(polycythaemia rubra vera, Vaquez–Osler disease) a disease in which the number of red cells in the blood is greatly increased (see also polycythaemia). There is often also an increase in the numbers of white blood cells and platelets. Symptoms include headache, thromboses, *cyanosis, *plethora, and itching. Polycythaemia vera may be treated by blood-letting, but more severe cases may need to be treated with cytotoxic drugs. The cause of the disease is not known.
Verapamil is a drug used in the treatment of HYPERTENSION, disordered rhythms of the heart, and ANGINA PECTORIS. The drug is one of the CALCIUM-CHANNEL BLOCKERS and acts by reducing cardiac output and slowing the heart rate. It may, however, precipitate heart failure, cause HYPOTENSION and aggravate conduction problems in the heart, so should be prescribed with care. It should not be used with BETA-ADRENOCEPTOR-BLOCKING DRUGS.... verapamil