Polycystic ovary Health Dictionary

Characterised by scanty (or absent) MENSTRUATION, INFERTILITY, hirsutism (excessive hairiness) and OBESITY and the sufferers often have multiple cysts in their OVARIES.

The condition is caused by an imbalance between LUTEINISING HORMONE (LH) and FOLLICLE-STIMULATING HORMONE (FSH); this imbalance stops OVULATION and varies the TESTOSTERONE output of the ovaries. The treatment may be with CLOMIPHENE; with a PROGESTOGEN drug; with LUTEINISING HORMONE-RELEASING HORMONE (LHRH); or with oral contraceptives (see under CONTRACEPTION – Non-barrier methods). The treatment chosen depends on the severity of the disease and whether the woman wants to conceive. Rarely a section of ovarian tissue is surgically removed.... polycystic ovary syndrome

One of a pair of almond-shaped glands situated on either side of the uterus immediately below the opening of the fallopian tubes. Each ovary contains numerous cavities called follicles, in which egg cells (see ovum) develop. The ovaries also produce the female sex hormones oestrogen and progesterone.... ovary

An inherited disease in which the KIDNEYS contain many cysts. These grow in size until normal kidney tissue is largely destroyed. Cysts may also occur in other organs such as the liver. In adults, the disease will cause HYPERTENSION and kidney failure. There is also a juvenile form. There is no e?ective treatment, although symptoms can be alleviated by DIALYSIS and sometimes kidney transplant (see TRANSPLANTATION).... polycystic disease of the kidney

An inherited disorder in which both kidneys are affected by numerous cysts that gradually enlarge until most of the normal kidney tissue is destroyed.

Polycystic kidney disease is distinguished from multiple simple kidney cysts, which occur commonly with age.

There are 2 types of polycystic disease.

The most common usually becomes apparent in middle age, producing abdominal swelling, pain, and blood in the urine.

As the disease progresses, hypertension and kidney failure may result.

The rare type causes enlargement of the kidneys and kidney failure in infants and young children.

There is no effective treatment for preserving kidney function in either type, but symptoms of kidney failure can be treated by dialysis and kidney transplant.... kidney, polycystic

A malignant growth of the ovary. The cancer may be either primary (arising in the ovary) or secondary (due to the spread of cancer from another part of the body). Ovarian cancer can occur at any age but is most common after 50 and in women who have never had children. A family history of cancer of the ovary, breast, or colon, especially in close relatives under 50, is an important risk factor. Taking oral contraceptives reduces the risk.

In most cases, ovarian cancer causes no symptoms until it is widespread. The first symptoms may include vague discomfort and swelling in the abdomen; nausea and vomiting; abnormal vaginal bleeding; and ascites.

If ovarian cancer is suspected, a doctor will carry out a physical examination to detect any swellings in the pelvis. A laparoscopy will usually be performed to confirm the diagnosis.

Treatment is by surgical removal of the growth or as much cancerous tissue as possible.

This usually involves salpingooophorectomy and hysterectomy followed by radiotherapy and anticancer drugs.... ovary, cancer of

Diseases and abnormalities of the ovaries can occur for various reasons. Absence of ovaries, or their failure to develop normally, is rare and is usually due to a chromosomal abnormality (see Turner’s syndrome). Oophoritis (inflammation of an ovary) may result from infections such as gonorrhoea or pelvic inflammatory disease. Ovarian cysts are common and usually noncancerous. Polycystic ovary syndrome is due to an imbalance of sex hormones. Ovarian cancer (see ovary, cancer of) occurs mainly in women over 50. Ovarian failure causes premature menopause in about 5 per cent of women.... ovary, disorders of

A condition, also called Stein–Leventhal syndrome, that is characterized by oligomenorrhea or amenorrhoea (scanty or absent periods), infertility, hirsutism (excessive hairiness), and obesity. Often, there are multiple ovarian cysts. Most women with polycystic ovaries begin menstruation at a normal age, but after a year or two periods become highly irregular and then cease. Hirsutism and obesity occur in about 50 per cent of cases.

The condition results from an imbalance of two gonadotrophin hormones: follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This hormonal imbalance is associated with raised levels of testosterone and oestrogen.

Treatments include clomifene and oral contraceptives. Polycystic ovaries are often associated with high oestrogen levels in the body, which increase the risk of endometrial cancer (see uterus, cancer of); treatment with progesterone may be recommended for this problem. ... ovary, polycystic

See kidney, polycystic.... polycystic kidney

either of two inherited disorders in which renal cysts are a common feature. Autosomal recessive polycystic kidney disease (ARPKD) occurs in about 1 in 20,000 live births. It is due to a single mutation on chromosome 6 for the gene encoding the protein fibrocystin. The majority of cases are diagnosed before or at birth. The most severely affected fetuses have enlarged kidneys and *oligohydramnios due to poor fetal renal output. These fetuses develop the ‘Potter’ phenotype with characteristic facies, pulmonary hypoplasia, and deformities of the spine and limbs. Those surviving the neonatal period (50–70%) develop varying degrees of renal impairment but this may not proceed to end-stage until early adulthood.

Autosomal dominant polycystic kidney disease (ADPKD) affects between 1 in 400 and 1 in 1000 individuals and is one of the most common hereditary diseases. Two types have been defined. ADPKD 1 is the commonest and responsible for about 85% of cases. It is due to a mutation in the PKD1 gene on chromosome 16, which encodes polycystin 1, an *ion-channel-regulating protein. ADPKD2 is due to a mutation in the PKD2 gene on chromosome 4, which encodes the protein polycystin 2, a calcium-release channel. ADPKD2 tends to be a milder disease with later presentation.

ADPKD is a multisystem disorder that is also associated with cyst formation in other organs (particularly the liver), cardiovascular disorders, and colonic diverticular disease. Renal disease presents in early adult life with haematuria, loin pain, urinary tract infection, hypertension, renal stone disease, or the finding of a mass in the abdomen. Other cases are identified by family contact tracing; the findings of a few cysts on renal ultrasonography in a young adult with a family history of ADPKD is highly suggestive of the disease. Renal disease is progressive and about 50% of patients will have reached end-stage by the time they enter their seventh decade. The progress of the renal failure can be slowed by good blood pressure control. In the UK, patients with ADPKD are responsible for 5–10% of the total on renal replacement therapy.

There are a number of separate rare autosomal dominant conditions other than ADPKD1 and ADPKD 2 that can present with polycystic kidneys. These include *von Hippel-Lindau disease and *tuberous sclerosis.... polycystic disease of the kidneys