Post-traumatic Stress Disorder: From 2 Different Sources
A form of anxiety that develops after a stressful or frightening event.
Common causes include natural disasters, violence, rape, torture, serious physical injury, and military combat.
Symptoms, which may develop many months after the event, include recurring memories or dreams of the event, a sense of personal isolation, and disturbed sleep and concentration.
There may be a deadening of feelings, or irritability and feelings of guilt, sometimes building up to depression.
Most people recover, in time, with emotional support and counselling.
(PTSD) an anxiety disorder caused by a major physical or emotional trauma, such as an injury, assault, rape, or exposure to warfare or a disaster involving many casualties. The onset is at least one month after the traumatic event. The patient experiences the persistent recurrence of images or memories of the event, together with nightmares, insomnia, a sense of isolation, guilt, irritability, and loss of concentration. Emotions may be flat and depression may develop. The condition usually settles with time, but support and skilled counselling may be needed. More severe cases may be treated by *eye movement desensitization and reprocessing therapy (EMDR), *cognitive behavioural therapy, *antidepressants, and in severe cases also with *antipsychotics.
A psychological disorder, also called hysterical conversion, in which the affected individual presents with striking neurological symptoms – such as weakness, paralysis, sensory disturbances or memory loss – for which no organic cause can be identi?ed. Up to 4 per cent of patients attending neurological outpatient clinics have been estimated as having conversion disorders. The disorder remains controversial, with theories about its cause unsupported by controlled research results. In clinical practice the physician’s experience and intuition are major factors in diagnosis. It has been suggested that the physical symptoms represent guilt about a physical or emotional assault on someone else. Treatment using a COGNITIVE BEHAVIOUR approach may help those with conversion disorders.... conversion disorder
A type of mental illness typi?ed by mood swings between elation (mania) and depression (see MENTAL ILLNESS).... bipolar disorder
Bone is not an inert sca?olding for the human body. It is a living, dynamic organ, being continuously remodelled in response to external mechanical and chemical in?uences and acting as a large reservoir for calcium and phosphate. It is as susceptible to disease as any other organ, but responds in a way rather di?erent from the rest of the body.
Bone fractures These occur when there is a break in the continuity of the bone. This happens either as a result of violence or because the bone is unhealthy and unable to withstand normal stresses.
SIMPLE FRACTURES Fractures where the skin remains intact or merely grazed. COMPOUND FRACTURES have at least one wound which is in communication with the fracture, meaning that bacteria can enter the fracture site and cause infection. A compound fracture is also more serious than a simple fracture because there is greater potential for blood loss. Compound fractures usually need hospital admission, antibiotics and careful reduction of the fracture. Debridement (cleaning and excising dead tissue) in a sterile theatre may also be necessary.
The type of fracture depends on the force which has caused it. Direct violence occurs when an object hits the bone, often causing a transverse break – which means the break runs horizontally across the bone. Indirect violence occurs when a twisting injury to the ankle, for example, breaks the calf-bone (the tibia) higher up. The break may be more oblique. A fall on the outstretched hand may cause a break at the wrist, in the humerus or at the collar-bone depending on the force of impact and age of the person. FATIGUE FRACTURES These occur after the bone has been under recurrent stress. A typical example is the march fracture of the second toe, from which army recruits suffer after long marches. PATHOLOGICAL FRACTURES These occur in bone which is already diseased – for example, by osteoporosis (see below) in post-menopausal women. Such fractures are typically crush fractures of the vertebrae, fractures of the neck of the femur, and COLLES’ FRACTURE (of the wrist). Pathological fractures also occur in bone which has secondary-tumour deposits. GREENSTICK FRACTURES These occur in young children whose bones are soft and bend, rather than break, in response to stress. The bone tends to buckle on the side opposite to the force. Greenstick fractures heal quickly but still need any deformity corrected and plaster of Paris to maintain the correction. COMPLICATED FRACTURES These involve damage to important soft tissue such as nerves, blood vessels or internal organs. In these cases the soft-tissue damage needs as much attention as the fracture site. COMMINUTED FRACTURES A fracture with more than two fragments. It usually means that the injury was more violent and that there is more risk of damage to vessels and nerves. These fractures are unstable and take longer to unite. Rehabilitation tends to be protracted. DEPRESSED FRACTURES Most commonly found in skull fractures. A fragment of bone is forced inwards so that it lies lower than the level of the bone surrounding it. It may damage the brain beneath it.
HAIR-LINE FRACTURES These occur when the bone is broken but the force has not been severe enough to cause visible displacement. These fractures may be easily missed. Symptoms and signs The fracture site is usually painful, swollen and deformed. There is asymmetry of contour between limbs. The limb is held uselessly. If the fracture is in the upper
limb, the arm is usually supported by the patient; if it is in the lower limb then the patient is not able to bear weight on it. The limb may appear short because of muscle spasm.
Examination may reveal crepitus – a bony grating – at the fracture site. The diagnosis is con?rmed by radiography.
Treatment Healing of fractures (union) begins with the bruise around the fracture being resorbed and new bone-producing cells and blood vessels migrating into the area. Within a couple of days they form a bridge of primitive bone across the fracture. This is called callus.
The callus is replaced by woven bone which gradually matures as the new bone remodels itself. Treatment of fractures is designed to ensure that this process occurs with minimal residual deformity to the bone involved.
Treatment is initially to relieve pain and may involve temporary splinting of the fracture site. Reducing the fracture means restoring the bones to their normal position; this is particularly important at the site of joints where any small displacement may limit movement considerably.
with plaster of Paris. If closed traction does not work, then open reduction of the fracture may
be needed. This may involve ?xing the fracture with internal-?xation methods, using metal plates, wires or screws to hold the fracture site in a rigid position with the two ends closely opposed. This allows early mobilisation after fractures and speeds return to normal use.
External ?xators are usually metal devices applied to the outside of the limb to support the fracture site. They are useful in compound fractures where internal ?xators are at risk of becoming infected.
Consolidation of a fracture means that repair is complete. The time taken for this depends on the age of the patient, the bone and the type of fracture. A wrist fracture may take six weeks, a femoral fracture three to six months in an adult.
Complications of fractures are fairly common. In non-union, the fracture does not unite
– usually because there has been too much mobility around the fracture site. Treatment may involve internal ?xation (see above). Malunion means that the bone has healed with a persistent deformity and the adjacent joint may then develop early osteoarthritis.
Myositis ossi?cans may occur at the elbow after a fracture. A big mass of calci?ed material develops around the fracture site which restricts elbow movements. Late surgical removal (after 6–12 months) is recommended.
Fractured neck of FEMUR typically affects elderly women after a trivial injury. The bone is usually osteoporotic. The leg appears short and is rotated outwards. Usually the patient is unable to put any weight on the affected leg and is in extreme pain. The fractures are classi?ed according to where they occur:
subcapital where the neck joins the head of the femur.
intertrochanteric through the trochanter.
subtrochanteric transversely through the upper end of the femur (rare). Most of these fractures of the neck of femur
need ?xing by metal plates or hip replacements, as immobility in this age group has a mortality of nearly 100 per cent. Fractures of the femur shaft are usually the result of severe trauma such as a road accident. Treatment may be conservative or operative.
In fractures of the SPINAL COLUMN, mere damage to the bone – as in the case of the so-called compression fracture, in which there is no damage to the spinal cord – is not necessarily serious. If, however, the spinal cord is damaged, as in the so-called fracture dislocation, the accident may be a very serious one, the usual result being paralysis of the parts of the body below the level of the injury. Therefore the higher up the spine is fractured, the more serious the consequences. The injured person should not be moved until skilled assistance is at hand; or, if he or she must be removed, this should be done on a rigid shutter or door, not on a canvas stretcher or rug, and there should be no lifting which necessitates bending of the back. In such an injury an operation designed to remove a displaced piece of bone and free the spinal cord from pressure is often necessary and successful in relieving the paralysis. DISLOCATIONS or SUBLUXATION of the spine are not uncommon in certain sports, particularly rugby. Anyone who has had such an injury in the cervical spine (i.e. in the neck) should be strongly advised not to return to any form of body-contact or vehicular sport.
Simple ?ssured fractures and depressed fractures of the skull often follow blows or falls on the head, and may not be serious, though there is always a risk of damage which is potentially serious to the brain at the same time.
Compound fractures may result in infection within the skull, and if the skull is extensively broken and depressed, surgery is usually required to check any intercranial bleeding or to relieve pressure on the brain.
The lower jaw is often fractured by a blow on the face. There is generally bleeding from the mouth, the gum being torn. Also there are pain and grating sensations on chewing, and unevenness in the line of the teeth. The treatment is simple, the line of teeth in the upper jaw forming a splint against which the lower jaw is bound, with the mouth closed.
Congenital diseases These are rare but may produce certain types of dwar?sm or a susceptibility to fractures (osteogenesis imperfecta).
Infection of bone (osteomyelitis) may occur after an open fracture, or in newborn babies with SEPTICAEMIA. Once established it is very di?cult to eradicate. The bacteria appear capable of lying dormant in the bone and are not easily destroyed with antibiotics so that prolonged treatment is required, as might be surgical drainage, exploration or removal of dead bone. The infection may become chronic or recur.
Osteomalacia (rickets) is the loss of mineralisation of the bone rather than simple loss of bone mass. It is caused by vitamin D de?ciency and is probably the most important bone disease in the developing world. In sunlight the skin can synthesise vitamin D (see APPENDIX 5: VITAMINS), but normally rickets is caused by a poor diet, or by a failure to absorb food normally (malabsorbtion). In rare cases vitamin D cannot be converted to its active state due to the congenital lack of the speci?c enzymes and the rickets will fail to respond to treatment with vitamin D. Malfunction of the parathyroid gland or of the kidneys can disturb the dynamic equilibrium of calcium and phosphate in the body and severely deplete the bone of its stores of both calcium and phosphate.
Osteoporosis A metabolic bone disease resulting from low bone mass (osteopenia) due to excessive bone resorption. Su?erers are prone to bone fractures from relatively minor trauma. With bone densitometry it is now possible to determine individuals’ risk of osteoporosis and monitor their response to treatment.
By the age of 90 one in two women and one in six men are likely to sustain an osteoporosis-related fracture. The incidence of fractures is increasing more than would be expected from the ageing of the population, which may re?ect changing patterns of exercise or diet.
Osteoporosis may be classi?ed as primary or secondary. Primary consists of type 1 osteoporosis, due to accelerated trabecular bone loss, probably as a result of OESTROGENS de?ciency. This typically leads to crush fractures of vertebral bodies and fractures of the distal forearm in women in their 60s and 70s. Type 2 osteoporosis, by contrast, results from the slower age-related cortical and travecular bone loss that occurs in both sexes. It typically leads to fractures of the proximal femur in elderly people.
Secondary osteoporosis accounts for about 20 per cent of cases in women and 40 per cent of cases in men. Subgroups include endocrine (thyrotoxicosis – see under THYROID GLAND, DISEASES OF, primary HYPERPARATHYROIDISM, CUSHING’S SYNDROME and HYPOGONADISM); gastrointestinal (malabsorption syndrome, e.g. COELIAC DISEASE, or liver disease, e.g. primary biliary CIRRHOSIS); rheumatological (RHEUMATOID ARTHRITIS or ANKYLOSING SPONDYLITIS); malignancy (multiple MYELOMA or metastatic CARCINOMA); and drugs (CORTICOSTEROIDS, HEPARIN). Additional risk factors for osteoporosis include smoking, high alcohol intake, physical inactivity, thin body-type and heredity.
Individuals at risk of osteopenia, or with an osteoporosis-related fracture, need investigation with spinal radiography and bone densitometry. A small fall in bone density results in a large increase in the risk of fracture, which has important implications for preventing and treating osteoporosis.
Treatment Antiresorptive drugs: hormone replacement therapy – also valuable in treating menopausal symptoms; treatment for at least ?ve years is necessary, and prolonged use may increase risk of breast cancer. Cyclical oral administration of disodium etidronate – one of the bisphosphonate group of drugs – with calcium carbonate is also used (poor absorption means the etidronate must be taken on an empty stomach). Calcitonin – currently available as a subcutaneous injection; a nasal preparation with better tolerance is being developed. Calcium (1,000 mg daily) seems useful in older patients, although probably ine?ective in perimenopausal women, and it is a safe preparation. Vitamin D and calcium – recent evidence suggests value for elderly patients. Anabolic steroids, though androgenic side-effects (masculinisation) make these unacceptable for most women.
With established osteoporosis, the aim of treatment is to relieve pain (with analgesics and physical measures, e.g. lumbar support) and reduce the risk of further fractures: improvement of bone mass, the prevention of falls, and general physiotherapy, encouraging a healthier lifestyle with more daily exercise.
Further information is available from the National Osteoporosis Society.
Paget’s disease (see also separate entry) is a common disease of bone in the elderly, caused by overactivity of the osteoclasts (cells concerned with removal of old bone, before new bone is laid down by osteoblasts). The bone affected thickens and bows and may become painful. Treatment with calcitonin and bisphosphonates may slow down the osteoclasts, and so hinder the course of the disease, but there is no cure.
If bone loses its blood supply (avascular necrosis) it eventually fractures or collapses. If the blood supply does not return, bone’s normal capacity for healing is severely impaired.
For the following diseases see separate articles: RICKETS; ACROMEGALY; OSTEOMALACIA; OSTEOGENESIS IMPERFECTA.
Tumours of bone These can be benign (non-cancerous) or malignant (cancerous). Primary bone tumours are rare, but secondaries from carcinoma of the breast, prostate and kidneys are relatively common. They may form cavities in a bone, weakening it until it breaks under normal load (a pathological fracture). The bone eroded away by the tumour may also cause problems by causing high levels of calcium in the plasma.
EWING’S TUMOUR is a malignant growth affecting long bones, particularly the tibia (calfbone). The presenting symptoms are a throbbing pain in the limb and a high temperature. Treatment is combined surgery, radiotherapy and chemotherapy.
MYELOMA is a generalised malignant disease of blood cells which produces tumours in bones which have red bone marrow, such as the skull and trunk bones. These tumours can cause pathological fractures.
OSTEOID OSTEOMA is a harmless small growth which can occur in any bone. Its pain is typically removed by aspirin.
OSTEOSARCOMA is a malignant tumour of bone with a peak incidence between the ages of ten and 20. It typically involves the knees, causing a warm tender swelling. Removal of the growth with bone conservation techniques can often replace amputation as the de?nitive treatment. Chemotherapy can improve long-term survival.... bone, disorders of
A collection of psychological disorders in which a particular mental function becomes cut o? from a person’s mind. Hysterical AMNESIA is one example, when the person forgets his or her personal history but can still absorb and talk about new events. Other examples are FUGUE, depersonalisation (detachment from self and environment), and MULTIPLE PERSONALITY DISORDER.... dissociative disorder
Arcus senilis The white ring or crescent which tends to form at the edge of the cornea with age. It is uncommon in the young, when it may be associated with high levels of blood lipids (see LIPID).
Astigmatism (See ASTIGMATISM.)
Blepharitis A chronic in?ammation of the lid margins. SEBORRHOEA and staphylococcal infection are likely contributors. The eyes are typically intermittently red, sore and gritty over months or years. Treatment is di?cult and may fail. Measures to reduce debris on the lid margins, intermittent courses of topical antibiotics, steroids or systemic antibiotics may help the sufferer.
Blepharospasm Involuntary closure of the eye. This may accompany irritation but may also occur without an apparent cause. It may be severe enough to interfere with vision. Treatment involves removing the source of irritation, if present. Severe and persistent cases may respond to injection of Botulinum toxin into the orbicularis muscle.
Cataract A term used to describe any opacity in the lens of the eye, from the smallest spot to total opaqueness. The prevalence of cataracts is age-related: 65 per cent of individuals in their sixth decade have some degree of lens opacity, while all those over 80 are affected. Cataracts are the most important cause of blindness worldwide. Symptoms will depend on whether one or both eyes are affected, as well as the position and density of the cataract(s). If only one eye is developing a cataract, it may be some time before the person notices it, though reading may be affected. Some people with cataracts become shortsighted, which in older people may paradoxically ‘improve’ their ability to read. Bright light may worsen vision in those with cataracts.
The extent of visual impairment depends on the nature of the cataracts, and the ?rst symptoms noticed by patients include di?culty in recognising faces and in reading, while problems watching television or driving, especially at night, are pointers to the condition. Cataracts are common but are not the only cause of deteriorating vision. Patients with cataracts should be able to point to the position of a light and their pupillary reactions should be normal. If a bright light is shone on the eye, the lens may appear brown or, in advanced cataracts, white (see diagram).
While increasing age is the commonest cause of cataract in the UK, patients with DIABETES MELLITUS, UVEITIS and a history of injury to the eye can also develop the disorder. Prolonged STEROID treatment can result in cataracts. Children may develop cataracts, and in them the condition is much more serious as vision may be irreversibly impaired because development of the brain’s ability to interpret visual signals is hindered. This may happen even if the cataracts are removed, so early referral for treatment is essential. One of the physical signs which doctors look for when they suspect cataract in adults as well as in children is the ‘red re?ex’. This is observable when an ophthalmoscopic examination of the eye is made (see OPHTHALMOSCOPE). Identi?cation of this red re?ex (a re?ection of light from the red surface of the retina –see EYE) is a key diagnostic sign in children, especially young ones.
There is no e?ective medical treatment for established cataracts. Surgery is necessary and the decision when to operate depends mainly on how the cataract(s) affect(s) the patient’s vision. Nowadays, surgery can be done at any time with limited risk. Most patients with a vision of 6/18 – 6/10 is the minimum standard for driving – or worse in both eyes should
E
bene?t from surgery, though elderly people may tolerate visual acuity of 6/18 or worse, so surgery must be tailored to the individual’s needs. Younger people with a cataract will have more demanding visual requirements and so may opt for an ‘earlier’ operation. Most cataract surgery in Britain is now done under local anaesthetic and uses the ‘phaco-emulsi?cation’ method. A small hole is made in the anterior capsule of the lens after which the hard lens nucleus is liqui?ed ultrasonically. A replacement lens is inserted into the empty lens bag (see diagram). Patients usually return to their normal activities within a few days of the operation. A recent development under test in the USA for children requiring cataract operations is an intra-ocular ?exible implant whose magnifying power can be altered as a child develops, thus precluding the need for a series of corrective operations as happens now.
Chalazion A ?rm lump in the eyelid relating to a blocked meibomian gland, felt deep within the lid. Treatment is not always necessary; a proportion spontaneously resolve. There can be associated infection when the lid becomes red and painful requiring antibiotic treatment. If troublesome, the chalazion can be incised under local anaesthetic.
Conjunctivitis In?ammation of the conjunctiva (see EYE) which may affect one or both eyes. Typically the eye is red, itchy, sticky and gritty but is not usually painful. Redness is not always present. Conjunctivitis can occasionally be painful, particularly if there is an associated keratitis (see below) – for example, adenovirus infection, herpetic infection.
The cause can be infective (bacteria, viruses or CHLAMYDIA), chemical (e.g. acids, alkalis) or allergic (e.g. in hay fever). Conjunctivitis may also be caused by contact lenses, and preservatives or even the drugs in eye drops may cause conjunctival in?ammation. Conjunctivitis may addtionally occur in association with other illnesses – for example, upper-respiratory-tract infection, Stevens-Johnson syndrome (see ERYTHEMA – erythema multiforme) or REITER’S SYNDROME. The treatment depends on the cause. In many patients acute conjunctivitis is self-limiting.
Dacryocystitis In?ammation of the lacrimal sac. This may present acutely as a red, painful swelling between the nose and the lower lid. An abscess may form which points through the skin and which may need to be drained by incision. Systemic antibiotics may be necessary. Chronic dacryocystitis may occur with recurrent discharge from the openings of the tear ducts and recurrent swelling of the lacrimal sac. Obstruction of the tear duct is accompanied by watering of the eye. If the symptoms are troublesome, the patient’s tear passageways need to be surgically reconstructed.
Ectropion The lid margin is everted – usually the lower lid. Ectropion is most commonly associated with ageing, when the tissues of the lid become lax. It can also be caused by shortening of the skin of the lids such as happens with scarring or mechanical factors – for example, a tumour pulling the skin of the lower lid downwards. Ectropion tends to cause watering and an unsightly appearance. The treatment is surgical.
Entropion The lid margin is inverted – usually the lower lid. Entropion is most commonly associated with ageing, when the tissues of the lid become lax. It can also be caused by shortening of the inner surfaces of the lids due to scarring – for example, TRACHOMA or chemical burns. The inwardly directed lashes cause irritation and can abrade the cornea. The treatment is surgical.
Episcleritis In?ammation of the EPISCLERA. There is usually no apparent cause. The in?ammation may be di?use or localised and may affect one or both eyes. It sometimes recurs. The affected area is usually red and moderately painful. Episcleritis is generally not thought to be as painful as scleritis and does not lead to the same complications. Treatment is generally directed at improving the patient’s symptoms. The in?ammation may respond to NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) or topical CORTICOSTEROIDS.
Errors of refraction (Ametropia.) These will occur when the focusing power of the lens and cornea does not match the length of the eye, so that rays of light parallel to the visual axis are not focused at the fovea centralis (see EYE). There are three types of refractive error: HYPERMETROPIA or long-sightedness. The refractive power of the eye is too weak, or the eye is too short so that rays of light are brought to a focus at a point behind the retina. Longsighted people can see well in the distance but generally require glasses with convex lenses for reading. Uncorrected long sight can lead to headaches and intermittent blurring of vision following prolonged close work (i.e. eye strain). As a result of ageing, the eye becomes gradually long-sighted, resulting in many people needing reading glasses in later life: this normal process is known as presbyopia. A particular form of long-sightedness occurs after cataract extraction (see above). MYOPIA(Short sight or near sight.) Rays of light are brought to a focus in front of the retina because the refractive power of the eye is too great or the eye is too short. Short-sighted people can see close to but need spectacles with concave lenses in order to see in the distance. ASTIGMATISMThe refractive power of the eye is not the same in each meridian. Some rays of light may be focused in front of the retina while others are focused on or behind the retina. Astigmatism can accompany hypermetropia or myopia. It may be corrected by cylindrical lenses: these consist of a slice from the side of a cylinder (i.e. curved in one meridian and ?at in the meridian at right-angles to it).
Keratitis In?ammation of the cornea in response to a variety of insults – viral, bacterial, chemical, radiation, or mechanical trauma. Keratitis may be super?cial or involve the deeper layers, the latter being generally more serious. The eye is usually red, painful and photophobic. Treatment is directed at the cause.
Nystagmus Involuntary rhythmic oscillation of one or both eyes. There are several causes including nervous disorders, vestibular disorders, eye disorders and certain drugs including alcohol.
Ophthalmia In?ammation of the eye, especially the conjunctiva (see conjunctivitis, above). Ophthalmia neonatorum is a type of conjunctivitis that occurs in newborn babies. They catch the disease when passing through an infected birth canal during their mother’s labour (see PREGNANCY AND LABOUR). CHLAMYDIA and GONORRHOEA are the two most common infections. Treatment is e?ective with antibiotics: untreated, the infection may cause permanent eye damage.
Pinguecula A benign degenerative change in the connective tissue at the nasal or temporal limbus (see EYE). This is visible as a small, ?attened, yellow-white lump adjacent to the cornea.
Pterygium Overgrowth of the conjunctival tissues at the limbus on to the cornea (see EYE). This usually occurs on the nasal side and is associated with exposure to sunlight. The pterygium is surgically removed for cosmetic reasons or if it is thought to be advancing towards the visual axis.
Ptosis Drooping of the upper lid. May occur because of a defect in the muscles which raise the lid (levator complex), sometimes the result of ageing or trauma. Other causes include HORNER’S SYNDROME, third cranial nerve PALSY, MYASTHENIA GRAVIS, and DYSTROPHIA MYOTONICA. The cause needs to be determined and treated if possible. The treatment for a severely drooping lid is surgical, but other measures can be used to prop up the lid with varying success.
Retina, disorders of The retina can be damaged by disease that affects the retina alone, or by diseases affecting the whole body.
Retinopathy is a term used to denote an abnormality of the retina without specifying a cause. Some retinal disorders are discussed below. DIABETIC RETINOPATHY Retinal disease occurring in patients with DIABETES MELLITUS. It is the commonest cause of blind registration in Great Britain of people between the ages of 20 and 65. Diabetic retinopathy can be divided into several types. The two main causes of blindness are those that follow: ?rst, development of new blood vessels from the retina, with resultant complications and, second, those following ‘water logging’ (oedema) of the macula. Treatment is by maintaining rigid control of blood-sugar levels combined with laser treatment for certain forms of the disease – in particular to get rid of new blood vessels. HYPERTENSIVE RETINOPATHY Retinal disease secondary to the development of high blood pressure. Treatment involves control of the blood pressure (see HYPERTENSION). SICKLE CELL RETINOPATHY People with sickle cell disease (see under ANAEYIA) can develop a number of retinal problems including new blood vessels from the retina. RETINOPATHY OF PREMATURITY (ROP) Previously called retrolental ?broplasia (RLF), this is a disorder affecting low-birth-weight premature babies exposed to oxygen. Essentially, new blood vessels develop which cause extensive traction on the retina with resultant retinal detachment and poor vision. RETINAL ARTERY OCCLUSION; RETINAL VEIN OCCLUSION These result in damage to those areas of retina supplied by the affected blood vessel: the blood vessels become blocked. If the peripheral retina is damaged the patient may be completely symptom-free, although areas of blindness may be detected on examination of ?eld of vision. If the macula is involved, visual loss may be sudden, profound and permanent. There is no e?ective treatment once visual loss has occurred. SENILE MACULAR DEGENERATION (‘Senile’ indicates age of onset and has no bearing on mental state.) This is the leading cause of blindness in the elderly in the western world. The average age of onset is 65 years. Patients initially notice a disturbance of their vision which gradually progresses over months or years. They lose the ability to recognise ?ne detail; for example, they cannot read ?ne print, sew, or recognise people’s faces. They always retain the ability to recognise large objects such as doors and chairs, and are therefore able to get around and about reasonably well. There is no e?ective treatment in the majority of cases. RETINITIS PIGMENTOSAA group of rare, inherited diseases characterised by the development of night blindness and tunnel vision. Symptoms start in childhood and are progressive. Many patients retain good visual acuity, although their peripheral vision is limited. One of the characteristic ?ndings on examination is collections of pigment in the retina which have a characteristic shape and are therefore known as ‘bone spicules’. There is no e?ective treatment. RETINAL DETACHMENTusually occurs due to the development of a hole in the retina. Holes can occur as a result of degeneration of the retina, traction on the retina by the vitreous, or injury. Fluid from the vitreous passes through the hole causing a split within the retina; the inner part of the retina becomes detached from the outer part, the latter remaining in contact with the choroid. Detached retina loses its ability to detect light, with consequent impairment of vision. Retinal detachments are more common in the short-sighted, in the elderly or following cataract extraction. Symptoms include spots before the eyes (?oaters), ?ashing lights and a shadow over the eye with progressive loss of vision. Treatment by laser is very e?ective if caught early, at the stage when a hole has developed in the retina but before the retina has become detached. The edges of the hole can be ‘spot welded’ to the underlying choroid. Once a detachment has occurred, laser therapy cannot be used; the retina has to be repositioned. This is usually done by indenting the wall of the eye from the outside to meet the retina, then making the retina stick to the wall of the eye by inducing in?ammation in the wall (by freezing it). The outcome of surgery depends largely on the extent of the detachment and its duration. Complicated forms of detachment can occur due to diabetic eye disease, injury or tumour. Each requires a specialised form of treatment.
Scleritis In?ammation of the sclera (see EYE). This can be localised or di?use, can affect the anterior or the posterior sclera, and can affect one or both eyes. The affected eye is usually red and painful. Scleritis can lead to thinning and even perforation of the sclera, sometimes with little sign of in?ammation. Posterior scleritis in particular may cause impaired vision and require emergency treatment. There is often no apparent cause, but there are some associated conditions – for example, RHEUMATOID ARTHRITIS, GOUT, and an autoimmune disease affecting the nasal passages and lungs called Wegener’s granulomatosis. Treatment depends on severity but may involve NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS), topical CORTICOSTEROIDS or systemic immunosuppressive drugs.
Stye Infection of a lash follicle. This presents as a painful small red lump at the lid margin. It often resolves spontaneously but may require antibiotic treatment if it persists or recurs.
Sub-conjunctival haemorrhage Haemorrhage between the conjunctiva and the underlying episclera. It is painless. There is usually no apparent cause and it resolves spontaneously.
Trichiasis Inward misdirection of the lashes. Trichiasis occurs due to in?ammation of or trauma to the lid margin. Treatment involves removal of the patient’s lashes. Regrowth may be prevented by electrolysis, by CRYOTHERAPY to the lid margin, or by surgery.
For the subject of arti?cial eyes, see under PROSTHESIS; also GLAUCOMA, SQUINT and UVEITIS.... eye, disorders of
The individual with this psychiatric disorder has two or more di?erent personalities, often contrasting. The dominant personality at the time determines the behaviour and attitude of the individual, who customarily seems not to know about the other personality – or personalities. The switch from one personality to another is abrupt and the mental condition of the di?ering personalities is usually normal. It is possible that child abuse is a factor in the disorder, which is treated by psychotherapy. The classic multiple personality was the ?ctional form of Dr Jekyll and Mr Hyde.... multiple personality disorder
A mental-health problem which will be experienced at some time by up to 3 per cent of adults. The main feature is the occurrence of spontaneous intrusive thoughts that cause intense anxiety. Many of these thoughts prompt urges, or compulsions, to carry out particular actions in order to reduce the anxiety. One of the commonest obsessions is a fear of dirt and contamination that prompts compulsive cleaning or repeated and unnecessary handwashing. (See MENTAL ILLNESS.)... obsessive compulsive disorder
An umbrella description for a wide variety of conditions in which there is increased deterioration of the structure or function (or both) of the body. Ageing causes a steady degeneration of many tissues and organs – for example, wrinkling of the skin, CATARACT and poor neuromuscular coordination. In degenerative disorders the changes occur earlier in life. The nervous system, muscles, arteries, joints and eyes are all susceptible. Specialised tissues are replaced by CONNECTIVE TISSUE. The commonest example in the nervous system is ALZHEIMER’S DISEASE, which causes dementia; while in HUNTINGTON’S CHOREA, a genetic disorder, dementia is accompanied by incoordination of movements.... degenerative disorders
A pre?x signifying after or behind.... post
See MYALGIC ENCEPHALOMYELITIS (ME).... post-viral fatigue syndrome
A type of anxiety disorder, characterized by recurrent panic attacks of intense anxiety and distressing physical symptoms.... panic disorder
Obstruction of the larynx is potentially dangerous in adults but can sometimes be life-threatening in infants and children. Stridor – noisy, di?cult breathing – is a symptom of obstruction. There are several causes, including congenital abnormalities of the larynx. Others are in?ammatory conditions such as acute laryngitis (see below), acute EPIGLOTTITIS and laryngo-tracheo-bronchitis (croup – see below); neurological abnormalities; trauma; and inhalation of foreign bodies.
Laryngitis In?ammation of the mucous membrane of the larynx and vocal chords may be acute or chronic. The cause is usually an infection, most commonly viral, although it may be the result of secondary bacterial infection, voice abuse or irritation by gases or chemicals. ACUTE LARYNGITIS may accompany any form of upper-respiratory-tract infection. The main symptom is hoarseness and often pain in the throat. The voice becomes husky or it may be lost. Cough, breathing diffculties and sometimes stridor may occur. Acute airway obstruction is unusual following laryngitis but may occasionally occur in infants (see laryngotracheo-bronchitis, below).
Treatment Vapour inhalations may be soothing and reduce swelling. Usually all that is needed is rest and analgesics such as paracetamol. Rarely, airway intervention – either ENDOTRACHEAL INTUBATION or TRACHEOSTOMY – may be necessary if severe airway obstruction develops (see APPENDIX 1: BASIC FIRST AID). A?ected patients should rest their voice and avoid smoking.
Chronic laryngitis can result from repeated attacks of acute laryngitis; excessive use of the voice – loud and prolonged, singing or shouting; tumours, which may be benign or malignant; or secondary to diseases such as TUBERCULOSIS and SYPHILIS.
Benign tumours or small nodules, such as singer’s nodules, may be surgically removed by direct laryngoscopy under general anaesthetic; while cancer of the larynx may be treated either by RADIOTHERAPY or by SURGERY, depending on the extent of the disease. Hoarseness may be the only symptom of vocal-chord disturbance or of laryngeal cancer: any case which has lasted for six weeks should be referred for a specialist opinion.
Laryngectomy clubs are being established
A laryngoscopic view of the interior of the larynx.
throughout the country to support patients following laryngectomy. Speech therapists provide speech rehabilitation.... larynx, disorders of
Known colloquially as SADS, this is a disorder in which an affected individual’s mood changes with the seasons. He or she is commonly depressed in winter, picking up again in the spring. The diagnosis is controversial and its prevalence is not known. The mood-change is probably related to light, with MELATONIN playing a key role. (See also MENTAL ILLNESS.)... seasonal affective disorder syndrome
Thought is a mental activity by which people reason, solve problems, form judgements and communicate with each other by speech, writing and behaviour. Disturbances of thought are re?ected in how a person communicates: the normal logic of thought is broken up and a person may randomly move from one subject to another. SCHIZOPHRENIA is a mental illness characterised by thought disorder. Confusion, DEMENTIA, DEPRESSION and MANIA are other conditions in which thought disorders may be a marked feature. (See also MENTAL ILLNESS.)... thought disorders
These are caused when there are mutations or other abnormalities which disrupt the code of a gene or set of GENES. These are divided into autosomal (one of the 44 CHROMOSOMES which are not sex-linked), dominant, autosomal recessive, sex-linked and polygenic disorders.
Dominant genes A dominant characteristic is an e?ect which is produced whenever a gene or gene defect is present. If a disease is due to a dominant gene, those affected are heterozygous – that is, they only carry a fault in the gene on one of the pair of chromosomes concerned. A?ected people married to normal individuals transmit the gene directly to one-half of the children, although this is a random event just like tossing a coin. HUNTINGTON’S CHOREA is due to the inheritance of a dominant gene, as is neuro?bromatosis (see VON RECKLINGHAUSEN’S DISEASE) and familial adenomatous POLYPOSIS of the COLON. ACHONDROPLASIA is an example of a disorder in which there is a high frequency of a new dominant mutation, for the majority of affected people have normal parents and siblings. However, the chances of the children of a parent with the condition being affected are one in two, as with any other dominant characteristic. Other diseases inherited as dominant characteristics include spherocytosis, haemorrhagic telangiectasia and adult polycystic kidney disease.
Recessive genes If a disease is due to a recessive gene, those affected must have the faulty gene on both copies of the chromosome pair (i.e. be homozygous). The possession of a single recessive gene does not result in overt disease, and the bearer usually carries this potentially unfavourable gene without knowing it. If that person marries another carrier of the same recessive gene, there is a one-in-four chance that their children will receive the gene in a double dose, and so have the disease. If an individual sufferer from a recessive disease marries an apparently normal person who is a heterozygous carrier of the same gene, one-half of the children will be affected and the other half will be carriers of the disease. The commonest of such recessive conditions in Britain is CYSTIC FIBROSIS, which affects about one child in 2,000. Approximately 5 per cent of the population carry a faulty copy of the gene. Most of the inborn errors of metabolism, such as PHENYLKETONURIA, GALACTOSAEMIA and congenital adrenal hyperplasia (see ADRENOGENITAL SYNDROME), are due to recessive genes.
There are characteristics which may be incompletely recessive – that is, neither completely dominant nor completely recessive – and the heterozygotus person, who bears the gene in a single dose, may have a slight defect whilst the homozygotus, with a double dose of the gene, has a severe illness. The sickle-cell trait is a result of the sickle-cell gene in single dose, and sickle-cell ANAEMIA is the consequence of a double dose.
Sex-linked genes If a condition is sex-linked, affected males are homozygous for the mutated gene as they carry it on their single X chromosome. The X chromosome carries many genes, while the Y chromosome bears few genes, if any, other than those determining masculinity. The genes on the X chromosome of the male are thus not matched by corresponding genes on the Y chromosome, so that there is no chance of the Y chromosome neutralising any recessive trait on the X chromosome. A recessive gene can therefore produce disease, since it will not be suppressed by the normal gene of the homologous chromosome. The same recessive gene on the X chromosome of the female will be suppressed by the normal gene on the other X chromosome. Such sex-linked conditions include HAEMOPHILIA, CHRISTMAS DISEASE, DUCHENNE MUSCULAR
DYSTROPHY (see also MUSCLES, DISORDERS OF – Myopathy) and nephrogenic DIABETES INSIPIDUS.
If the mother of an affected child has another male relative affected, she is a heterozygote carrier; half her sons will have the disease and half her daughters will be carriers. The sister of a haemophiliac thus has a 50 per cent chance of being a carrier. An affected male cannot transmit the gene to his son because the X chromosome of the son must come from the mother; all his daughters, however, will be carriers as the X chromosome for the father must be transmitted to all his daughters. Hence sex-linked recessive characteristics cannot be passed from father to son. Sporadic cases may be the result of a new mutation, in which case the mother is not the carrier and is not likely to have further affected children. It is probable that one-third of haemophiliacs arise as a result of fresh mutations, and these patients will be the ?rst in the families to be affected. Sometimes the carrier of a sex-linked recessive gene can be identi?ed. The sex-linked variety of retinitis pigmentosa (see EYE, DISORDERS OF) can often be detected by ophthalmoscopic examination.
A few rare disorders are due to dominant genes carried on the X chromosome. An example of such a condition is familial hypophosphataemia with vitamin-D-resistant RICKETS.
Polygenic inheritance In many inherited conditions, the disease is due to the combined action of several genes; the genetic element is then called multi-factorial or polygenic. In this situation there would be an increased incidence of the disease in the families concerned, but it will not follow the Mendelian (see MENDELISM; GENETIC CODE) ratio. The greater the number of independent genes involved in determining a certain disease, the more complicated will be the pattern of inheritance. Furthermore, many inherited disorders are the result of a combination of genetic and environmental in?uences. DIABETES MELLITUS is the most familiar of such multi-factorial inheritance. The predisposition to develop diabetes is an inherited characteristic, although the gene is not always able to express itself: this is called incomplete penetrance. Whether or not the individual with a genetic predisposition towards the disease actually develops diabetes will also depend on environmental factors. Diabetes is more common in the relatives of diabetic patients, and even more so amongst identical twins. Non-genetic factors which are important in precipitating overt disease are obesity, excessive intake of carbohydrate foods, and pregnancy.
SCHIZOPHRENIA is another example of the combined effects of genetic and environmental in?uences in precipitating disease. The risk of schizophrenia in a child, one of whose parents has the disease, is one in ten, but this ?gure is modi?ed by the early environment of the child.... genetic disorders
The list of disorders resulting in poor or dim vision is huge. Disturbance of vision can result from an uncorrected refractive error, disease or injury of the cornea, iris, lens, vitreous, retina, choroid or sclera of the EYE. It may also result from disease or injury to the structures comprising the visual pathway from the retina to the occipital cortex (see VISION – Pathway of light from the eye to the brain) and from lesions of the structures around the eye – for example, swollen lids, drooping eyelids. (See EYE, DISORDERS OF.)... vision, disorders of
The kidneys are responsible for the excretion of many waste products, chiefly urea from the blood. They maintain the correct balance of salts and water. Any of the individual kidney disorders may interfere with these important functions. See: ABSCESS (kidney). BRIGHT’S DISEASE. CARDIAC DROPS. RENAL FLUID RETENTION. GRAVEL. HYDRONEPHROSIS. NEPHROSIS. PROTEINURIA. PYELITIS. RENAL COLIC. RETENTION OF URINE. STONE IN THE KIDNEY. SUPPRESSION OF URINE. URAEMIA. ... kidney disorders
Condition in which the individual fails to learn from experience or to adapt to changes. The outcome is impaired social functioning and personal distress. There are three broad overlapping groups. One group is characterised by eccentric behaviour with paranoid or schizoid overtones. The second group shows dramatic and emotional behaviour with self-centredness and antisocial behaviour as typical components of the disorder. In the third group, anxiety and fear are the main characteristics, which are accompanied by dependency and compulsive behaviour. These disorders are not classed as illnesses but psychotherapy and behavioural therapy may help. The individuals affected are notoriously resistant to any help that is o?ered, tending to blame other people, circumstances or bad luck for their persistent diffculties. (See MENTAL ILLNESS; MULTIPLE PERSONALITY DISORDER; MUNCHAUSEN’S SYNDROME.)... personality disorder
A psychiatric disorder in which a person suffers intense anxiety about an imagined defect in part of his or her body.... body dysmorphic disorder
A fracture that occurs as a result of repetitive jarring of a bone. Common sites include the metatarsal bones in the foot (see March fracture), the tibia or fibula, the neck of the femur, and the lumbar spine. The main symptoms are pain and tenderness at the fracture site. Diagnosis is by bone imaging. Treatment consists of resting the affected area for 4–6 weeks. The fracture may be immobilized in a cast.... stress fracture
A lifelong disorder characterised by overactive behaviour, short attention span and poor concentration. It is thought to be caused by a minor abnormality that affects the part of the brain that allows us to concentrate and focus on tasks. Some scientists have suggested that it may be caused by particular foods, particularly processed foods containing arti?cial additives, and recommend special diets. In some countries, attention de?cit disorder is diagnosed in up to a tenth of all children; this may re?ect di?erences in paediatric practice and diagnosis rather than a real variation in prevalence of the disorder. Behaviour therapy is the main treatment. Those children with very severe symptoms of restlessness, short attention span and disturbed behaviour may respond to additional treatment with methylphenidate (Ritalin®). This is an amphetamine-like drug that is thought to stimulate the part of the brain that is not working properly. Use of this drug has, however, been controversial.... attention deficit disorder (hyperactivity syndrome)
A persistent or recurring condition or group of symptoms. Chronic disorders are customarily contrasted with acute diseases which start suddenly and last a short time. The symptoms of acute disease often include breathlessness, fever, severe pain and malaise, with the patient’s condition changing from day to day or even hour to hour. Those suffering from chronic conditions – for example, severe arthritis, protracted lung disease, ASTHMA or SILICOSIS – should be distinguished from those with a ‘static disability’ following a stroke or injury. Chronic disorders steadily deteriorate, often despite treatment and the patient is increasingly unable to carry out his or her daily activities.... chronic disorder
A group of generalised in?ammatory diseases that affect CONNECTIVE TISSUE in almost any system in the body. The term does not include those disorders of genetic origin. RHEUMATIC FEVER and RHEUMATOID ARTHRITIS were traditionally classi?ed in this group, as were those diseases classed under the outdated heading COLLAGEN DISEASES.... connective tissue disorders
See OTORHINOLARYNGOLOGY.... ent disorders
Compression syndrome The tense, painful state of muscles induced by excessive accumulation of INTERSTITIAL ?uid in them, following unusual exercise. This condition is more liable to occur in the muscles at the front of the shin, because they lie within a tight fascial membrane: here the syndrome is known as the anterior tibial syndrome (‘shin splints’). Prevention consists of always keeping ?t and in training for the amount of exercise to be undertaken. Equally important is what is known in sporting circles as ‘warming down’: i.e., at the end of training or a game, exercise should be gradually tailed o?. Treatment consists of elevation of the affected limb, compression of it by compression bandages, with ample exercise of the limb within the bandage, and massage. In more severe cases DIURETICS may be given. Occasionally surgical decompression may be necessary.
Cramp Painful spasm of a muscle usually caused by excessive and prolonged contraction of the muscle ?bres. Cramps are common, especially among sportsmen and women, normally lasting a short time. The condition usually occurs during or immediately following exercise as a result of a build-up of LACTIC ACID and other chemical by-products in the muscles
– caused by the muscular e?orts. Cramps may occur more frequently, especially at night, in people with poor circulation, when the blood is unable to remove the lactic acid from the muscles quickly enough.
Repetitive movements such as writing (writer’s cramp) or operating a keyboard can cause cramp. Resting muscles may suffer cramp if a person sits or lies in an awkward position which limits local blood supply to them. Profuse sweating as a result of fever or hot weather can also cause cramp in resting muscle, because the victim has lost sodium salts in the sweat; this disturbs the biochemical balance in muscle tissue.
Treatment is to massage and stretch the affected muscle – for example, cramp in the calf muscle may be relieved by pulling the toes on the affected leg towards the knee. Persistent night cramps sometimes respond to treatment with a drug containing CALCIUM or QUININE. If cramp persists for an hour or more, the person should seek medical advice, as there may be a serious cause such as a blood clot impeding the blood supply to the area affected.
Dystrophy See myopathy below.
In?ammation (myositis) of various types may occur. As the result of injury, an ABSCESS may develop, although wounds affecting muscle generally heal well. A growth due to SYPHILIS, known as a gumma, sometimes forms a hard, almost painless swelling in a muscle. Rheumatism is a vague term traditionally used to de?ne intermittent and often migratory discomfort, sti?ness or pain in muscles and joints with no obvious cause. The most common form of myositis is the result of immunological damage as a result of autoimmune disease. Because it affects many muscles it is called POLYMYOSITIS.
Myasthenia (see MYASTHENIA GRAVIS) is muscle weakness due to a defect of neuromuscular conduction.
Myopathy is a term applied to an acquired or developmental defect in certain muscles. It is not a neurological disease, and should be distinguished from neuropathic conditions (see NEUROPATHY) such as MOTOR NEURONE DISEASE (MND), which tend to affect the distal limb muscles. The main subdivisions are genetically determined, congenital, metabolic, drug-induced, and myopathy (often in?ammatory) secondary to a distant carcinoma. Progressive muscular dystrophy is characterised by symmetrical wasting and weakness, the muscle ?bres being largely replaced by fatty and ?brous tissue, with no sensory loss. Inheritance may take several forms, thus affecting the sex and age of victims.
The commonest type is DUCHENNE MUSCULAR DYSTROPHY, which is inherited as a sex-linked disorder. It nearly always occurs in boys.
Symptoms There are three chief types of myopathy. The commonest, known as pseudohypertrophic muscular dystrophy, affects particularly the upper part of the lower limbs of children. The muscles of the buttocks, thighs and calves seem excessively well developed, but nevertheless the child is clumsy, weak on his legs, and has di?culty in picking himself up when he falls. In another form of the disease, which begins a little later, as a rule at about the age of 14, the muscles of the upper arm are ?rst affected, and those of the spine and lower limbs become weak later on. In a third type, which begins at about this age, the muscles of the face, along with certain of the shoulder and upper arm muscles, show the ?rst signs of wasting. All the forms have this in common: that the affected muscles grow weaker until their power to contract is quite lost. In the ?rst form, the patients seldom reach the age of 20, falling victims to some disease which, to ordinary people, would not be serious. In the other forms the wasting, after progressing to a certain extent, often remains stationary for the rest of life. Myopathy may also be acquired when it is the result of disease such as thyrotoxicosis (see under THYROID GLAND, DISEASES OF), osteomalacia (see under BONE, DISORDERS OF) and CUSHING’S DISEASE, and the myopathy resolves when the primary disease is treated.
Treatment Some myopathies may be the result of in?ammation or arise from an endocrine or metabolic abnormality. Treatment of these is the treatment of the cause, with supportive physiotherapy and any necessary physical aids while the patient is recovering. Treatment for the hereditary myopathies is supportive since, at present, there is no cure – although developments in gene research raise the possibility of future treatment. Physiotherapy, physical aids, counselling and support groups may all be helpful in caring for these patients.
The education and management of these children raise many diffculties. Much help in dealing with these problems can be obtained from Muscular Dystrophy Campaign.
Myositis ossi?cans, or deposition of bone in muscles, may be congenital or acquired. The congenital form, which is rare, ?rst manifests itself as painful swellings in the muscles. These gradually harden and extend until the child is encased in a rigid sheet. There is no e?ective treatment and the outcome is fatal.
The acquired form is a result of a direct blow on muscle, most commonly on the front of the thigh. The condition should be suspected whenever there is severe pain and swelling following a direct blow over muscle. The diagnosis is con?rmed by hardening of the swelling. Treatment consists of short-wave DIATHERMY with gentle active movements. Recovery is usually complete.
Pain, quite apart from any in?ammation or injury, may be experienced on exertion. This type of pain, known as MYALGIA, tends to occur in un?t individuals and is relieved by rest and physiotherapy.
Parasites sometimes lodge in the muscles, the most common being Trichinella spiralis, producing the disease known as TRICHINOSIS (trichiniasis).
Rupture of a muscle may occur, without any external wound, as the result of a spasmodic e?ort. It may tear the muscle right across – as sometimes happens to the feeble plantaris muscle in running and leaping – or part of the muscle may be driven through its ?brous envelope, forming a HERNIA of the muscle. The severe pain experienced in many cases of LUMBAGO is due to tearing of one of the muscles in the back. These conditions are usually relieved by rest and massage. Partial muscle tears, such as occur in sport, require more energetic treatment: in the early stages this consists of the application of an ice or cold-water pack, ?rm compression, elevation of the affected limb, rest for a day or so and then gradual mobilisation (see SPORTS MEDICINE).
Tumours occur occasionally, the most common being ?broid, fatty, and sarcomatous growths.
Wasting of muscles sometimes occurs as a symptom of disease in other organs: for example, damage to the nervous system, as in poliomyelitis or in the disease known as progressive muscular atrophy. (See PARALYSIS.)... muscles, disorders of
The following conditions are discussed under their individual headings: APHASIA; BRAIN, DISEASES OF; CATALEPSY; CHOREA; CRAMP; EPILEPSY; HYSTERIA; LEARNING DISABILITY; MEMORY; MENTAL ILLNESS; MULTIPLE SCLEROSIS (MS); NERVES, INJURIES TO; NEURALGIA; NEURITIS; PARALYSIS; PSYCHOSOMATIC DISEASES; SPINE AND SPINAL CORD, DISEASES AND INJURIES OF; STROKE; TABES.... nervous system, disorders of
The ear is susceptible to various disorders, some of which can lead to deafness. In rare cases, the ear canal, ossicles in the middle ear, or pinna are absent or deformed at birth. Rubella in early pregnancy can damage the baby’s developing ear, leading to deafness. Most cases of congenital sensorineural deafness are genetic.
Infection is the most common cause of ear disorders; it may occur in the ear canal, leading to otitis externa, or affect the middle ear, causing otitis media. This can lead to perforation of the eardrum (see eardrum, perforated). Persistent glue ear, often due to infection, is the most common cause of childhood hearing difficulties. Viral infection of the inner ear may cause labyrinthitis.
Cauliflower ear is the result of one large or several small injuries to the pinna. Perforation of the eardrum can result from poking objects into the ear or loud noise. Prolonged exposure to loud noise can cause tinnitus and/or deafness. Pressure changes associated with flying or scuba diving can also cause minor damage (see barotrauma).Tumours of the ear are rare. Acoustic neuroma is a noncancerous tumour of the acoustic nerve that may press on structures in the ear to cause deafness, tinnitus, and problems with balance.
In cholesteatoma, skin cells and debris collect in the middle ear. Obstruction of the ear canal is most often the result of earwax, although in small children, an object may have been pushed into the ear (see ear, foreign body in).
In otosclerosis, a hereditary condition, a bone in the middle ear becomes fixed, causing deafness. Meniérè’s disease is an uncommon condition in which deafness, vertigo, and tinnitus result from the accumulation of fluid in the inner ear. Deafness in many elderly people is due to presbyacusis, in which hair cells in the cochlea deteriorate.
Certain drugs, such as aminoglycoside drugs and some diuretic drugs, can damage ear function.... ear, disorders of
A wide range of disorders can disrupt the heart’s action.
In general, genetic factors do not play a large part in causing heart disorders, however they do contribute to the hyperlipidaemias that predispose a person to atherosclerosis and coronary artery disease. Structural abnormalities in the heart are among the most common birth defects (see heart disease, congenital).
Infections after birth may result in endocarditis or myocarditis. Tumours arising from the heart tissues are rare. They include noncancerous myxomas and cancerous sarcomas.
The heart muscle may become thin and flabby from lack of protein and calories. Thiamine (vitamin B1) deficiency, common in alcoholics, causes beriberi with congestive heart failure. Alcohol poisoning over many years may cause a type of cardiomyopathy. Obesity is an important factor in heart disease, probably through its effect on other risk factors, such as hypertension, diabetes, and cholesterol.
The coronary arteries may become narrowed due to atherosclerosis, depriving areas of heart muscle of oxygen. The result may be angina pectoris or, eventually, a myocardial infarction.
Some drugs, such as the anticancer drug doxorubicin, tricyclic antidepressants, and even drugs used to treat heart disease, may disturb the heartbeat or damage the heart muscle.
Many common and serious heart disorders may be a complication of an underlying condition, such as cardiomyopathy or a congenital defect. Such disorders include cardiac arrhythmia, some cases of heart block, and heart failure. Cor pulmonale is a failure of the right side of the heart as a consequence of lung disease.... heart, disorders of
Conditions caused by malfunction of an endocrine gland.... hormonal disorders
Problems affecting the ability to communicate and/or comprehend the spoken and/or written word (see speech; speech disorders).... language disorders
Disorders in which the emotions are affected: mania, depression, and manic–depressive illness.... mood disorders
The term ‘eating disorders’ covers OBESITY, feeding problems in childhood, anorexia nervosa, and bulimia nervosa. The latter two are described here.
Anorexia nervosa Often called the slimmer’s disease, this is a syndrome characterised by the loss of at least a quarter of a person’s normal body weight; by fear of normal weight; and, in women, by AMENORRHOEA. An individual’s body image may be distorted so that the sufferer cannot judge real weight and wants to diet even when already very thin.
Anorexia nervosa usually begins in adolescence, affecting about 1–2 per cent of teenagers and college students at any time. It is 20 times more common among women than men. Up to 10 per cent of sufferers’ sisters also have the syndrome. Anorexia may be linked with episodes of bulimia (see below).
The symptoms result from secretive self-starvation, usually with excessive exercise, self-induced vomiting, and misuse of laxatives. An anorexic (or anorectic) person may wear layers of baggy clothes to keep warm and to hide the ?gure. Starvation can cause serious problems such as ANAEMIA, low blood pressure, slow heart rate, swollen ankles, and osteoporosis. Sudden death from heart ARRHYTHMIA may occur, particularly if the sufferer misuses DIURETICS to lose weight and also depletes the body’s level of potassium.
There is probably no single cause of anorexia nervosa. Social pressure to be thin seems to be an important factor and has increased over the past 20–30 years, along with the incidence of the syndrome. Psychological theories include fear of adulthood and fear of losing parents’ attention.
Treatment should start with the general practitioner who should ?rst rule out other illnesses causing similar signs and symptoms. These include DEPRESSION and disorders of the bowel, PITUITARY GLAND, THYROID GLAND, and OVARIES.
If the diagnosis is clearly anorexia nervosa, the general practitioner may refer the sufferer to a psychiatrist or psychologist. Moderately ill sufferers can be treated by COGNITIVE BEHAVIOUR THERAPY. A simple form of this is to agree targets for daily calorie intake and for acceptable body weight. The sufferer and the therapist (the general practitioner or a member of the psychiatric team) then monitor progress towards both targets by keeping a diary of food intake and measuring weight regularly. Counselling or more intensely personal PSYCHOTHERAPY may help too. Severe life-threatening complications will need urgent medical treatment in hospital, including rehydration and feeding using a nasogastric tube or an intravenous drip.
About half of anorectic sufferers recover fully within four years, a quarter improve, and a quarter remain severely underweight with (in the case of women) menstrual abnormalities. Recovery after ten years is rare and about 3 per cent die within that period, half of them by suicide.
Bulimia nervosa is a syndrome characterised by binge eating, self-induced vomiting and laxative misuse, and fear of fatness. There is some overlap between anorexia nervosa and bulimia but, unlike the former, bulimia may start at any age from adolescence to 40 and is probably more directly linked with ordinary dieting. Bulimic sufferers say that, although they feel depressed and guilty after binges, the ‘buzz’ and relief after vomiting and purging are addictive. They often respond well to cognitive behaviour therapy.
Bulimia nervosa does not necessarily cause weight loss because the binges – for example of a loaf of bread, a packet of cereal, and several cans of cold baked beans at one sitting – are cancelled out by purging, by self-induced vomiting and by brief episodes of starvation. The full syndrome has been found in about 1 per cent of women but mild forms may be much more common. In one survey of female college students, 13 per cent admitted to having had bulimic symptoms.
Bulimia nervosa rarely leads to serious physical illness or death. However, repeated vomiting can cause oesophageal burns, salivary gland infections, small tears in the stomach, and occasionally dehydration and chemical imbalances in the blood. Inducing vomiting using ?ngers may produce two tell-tale signs – bite marks on the knuckles and rotten, pitted teeth.
Those suffering from this condition may obtain advice from the Eating Disorders Association.... eating disorders
These are rare. POLYPS may form and, if symptomatic, should be removed. Malignant change is rare. CARCINOMA of the gall-bladder is a disease of the elderly and is almost exclusively associated with gall-stones. By the time such a cancer has produced symptoms, the prognosis is bleak: 80 per cent of these patients die within one year of diagnosis. If the tumour is discovered early, 60 per cent of patients will survive ?ve years.... other disorders of the gall-bladder
See “transitional care”.... post-acute care
A test for INFERTILITY. A specimen of cervical mucus, taken up to 24 hours after coitus (during the post-ovulatory phase of the menstrual cycle), is examined microscopically to assess the motility of the sperms. If motility is above a certain level, then sperms and mucus are not interacting abnormally – thus eliminating one cause of sterility.... post-coital test
The period after an operation, the patient’s condition after operation, or any investigations or treatment during this time.... post-operative
The term applied to anything happening immediately after childbirth: for example, postpartum haemorrhage. (See also PREGNANCY AND LABOUR.)... post-partum
The liver is a common site of disease. The most significant liver conditions include alcohol-related disorders (see liver disease, alcoholic), hepatitis, and liver cancer. Disorders can also result from infection. Certain viruses cause hepatitis (see hepatitis, viral). Bacteria may spread up the biliary system to the liver, causing cholangitis or liver abscess. Parasitic diseases affecting the liver include schistosomiasis, liver fluke, and hydatid disease. Certain metabolic disorders, such as haemochromatosis and Wilson’s disease, may involve the liver. Other types of liver disorder include Budd–Chiari syndrome, in which the veins draining the liver become blocked. Occasionally, defects of liver structure are present at birth. Such defects principally affect the bile ducts; one example is biliary atresia, in which the bile ducts are absent. Because the liver breaks down drugs and toxins, damage to liver cells can also be caused through overdose or drug allergy. (See also jaundice; liver failure; portal hypertension.)... liver, disorders of
Diseases and abnormalities of the ovaries can occur for various reasons. Absence of ovaries, or their failure to develop normally, is rare and is usually due to a chromosomal abnormality (see Turner’s syndrome). Oophoritis (inflammation of an ovary) may result from infections such as gonorrhoea or pelvic inflammatory disease. Ovarian cysts are common and usually noncancerous. Polycystic ovary syndrome is due to an imbalance of sex hormones. Ovarian cancer (see ovary, cancer of) occurs mainly in women over 50. Ovarian failure causes premature menopause in about 5 per cent of women.... ovary, disorders of
A range of disorders that are related to sexual function. Psychosexual disorders include transsexualism, psychosexual dysfunction, and sexual deviation.... psychosexual disorders
Inability to relate socially to other people. People with this trait, which is apparent from childhood, are often described as “loners” and have few, if any, friends. They are eccentric, seem to lack concern for others, and are apparently detached from normal day-to-day activities.... schizoid personality disorder
A collective term for disorders such as Asperger’s syndrome and autism, which begin in childhood. Problems tend to persist throughout life.... social and communication disorders
A condition in which a person complains over a period of several years of various physical problems for which no organic cause can be found. The disorder, which is more common in women, usually begins before age 30 and leads to numerous tests by many doctors. Unnecessary surgery and other treatments may result. The condition is often associated with anxiety, depression, or substance abuse. (See also conversion disorder; hypochondriasis.)... somatization disorder
The stomach may be affected by various disorders, including gastrointestinal infections, peptic ulcers, gastritis, pyloric stenosis, volvulus, polyps, and stomach cancer.... stomach, disorders of the
see auditory processing disorder.... central auditory processing disorder
any one of a group of conditions in infancy or childhood, that are characterized by delays in biologically determined psychological functions, such as language. They are more common in males than females and tend to follow a course of disability with gradual improvement. They are classified into pervasive conditions, in which many types of development are involved (e.g. *autism), and specific disorders, in which the disability is an isolated problem (such as *dyslexia).... developmental disorder
see DSM.... diagnostic and statistical manual of mental disorders
(DSDs) see intersex.... disorders of sexual development
(FASD, fetal alcohol syndrome, FAS) a condition of newborn babies that results from the toxic effects on the fetus of maternal alcohol abuse. Babies have a low birth weight and growth is retarded. They have a small head (*microcephaly), low-set ears, eye, nose, lip, and nail abnormalities, and disturbances of behaviour and intellect. The greater the alcohol abuse, the more severe the fetal manifestations.... fetal alcohol spectrum disorder
See EYE, DISORDERS OF.... retina, disorders of
Certain skin diseases – particularly CHILBLAIN, ACNE, LUPUS and ERYSIPELAS – tend to affect the NOSE, and may be very annoying. Redness of the skin may be caused by poor circulation in cold weather.
Acute in?ammation is generally the result of a viral infection (see COLD, COMMON) affecting the mucous membrane and paranasal sinuses (see SINUSITIS); less commonly it results from the inhalation of irritant gases. Boils may develop just inside the entrance to the nose, causing pain; these are potentially troublesome as infection can spread to the sinuses. HAY FEVER is one distressing form of acute rhinitis.
Malformations are of various kinds. Racial and familial variations in the external nose occur and may be a reason for RHINOPLASTY. Di?erences in the size and shape of the nose occur, often forming the starting point for chronic in?ammation of the nose, perennial rhinitis (all the year round), hay fever, or ASTHMA. More commonly, obstruction results from nasal polyps or adenoids, leading to inhalation through the mouth. Adenoids are an overgrowth of glandular tissue at the back of the throat, into which the nose opens. Polyps are growths of soft jelly-like character: they arise from chronic in?ammation associated with allergic rhinitis, chronic sinusitis, asthma, and aspirin abuse. Large polyps can cause erosion of the nasal bones and should be surgically removed.
Bleeding (see HAEMORRHAGE).
Foreign bodies At ?rst these may not cause any symptoms, but in time they can cause obstruction of the affected nostril with a foul-smelling bloody discharge. The problem is common with small children who tend to push small objects into their noses. Foreign bodies require removal, sometimes in hospital. Anyone attempting to remove a foreign body should take care not to push it further into the nose.
Loss of sense of smell, or anosmia, may be temporary or permanent. Temporary anosmia is caused by conditions of the nose which are reversible, whereas permanent
anosmia is caused by conditions which destroy the OLFACTORY NERVES. Temporary conditions are those such as the common cold, or other in?ammatory conditions of the nasal mucosa or the presence of nasal polyps (see above). Permanent anosmia may follow in?uenzal NEURITIS or it may also follow injuries to the brain and fractures of the skull involving the olfactory nerves.
Injury to nose The commonest injury is a fracture of the nasal bones or displacement of the cartilage that forms the bridge of the nose. The nasal SEPTUM may also be displaced sideways by a lateral blow. Sporting activities, especially boxing and rugby football, are commonly a cause of nasal injury. If a fracture is suspected, or if there is substantial tissue swelling, an X-ray examination is necessary. Resetting a damaged bone should be done either immediately, before swelling makes surgery di?cult, or ten days or so later when the swelling has subsided. Results are usually good, ensuring a clear airway as well as a restored pro?le. It is not unusual for the cheek-bone to sustain a depressed fracture at the same time as the nose is broken. Careful assessment and prompt surgery are called for. (For more information on fractures, see under BONE, DISORDERS OF).
Rhinitis In?ammation of the MUCOUS MEMBRANE lining the nose. Symptoms include nasal discharge and obstruction, sneezing and sometimes pain in the sinuses. There are several types of rhinitis:
•Allergic – due to allergy to dust, pollen or other airborne particles. Also called hay fever, allergic rhinitis causes a runny nose, sneezing and local congestion. It affects up to 10 per cent of the population and is more common in people suffering from other allergic disorders such as asthma or eczema (see DERMATITIS). Skin tests help to identify the causative ALLERGEN which the sufferer can then try to avoid, although in the case of pollen this is di?cult. Decongestant drugs, ANTIHISTAMINE DRUGS, and CORTICOSTEROIDS may help, as can SODIUM CROMOGLYCATE inhaled regularly during the pollen season. A desensitisation course to a particular allergen sometimes provides long-term relief.
Atrophic rhinitis is caused by a deterioration in the nasal mucous membrane as a result of chronic bacterial infection, nasal surgery or AGEING. Symptoms include persistent nasal infection and discharge and loss of sense of smell. ANTIBIOTICS and, in some cases, OESTROGENS alleviate the symptoms.
Hypertrophic rhinitis results from repeated nasal infection, and is characterised by thickened nasal membranes and congestion of the nasal veins. Removal of thickened mucosa may help severe cases.
Vasomotor rhinitis occurs when the mucosa becomes oversensitive to stimuli such as pollutants, temperature changes or certain foods or medicines. It may occur as a result of emotional disturbances and is common in pregnancy.
Viral rhinitis occurs as a result of infection by the common cold virus; treatment is symptomatic. Sinusitis is sometimes a complication.... nose, disorders of
Associated with a number of conditions including PMT, low blood pressure, etc. Treatment: same as for MENIERE’S DISEASE. ... balance – disorders of
The bladder is a hollow muscular organ with a wall of smooth muscle. It stores urine received from the kidneys which is released via the urethra in an action known as micturition. Common disorders, see: ENEURESIS. FREQUENCY OF URINE. GRAVEL. HAEMATURIA. INCONTINENCE. STONE IN THE BLADDER. STRANGURY. STRICTURE. URETHRITIS. URINE – PAIN ON PASSING. ... bladder disorders
Mental illnesses characterized predominantly by marked changes in affect. Mood may vary over a period of time between mania (extreme elation) and severe depression. (See also manic–depressive illness.)... affective disorders
Loss of a finger, toe, or limb through injury. (See also microsurgery.)... amputation, traumatic
A range of developmental disorders, usually first diagnosed in childhood, that are characterized by obsessive behaviour and impaired communication and social skills (see autism; Asperger’s syndrome).... autism spectrum disorders
A personality disorder that falls between neurotic and psychotic levels. Mood changes are often rapid and inappropriate. Angry outbursts are common, as are impulsive, self-damaging acts such as gambling or suicide attempts.... borderline personality disorder
One of a group of tests used to assess the function of the heart in people who experience chest pain, breathlessness, or palpitations during exercise. The test establishes whether the patient has coronary artery disease. An ECG machine records the patterns of the heart’s electrical activity while the heart is stressed. This is usually achieved by the patient exercising on a treadmill or cycling. Specific changes in the electrical pattern as exercise levels increase indicate angina. Cardiac stress testing may be used in conjunction with radionuclide scanning to identify damaged areas of heart muscle.... cardiac stress test
Action taken to prevent CONCEPTION after sexual intercourse. The type of contraception may be hormonal, or it may be an intrauterine device (see below, and under CONTRACEPTION). Pregnancy after intercourse without contraception – or where contraception has failed as a result, for example, of a leaking condom – may be avoided with a course of ‘morning-after’ contraceptive pills. Such preparations usually contain an oestrogen (see OESTROGENS) and a PROGESTOGEN. Two doses should be taken within 72 hours of ‘unprotected’ intercourse. An alternative for the woman is to take a high dose of oestrogen on its own. The aim is to postpone OVULATION and to affect the lining of the UTERUS so that the egg is unable to implant itself.
Intrauterine contraceptive device (IUCD) This, in e?ect, is a form of post-coital contraception. The IUCD is a plastic shape up to 3 cm long around which copper wire is wound, carrying plastic thread from its tail. Colloquially known as a coil, it acts by inhibiting implantation and may also impair migration of sperm. Devices need changing every 3–5 years. Coils have generally replaced the larger, non-copper-bearing ‘inert’ types of IUCD, which caused more complications but did not need changing (so are sometimes still found in situ). They tend to be chosen as a method of contraception (6 per cent) by older, parous women in stable relationships, with a generally low problem rate.
Nevertheless, certain problems do occur with IUCDs, the following being the most common:
They tend to be expelled by the uterus in women who have never conceived, or by a uterus distorted by, say, ?broids.
ECTOPIC PREGNANCY is more likely.
They are associated with pelvic infection and INFERTILITY, following SEXUALLY TRANSMITTED DISEASES (STDS) – or possibly introduced during insertion.
They often produce heavy, painful periods (see MENSTRUATION), and women at high risk of these problems (e.g. women who are HIV positive [see AIDS/HIV], or with WILSON’S DISEASE or cardiac lesions) should generally be excluded – unless the IUCD is inserted under antibiotic cover.... post-coital contraception
Also called an autopsy (and less commonly, necropsy), this is an examination of a body to discover the causes of death. Such an examination is sometimes required by law. An unnatural death; a death occurring in suspicious circumstances; or a death when a doctor feels unable to complete a certi?cate about the cause – all must be reported to the CORONER (in Scotland, to the procurator ?scal). He or she may order an autopsy to be carried out as part of the inquiry into cause of death. Sometimes doctors may request the permission of relatives to perform a post-mortem so that they may discover something of value for the improvement of medical care. Relatives may refuse consent. (See also DEATH, CAUSES OF.)... post-mortem examination
A term introduced to PSYCHIATRY in 1980 after the Vietnam War. It is one of several psychiatric disorders that can develop in people exposed to severe trauma, such as a major physical injury, participation in warfare, assault or rape, or any event in which there is major loss of life or a threat of loss of life. Most people exposed to trauma do not develop psychiatric disorder; however, some develop immediate distress and, occasionally, the reaction can be delayed for many months. Someone with PTSD has regular recurrences of memories or images of the stressful event (‘?ashbacks’), especially when reminded of it. Insomnia, feelings of guilt and isolation, an inability to concentrate and irritability may result. DEPRESSION is very common. Support from friends and family is probably the best management, but those who do not recover quickly can be helped by antidepressants and psychological treatments such as COGNITIVE BEHAVIOUR THERAPY. Over the past few years, PTSD has featured increasingly in compensation litigation.... post-traumatic stress disorder (ptsd)
Disorders of the heart, blood vessels, and blood circulation (see heart disorders; arteries, disorders of; veins, disorders of).... cardiovascular disorders
Conditions affecting blood flow around the body (see arteries, disorders of; veins, disorders of).... circulation, disorders of
See intestine, disorders of.... colon, disorders of
Any abnormality of physical or mental function.... disorder
Stress fractures are comparatively common in sportspeople. They tend to occur when an undue amount of exercise is taken – that is, an amount of exercise which an individual is not capable of coping with in his or her state of training. The main initial feature is pain over the affected bone that has been subjected to abnormal physical stress. This is usually insidious in onset, and worse at night and during and after exercise. It is accompanied by tenderness, and a lump may be felt over the affected site. X-ray evidence only appears after several weeks. Treatment consists of rest, some form of external support, and in the initial stage ANALGESICS to deaden or kill the pain. (See also BONE, DISORDERS OF – Bone fractures.)... stress fractures
Conditions of the tongue At rest, the TONGUE touches all the lower teeth and is slightly arched from side to side. It has a smooth surface with a groove in the middle and an even but de?nite edge. It is under voluntary control and the tip can be moved in all directions.
Ankyloglossia or tongue-tie is a rare disorder in which the frenum or band connecting the lower surface of the tongue to the ?oor of the mouth is so short or tight that the tongue cannot be protruded. Surgery can remedy the defect. It is easy to overdiagnose and is not a common cause of di?culty in feeding at birth or speech defects in infancy.
Gross enlargement of the tongue can make speech indistinct or make swallowing and even breathing di?cult. This is known as macroglossia and may be such that the tongue is constantly protruded from the mouth. The cause may be CONGENITAL, as in severe cases of DOWN’S (DOWN) SYNDROME, or it may occur as a result of ACROMEGALY or be due to abnormal deposits as in AMYLOIDOSIS.
A marked tremor of the tongue when protruded may be seen in various neurological diseases, but may be caused by alcoholism.
After a STROKE involving the motor nerve centre, the control of one side of the tongue musculature will be lost. This will result in the protruded tongue pointing to the side of the body which is paralysed. The sense of taste on one side of the tongue may also be lost in some diseases of the brain and facial nerve.
The presence of fur on the tongue may be obvious and distressing. This is due to thickening of the super?cial layers of the tongue which may appear like hairs which trap food debris and become discoloured. Furring is common during fever and as a result of mouth-breathing and smoking.
In some conditions the tongue may appear dry, red and raw (GLOSSITIS). An in?amed beefy tongue is characteristic of pellagra, a disease caused by de?ciency of NICOTINIC ACID in the diet. A magenta-coloured tongue may be seen when there is a lack of RIBOFLAVIN.
Ulcers of the tongue are similar to those elsewhere in the mouth. The most common are aphthous ulcers which are small, red and painful and last for about ten days. They are associated with stress, mild trauma (such as from jagged teeth), and occasionally with folic acid and vitamin B12 de?ciency. Ulcers of the tongue are sometimes found in patients with chronic bowel disease.... tongue, disorders of
Conditions in which the normal process of erection of the penis is disrupted. They include total or partial failure to attain or maintain erection (see impotence), persistent erection in the absence of sexual desire (see priapism), and curving of the penis during erection (see chordee).... erection, disorders of
Stress is known as a general state of fatigue and exhaustion due to sleeplessness or other causes such as sitting in one position for too long or having a lot to deal with.
Stress is both a physical and a mental disorder, triggered by the body exhaustion due to hard working. The best way to deal with stress is to take some time off from school or work, but if you cannot afford that luxury, try a natural remedy.
Some say that stress implies having too little time to solve too many problems while already being exhausted. At times, stress accumulations may lead to faints, blackouts or severe mental problems, such as paranoia or schizophrenia.
How Tea for Stress Works
A Tea for Stress’ main purpose is to make your body release enough endorphins to create a state of relaxation. These teas contain nutrients, enzymes and volatile oils capable to induce joy and happiness.
Many of these teas can contain tannins, which is a substance whose main purpose is to calm the affected areas and nourish the nervous system. If you’re feeling down and stress is the main cause, try a Tea for Stress and enjoy its organic benefits!
Efficient Tea for Stress
When choosing a Tea for Stress, you need to make sure the one you’re picking is both safe and very effective, in order to avoid other unnecessary complications. If you’re thinking about taking a tea and you don’t know which one fits your needs best, here are some guidelines:
- Chamomile Tea – also used as an adjuvant in the pharmaceutical and the cosmetic industry, Chamomile Tea can treat a number of affections, such as sore throat, flu, colds, pleurisy and pulmonary edema. Also, Chamomile is one of the safest and the most popular stress treatments and it can be found in almost any teashop or grocery store!
- Mint Tea – contains an active ingredient called menthol which is responsible for this tea’s curative properties. This is a very important Tea for Stress, since its action doesn’t imply only the stress triggers, but also a large variety of affections, such as respiratory problems and ailments of the digestive tract (diarrhea, upset stomach, gastritis). This tea is also one hundred percent safe; just don’t take more than 6 cups per day!
- Ginseng Tea – probably the most effective Tea for Stress, Ginseng Tea is also the most dangerous one. Make sure you don’t drink more than a cup per day for a short amount of time and that in case you’re experiencing some unusual reactions, you’ll talk to a specialist right away!
- Lavender Tea – used for its fragrance and curative properties, lavender was used by the ancient Romans as a sleeping aid and a good relaxer. Modern medicine, however, found out that a cup of Lavender Tea per day will destroy both the stress and the tension in your body. Besides, you can find it almost anywhere!
Tea for Stress Side Effects
When taken properly, a Tea for Stress is generally safe. However, high dosages may lead to a number of health complications, such as diarrhea, constipation, upset stomach, vomiting and ulcers. Just make sure you follow the instructions.
To gather more information, talk to a specialist before making any move. If you’re pregnant, breastfeeding, on blood thinners or anticoagulants or if you’re preparing for a major surgery, it’s best to talk to your doctor before taking one of these teas.
Other than that, give any Tea for Stress a try and enjoy its wonderful benefits responsibly!... tea for stress
A group of injuries resulting from overuse of a part of the limb. One example is TENNIS ELBOW (epicondylitis) caused by in?ammation of the tendon attaching the extensor muscles of the forearm to the humerus because of overuse of the muscles. Overuse of the shoulder muscles may cause in?ammation and pain around the joint. Perhaps the best-known example is repetitive strain injury (RSI) affecting keyboard workers and musicians: the result is pain in and weakness of the wrists and ?ngers. This has affected thousands of people and been the subject of litigation by employees against their employers. Working practices have been improved and the complaint is now being recognised at an early stage. Treatment includes PHYSIOTHERAPY, but some sufferers have been obliged to give up their work.... upper limb disorders
A term for any illness in which there is no evidence of organic disturbance even though physical performance is impaired.... functional disorders
Unlike migraines, stress is an accumulation of disorganized pain that takes your body by surprise, inducing a state of general fatigue and irritation.
Although migraines teas could also be used as a remedy for stress, it is possible that their effect on your general health to pass unnoticed. Since stress has a more profound characteristic, it’s best if you choose one of the following teas:
- Green Tea (thanks to its calming amino acid which can be found in the leaves)
- Kava Tea (induces a state of calmness without having the side effects of a traditional drug).
How Teas for Stress Work
First of all, if you’ve decided to go with Teas for Stress instead of traditional drugs, you need to know that, although the amount of side effects is very low, you still have to pay attention to the amount of tea you’re taking.
Thanks to their main ingredients, which include tannin, caffeine, proteins, carbohydrates and vitamin C, their main responsibility is restoring your general well-being by enhancing the number of anti bodies and by fighting all pain triggers.
Actually, these Teas for Stress focus on any type of fatigue accumulation that shouldn’t appear in your system. The enzymes contained have anti-inflammatory properties which can lower your nervous deviations and increase your blood flow in order to wash away the unwanted microbes.
Efficient Teas for Stress
When you’re looking for Teas for Stress, you have plenty oh choices. Aside from Green Tea and Kava Tea, you can also add the following teas to your medical cabinet:
- Chamomile Tea – thanks to its curative properties, this remedy can bring you calmness without having to worry about any side effects. Its main plus consists in the fact that it is one hundred percent safe.
- Valerian Tea – also used as a diuretic and a pain reliever, Valerian Tea is probably the most notorious name in this Teas for Stress list. Ancient Romans used it as a sedative and sleep aid. All these curative properties are generated by a substance called valepotriates, which can be found in both Valerian leaves and flowers.
- Mint Tea – one of the world’s greatest panacea and a good replacer for your morning coffee, Mint Tea is the most popular medical treatment when it comes to stress too. When looking for Teas for Stress, you don’t have to go too far. If you have Mint in your kitchen, just reach for it and enjoy its wonderful benefits!
- Ginseng Tea – you might find Ginseng a bit strong for your taste, but its action is strong and quickly. It is said that Ginseng clears out the exhaust and stress immediately, thanks to a series of natural enzymes. If the taste seems a bit unpleasant to you, just add a small amount of honey and lemon.
Teas for Stress Side Effects
It is important to remember that all medical treatments should be taken according to their specifications and that exceeding the number of teacups per day might cause you severe damages. However, when it comes to these Teas for Stress, the only thing you need to be careful about is the time period in which you take them.
If you know you suffer from chronic stress symptoms, drink Mint Tea or Chamomile Tea, since they have no side effects. Aside from being a good help in cases of stress, Ginger Tea may cause diarrhea, nausea and other problems, so you need to pay attention to your treatment.
Also, only take the tea are long as you feel sick and don’t make a habit out of it!
Other than that, there’s no reason not to give these Teas for Stress a try and enjoy their natural benefits wisely!... teas for stress
Usually associated with some loss of sensation and power in another part of the body. Taste, smell, hearing, sight and movement may be affected. The following are some of the disorders that may affect the brain. Each has a separate entry in this book.
Abscess, Alzheimer’s Disease, anoxia (oxygen starvation), coma, concussion, haemorrhage, Down’s syndrome, epilepsy, tumour, hydrocephalus (water on the brain), meningitis, multiple sclerosis, stroke (rupture of blood vessel), spina bifida, syphilis (general paralysis of the insane), sleepy sickness.
Poor circulation through the brain due to hardening of the arteries: Ginkgo, Ginseng. Ginseng stimulates the hypothalmic/pituitary axis of the brain and favourably influences its relationship with the adrenal glands.
Congestion of the brain – Cowslip (Boerwicke). Irritability of brain and spine – Hops. Oats. Inflammation of the brain (encephalitis) as in viral infection, poliomyelitis, rabies, sleepy sickness, etc: Echinacea, Passion flower, Skullcap and Lobelia. Gelsemium acts as a powerful relaxant in the hands of a practitioner: Tincture BPC (1973): dose 0.3ml.
Brain storm from hysteria, locomotor ataxia, etc – Liquid Extract Lobelia: 5ml teaspoon in water when necessary (Dr Jentzsch, 1915, Ellingwood) Supplement with Zinc, Vitamins C and E.
Blood clot, thrombosis: Yarrow. Neurasthenia: Oats, Basil, Hops.
Brain fag and jet-lag: Chamomile, Skullcap, Oats, Ginseng, Ginkgo.
Tumour may be present years before manifesting: Goldenseal.
Mental state: depression, anxiety, schizophrenia.
Tea. Formula. Skullcap, Gotu Kola and German Chamomile; equal parts. 1 heaped teaspoon to each cup water gently simmered 10 minutes. Strain. 1 cup thrice daily.
Unspecified tensive state. Formula. Tinctures. Hops 1; Passion flower 2; Valerian 2. Dose: 2 teaspoons thrice daily until diagnosis is concluded.
Unspecified torpor. Formula. Tinctures. Ginseng 1; Kola 1; Capsicum quarter. 2 teaspoons in water thrice daily until diagnosis is concluded.
Brain weakness in the elderly: Ginkgo. See: ALZHEIMER’S DISEASE.
Fluid on the brain: see HYDROCEPHALUS.
Abscess of the brain: see ABSCESS.
Brain restoratives. Black Haw, True Unicorn root, Galangal, Oats, Oatstraw, False Unicorn root, Kola, Hops. Vitamin B6. Magnesium.
Cerebral thrombosis. See entry.
Note: Cold water may help victims to survive: rapid loss of body heat protects the brain. (Child Health Department, University of Wales)
Treatment by or in liaison with general medical practitioner or hospital specialist. ... brain disorders
The principal gallbladder disorder is gallstones, which are common and often symptomless. Attempts by the gallbladder to expel the stones can cause biliary colic. If a gallstone becomes stuck in the gallbladder outlet, acute cholecystitis may develop. Occasionally, this leads to a painful condition called empyema of the gallbladder. If a gallbladder is empty when a stone obstructs its outlet, it may fill with mucus, resulting in a mucocele. Gallbladder cancer is rare.... gallbladder, disorders of
Poor circulation may be due to a number of disorders including varicose veins, high or low blood pressure, arterio-sclerosis, thrombosis, phlebitis, chilblains, anaemia, weak heart. A common cause is auto-toxaemia, calling for blood tonics and agents to assist elimination of wastes and poisons via the kidneys, skin and bowels.
Other causes requiring specific treatment are: thickening and narrowing of blood vessels, diabetes, Buerger’s disease, Raynaud’s disease (spasm of the arterioles and veins), arteritis. See appropriate entries.
As a protection against these diseases Garlic becomes increasingly popular. Control of blood fats through diet and exercise necessary.
Alternatives. Cayenne, Ginger, Hawthorn berries, Horseradish, Mustard, Prickly Ash bark, Buckwheat, Dandelion, Lime flowers, Mistletoe, Rosemary, Yarrow, Ginkgo.
Tea: Lime flowers, Hawthorn berries, Yarrow. Equal parts. Mix. Ginger, quarter part (or pinch of Red Pepper). Mix. 1-2 teaspoons to each cup water. Bring to boil. Remove vessel when boiling point is reached. Dose: 1 cup 2-3 times daily.
Tablets or capsules: Prickly Ash, Hawthorn, Mistletoe, Ginkgo.
Formula. Hawthorn 2; Yarrow 2; Prickly Ash 1; Ginger quarter. Dose: Powders: 500mg (two 00 capsules or one-third teaspoon). Liquid extracts: 1 teaspoon. Tinctures 2 teaspoons 2-3 times daily.
Practitioner. Liquid extracts: Hawthorn 2; Lily of the Valley 2; Prickly Ash 1; Tincture Capsicum (one- tenth part). Dose: 30-60 drops in water or honey, 2-3 times daily.
Diet and Supplements. See: DIET – HEART AND CIRCULATION. ... circulatory disorders
Low fat, low salt, high fibre. Dairy-free (no milk, cream, cheese, eggs). Soya milk is more suitable for children and adults than cow’s milk and provides protein, calories, calcium and vitamins. Polyunsaturates: oils of safflower, corn, Soya, sunflower seed, etc which are rich in essential fatty acids, low levels of which are frequently found in the blood of those with chronic skin disorders. Evening Primrose oil is a rich source of EFAs. Gluten-free diet has proved successful in some cases.
Accept. Goat’s milk, yoghurt, eggs – twice weekly. The high potassium and low salt content of bananas help reduce itching. Lecithin. Oily fish. Purslane is a non-fish source of EPA and suitable for the vegetarian approach. Cottage cheese. Pumpkin seeds as a source of zinc. Dandelion coffee. Artichoke: such as Schoenenberger plant juice. Salad dressing: emulsify 1 teaspoon Cider vinegar to each 2 teaspoons safflower seed oil.
Reject: Fried and greasy foods, pastries, chocolates, sweets, ice cream, spicy foods, seasoning, sausage meats, white flour products, white sugar products, alcoholic drinks, meat from the pig (ham, pork, bacon), peppers, horseradish, condiments. Powdered kelp in place of salt, powdered garlic or celery.
Foods known to contain artificial colours and preservatives. All soft drinks, except those made at home from fresh fruits or raw vegetables; coffee, strong tea, oranges. Cola drinks, chocolate, milk, cream, cheese, whey.
Supplement. Beta carotene.
Study. A flare-up can be caused by nuts, jams, fruits, artificially coloured or flavoured foods. (British Journal of Dermatology, 110, 457, (1984)) ... diet - skin disorders
A set of congenital defects caused by failure of the thyroglossal duct to disappear during embryonic development. In embryos, this duct runs from the base of the tongue to the thyroid gland. Abnormal development may cause the duct to persist in its entirety or partly as a cyst. A cyst usually becomes infected and swollen, which may lead to formation of a fistula. The cyst and any remaining parts of the duct are removed.... thyroglossal disorders
Common disorders affecting veins include varicose veins, deep vein thrombosis (see thrombosis, deep vein), and thrombophlebitis.... veins, disorders of
Disorders of the arteries may take the form of abnormal narrowing (which reduces blood flow and may cause tissue damage), complete obstruction (which may cause tissue death), or abnormal widening and thinning of an artery wall (which may cause rupture of the blood vessel).
Atherosclerosis, in which fat deposits build up on artery walls, is the most common arterial disease.
It can involve arteries throughout the body, including the brain (see cerebrovascular disease), heart (see coronary artery disease), and legs (see peripheral vascular disease).
Atherosclerosis is the main type of arteriosclerosis, a group of disorders that cause thickening and loss of elasticity of artery walls.
Hypertension is another common cause of thickening and narrowing of arteries, and it increases the risk of a stroke or kidney failure.
Arteritis is inflammation of artery walls that causes narrowing and sometimes blockage.
Aneurysm is ballooning of an artery wall caused by the pressure of blood flowing through a weakened area.
Thrombosis occurs when a blood clot forms in a blood vessel, causing obstruction of the blood flow.
Blockage of an artery by a fragment of blood clot or other material travelling in the circulation is called an embolism.
Raynaud’s disease is a disorder involving intermittent spasm of small arteries in the hands and feet, usually due to cold.... arteries, disorders of
Sex-linked genetic disorders in which the abnormal gene or genes (the causative factors) are located on the X chromosome. Almost all affected people are males. Haemophilia, fragile X syndrome. and colour vision deficiency are examples.... x-linked disorders
(mood disorder) any psychiatric disorder featuring abnormalities of mood or emotion (*affect). The most serious of these are *depression and *mania. Other affective disorders include *SAD (seasonal affective disorder).... affective disorder
a psychiatric disorder in infants and young children resulting from *institutionalization, poor parenting, emotional neglect, or *child abuse. Affected children may be withdrawn or aggressive, and fearful or attention-seeking and indiscriminately friendly. Treatment requires the provision of stable caring adults as parents over a long period of time.... attachment disorder
(auditory neuropathy, auditory dyssynchrony) a form of hearing loss characterized by normal cochlear function as measured by *otoacoustic emissions or detection of *cochlear microphonics but abnormal or absent *middle ear reflexes and abnormal *auditory brainstem responses.... auditory neuropathy spectrum disorder
(APD, central auditory processing disorder, CAPD) a series of conditions characterized by difficulty in hearing and processing auditory information, especially in poor acoustic environments, despite normal or near-normal ear function. It may be due to genetic factors, maturational delay in the central nervous system, or focal abnormalities of the central nervous system (such as tumours). Treatments include *hearing therapy, *auditory skills training, educational support, use of *assistive listening devices, and training with computerized therapy tools.... auditory processing disorder
thought disturbance characterized by disconnected thinking, manifested by disturbed speech in which the patient’s train of thought cannot be followed. Formal thought disorder was first described by the German psychiatrist Kurt Schneider and later elaborated on by various authors. Looking for evidence of formal thought disorder is part of every *mental state examination. It includes *loosening of associations, omissions, and *knight’s-move thinking.... formal thought disorder
a condition in which a patient complains of symptoms for which no physical cause can be found. Such a condition is frequently an indication of a psychiatric disorder. Compare organic disorder.... functional disorder
see incontinence.... genuine stress incontinence
Disorders resulting from abnormalities in any of the components of blood or from infection. Disorders include types of anaemia, polycythaemia, bleeding disorders, and unwanted clot formation (thrombosis), hypoalbuminaemia (albumin deficiency) and agammaglobulinaemia (deficiency of gamma-globulin). Blood disorders such as sickle cell anaemia, thalassaemia, and haemophilia are inherited. Bone marrow cancers that affect production of blood components include leukaemia, polycythaemia vera, and multiple myeloma. Blood poisoning is usually due to septicaemia or a toxin such as carbon monoxide. Some drugs can cause blood abnormalities as a side effect. (See also anaemia, haemolytic; anaemia, iron-deficiency; anaemia, megaloblastic; malaria; hyperbilirubinaemia.)... blood, disorders of
Disorders affecting the breast that are mostly minor and respond readily to treatment. The most important causes of problems are infection, such as mastitis, tumours, and hormonal changes. Breast cysts, fibroadenomas, other noncancerous tumours, or, more rarely, breast cancer may occur. Breast pain and tenderness is common just before menstruation or when a woman is taking hormones. Before menstruation, breasts may become bigger and lumpy. Such lumps shrink when menstruation is over. Hormonal disorders may, rarely, cause galactorrhoea (abnormal milk production). In men, gynaecomastia may result from hormonal disturbance or treatment with certain drugs.... breast, disorders of the
a condition in which a person struggles to discard useless or worn-out possessions, acquires an excessive number of such items, and stores them in a chaotic manner resulting in unmanageable clutter. The items are nearly always of little or no monetary value, although valuable items are often found mixed indiscriminately with the rest. Hoarding disorder was included in DSM-5 in 2013 as a new disorder and has been considered for introduction in ICD-11.... hoarding disorder
see attention-deficit/hyperactivity disorder.... hyperkinetic disorder
see hypochondria.... illness anxiety disorder
a group of inherited conditions transmitted through mitochondrial DNA (see mitochondrion), which can affect any organ and can present at any age. Most of these conditions are very rare; examples of those that are less rare include *Leigh syndrome, congenital *lactic acidosis, *MELAS, and Pearson syndrome.... mitochondrial disorders
a condition marked by a persistent delusion not associated with any other *mental illness. It is often of a *paranoid or persecutory nature, but can have any delusional content. Treatment is often difficult because patients commonly lack insight and refuse to try medication. When compliance can be achieved, the majority of patients respond well to antipsychotic medication.... monodelusional disorder
a repetitive and persistent pattern of aggressive or otherwise antisocial behaviour. It is usually recognized in childhood or adolescence and may include such behaviours as unusually frequent and severe temper tantrums, arguing with adults, defying rules, being angry and resentful, cruelty to animals, lying or breaking promises, use of weapons, sexual aggression, destroying property, truancy, bullying, and general delinquency. It can lead to *antisocial personality disorder. Treatment is usually with *behaviour therapy or *family therapy, although there is some debate as to whether it should be seen as a social rather than a medical problem.... conduct disorder
a *personality disorder characterized by a tendency to act impulsively without consideration of the consequences, unpredictable and capricious mood, a tendency towards outbursts of emotion, inability to control behavioural explosions, quarrelsome behaviour, and conflict with others. There is an impulsive type, with particular emphasis on impulsivity and quarrelsome behaviour, especially when criticized; and a borderline type, with an emphasis on disturbance and uncertainty about self-image (including sexual preference), liability to become involved in intense and unstable relationships, excessive efforts to avoid abandonment, recurrent threats or acts of self-harm, and chronic feelings of emptiness. Treatments include cognitive analytical therapy (see cognitive therapy), *antipsychotic medication, and occasionally *SSRIs and *lithium. In DSM-5 the disorder is called borderline personality disorder.... emotionally unstable personality disorder
a pattern of behaviour characterized by impaired control over digital gaming, increased priority given to gaming over other interests and activities, and continuation or escalation of gaming despite negative consequences. For gaming disorder to be diagnosed, the behaviour pattern must be of sufficient severity to result in significant impairment of personal, family, social, educational, occupational, or other important areas of functioning and would normally have been evident for at least 12 months. Gaming disorder was first introduced as a diagnostic entity in ICD-11 in 2018. It is estimated that around 2% of people who regularly play digital games are affected. Treatment follows the principles of other *addiction treatments.... gaming disorder
an important but potentially dangerous test of anterior pituitary function involving the deliberate induction of a hypoglycaemic episode with injected insulin and the subsequent measurement of plasma cortisol and growth hormone at regular intervals over the next three hours. The stress of the hypoglycaemia should induce a rise in the levels of these hormones unless the anterior pituitary or the adrenal glands are diseased. The test can induce epileptic seizures or angina in those with a predisposition and should not be performed in susceptible individuals. It is often combined with the thyrotrophin-releasing hormone (TRH) test and the gonadotrophin-releasing hormone (GnRH) test in what is known as the triple test (or dynamic pituitary function test).... insulin stress test
see affective disorder.... mood disorder
(MPD) a group of diseases in which there is excessive production of blood cells in the bone marrow. Myeloproliferative disorders include *polycythaemia vera, essential *thrombocythaemia, idiopathic *myelofibrosis, and chronic *myeloid leukaemia.... myeloproliferative disorders
(NEAD) a condition characterized by episodes that resemble epileptic seizures but lack the abnormal electrical activity in the brain typically associated with *epilepsy. See non-epileptic seizure.... non-epileptic attack disorder
a disorder associated with changes in the structure of an organ or tissue. Compare functional disorder.... organic disorder
Latin: after death. See autopsy.... post mortem
insidious numbness in muscles that develops 15–20 years after an attack of *poliomyelitis; the muscles may or may not have been previously affected. It may be caused by loss of nerve cells that have been under greater strain than normal as a result of the polio; there is no evidence of reactivation of the poliovirus. The syndrome also includes other symptoms, such as fatigue and pain, which may be due to secondary mechanical causes.... post-polio syndrome
n. (in radiology) the electronic manipulation of digitally acquired images (see digitization) following an examination in order to improve diagnostic accuracy or to improve and optimize visualization.... post-processing
a pregnancy that has gone beyond 42 weeks gestation or 294 days from the first date of the last menstrual period.... post-term pregnancy
a personality disorder characterized by cold aloof feelings, eccentricities of behaviour, odd ways of thinking and talking, and occasional short periods of intense illusions, hallucinations, or delusion-like ideas.... schizotypal personality disorder
see SAD.... seasonal affective disorder
(SDB) abnormal patterns of respiration seen during sleep. *Obstructive sleep apnoea is the most common SDB; other types include central *sleep apnoea, such as *Cheyne–Stokes respiration.... sleep disordered breathing
an extreme fear of humiliating or embarrassing oneself in social situations (e.g. dating, parties, eating with other people, asking questions, etc.). Symptoms include shaking, blushing, gastrointestinal disturbances, sweating, and other signs of anxiety; people with social anxiety disorder may avoid social situations. Treatment includes cognitive behavioural therapy, occupational therapy, and medication (e.g. antidepressants, anxiolytics, or beta blockers).... social anxiety disorder
in DSM-5, a psychiatric disorder characterized by one or more chronic somatic symptoms about which patients are excessively concerned, preoccupied, or fearful, formerly called somatization disorder. These fears and behaviours cause significant distress and dysfunction, and although patients may make frequent use of health-care services, they are rarely reassured and often feel their medical care has been inadequate. The disorder can disrupt personal and family relationships and lead to unnecessary medical and surgical treatment. It is sometimes treated with *cognitive behavioural therapy, *psychotherapy, and/or *antidepressants.... somatic symptom disorder
a group of disorders in which there is a history of repeated physical complaints with no physical basis. They include *somatic symptom disorder and illness anxiety disorder (see hypochondria).... somatoform disorders
see incontinence.... stress incontinence
an investigation to seek evidence of cardiac *ischaemia. The heart is stressed by exercise or by the administration of an intravenous drug that increases heart rate (i.e. mimicked exercise). Ischaemia may then be detected by electrocardiography (stress ECG or exercise ECG), *echocardiography (showing the development of impaired function in areas of heart muscle that are ischaemic), *myocardial perfusion scan, or cardiac MRI.... stress test
gastric or duodenal ulcers that can be associated with physiological stress from severe head injury (Cushing’s ulcers) or major burns (Curling’s ulcers).... stress ulcers
(TBI) injury to the brain due to external force, such as occurs following falls, road traffic accidents, and violence. It is a major cause of death and chronic disability worldwide, especially in young males.... traumatic brain injury
a fever resulting from a serious injury.... traumatic fever
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