Poly- Health Dictionary

Poly: From 2 Different Sources


A prefix meaning many or much.
Health Source: BMA Medical Dictionary
Author: The British Medical Association

Polyp

The immature life-cycle form of a jellyfish (or other cnidarian) which is attached to a substrate. Tumour projecting from mucosal surface.... polyp

Polypharmacy

1 The administration of many drugs at the same time. 2 The administration of an excessive number of drugs.... polypharmacy

Polyuria

Excess urination. The excreted wastes may stay unchanged but they are dissolved in a far higher volume of water. The causes range from diabetes, kidney disease, elevated thyroid function and the aftermath of diuretic-treated heart failure to booting a half keg of generic beer at a frat blowout... polyuria

Polyarteritis Nodosa

Also known as periarteritis nodosa. A rare but potentially serious disease, probably caused by a disturbance of the immune system (see IMMUNITY). Prolonged fever and obscure symptoms referable to any system of the body are associated with local areas of in?ammation along the arteries, giving rise to nodules in their walls. Large doses of CORTICOSTEROIDS, coupled with IMMUNOSUPPRESSANT treatment, usually curtail the disorder. Recovery occurs in about 50 per cent of cases.... polyarteritis nodosa

Polyarthritis

Inflammation in several joints. Common features of a number of arboviral infections (e.g. Ross River virus and Barmah Forrest virus infections).... polyarthritis

Polycythaemia

A rise in the amount of HAEMOGLOBIN in the blood. This may be caused by an excess in the number of ERYTHROCYTES produced in the BONE MARROW or to a fall in the total volume of PLASMA in the circulatory system. It may also be a response to reduced oxygen levels – for example, among people living at high altitudes – or to liver or kidney disease: this type is called secondary polycythaemia.

The disorder may, however, occur for no obvious reason and is then called polycythaemia vera. This type develops mainly in people over 40 and about 400 people develop the disorder every year in the United Kingdom. The blood thickens, the sufferer may develop high blood pressure, ?ushing, headaches, itching and an enlarged spleen. A stroke may occur later in the disease process. Treatment of polycythaemia vera is by regular removal of blood by VENESECTION, sometimes in combination with an anticancer drug. Secondary polycythaemia is treated by remedying the underlying cause.

Polycythaemia rubra vera A disorder in which the red blood cells increase in number along with an increase in the number of white blood cells and platelets. The cause is unknown. Severe cases may require treatment with CYTOTOXIC drugs or RADIOTHERAPY.... polycythaemia

Polydipsia

Excessive thirst, which is a symptom of DIABETES MELLITUS and some other diseases.... polydipsia

Polymyalgia Rheumatica

A form of rheumatism characterised by gross early-morning sti?ness, which tends to ease o? during the day, and pain in the shoulders and sometimes around the hips. It affects women more than men, and is rare under the age of 60. The cause is still obscure. It responds well to PREDNISOLONE, but treatment may need to be long continued. On the other hand the condition is not progressive and does not lead to disability.... polymyalgia rheumatica

Polymyositis

A connective-tissue disease affecting the muscles throughout the body. This rare disorder, which is associated with DERMATOMYOSITIS, may be acute or chronic but it usually affects the muscles of the shoulders or hip areas. The muscles weaken and are tender to the touch. Di?use in?ammatory changes occur and symptomatic relief may be obtained with CORTICOSTEROIDS.... polymyositis

Polypeptide

A molecule in which several AMINO ACIDS are joined together by peptide bonds. PROTEIN molecules are polypeptides.... polypeptide

Polychromasia

Also polychromatophilia; terms applied to an abnormal reaction of the red blood cells in severe ANAEMIA. They have a bluish tinge instead of the normal red colour in a blood ?lm stained by the usual method. It is a sign that the cell is not fully developed.... polychromasia

Polycystic Ovary Syndrome

Characterised by scanty (or absent) MENSTRUATION, INFERTILITY, hirsutism (excessive hairiness) and OBESITY and the sufferers often have multiple cysts in their OVARIES.

The condition is caused by an imbalance between LUTEINISING HORMONE (LH) and FOLLICLE-STIMULATING HORMONE (FSH); this imbalance stops OVULATION and varies the TESTOSTERONE output of the ovaries. The treatment may be with CLOMIPHENE; with a PROGESTOGEN drug; with LUTEINISING HORMONE-RELEASING HORMONE (LHRH); or with oral contraceptives (see under CONTRACEPTION – Non-barrier methods). The treatment chosen depends on the severity of the disease and whether the woman wants to conceive. Rarely a section of ovarian tissue is surgically removed.... polycystic ovary syndrome

Polydactyly

The presence of extra, or supernumerary, ?ngers or toes.... polydactyly

Polygene

One of several GENES that between them control a single characteristic in an individual. With each polygene exerting a slight e?ect, the genetic outcome is the consequence of ‘group action’. The hereditary characteristics produced in this way are usually those of a quantitative type – for instance, an individual’s height.... polygene

Polymorph

(Diminutive of polymorphonuclear leucocyte.) A name applied to certain white corpuscles of the blood which have a nucleus of irregular and varied shape. These form between 70 and 75 per cent of all the white corpuscles. (See BLOOD.)... polymorph

Polymorphism

Wide varieties of form of a species.... polymorphism

Polyneuritis

An in?ammatory condition of nerves in various parts of the body. (See NEURITIS.)... polyneuritis

Polyposis

The presence of a crop, or large number, of polypi (see POLYPUS). The most important form of polyposis is that known as familial polyposis coli. This is a hereditary disease characterised by the presence of large numbers of polypoid tumours in the large bowel. Every child born to an affected parent stands a ?fty-?fty chance of developing the disease. Its importance is that sooner or later one or more of these tumours undergoes cancerous change. If the affected gut is removed surgically before this occurs, and preferably before the age of 20, the results are excellent.... polyposis

Polypus

or polyp (plural: polypi). A general name applied to tumours which are attached by a stalk to the surface from which they spring. The term refers only to the shape of the growth and has nothing to do with its structure or nature. Most polypi are of a simple nature, although malignant polypi are also found. The usual structure of a polypus is that of a ?ne ?brous core covered with epithelium resembling that of the surrounding surface. The sites in which polypi are most usually found are the interior of the nose, the outer meatus of the ear, and the interior of the womb, bladder, or bowels (see POLYPOSIS).

Their removal is generally easy, as they are simply twisted o?, or cut o?, by some form of snare or ligature. (The tissue removed should be checked for malignant cells.) Those which are situated in the interior of the bladder or bowels, and whose presence is usually recognised because blood appears in the urine or stools, require a more serious operation – usually an endoscopic examination (see ENDOSCOPE).... polypus

Polysaccharide

A CARBOHYDRATE comprising several monosaccharides linked in long chains. Polysaccharides store energy – as starch in plants and glycogen in animals – and they also form the structural parts of plants (as cellulose) and animals (as mucopolysaccharides).... polysaccharide

Polycystic Ovary

See ovary, polycystic.... polycystic ovary

Polymerase Chain Reaction

(PCR) A method of rapidly copying DNA sequences so that they can be analysed.... polymerase chain reaction

Polyhydramnios

Excess amniotic fluid surrounding the fetus during pregnancy. It occurs in about 1 in 250 pregnancies and often has no known cause. The condition sometimes occurs if the fetus has a malformation that makes normal swallowing impossible, or if the pregnant woman has diabetes mellitus. The excess amniotic fluid usually accumulates in the 2nd half of pregnancy, producing symptoms from about week 32. The main symptom is abdominal discomfort. Other possible symptoms are breathlessness and swelling of the legs. The uterus is larger than would usually be expected. Occasionally, fluid accumulates rapidly, causing abdominal pain, breathlessness, nausea, and vomiting, and leg swelling. Premature labour may result.

The condition is usually evident from a physical examination, but ultrasound scanning may be needed.

In mild cases, only rest is needed.

In more severe cases, amniotic fluid may be withdrawn using a needle.

In late pregnancy, induction of labour may be performed.... polyhydramnios

Aphanamixis Polystachya

(Wall.) Parker.

Synonym: Amoora rohituka W. and A.

Family: Meliaceae.

Habitat: The sub-Himalayas tracts, Sikkim, Assam, Bengal, western Ghats and the Andamans.

Ayurvedic: Rohitaka, Daadima- chhada, Daadima-pushpaka, Plihaghna. Tecoma undulata G. Don., Bignoniaceae, is also equated with Rohitaka.

Siddha/Tamil: Malampuluvan.

Action: Bark—strongly astringent, used in the diseases of the liver and spleen, and for tumours, enlarged glands. Seed oil—used in muscular pains and rheumatism. All parts of the plant exhibit pesticidal activity. Seed extract—antibacterial, antifungal.

An aqueous extract of the bark, when injected i.p. in normal guinea pigs, showed reduction in absolute lymphocyte count and an increase in spleen weight. The bark appears to be an effective immunosuppressive drug similar to prednisolone.

The stembark contains a limonoid, ammorinin and a saponin, poriferas- terol-3-rhamnoside.... aphanamixis polystachya

Dracontium Polyphyllum

Linn.

Family: Liliaceae.

Habitat: Native to East Africa and Saudi Arabia.

English: Dragon's Blood.

Ayurvedic: Khoonkharaabaa, Heeraadokhi.

Unani: Dammul-Akhwain.

Family: Araceae.

Habitat: Maharashtra and Karnata- ka; cultivated in the South.

Siddha/Tamil: Kattu Karunayikki- langu.

Folk: Jangali Suuran.

Action: Root—antidiarrhoeal, anti-inflammatory (prescribed for haemorrhoids), antispasmodic (used in asthma), emmenagogue, abortifacient.... dracontium polyphyllum

Epidemic Polyarthritis

Disease common in Australia and caused by the Ross River Virus, an arbovirus transmitted by mosquitoes.... epidemic polyarthritis

Lilium Polyphyllum

D. Don.

Family: Liliaceae.

Habitat: Uttaranchal, Himachal Pradesh.

Ayurvedic: Kaakoli, Madhuraa, Kshira, Vayhasthaa, Karnikaa, Vaayasoli.

Action: Tuberous root—used as a tonic in emaciation and as a source of energy, after dry roasting.

Dosage: Tuberous root—3-6 g. (API, Vol. III.)... lilium polyphyllum

Paris Polyphylla

Sm.

Family: Liliaceae.

Habitat: Temperate Himalayas from Simla to Bhutan and in Lushai and Aka Hills. Haimavati, Shveta-

Action: Plant—sedative, analgesic, haemostatic, anthelmintic.

The rhizome contains a glucoside, alpha-paristyphnin, which exhibited a depressant action on carotid pressure, myocardium, and respiratory movements experimentally. It produced vasoconstriction in kidney, but vasodilation in the spleen and limbs, and stimulated isolated intestines.... paris polyphylla

Polyalthia Longifolia

Thw.

Family: Annonaceae.

Habitat: Native to Sri Lanka; grown in gardens throughout the warmer parts of India.

English: Mast tree, Fake Asoka tree, False Devadaru, Cemetry tree

Ayurvedic: Devadaari (Devadaaru is equated with Cedrus deodara). (An adulterant to the bark of Saraca asoca.)

Siddha/Tamil: Nettilingam.

Action: Febrifuge. Causes cardiac depression.

The stem bark contains clerodane diterpenes, polyalthialdoic acid and kolavenic acid. The stem and its bark also contain the cytotoxic aporphine alkaloid, liriodenine, besides nor-oli- veroline and oliveroline-beta-N-oxide. Azafluorene alkaloids are also present in the bark and leaves. The leaf exhibits fungitoxic activity.

Polyalthia simiarum Hook. f. & Thoms. (Orissa, Assam, Bengal, Bihar, Eastern Himalaya) is also equated with Fake Ashoka tree. It is known as Boga-khamtou in Assam, Wojarah, Mongai in Orissa and Labshi, Kutti in Nepal.

Polyalthia suberosa Thw. (from Assam to Uttar Pradesh in the North and Kerala in the South) is known as Chamkhirni. The leaves contain alpha-and beta-amyrin, lupeol, beta- sitosterol, stigmasterol and campes- terol. The stems and leaves contain the triterpene, suberosol, which showed anti-HIV replication activity. The stem bark contains alkaloids, oxostepha- nine and lanuginosine, which exhibited antibacterial activity against several Gram-positive and Gram-negative bacteria.... polyalthia longifolia

Polycarpaea Corymbosa

Lam.

Family: Caryophyllaceae.

Habitat: Throughout the greater part of India, ascending up to 2,100 m in the Himalaya.

Ayurvedic: Parpata (substitute).

Siddha/Tamil: Nilaisedachi.

Folk: Pittapaaparaa (Uttar Pradesh), Rupaaphuli (Gujarat).

Action: Leaves—anti-inflammatory, applied as poultice. Also prescribed in jaundice in the form of pills with molasses. Flowering head, along with stem and leaves—astringent, demulcent. Plant—spermicidal.

The plant gave camelliagenins (bar- rigenol) and stigmasterol.... polycarpaea corymbosa

Polycarpon Prostratum

(Forsk.) Alschers & Schweinf.

Synonym: P. loeflingii Benth. & Hook. f.

Habitat: Throughout the warmer parts of India in fields and waste places.

Folk: Ghima, Suretaa.

Action: Leaves—an infusion of roasted leaves is given for cough following fever, particularly in measles.

Alcoholic extract of the plant exhibits spasmolytic activity. The aerial parts contain tetrahydroxy triterpenes. Presence ofa triterpenoid saponin, and hentriacontane, hentriacontanol, beta- amyrin and its acetate, beta-sitosterol and stigmasterol is also reported.... polycarpon prostratum

Polychromatophilia

See POLYCHROMASIA.... polychromatophilia

Polycystic Disease Of The Kidney

An inherited disease in which the KIDNEYS contain many cysts. These grow in size until normal kidney tissue is largely destroyed. Cysts may also occur in other organs such as the liver. In adults, the disease will cause HYPERTENSION and kidney failure. There is also a juvenile form. There is no e?ective treatment, although symptoms can be alleviated by DIALYSIS and sometimes kidney transplant (see TRANSPLANTATION).... polycystic disease of the kidney

Polyenes

Antifungal agents that include AMPHOTERICIN (given by intravenous injection in the treatment of systemic ASPERGILLOSIS) and NYSTATIN, applied topically for fungus infection of the skin, mouth and other mucous membranes.... polyenes

Polygala Crotalarioides

Buch.-Ham. ex DC.

Family: Polygalaceae.

Habitat: Tropical Himalayas from Simla to Sikkim and the Khasi Hills.

Folk: Lilakanthi, Lilakaathi. (Bihar). Maraad (var.).

Action: Root—used for cough and pulmonary catarrh; chewed or ground and drunk with water to expel phlegm from the throat; provokes coughing.... polygala crotalarioides

Polygonum Affine

D. Don.

Synonym: Bistorta affinis (D. Don) Green.

Family: Polygonaceae.

Habitat: Himalayas from Kashmir to Nepal at altitudes of 2,4004,800 m.

Folk: Khukhudi.

Action: Flowers—stimulant.

The inflorescence gave flavonoids, including quercetin, isorhamnetin, lu- teolin and apigenin derivatives. The leaves contain the flavonoids, 8-C- glucosyltricin and isorhamnetin.... polygonum affine

Polygala Chinensis

Auct. Non Linn.

Synonym: P. arvensis Willd.

Family: Polygalaceae.

Habitat: Throughout India and the Andamans.

English: Senega.

Folk: Meradu, Maraad, Negali (Maharashtra). Maraad (Nepal).

Action: Root—antiasthmatic; used as a substitute for Senega obtained from the American plant Polygala senega. (In Chinese medicine Senega refers to P. tenuifolia Willd.)

Key application: Senega Root— in productive cough, catarrh of the respiratory tract and chronic bronchitis. (German Commission E, ESCOP, WHO.)

Senega yielded lactonic lignans, their glycosides and flavonol glycosides. The root gave arctiin, afzelin, myricitrin and rutin. A triterpenic saponin was also obtained from the plant. The root contains salicylic acid, methyl salicylate and senegin (a sapo- nin mixture).

Senega is used for chronic bronchitis, catarrh, asthma and croup, as an infusion.

Related species are: P. chinesis Linn., synonym P. glomerata Lour; P. tele- phioides Willd., synonym P. brachys- tachya DC. non-Bl., found throughout the plains of India. Both the plants are used as expectorant, antiasthmatic and anticatarrhal.

Toxic constituents of Polygala senega root are: triterpene saponins—6- 16% senegasaponins A-D with agly- cone presenegenin or senegin. Sapo- nins irritate GI tract mucosa and cause reflex secretion of mucous in the bronchioles.

A French patent is used against graft rejection, eczema and multiple sclerosis as an anti-inflammatory drug.... polygala chinensis

Polygala Sibirica

Linn.

Synonym: P. heyneana Wall. ex W. & A.

Family: Polygalaceae.

Habitat: Throughout the Himalayas and Western Ghats.

English: Common Milkwort.

Folk: Negali, Meradu (var.).

Action: Leaves—used in spermatorrhoea. Root—a decoction is given as an expectorant in cold and cough and chronic chest diseases. (Used as a substitute for Senega.) Also used for inflammation of urinary bladder; externally for mammary abscesses and carbuncles.... polygala sibirica

Polygonatum Cirrhifolium

(Wall.) Royle.

Family: Liliaceae.

Habitat: Northern Himalayas, from 1,500 to 3,300 m.

Ayurvedic: Mahaa-medaa, Medaa, (substitute: Asparagus racemosus, also Saalab-misri.)

Folk: Devarigaanl (Gharwal).

Action: Root—rejuvenating tonic for nervous system.

The root gave neoprazerigenin A- 3-O-beta-lycotetraoside (PS-III) and its methyl proto-type congener (PS- II) and steroidal saponins, sibiricoside A (PS-I) and sibiricoside B (PS-IV).

Dosage: Root—3-5 g powder. (CCRAS.)... polygonatum cirrhifolium

Polygonatum Multiflorum

All.

Family: Liliaceae.

Habitat: Western Himalayas from Kashmir to Kumaon and in Manipur.

English: Solomon's Seal.

Ayurvedic: Mahaa-medaa, Medaa (var.). (Substitute: Asparagus racemosus.)

Action: Anti-inflammatory, nervine, astringent. Used as an infusion for pulmonary complaints; as a poultice for piles and bruises.

The root and herb gave diosgenin and its glycosides.

Dosage: Root—3-5 g powder. (CCRAS.)... polygonatum multiflorum

Polygonatum Verticillatum

All.

Family: Liliaceae.

Habitat: Temperate Himalayas and Manipur.

Ayurvedic: Medaa. (Substitute: Asparagus racemosus.)

Unani: Shaqaaqul. (Substitute: Pastinaca secacul.)

Folk: Mithaa-dudhiaa.

Action: Used in Tibetan medicine for treating emaciation, senility, pulmonary affections. The rhizomes is valued as salep.

The dried rhizomes contain 6.2-9% diosgenin.

The lactins of the rootstock did not contain carbohydrates; the amino acid revealed presence of 28% aspartic acid and asparagine.

The plant exhibits diuretic properties. It gave a digitalis glucoside and is considered poisonous by the hill people in the Himalayas.... polygonatum verticillatum

Polygonum Plebeium

R.Br.

Family: Polygonaceae.

English: Throughout warmer parts of India in moist areas, ascending to 2,100 m in the Himalayas.

Ayurvedic: Sarpaakshi (a confusing synonym).... polygonum plebeium

Polyhymnia

(Greek) In mythology, the muse of sacred songs and dance Polyhymniah, Polymnia, Polymniah... polyhymnia

Polygonum Aviculare

Linn.

Family: Polygonaceae.

Habitat: From Kashmir to Kumaon.

English: Knotgrass, Knotweed, Mexican Sanguinaria.

Folk: Machoti, Kesri.

Action: Astringent and haemostatic. Used for excessive menstruation, bleeding piles; bleeding from bowel, stomach, lungs, nose, throat; mucous colitis, children's summer diarrhoea.

Key application: In mild catarrhs of the respiratory tract, inflammatory changes to the oral and pharyngeal mucosa. (German Commission E.)

The plant gave flavonoids including quercetin, avicularin, quercitrin, and derivatives of kaempferol, esculetin and scopoletin. The plant also gave gallic, caffeic, oxalic., silicic, chloro- genic and p-coumaric acids; tannins including catechin.

The methanolic extract of the plant showed high protection against CCl4- induced hepatotoxicity in mice. This activity is attributed to the presence of flavonoid glucosides.

The flavonoids exhibit astringent properties and are found to decrease capillary fragility and have a cortisonelike-effect on gingival tissue. (J Ethno- pharmacol, 74(1), 2001.)... polygonum aviculare

Polygonum Bistorta

Linn.

Synonym: P. paleaceum Wall. ex Hook. f.

Family: Polygonaceae.

Habitat: The Himalayas from Kashmir to Sikkim and the hills of Assam.

English: Snake Weed, Bistort, Dragon Wort.

Unani: Anjabaar.

Action: Anti-inflammatory, haemostatic, astringent, demulcent, anticatarrhal, antidiarrhoeal. Used for internal haemorrhages, irritable bowel, diverticulosis, urinary and uterine affections. Used as a mouth wash and gargle for ulcerated mouth and bleeding gums.

The herb contains ferulic, sinapic, vanillic, syringic, melilotic, p-couma- ric, p-hydroxybenzoic, gentisic, sali- cyclic and ellagic acids, about 15-20% tannins mainly catechins.

When administered before the induction of adjuvant arthritis, the aqueous-ethanolic extract of the herb inhibited both the maximal oedema response and the total oedema response in rat.... polygonum bistorta

Polygonum Glabrum

Willd.

Family: Polygonaceae.

Habitat: Throughout India in marshy places, up to 1,900 m. in the hills.

Ayurvedic: Rakta-rohidaa (Gujarat).

Siddha/Tamil: Attalaree.

Action: Plant juice and rootstock— used in pneumonia, consumption, jaundice, fevers. Leaf— antispasmodic. Used for colic.

The leaves contain flavonoids— quercetin, rhamnetin, quercitrin, avic- ularin and rutin. Flowers contain pigments, delphinidin-3,5-diglucoside and cyanidin-3,5-diglucoside and quercetin.

The methanolic aqueous extract of the leaf gave a pure anthelmintic substance, a terpenoid (PGA). (The herb is used as an anthelmintic in Sudan.)... polygonum glabrum

Polygonum Hydropiper

Linn.

Family: Polygonaceae.

Habitat: Throughout India in wet places.

English: Water Pepper, Pepperwort, Smartweed.

Folk: Paakur-muula, Paani-maricha (Bengal).

Action: Haemostatic, astringent, anti-inflammatory, diuretic, lithotriptic, emmenagogue (used as infusion for delayed menses and amenorrhoea), antifungal (root and leaf used externally). Contraindicated during pregnancy.

The herb contains sesquiterpenes, including warburganal and polygodial, in the leaves; polygonal, isodrimeni- nol, isopolygodial and confertifolin in the seeds; and flavonoids including quercetin, kaempferol, isorhamnetin and rhamnesin; polygonolide (an iso- coumarin).

Isoquercitrin exhibited significant anti-oxidative activity. Polygodial and warburganal possess significant an- tifungal property. Warburganal also possesses potent cytotoxic and antibiotic activity. (The herb is used against cancer.)

Folk: Muniyaaraa (Bihar), Raani- phool, Macheti, Dubiaa Saaga.

Action: Galactogenic, antidiar- rhoeal. Powdered herb is given in pneumonia.

The whole plant yields 11% tannin. The rootstock contains oxymethylan- thraquinone.

Flowers gave oleanolic acid, betulin- ic acid, epi-friedelanol, beta-sitosterol, and flavonoids—quercetin, quercetin- 3-arabinoside and quercetin-3-rutino- side.... polygonum hydropiper

Polymyxin

A group of antibiotics derived from various species of Bacillus polymyxa. One variety, colistin, is used to sterilise the bowels before surgery as it is not absorbed when given by mouth. The drugs are sometimes used in topical applications for infections of the skin, eye and ear.... polymyxin

Polygonum Viviparum

Linn.

Family: Polygonaceae.

Habitat: The Himalayas from Kashmir to Sikkim at 3,3004,800 m.

English: Viviparous Bistort.

Unani: Anjabaar. (substitute).

Folk: Billori, Maamekh (Punjab).

Action: Rootstock—astringent, antidiarrhoeal, antileucorrhoeic, antiseptic, antiperiodic. Used in haemoptysis; also for gleet. A decoction is used as a gargle for sore throat and spungy gums, as a lotion for ulcers.... polygonum viviparum

Polypill

A suggestion by two epidemiologists, made in the British Medical Journal in 2003, that many lives could be saved if all persons aged over 55 took a daily combination pill they termed the polypill. Its components would be ASPIRIN, a CHOLESTEROL-lowering agent, FOLIC ACID and two blood-pressure-lowering agents. The suggestion caused a massive correspondence as it implied treating a whole population rather than individuals considered to be at special risk.... polypill

Polypodium Vulgare

Linn.

Family: Polypodiaceae. English: Polypody Root. Unani: Bisfaayaj.

Action: Expectorant, laxative, stomachic, cholagogue, alterative, antistress. Used in cough, bronchitis, catarrh, loss of appetite, dyspepsia; and in skin diseases.

The rhizome gave saponin glyco- sides, based on polypodosapogenin, including osladin; ecdysteroids; phlo- roglucin derivatives; tannin.... polypodium vulgare

Polyporus Officinalis

Fries

Family: Polyporaceae.

Habitat: On the old trunks of various coniferous trees.

English: White Agaric.

Unani: Ghaariqoon.

Action: Used in the treatment of sweats in wasting diseases such as phthisis (it checks profuse sweats); also as an expectorant and diuretic.

The drug contains agaric acid (agari- cin). The resinous extract, when burnt, yields not more than 2% of a white ash, rich in phosphates. The drug gives 46% soft resin.

Agaric acid acts as a counter-irritant when applied to abraded surfaces or mucous membrane.... polyporus officinalis

Polyxena

(Greek) In mythology, a daughter of Priam who was loved by Achilles Polyxenah, Polyxenia, Polyxenna, Polyxene, Polyxenea... polyxena

Nasal Polyp

A growth in the lining of the nose, usually attached by a small stalk.

Most nasal polyps are noncancerous, but they may need to be removed if they cause nasal obstruction.... nasal polyp

Polycystic Kidney

See kidney, polycystic.... polycystic kidney

Polymyxins

A group of antibiotic drugs derived from the bacterium BACILLUS POLYMYXA. Polymyxins, which include colistin, are commonly given to treat eye, ear, and skin infections.... polymyxins

Polyscias Fruticosa

(L.) Harms.

Synonym: Nothopanaxfruticosum (L.) Miq.

Panax fruticosus L.

Family: Araliaceae.

Habitat: Cultivated in gardens all over India.

Action: Leaf—used in sinusitis, headache, migraine, tonsillitis. Stem bark—used for promoting expulsion of placenta after child birth. Root— antibacterial, antifungal, diuretic. Leaf and root—used in dysuria.

The root contains polyacetylenes, falcarinol and heptadeca derivatives. Falcarinol and heptadeca exhibited strong antibacterial activity against Gram-positive bacteria and the der- matophytic bacteria, also showed an- tifungal activity. The antibacterial activity of falcarinol was found to be 15 to 35 times stronger than that of erythromycin, chloramphenicol and oxytetracyclin.

Polyscias scutellaria (Burm. f.) F. R. Fosberg (commonly grown in Indian gardens) exhibits anti-inflammatory activity. The leaves contain several tri- terpenoid saponins, polyscisaponins, oleanolic acid derivatives.... polyscias fruticosa

Kidney, Polycystic

An inherited disorder in which both kidneys are affected by numerous cysts that gradually enlarge until most of the normal kidney tissue is destroyed.

Polycystic kidney disease is distinguished from multiple simple kidney cysts, which occur commonly with age.

There are 2 types of polycystic disease.

The most common usually becomes apparent in middle age, producing abdominal swelling, pain, and blood in the urine.

As the disease progresses, hypertension and kidney failure may result.

The rare type causes enlargement of the kidneys and kidney failure in infants and young children.

There is no effective treatment for preserving kidney function in either type, but symptoms of kidney failure can be treated by dialysis and kidney transplant.... kidney, polycystic

Ovary, Polycystic

A condition, also called Stein–Leventhal syndrome, that is characterized by oligomenorrhea or amenorrhoea (scanty or absent periods), infertility, hirsutism (excessive hairiness), and obesity. Often, there are multiple ovarian cysts. Most women with polycystic ovaries begin menstruation at a normal age, but after a year or two periods become highly irregular and then cease. Hirsutism and obesity occur in about 50 per cent of cases.

The condition results from an imbalance of two gonadotrophin hormones: follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This hormonal imbalance is associated with raised levels of testosterone and oestrogen.

Treatments include clomifene and oral contraceptives. Polycystic ovaries are often associated with high oestrogen levels in the body, which increase the risk of endometrial cancer (see uterus, cancer of); treatment with progesterone may be recommended for this problem. ... ovary, polycystic

Polyposis, Familial

A rare, inherited disorder, also known as polyposis coli, in which many polyps are present throughout the gut, but mainly in the colon. If not treated, cancer of the colon (see colon, cancer of) is almost certain to develop. The polyps may appear from age 10. They may cause bleeding and diarrhoea; however, there are often no symptoms until cancer has developed. The polyps are detected by colonoscopy.

Since there is a 50 per cent chance that children of an affected person will inherit the disease, medical surveillance is necessary from around the age of 12.

Individual polyps may be cauterized (see cauterization).

The high risk of developing cancer often means that a colectomy and an ileostomy are performed.... polyposis, familial

Polyunsaturated Fats

Fats (see fats and oils) with with relatively few hydrogen atoms in their chemical structure.

Polyunsaturated fats tend to protect against cardiovascular disease.... polyunsaturated fats

Dna Polymerase Inhibitor

any one of a class of antiviral drugs that inhibit the action of DNA polymerase enzymes, which are used by viruses to form their own DNA. These drugs prevent, to a varying degree, the reproduction of viruses. They include *aciclovir, *foscarnet, *ganciclovir, and *valaciclovir.... dna polymerase inhibitor

Eosinophilic Granulomatosis With Polyangiitis

see Churg–Strauss syndrome.

EPA (eicosapentaenoic acid) see omega-3 fatty acids.... eosinophilic granulomatosis with polyangiitis

Familial Adenomatous Polyposis

(FAP) see polyposis.... familial adenomatous polyposis

Fibroepithelial Polyp

a fibrous overgrowth covered by epithelium, often occurring inside the mouth in response to chronic irritation (usually following accidental biting). It is sometimes called a fibrous *epulis.... fibroepithelial polyp

Granulomatosis With Polyangiitis

(GPA) an autoimmune disease, formerly known as Wegener’s granulomatosis, predominantly affecting the sinuses, lungs, and kidneys, and characterized by blood-vessel inflammation and the formation of necrotizing *granulomas. It is associated with the presence of antineutrophil cytoplasmic antibodies (*ANCA). Untreated the disease is usually fatal, but it can be controlled with corticosteroids, cyclophosphamide, or rituximab.... granulomatosis with polyangiitis

Juvenile Polyp

see polyp.... juvenile polyp

Microscopic Polyangiitis

(MPA) an autoimmune disease characterized by inflammation of small blood vessels, leading to reduced kidney function and breathlessness. It is associated with the presence of antinuclear cytoplasmic antibodies (*ANCA) and can be treated with corticosteroids, cyclophosphamide, or rituximab.... microscopic polyangiitis

Pancreatic Polypeptide

a hormone released from the D cells of the *islets of Langerhans of the pancreas in response to protein in the small intestine. Its actions are to inhibit pancreatic bicarbonate and protein enzyme secretion and to relax the gall bladder. It belongs to a family of similar hormones that have actions on appetite and food metabolism.... pancreatic polypeptide

Polyclinic

n. see health centre.... polyclinic

Polycoria

n. a rare congenital abnormality of the eye in which there are one or more holes in the iris in addition to the pupil.... polycoria

Polycystic Disease Of The Kidneys

either of two inherited disorders in which renal cysts are a common feature. Autosomal recessive polycystic kidney disease (ARPKD) occurs in about 1 in 20,000 live births. It is due to a single mutation on chromosome 6 for the gene encoding the protein fibrocystin. The majority of cases are diagnosed before or at birth. The most severely affected fetuses have enlarged kidneys and *oligohydramnios due to poor fetal renal output. These fetuses develop the ‘Potter’ phenotype with characteristic facies, pulmonary hypoplasia, and deformities of the spine and limbs. Those surviving the neonatal period (50–70%) develop varying degrees of renal impairment but this may not proceed to end-stage until early adulthood.

Autosomal dominant polycystic kidney disease (ADPKD) affects between 1 in 400 and 1 in 1000 individuals and is one of the most common hereditary diseases. Two types have been defined. ADPKD 1 is the commonest and responsible for about 85% of cases. It is due to a mutation in the PKD1 gene on chromosome 16, which encodes polycystin 1, an *ion-channel-regulating protein. ADPKD2 is due to a mutation in the PKD2 gene on chromosome 4, which encodes the protein polycystin 2, a calcium-release channel. ADPKD2 tends to be a milder disease with later presentation.

ADPKD is a multisystem disorder that is also associated with cyst formation in other organs (particularly the liver), cardiovascular disorders, and colonic diverticular disease. Renal disease presents in early adult life with haematuria, loin pain, urinary tract infection, hypertension, renal stone disease, or the finding of a mass in the abdomen. Other cases are identified by family contact tracing; the findings of a few cysts on renal ultrasonography in a young adult with a family history of ADPKD is highly suggestive of the disease. Renal disease is progressive and about 50% of patients will have reached end-stage by the time they enter their seventh decade. The progress of the renal failure can be slowed by good blood pressure control. In the UK, patients with ADPKD are responsible for 5–10% of the total on renal replacement therapy.

There are a number of separate rare autosomal dominant conditions other than ADPKD1 and ADPKD 2 that can present with polycystic kidneys. These include *von Hippel-Lindau disease and *tuberous sclerosis.... polycystic disease of the kidneys

Polycystin

n. see polycystic disease of the kidneys.... polycystin

Polycythaemia Vera

(polycythaemia rubra vera, Vaquez–Osler disease) a disease in which the number of red cells in the blood is greatly increased (see also polycythaemia). There is often also an increase in the numbers of white blood cells and platelets. Symptoms include headache, thromboses, *cyanosis, *plethora, and itching. Polycythaemia vera may be treated by blood-letting, but more severe cases may need to be treated with cytotoxic drugs. The cause of the disease is not known.... polycythaemia vera

Polydactylism

n. see hyperdactylism.... polydactylism

Polymastia

n. see pleomastia.... polymastia

Polymer

n. a substance formed by the linkage of a large number of smaller molecules known as monomers. An example of a monomer is glucose, whose molecules link together to form glycogen, a polymer. Polymers may have molecular weights from a few thousands to many millions. Polymers made up of a single type of monomer are known as homopolymers; those of two or more monomers as heteropolymers.... polymer

Polymorphic Eruption Of Pregnancy

(PEP) intensely itchy papules and weals on the abdomen (except the umbilicus), upper limbs, and buttocks, usually within the *striae gravidarum; it is also known as PUPPP (pruritic urticarial papules and plaques of pregnancy). It occurs in 1 in 250 first pregnancies late in the third trimester. This condition is harmless to mother and baby, but can be very annoying. It lasts an average of 6 weeks and resolves spontaneously 1–2 weeks after delivery. The most severe itching normally lasts for no more than a week.... polymorphic eruption of pregnancy

Polymorphous Light Eruption

see photodermatosis.... polymorphous light eruption

Polymyxin B

an *antibiotic used to treat severe infections caused by Gram-negative bacteria. Formulated with other drugs, it is administered for ear, eye, and skin infections.... polymyxin b

Polyneuropathy

n. see peripheral neuropathy.... polyneuropathy

Polynucleotide

n. a long chain of linked *nucleotides, of which molecules of DNA and RNA are made.... polynucleotide

Polyopia

n. the sensation of multiple images of one object. It is sometimes experienced by people with early cataract. See also diplopia.... polyopia

Polyorchidism

n. a congenital abnormality resulting in more than two testes.... polyorchidism

Polypectomy

n. the endoscopic or surgical removal of a *polyp. The technique used depends upon the site and size of the polyp. Endoscopically, polyps can be removed by various methods. A hot biopsy involves coagulation of a small polyp using a diathermy current passed through biopsy forceps, which obtains a sample for analysis at the same time. Cold biopsy involves removal of a polyp using forceps alone, thereby decreasing the perforation risk. Snare polypectomy uses a wire loop (snare) to cut through the base of the polyp. This is performed with or without a diathermy current (hot snare vs. cold snare); the current reduces the risk of bleeding by coagulating local blood vessels as the snare cuts through the polyp. Endoscopic mucosal resection (EMR) involves lifting a flat polyp by injecting a hypertonic solution into the submucosa beneath the polyp followed by snare polypectomy with diathermy. Nasal polyps may be removed using *endoscopic sinus surgery techniques, sometimes utilizing a *microdebrider.... polypectomy

Polyphagia

n. excessive eating.... polyphagia

Polyphyletic

adj. describing a number of individuals, species, etc., that have evolved from more than one ancestral group. Compare monophyletic.... polyphyletic

Polyploid

adj. describing cells, tissues, or individuals in which there are three or more complete sets of chromosomes. Compare diploid; haploid. —polyploidy n.... polyploid

Polypoid

adj. having the appearance of a *polyp.... polypoid

Polyradiculitis

(polyradiculopathy) n. any disorder of the peripheral nerves (see neuropathy) in which the brunt of the disease falls on the nerve roots where they emerge from the spinal cord. An abnormal allergic response in the nerve fibres is thought to be one cause of this condition; the *Guillain-Barré syndrome is an example. Other causes include infections (such as syphilis), herpesviruses, and tumours (such as lymphoma or other forms of cancer).... polyradiculitis

Polyribosome

n. see polysome.... polyribosome

Polyserositis

n. inflammation of the membranes that line the chest, abdomen, and joints, with accumulation of fluid in the cavities. Commonly the condition is inherited and intermittent and is termed familial Mediterranean fever. If complicated by infiltration of major organs by a glycoprotein (see amyloidosis) the disease usually proves fatal. Regular administration of colchicine will prevent the attacks in 95% of patients.... polyserositis

Polysome

(polyribosome) n. a structure that occurs in the cytoplasm of cells and consists of a group of *ribosomes linked together by *messenger RNA molecules: formed during protein synthesis.... polysome

Polysomnograph

n. a record of measurements of various bodily parameters during sleep. It is used in the diagnosis of sleep disorders, such as *obstructive sleep apnoea.... polysomnograph

Polyspermia

n. 1. excessive formation of semen. 2. see polyspermy.... polyspermia

Polyspermy

(polyspermia) n. fertilization of a single ovum by more than one spermatozoon: the development is abnormal and the embryo dies.... polyspermy

Polythelia

n. a congenital excess of nipples (see pleomastia).... polythelia

Psychogenic Polydipsia

see polydipsia.... psychogenic polydipsia



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