Prednisolone Health Dictionary

(Wall.) Parker.

Synonym: Amoora rohituka W. and A.

Family: Meliaceae.

Habitat: The sub-Himalayas tracts, Sikkim, Assam, Bengal, western Ghats and the Andamans.

Ayurvedic: Rohitaka, Daadima- chhada, Daadima-pushpaka, Plihaghna. Tecoma undulata G. Don., Bignoniaceae, is also equated with Rohitaka.

Siddha/Tamil: Malampuluvan.

Action: Bark—strongly astringent, used in the diseases of the liver and spleen, and for tumours, enlarged glands. Seed oil—used in muscular pains and rheumatism. All parts of the plant exhibit pesticidal activity. Seed extract—antibacterial, antifungal.

An aqueous extract of the bark, when injected i.p. in normal guinea pigs, showed reduction in absolute lymphocyte count and an increase in spleen weight. The bark appears to be an effective immunosuppressive drug similar to prednisolone.

The stembark contains a limonoid, ammorinin and a saponin, poriferas- terol-3-rhamnoside.... aphanamixis polystachya

Linn.

Family: Aristolochiaceae. English: European Birthwort. Unani: Zaraawand Taweel.

Action: Oxytocic, abortifacient, emmenagogue.

Aristolochic acid and its Me es- ter—strongly abortifacient, showed damage to liver and kidney. Roots— anti-oestrogenic. A cytotoxic lignan, savinin, has been isolated from the roots.

Aristolochic acid also has an effect against adenosarcoma and HeLa cells in culture; however, it is suspected to be carcinogenic.

Aristolochia extracts show a pronounced enhancement of phagocytosis by leucocytes, granulocytes and peritoneal macrophages, due to the presence of aristolochic acids.

Tardolyt-coated tablets, which contain 0.3 mg of aristolochic acid, increase phagocytosis in healthy men.

Aristolochic acid also exhibits reduction of some of the toxic effects of prednisolone, chloramphenicol and tetracycline in experiments in vitro, and a reduction in the rate of recurrent herpes lesions in vivo.... aristolochia longa

One of the CORTICOSTEROIDS which has an action comparable to that of PREDNISOLONE, but in much lower dosage. In the form of betamethasone valerate it is used as an application to the skin as an ointment or cream.... betamethasone

An early corticosteroid drug (see CORTICOSTEROIDS), now obsolete and replaced by PREDNISOLONE and HYDROCORTISONE.... cortisone

A CORTICOSTEROIDS derivative. As an antiin?ammatory agent it is approximately 30 times as e?ective as cortisone and eight times as e?ective as prednisolone. On the other hand, it has practically none of the salt-retaining properties of cortisone.... dexamethasone

A rare in?ammation of the skin which causes universal itching. The skin is red, thickened and scaly. It is also called generalised exfoliative dermatitis (see SKIN, DISEASES OF). It may complicate chronic eczema (see DERMATITIS) or PSORIASIS, particularly in men, in the second half of life. It may also result from HYPERSENSITIVITY to a drug, such as gold injections used in RHEUMATOID ARTHRITIS. Rarely, it may be a manifestation of T-cell LYMPHOMA.

Universal in?ammation of the skin may cause heart failure, particularly in elderly people with pre-existing heart disease. It may lead to HYPOTHERMIA due to excessive heat loss from the skin and protein de?ciency caused by the shedding of large quantities of skin scales containing keratin. Rarely, these complications can be fatal.

Treatment depends on the cause, but in eczematous erythroderma, oral CORTICOSTEROIDS (PREDNISOLONE) in full dosage may be needed.... erythroderma

Also known as croup. An acute infection of the respiratory tract in infants and young children, usually caused by parain?uenza virus. The onset is variable but the croupy cough and stridulous breathing usually occur a few days after the onset of a viral upper-respiratory-tract infection. A harsh barking cough is typical of the condition. The majority of affected children can be treated with HUMIDIFICATION and a single dose of inhaled corticosteroid (budesonide – see CORTICOSTEROIDS) or a single day’s treatment with oral prednisolone. Severe croup can cause serious breathing problems when the child should be referred for urgent specialist assessment, and hospitalisation is preferable in all cases. Rarely, some form of intervention is necessary and this will either be in the form of endotracheal intubation or of a tracheostomy.... laryngo-tracheo-bronchitis

A mineralcorticoid drug (see CORTICOSTEROIDS) with an action comparable to that of PREDNISOLONE, but e?ective at a somewhat lower dose.... methylprednisolone

A form of rheumatism characterised by gross early-morning sti?ness, which tends to ease o? during the day, and pain in the shoulders and sometimes around the hips. It affects women more than men, and is rare under the age of 60. The cause is still obscure. It responds well to PREDNISOLONE, but treatment may need to be long continued. On the other hand the condition is not progressive and does not lead to disability.... polymyalgia rheumatica

This corticosteroid drug has a similar level of glucocorticoid activity as PREDNISOLONE and is converted to prednisolone in the liver. Though prednisone is still in use, prednisolone is the most commonly used oral corticosteroid for long-term anti-in?ammatory treatment. (See CORTICOSTEROIDS; GLUCOCORTICOIDS.)... prednisone

A group of drugs that reduce the activity of the immune system. They include azathioprine, ciclosporin, cyclophosphamide, methotrexate, and prednisolone. Immunosuppressants are given to prevent rejection after transplant surgery and to slow the progress of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus.

The drugs work by suppressing the production and activity of white blood cells called lymphocytes. Side effects vary, but all the drugs increase the risk of infection and of the development of certain cancers.... immunosuppressant drugs

The generic term for the group of hormones produced by the ADRENAL GLANDS, with a profound e?ect on mineral and glucose metabolism.

Many modi?cations have been devised of the basic steroid molecule in an attempt to keep useful therapeutic effects and minimise unwanted side-effects. The main corticosteroid hormones currently available are CORTISONE, HYDROCORTISONE, PREDNISONE, PREDNISOLONE, methyl prednisolone, triamcinolone, dexamethasone, betamethasone, paramethasone and de?azacort.

They are used clinically in three quite distinct circumstances. First they constitute replacement therapy where a patient is unable to produce their own steroids – for example, in adrenocortical insu?ciency or hypopituitarism. In this situation the dose is physiological – namely, the equivalent of the normal adrenal output under similar circumstances – and is not associated with any side-effects. Secondly, steroids are used to depress activity of the adrenal cortex in conditions where this is abnormally high or where the adrenal cortex is producing abnormal hormones, as occurs in some hirsute women.

The third application for corticosteroids is in suppressing the manifestations of disease in a wide variety of in?ammatory and allergic conditions, and in reducing antibody production in a number of AUTOIMMUNE DISORDERS. The in?ammatory reaction is normally part of the body’s defence mechanism and is to be encouraged rather than inhibited. However, in the case of those diseases in which the body’s reaction is disproportionate to the o?ending agent, such that it causes unpleasant symptoms or frank illness, the steroid hormones can inhibit this undesirable response. Although the underlying condition is not cured as a result, it may resolve spontaneously. When corticosteroids are used for their anti-in?ammatory properties, the dose is pharmacological; that is, higher – often much higher – than the normal physiological requirement. Indeed, the necessary dose may exceed the normal maximum output of the healthy adrenal gland, which is about 250–300 mg cortisol per day. When doses of this order are used there are inevitable risks and side-effects: a drug-induced CUSHING’S SYNDROME will result.

Corticosteroid treatment of short duration, as in angioneurotic OEDEMA of the larynx or other allergic crises, may at the same time be life-saving and without signi?cant risk (see URTICARIA). Prolonged therapy of such connective-tissue disorders, such as POLYARTERITIS NODOSA with its attendant hazards, is generally accepted because there are no other agents of therapeutic value. Similarly the absence of alternative medical treatment for such conditions as autoimmune haemolytic ANAEMIA establishes steroid therapy as the treatment of choice which few would dispute. The use of steroids in such chronic conditions as RHEUMATOID ARTHRITIS, ASTHMA and DERMATITIS needs careful assessment and monitoring.

Although there is a risk of ill-effects, these should be set against the misery and danger of unrelieved chronic asthma or the incapacity, frustration and psychological trauma of rheumatoid arthritis. Patients should carry cards giving details of their dosage and possible complications.

The incidence and severity of side-effects are related to the dose and duration of treatment. Prolonged daily treatment with 15 mg of prednisolone, or more, will cause hypercortisonism; less than 10 mg prednisolone a day may be tolerated by most patients inde?nitely. Inhaled steroids rarely produce any ill-e?ect apart from a propensity to oral thrush (CANDIDA infection) unless given in excessive doses.

General side-effects may include weight gain, fat distribution of the cushingoid type, ACNE and HIRSUTISM, AMENORRHOEA, striae and increased bruising tendency. The more serious complications which can occur during long-term treatment include HYPERTENSION, oedema, DIABETES MELLITUS, psychosis, infection, DYSPEPSIA and peptic ulceration, gastrointestinal haemorrhage, adrenal suppression, osteoporosis (see BONE, DISORDERS OF), myopathy (see MUSCLES, DISORDERS OF), sodium retention and potassium depletion.... corticosteroids

The rash produced by the sudden release of HISTAMINE in the skin. It is characterised by acute itching, redness and wealing which subsides within a few minutes or may persist for a day or more. Depending upon the cause, it may be localised or widespread and transient or constantly recurrent over years. It has many causes.

External injuries to the skin such as the sting of a nettle (‘nettle-rash’) or an insect bite cause histamine release from MAST CELLS in the skin directly. Certain drugs, especially MORPHINE, CODEINE and ASPIRIN, can have the same e?ect. In other cases, histamine release is caused by an allergic mechanism, mediated by ANTIBODIES of the immunoglobulin E (IgE) class – see IMMUNOGLOBULINS. Thus many foods, food additives and drugs (such as PENICILLIN) can cause urticaria. Massive release of histamine may affect mucous membranes – namely the tongue or throat – and can cause HYPOTENSION and anaphylactic shock (see ANAPHYLAXIS) which can occasionally be fatal.

Physical factors can cause urticaria. Heat, exercise and emotional stress may induce a singular pattern with small pinhead weals, but widespread ?ares of ERYTHEMA, activated via the AUTONOMIC NERVOUS SYSTEM (CHOLINERGIC urticaria) may also occur.

Rarely, exposure to cold may have a smiilar e?ect (‘cold urticaria’) and anaphylactic shock following a dive into cold water in winter is occasionally fatal. The diagnosis of cold urticaria can be con?rmed by applying a block of ice to the arm which quickly induces a local weal.

Transient urticaria due to rubbing or even stroking the skin is common in young adults (DERMOGRAPHISM or factitious urticaria). More prolonged deep pressure induces delayed urticaria in other subjects. IgE-mediated urticaria is part of the atopic spectrum (see ATOPY, and SKIN, DISEASES OF – Dermatitis and eczema). Allergy to peanuts is particularly dangerous in young atopic subjects. Notwithstanding the many known causes, chronic urticaria of unknown cause is common and may have an autoimmune basis (see AUTOIMMUNE DISORDERS).

Treatment Causative factors must be removed. Topical therapy is ine?ective except for the use of calamine lotion, which reduces itching by cooling the skin. Oral ANTIHISTAMINES are the mainstay of treatment and are remarkably safe. Rarely, injection of ADRENALINE is needed as emergency treatment of massive urticaria, especially if the tongue and throat are involved, following by a short course of the oral steroid, prednisolone.

Angio-oedema is a variant of urticaria where massive OEDEMA involves subcutaneous tissues rather than the skin. It may have many causes but bee and wasp stings in sensitised subjects are particularly dangerous. There is also a rare hereditary form of angio-oedema. Acute airway obstruction due to submucosal oedema of the tongue or larynx is best treated with immediate intramuscular adrenaline and antihistamine. Rarely, TRACHEOSTOMY may be life-saving. Patients who have had two or more episodes can be taught self-injection with a preloaded adrenaline syringe.... urticaria

Aristolochia longa, L. Aristolochia clematis L. Aristolochia indica L.

Part used: root. Long reputation in traditional medicine. Prescription by medical practitioner only. Action: stimulant, emmenagogue, diaphoretic, oxytocic (hence its name – to induce childbirth delivery). Immune enhancer. Stimulates action of white blood cells.

Reduces effects of Prednisolone, Chloramphenicol and Tetracycline (H. Wagner, “Economic & Medicinal Plant Research, vol 1, Pub: Academic Press (1985) UK)

Uses: Chinese medicine: ulcers, infectious diseases.

Preparations: Powdered root: dose – 2-4 grams. 2-3 times daily.

Madaus: Tardolyt: a sodium salt of aristolochic acid. ... birthwort

Contusions. Purple marks under the skin caused by capillary haemorrhage as from a blow. Spontaneous bruising may occur as a result of steroid therapy (corticosteroids, Prednisolone, etc) and haemophilia. People with a Vitamin K deficiency bruise easily.

Alternatives. Topical. Tincture Arnica: 5 drops in eggcup of water as a lotion. “In the absence of tincture Arnica,” says Finlay Ellingwood MD, “wipe the discoloured area with Liquid extract Echinacea which stimulates an active capillary circulation and promotes recovery.”

Arnica is never used on open wounds. Calendula (Marigold) is indicated.

Compress: any of the following: Arnica flowers, Chickweed, Cowslip, Hyssop, Black Bryony, Fenugreek seeds, Hemp, Agrimony, Calendula, Oak leaf, St John’s Wort, Linseed, Herb Robert, Sanicle, Rue, Yarrow. Pulped Comfrey root, potato, cabbage leaf or Horsetail.

Lotions, creams, etc. Arnica, Chickweed, Comfrey, Myrrh.

Bruised bones. Comfrey, Rue. Spinal injuries: St John’s Wort.

Others: ice or cold-water compresses fixed by bandages. Weleda Massage Balm. Diet. Yoghurt: to encourage production of Vitamin K – the anti-clot vitamin. Supplements. Vitamins: B-complex, C, E, K, bioflavonoids. ... bruises

a malignant disease of lymphatic tissue – a form of *lymphoma – usually characterized by painless enlargement of one or more groups of lymph nodes in the neck, axillae (armpits), groin, chest, or abdomen; the spleen, liver, bone marrow, and bones may also be involved. Apart from the enlarging nodes, there may also be weight loss, fever, profuse sweating at night, and itching (known as B symptoms). Hodgkin’s disease is distinguished from other forms of lymphoma by the presence of large binucleate cells (Reed–Sternberg cells) in the affected lymph nodes. Treatment depends on the extent of disease and may include surgery, radiotherapy, drug therapy, or a combination of these. Drugs used in the treatment of the disease include vincristine, procarbazine, prednisolone, chlorambucil, and vinblastine. Many patients can be cured; in the early stages of the disease this may be in the order of 90% or more. [T. Hodgkin (1798–1866), British physician]... hodgkin’s disease

n. cancer of the lymph nodes, including *Hodgkin’s disease and non-Hodgkin’s lymphomas. There is a broad spectrum of malignancy, with prognosis ranging from a few months to many years. The patient usually shows evidence of multiple enlarged lymph nodes and may have constitutional symptoms such as weight loss, fever, and sweating (the so-called ‘B symptoms’). Disease may be widespread, but in some cases is confined to a single area, which may be extranodal (such as the tonsil). Treatment is with drugs such as chlorambucil or combinations of cyclophosphamide, vincristine, and prednisolone, sometimes with the addition of doxorubicin and/or bleomycin; response to these drugs is often dramatic. New *targeted agents are used depending on the expression of cell surface molecules, particularly *rituximab against CD20 in diffuse B-cell lymphoma. Localized disease may be treated with radiotherapy followed by drugs. Patients with non-Hodgkin’s lymphoma who do not respond to chemotherapy may be considered for a bone-marrow transplant.... lymphoma