suppression will prevent the development of puberty and, if the tumour occurs after puberty, will result in amenorrhoea in the female and lack of LIBIDO in both sexes. The thyroid-stimulating hormone cells are the next to suffer and the pressure effects on these cells will result in hypothyroidism (see under THYROID GLAND, DISEASES OF).

Fortunately the ACTH-producing cells are the most resistant to extrinsic pressure and this is teleologically sound as ACTH is the one pituitary hormone that is essential to life. However, these cells can suffer damage from intracellular tumours, and adrenocortical insu?ciency is not uncommon.

Information about these disorders may be obtained from the Pituitary Foundation.... pituitary-linked disorders

Pituitary Tumours

Growths in the pituitary gland. Pituitary tumours are rare, and mostly noncancerous, but tumour enlargement can put pressure on the optic nerves, causing visual defects.

The causes of pituitary tumours are unknown. They may lead to inadequate hormone production, causing problems such as cessation of menstrual periods or reduced sperm production. They may also cause the gland to produce excess hormone. Overproduction of growth hormone causes gigantism or acromegaly; too much thyroid-stimulating hormone (TSH) can lead to hyperthyroidism. Investigations include blood tests, X-rays, MRI of the pituitary, and usually also vision tests. Treatment may be by surgical removal of the tumour, radiotherapy, hormone replacement, or a combination of these techniques. The drug bromocriptine may be used; it can reduce production of certain hormones and shrink some tumours.... pituitary tumours




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