A drug, procedure, or piece of equipment used to prevent disease; also a condom.
It usually begins at puberty – although young children can be affected – and tends to stop in middle age: in women, for example, attacks often cease after MENOPAUSE. It frequently disappears during pregnancy. The disorder tends to run in families. In susceptible individuals, attacks may be provoked by a wide variety of causes including: anxiety, emotion, depression, shock, and excitement; physical and mental fatigue; prolonged focusing on computer, television or cinema screens; noise, especially loud and high-pitched sounds; certain foods – such as chocolate, cheese, citrus fruits, pastry; alcohol; prolonged lack of food; irregular meals; menstruation and the pre-menstrual period.
Anything that can provoke a headache in the ordinary individual can probably precipitate an attack in a migrainous subject. It seems as if there is an inherited predispostion that triggers a mechanism whereby in the migrainous subject, the headache and the associated sickness persist for hours, a whole day or even longer.
The precise cause is not known, but the generally accepted view is that in susceptible individuals, one or other of these causes produces spasm or constriction of the blood vessels of the brain. This in turn is followed by dilatation of these blood vessels which also become more permeable and so allow ?uid to pass out into the surrounding tissues. This combination of dilatation and outpouring of ?uid is held to be responsible for the headache.
Two types of migraine have been recognised: classical and common. The former is relatively rare and the headache is preceded by a slowly extending area of blindness in one or both eyes, usually accompanied by intermittent ‘lights’. The phenomenon lasts for up to 30 minutes and is followed by a bad, often unilateral headache with nausea, sometimes vomiting and sensitivity to light. Occasionally, passing neurological symptoms such as weakness in a limb may accompany the attack. The common variety has similar but less severe symptoms. It consists of an intense headache, usually situated over one or other eye. The headache is usually preceded by a feeling of sickness and disturbance of sight. In 15–20 per cent of cases this disturbance of sight takes the form of bright lights: the so-called AURA of migraine. The majority of attacks are accompanied by vomiting. The duration of the headache varies, but in the more severe cases the victim is usually con?ned to bed for 24 hours.
Treatment consists, in the ?rst place, of trying to avoid any precipitating factor. Patients must ?nd out which drug, or drugs, give them most relief, and they must always carry these about with them wherever they go. This is because it is a not uncommon experience to be aware of an attack coming on and to ?nd that there is a critical quarter of an hour or so during which the tablets are e?ective. If not taken within this period, they may be ine?ective and the unfortunate victim ?nds him or herself prostrate with headache and vomiting. In addition, sufferers should immediately lie down; at this stage a few hours’ rest may prevent the development of a full attack.
When an attack is fully developed, rest in bed in a quiet, darkened room is essential; any loud noise or bright light intensi?es the headache or sickness. The less food that is taken during an attack the better, provided that the individual drinks as much ?uid as he or she wants. Group therapy, in which groups of around ten migrainous subjects learn how to relax, is often of help in more severe cases, whilst in others the injection of a local anaesthetic into tender spots in the scalp reduces the number of attacks. Drug treatment can be e?ective and those a?icted by migraine may ?nd a particular drug or combination of drugs more suitable than others. ANALGESICS such as PARACETAMOL, aspirin and CODEINE phosphate sometimes help. A combination of buclizine hydrochloride and analgesics, taken when the visual aura occurs, prevents or diminishes the severity of an attack in some people. A commonly used remedy for the condition is ergotamine tartrate, which causes the dilated blood vessels to contract, but this must only be taken under medical supervision. In many cases METOCLOPRAMIDE (an antiemetic), followed ten minutes later by three tablets of either aspirin or paracetamol, is e?ective if taken early in an attack. In milder attacks, aspirin, with or without codeine and paracetamol, may be of value. SUMATRIPTAN (5-hydroxytryptamine [5HT1] AGONIST – also known as a SEROTONIN agonist) is of value for acute attacks. It is used orally or by subcutaneous injection, but should not be used for patients with ischaemic heart disease. Naratriptan is another 5HT1 agonist that is an e?ective treatment for acute attacks; others are almotriptan, rizariptan and zolmitriptan. Some patients ?nd beta blockers such as propranolol a valuable prophylactic.
People with migraine and their relatives can obtain help and guidance from the Migraine Action Association.... migraine
Habitat: Native to tropical Africa; common along the west coast of India.
English: Baobab, Monkey Bread tree, African calabash.Ayurvedic: Sheet-phala, Ravanaam- likaa, Gorakshi, Panchparni.Unani: Gorakh Imli.Siddha/Tamil: Papparapuli.Folk: Gorakh Imli; Gorakh Chinchaa.Action: Cooling, refrigerant (allays burning sensation). Leaves— diaphoretic (used as a prophylactic against fevers). Fruit—antidysen- teric, antiseptic, antihistaminic.
The fruit pulp is a source of vitamin C (175.0-445.4 mg/100 g); dried pulp contains calcium and vitamin B1. Furfural (9.6%) is obtained after distillation of the fruit. In Africa, dried leaves provide much of the dietary calcium. Aqueous extract of the bark is used for treating sickle cell anaemia.An infusion of the leaves and flowers is given in respiratory disorders. (Powdered leaves prevented crisis in asthma induced by histamine in guinea pigs.) Dried fruit pulp also gives relief in bronchial asthma, allergic dermatitis and urticaria.Family: Leguminosae; Mimosaceae.Habitat: The western Ghats, the Andamans and sub-Himalayan tract; also cultivated.
English: Coral Wood, Red Wood.Ayurvedic: Rakta Kanchana, Rakta Kambala.Siddha/Tamil: Anai-gundumani.Folk: Ghumchi (bigger var.).Action: Astringent and styptic (used in diarrhoea, haemorrhage from the stomach, haematuria), anti-inflammatory (in rheumatic affections, gout). Seeds— anticephalgic; also used for the treatment of paralysis. A decoction is given in pulmonary affections.
The seed contains an anti-inflammatory active principle, O-acetyletha- nolamine. The leaves contain octa- cosanol, dulcitol, glucosides of beta- sitosterol and stigmasterol. The bark contains sitgmasterol glucoside.... adenanthera pavoninaBoth HIV-1 and HIV-2 are predominantly sexually transmitted and both are associated with secondary opportunistic infections. However, HIV-2 seems to result in slower damage to the immune system. HIV-1 is known to mutate rapidly and has given rise to other subtypes.
HIV is thought to have occurred in humans in the 1950s, but whether or not it infected humans from another primate species is uncertain. It became widespread in the 1970s but its latency in causing symptoms meant that the epidemic was not noticed until the following decade. Although it is a sexually transmitted disease, it can also be transmitted by intravenous drug use (through sharing an infected needle), blood transfusions with infected blood (hence the importance of e?ective national blood-screening programmes), organ donation, and occupationally (see health-care workers, below). Babies born of HIV-positive mothers can be infected before or during birth, or through breast feeding.
Although HIV is most likely to occur in blood, semen or vaginal ?uid, it has been found in saliva and tears (but not sweat); however, there is no evidence that the virus can be transmitted from these two body ?uids. There is also no evidence that HIV can be transmitted by biting insects (such as mosquitoes). HIV does not survive well in the environment and is rapidly destroyed through drying.
Prevalence At the end of 2003 an estimated 42 million people globally were infected with HIV – up from 40 million two years earlier. About one-third of those with HIV/AIDS are aged 15–24 and most are unaware that they are carrying the virus. During 2003 it is estimated that 5 million adults and children worldwide were newly infected with HIV, and that 3 million adults and children died. In Africa in 2003,
3.4 million people were newly infected and 2.3 million died, with more than 28 million carrying the virus. HIV/AIDS was the leading cause of death in sub-Saharan Africa where over half of the infections were in women and 90 per cent of cases resulted from heterosexual sex. In some southern African countries, one in three pregnant women had HIV.
In Asia and the Paci?c there were 1.2 million new infections and 435,000 deaths. The area with the fastest-growing epidemic is Eastern Europe, especially the Russian Federation where in 2002 around a million people had HIV and there were an estimated 250,000 new infections, with intravenous drug use a key contributor to this ?gure. Seventy-?ve per cent of cases occurred in men, with male-to-male sexual transmission an important cause of infection, though heterosexual activity is a rising cause of infection.
At the end of 2002 the UK had an estimated 55,900 HIV-infected adults aged between 15 and 59. More than 3,600 individuals were newly diagnosed with the infection in 2000, the highest annual ?gure since the epidemic started
– in 1998 the ?gure was 2,817 and in 1999 just over 3,000 (Department of Health and Communicable Disease Surveillance Centre). The incidence of AIDS in the UK has declined sharply since the introduction of highly active antiretroviral therapy (HAART) and HIV-related deaths have also fallen: in 2002 there were 777 reported new AIDS cases and 395 deaths, compared with 1,769 and 1,719 respectively in 1995. (Sources: UNAIDS and WHO, AIDS Epidemic Update, December 2001; Public Health Laboratory Services AIDS and STD Centre Communicable Disease Surveillance and Scottish Centre for Infection and Environmental Health, Quarterly Surveillance Tables.)
Poverty is strongly linked to the spread of AIDS, for various reasons including lack of health education; lack of e?ective public-health awareness; women having little control over sexual behaviour and contraception; and, by comparison with the developed world, little or no access to antiretroviral drugs.
Pathogenesis The cellular target of HIV infection is a subset of white blood cells called T-lymphocytes (see LYMPHOCYTE) which carry the CD4 surface receptor. These so-called ‘helper T-cells’ are vital to the function of cell-mediated immunity. Infection of these cells leads to their destruction (HIV replicates at an enormous rate – 109) and over the course of several years the body is unable to generate suf?cient new cells to keep pace. This leads to progressive destruction of the body’s immune capabilities, evidenced clinically by the development of opportunistic infection and unusual tumours.
Monitoring of clinical progression It is possible to measure the number of viral particles present in the plasma. This gives an accurate guide to the likely progression rate, which will be slow in those individuals with fewer than 10,000 particles per ml of plasma but progressively more rapid above this ?gure. The main clinical monitoring of the immune system is through the numbers of CD4 lymphocytes in the blood. The normal count is around 850 cells per ml and, without treatment, eventual progression to AIDS is likely in those individuals whose CD4 count falls below 500 per ml. Opportunistic infections occur most frequently when the count falls below 200 per ml: most such infections are treatable, and death is only likely when the CD4 count falls below 50 cells per ml when infection is developed with organisms that are di?cult to treat because of their low intrinsic virulence.
Simple, cheap and highly accurate tests are available to detect HIV antibodies in the serum. These normally occur within three months of infection and remain the cornerstone of the diagnosis.
Clinical features Most infected individuals have a viral illness some three weeks after contact with HIV. The clinical features are often non-speci?c and remain undiagnosed but include a ?ne red rash, large lymph nodes, an in?uenza-like illness, cerebral involvement and sometimes the development of opportunistic infections. The antibody test may be negative at this stage but there are usually high levels of virus particles in the blood. The antibody test is virtually always positive within three months of infection. HIV infection is often subsequently asymptomatic for a period of ten years or more, although in most patients progressive immune destruction is occurring during this time and a variety of minor opportunistic infections such as HERPES ZOSTER or oral thrush (see CANDIDA) do occur. In addition, generalised LYMPHADENOPATHY is present in a third of patients and some suffer from severe malaise, weight loss, night sweats, mild fever, ANAEMIA or easy bruising due to THROMBOCYTOPENIA.
The presentation of opportunistic infection is highly variable but usually involves either the CENTRAL NERVOUS SYSTEM, the gastrointestinal tract or the LUNGS. Patients may present with a sudden onset of a neurological de?cit or EPILEPSY due to a sudden onset of a STROKE-like syndrome, or epilepsy due to a space-occupying lesion in the brain – most commonly TOXOPLASMOSIS. In late disease, HIV infection of the central nervous system itself may produce progressive memory loss, impaired concentration and mental slowness called AIDS DEMENTIA. A wide variety of opportunistic PROTOZOA or viruses produces DYSPHAGIA, DIARRHOEA and wasting. In the respiratory system the commonest opportunistic infection associated with AIDS, pneumonia, produces severe shortness of breath and sometimes CYANOSIS, usually with a striking lack of clinical signs in the chest.
In very late HIV infection, when the CD4 count has fallen below 50 cells per ml, infection with CYTOMEGALOVIRUS may produce progressive retinal necrosis (see EYE, DISORDERS OF) which will lead to blindness if untreated, as well as a variety of gastrointestinal symptoms. At this stage, infection with atypical mycobacteria is also common, producing severe anaemia, wasting and fevers. The commonest tumour associated with HIV is Kaposi’s sarcoma which produces purplish skin lesions. This and nonHodgkin’s lymphoma (see LYMPHOMA), which is a hundred times more frequent among HIV-positive individuals than in the general population, are likely to be associated with or caused by opportunistic viral infections.
Prevention There is, as yet, no vaccine to prevent HIV infection. Vaccine development has been hampered
by the large number of new HIV strains generated through frequent mutation and recombination.
because HIV can be transmitted as free virus and in infected cells.
because HIV infects helper T-cells – the very cells involved in the immune response. There are, however, numerous research pro
grammes underway to develop vaccines that are either prophylactic or therapeutic. Vaccine-development strategies have included: recombinant-vector vaccines, in which a live bacterium or virus is genetically modi?ed to carry one or more of the HIV genes; subunit vaccines, consisting of small regions of the HIV genome designed to induce an immune response without infection; modi?ed live HIV, which has had its disease-promoting genes removed; and DNA vaccines – small loops of DNA (plasmids) containing viral genes – that make the host cells produce non-infectious viral proteins which, in turn, trigger an immune response and prime the immune system against future infection with real virus.
In the absence of an e?ective vaccine, preventing exposure remains the chief strategy in reducing the spread of HIV. Used properly, condoms are an extremely e?ective method of preventing exposure to HIV during sexual intercourse and remain the most important public-health approach to countering the further acceleration of the AIDS epidemic. The spermicide nonoxynol-9, which is often included with condoms, is known to kill HIV in vitro; however, its e?ectiveness in preventing HIV infection during intercourse is not known.
Public-health strategies must be focused on avoiding high-risk behaviour and, particularly in developing countries, empowering women to have more control over their lives, both economically and socially. In many of the poorer regions of the world, women are economically dependent on men and refusing sex, or insisting on condom use, even when they know their partners are HIV positive, is not a straightforward option. Poverty also forces many women into the sex industry where they are at greater risk of infection.
Cultural problems in gaining acceptance for universal condom-use by men in some developing countries suggests that other preventive strategies should also be considered. Microbicides used as vaginal sprays or ‘chemical condoms’ have the potential to give women more direct control over their exposure risk, and research is underway to develop suitable products.
Epidemiological studies suggest that male circumcision may o?er some protection against HIV infection, although more research is needed before this can be an established public-health strategy. Globally, about 70 per cent of infected men have acquired the virus through unprotected vaginal sex; in these men, infection is likely to have occurred through the penis with the mucosal epithelia of the inner surface of the foreskin and the frenulum considered the most likely sites for infection. It is suggested that in circumcised men, the glans may become keratinised and thus less likely to facilitate infection. Circumcision may also reduce the risk of lesions caused by other sexually transmitted disease.
Treatment AIDS/HIV treatment can be categorised as speci?c therapies for the individual opportunistic infections – which ultimately cause death – and highly active antiretroviral therapy (HAART) designed to reduce viral load and replication. HAART is also the most e?ective way of preventing opportunistic infections, and has had a signi?cant impact in delaying the onset of AIDS in HIV-positive individuals in developed countries.
Four classes of drugs are currently in use. Nucleoside analogues, including ZIDOVUDINE and DIDANOSINE, interfere with the activity of the unique enzyme of the retrovirus reverse transcriptase which is essential for replication. Nucleotide analogues, such as tenofovir, act in the same way but require no intracellular activation. Non-nucleoside reverse transcriptase inhibitors, such as nevirapine and EFAVIRENZ, act by a di?erent mechanism on the same enzyme. The most potent single agents against HIV are the protease inhibitors, such as lopinavir, which render a unique viral enzyme ineffective. These drugs are used in a variety of combinations in an attempt to reduce the plasma HIV viral load to below detectable limits, which is achieved in approximately 90 per cent of patients who have not previously received therapy. This usually also produces a profound rise in CD4 count. It is likely, however, that such treatments need to be lifelong – and since they are associated with toxicities, long-term adherence is di?cult. Thus the optimum time for treatment intervention remains controversial, with some clinicians believing that this should be governed by the viral load rising above 10,000 copies, and others that it should primarily be designed to prevent the development of opportunistic infections – thus, that initiation of therapy should be guided more by the CD4 count.
It should be noted that the drug regimens have been devised for infection with HIV-1; it is not known how e?ective they are at treating infection with HIV-2.
HIV and pregnancy An HIV-positive woman can transmit the virus to her fetus, with the risk of infection being particularly high during parturition; however, the risk of perinatal HIV transmission can be reduced by antiviral drug therapy. In the UK, HIV testing is available to all women as part of antenatal care. The bene?ts of antenatal HIV testing in countries where antiviral drugs are not available are questionable. An HIV-positive woman might be advised not to breast feed because of the risks of transmitting HIV via breastmilk, but there may be a greater risk associated with not breast feeding at all. Babies in many poor communities are thought to be at high risk of infectious diseases and malnutrition if they are not breast fed and may thus be at greater overall risk of death during infancy.
Counselling Con?dential counselling is an essential part of AIDS management, both in terms of supporting the psychological wellbeing of the individual and in dealing with issues such as family relations, sexual partners and implications for employment (e.g. for health-care workers). Counsellors must be particularly sensitive to culture and lifestyle issues. Counselling is essential both before an HIV test is taken and when the results are revealed.
Health-care workers Health-care workers may be at risk of occupational exposure to HIV, either through undertaking invasive procedures or through accidental exposure to infected blood from a contaminated needle (needlestick injury). Needlestick injuries are frequent in health care – as many as 600,000 to 800,000 are thought to occur annually in the United States. Transmission is much more likely where the worker has been exposed to HIV through a needlestick injury or deep cut with a contaminated instrument than through exposure of mucous membranes to contaminated blood or body ?uids. However, even where exposure occurs through a needlestick injury, the risk of seroconversion is much lower than with a similar exposure to hepatitis C or hepatitis B. A percutaneous exposure to HIV-infected blood in a health-care setting is thought to carry a risk of about one infection per 300 injuries (one in 1,000 for mucous-membrane exposure), compared with one in 30 for hepatitis C, and one in three for hepatitis B (when the source patient is e-antigen positive).
In the event of an injury, health-care workers are advised to report the incident immediately where, depending on a risk assessment, they may be o?ered post-exposure prophylaxis (PEP). They should also wash the contaminated area with soap and water (but without scrubbing) and, if appropriate, encourage bleeding at the site of injury. PEP, using a combination of antiretroviral drugs (in a similar regimen to HAART – see above), is thought to greatly reduce the chances of seroconversion; it should be commenced as soon as possible, preferably within one or two hours of the injury. Although PEP is available, safe systems of work are considered to o?er the greatest protection. Double-gloving (latex gloves remove much of the blood from the surface of the needle during a needlestick), correct use of sharps containers (for used needles and instruments), avoiding the resheathing of used needles, reduction in the number of blood samples taken from a patient, safer-needle devices (such as needles that self-blunt after use) and needleless drug administration are all thought to reduce the risk of exposure to HIV and other blood-borne viruses. Although there have been numerous cases of health-care workers developing HIV through occupational exposure, there is little evidence of health-care workers passing HIV to their patients through normal medical procedures.... aids/hiv
Treatment PENICILLIN in full dosage should be given orally for ten days. In those allergic to penicillin, ERYTHROMYCIN can be substituted. Recurrent attacks are common and may cause progressive lymphatic damage leading to chronic OEDEMA. Such recurrences can be prevented by long-term prophylactic oral penicillin.... erysipelas
Habitat: Western India, upper Gangetic plains and Peninsular India.
Ayurvedic: Dhanvayaasa, Dhan- vayavaasa, Dhanvayaasaka, Duraal- abhaa, Samudraantaa. Gaandhaari, Kachhuraa, Anantaa, Duhsparshaa. (Alhagi pseudalhagi is used as a substitute for F. cretica.)Unani: Dhamaasaa.Action: Astringent, antiseptic, blood-purifier and febrifuge. Applied to abscesses, scrofulous glands and wounds; also given as a prophylactic against smallpox. Bark—used for dermatosis Extract of aerial parts—antiviral, antiamphetaminic, spasmogenic. Plant ash—given to children suffering from anaemia.
The aerial parts contain several tri- terpenoid saponins which gave sa- pogenin, nahagenin, oleanolic acid. Aerial parts also gave diterpenes, fa- gonone and its derivatives, besides flavonoids.The flavonoids, quercetin and kaem- pferol, isolated from the leaves and flowers, showed antimicrobial activity.The fruits are rich in ascorbic acid.Dosage: Whole plant—50-100 ml decoction. (CCRAS.)... fagonia creticaHeat collapse is characterised by fatigue, giddiness, and temporary loss of consciousness. It is accompanied by HYPOTENSION and BRADYCARDIA; there may also be vomiting and muscular cramps. Urinary volume is diminished. Recovery is usual.
Heat exhaustion is characterised by increasing weakness, dizziness and insomnia. In the majority of sufferers, sweating is defective; there are few, if any, signs of dehydration. Pulse rate is normal, and urinary output good. Body temperature is usually 37·8–38·3 °C.
Heat cramps (usually in the legs, arms or back, and occasionally involving the abdominal muscles) are associated with hard physical work at a high temperature. Sweating, pallor, headache, giddiness and intense anxiety are present. Body temperature is only mildly raised.
Heat hyperpyrexia is heralded by energy loss and irritability; this is followed by mental confusion and diminution of sweating. The individual rapidly becomes restless, then comatose; body temperature rises to 41–42 °C or even higher. The condition is fatal unless expertly treated as a matter of urgency.
Treatment With the ?rst two syndromes, the affected individual must be removed immediately to a cool place, and isotonic saline administered – intravenously in a severe case. The fourth syndrome is a medical emergency. The patient should be placed in the shade, stripped, and drenched with water; fanning should be instigated. He or she should be wrapped in a sheet soaked in cool water and fanning continued. When rectal temperature has fallen to 39 °C, the patient is wrapped in a dry blanket. Immediately after consciousness returns, normal saline should be given orally; this usually provokes sweating. The risk of circulatory collapse exists. Convalescence may be protracted and the patient should be repatriated to a cool climate. Prophylactically, personnel intended for work in a tropical climate must be very carefully selected. Adequate acclimatisation is also essential; severe physical exertion must be avoided for several weeks, and light clothes should be worn. The diet should be light but nourishing, and ?uid intake adequate. Those performing hard physical work at a very high ambient temperature should receive sodium chloride supplements. Attention to ventilation and air-conditioning is essential; fans are also of value.... heat stroke
(2) An internationally agreed unit (see SI UNITS) for measuring the quantity of a substance at molecular level.... mole
Habitat: Native to Europe; found as an escape in some parts of Kashmir.
English: Tansy.Folk: Peilmundi (Kashmir).Action: Plant—anthelmintic, bitter tonic, emmenagogue. Used for migraine, neuralgia and nausea; as a lotion for scabies. Toxicity depends upon thujone content of the part used. Tansy oil is used as a liniment for gout and rheumatism.
Aerial parts afforded terpenoids— tanacetin, vulgarones A and B, tamirin, tanacin and tanavulgarol; germacano- lides, stearic acid, and flavonoids— apigenin trimethyl ether, apigenin, luteolin, chrysoeriol, diometin, iso- rhamnetin, quercetin and axillarin. The leaves contain parthenolide, caffe- ic, chlorogenic, iso-chlorogenic acids and vibernitol.Indian chemotype contains beta- thujone (28.1%) as the major constituent of the essential oil. Other constituents are: beta-thujyl alcohol 8.7, /-camphor 10.0 and cineol 11.8%. The leaves contain parthenolide, caf- feic, chlorogenic, isochlorogenic acid and vibernitol.Tanacetum parthenium (L.) Schultz Bip. (native to Europe and British Isles), known as Feverfew, is available in India for prophylactic treatment of migraine. The characteristic constituents of the herb (dried, whole or fragmented parts) are sesquiterpene lactones of which parthenolide, a ger- macanolide, is the major component. (Indian species, T. vulgare leaf also contains parthenolide).ESCOP recommends the herb for the management of migraine for at least a few months.(See ESCOP and WHO monographs.)It has been shown that Feverfew extract inhibits prostaglandin production and arachidonic acid release (this activity, at least partly, explains the herb's antiplatelet and antifebrile action). The extracts also inhibit secretion of serotonin from platelet granules and proteins from polymorphonuclear leucocytes (PMN's). Since serotonin is implicated in the aetiology of migraine and PMN secretion is increased in rheumatoid arthritis. Feverfew is used in migraine and rheumatoid arthritis. (Potter's New Cyclopaedia.) Somehow, beneficial effects were not observed in a double-blind placebo-controlled trial on 40 women with rheumatoid arthritis. (WHO.)... tanacetum vulgareConstituents: flavonoids, tannins, vitamins, carotenoids.
Natural source of Vitamin C.
Action. Antidiarrhoeal, anti-stress.
Uses: Rose hip capsules or tablets are taken as a prophylactic against colds and infections.
Teabags offer a popular daily ‘health’ tea as an alternative to caffeine drinks. See: VITAMIN C.
GSL ... dog rose
Acquired immunity depends upon the immune system recognising a substance as foreign the ?rst time it is encountered, storing this information so that it can mount a reaction the next time the substance enters the body. This is the usual outcome of natural infection or prophylactic IMMUNISATION. What happens is that memory of the initiating ANTIGEN persists in selected lymphocytes (see LYMPHOCYTE). Further challenge with the same antigen stimulates an accelerated, more vigorous secondary response by both T- and B-lymphocytes (see below). Priming the immune system in this manner forms the physiological basis for immunisation programmes.
Foreign substances which can provoke an immune response are termed ‘antigens’. They are usually proteins but smaller molecules such as drugs and chemicals can also induce an immune response. Proteins are taken up and processed by specialised cells called ‘antigenpresenting cells’, strategically sited where microbial infection may enter the body. The complex protein molecules are broken down into short amino-acid chains (peptides – see PEPTIDE) and transported to the cell surface where they are presented by structures called HLA antigens (see HLA SYSTEM).
Foreign peptides presented by human leucocyte antigen (HLA) molecules are recognised by cells called T-lymphocytes. These originate in the bone marrow and migrate to the THYMUS GLAND where they are educated to distinguish between foreign peptides, which elicit a primary immune response, and self-antigens (that is, constituents of the person themselves) which do not. Non-responsiveness to self-antigens is termed ‘tolerance’ (see AUTOIMMUNITY). Each population or clone of T-cells is uniquely responsive to a single peptide sequence because it expresses a surface molecule (‘receptor’) which ?ts only that peptide. The responsive T-cell clone induces a speci?c response in other T-and B-lymphocyte populations. For example, CYTOTOXIC T-cells penetrate infected tissues and kill cells which express peptides derived from invading micro-organisms, thereby helping to eliminate the infection.
B-lymphocytes secrete ANTIBODIES which are collectively termed IMMUNOGLOBULINS (Ig)
– see also GAMMA-GLOBULIN. Each B-cell population (clone) secretes antibody uniquely speci?c for antigens encountered in the blood, extracellular space, and the LUMEN of organs such as the respiratory passages and gastrointestinal tract.
Antibodies belong to di?erent Ig classes; IgM antibodies are synthesised initially, followed by smaller and therefore more penetrative IgG molecules. IgA antibodies are adapted to cross the surfaces of mucosal tissues so that they can adhere to organisms in the gut, upper and lower respiratory passages, thereby preventing their attachment to the mucosal surface. IgE antibodies also contribute to mucosal defence but are implicated in many allergic reactions (see ALLERGY).
Antibodies are composed of constant portions, which distinguish antibodies of di?erent class; and variable portions, which confer unique antigen-binding properties on the product of each B-cell clone. In order to match the vast range of antigens that the immune system has to combat, the variable portions are synthesised under the instructions of a large number of encoding GENES whose products are assembled to make the ?nal antibody. The antibody produced by a single B-cell clone is called a monoclonal antibody; these are now synthesised and used for diagnostic tests and in treating certain diseases.
Populations of lymphocytes with di?erent functions, and other cells engaged in immune responses, carry distinctive protein markers. By convention these are classi?ed and enumerated by their ‘CD’ markers, using monoclonal antibodies speci?c for each marker.
Immune responses are in?uenced by cytokines which function as HORMONES acting over a short range to accelerate the activation and proliferation of other cell populations contributing to the immune response. Speci?c immune responses collaborate with nonspeci?c defence mechanisms. These include the COMPLEMENT SYSTEM, a protein-cascade reaction designed to eliminate antigens neutralised by antibodies and to recruit cell populations which kill micro-organisms.... immunity
Traveller’s diarrhoea is an all-toocommon a?iction of the traveller, which basks in a multiplicity of names: for example, Aden gut, Aztec two-step, Basra belly, Delhi belly, Gippy tummy, Hong Kong dog, Montezuma’s revenge, Tokyo trots, turista. It is caused by a variety of micro-organisms, usually E. coli. Some people seem to be more prone to it than others, although for no good cause. Obvious preventive measures include the avoidance of salads, unpeeled fruit and ice cream, and never drinking unboiled or unbottled water. If diarrhoea occurs, co-phenotrope and loperamide are often used to reduce the frequency of bowel movements in adults. Prophylactic antibacterial drugs are not advisable.... travel sickness
During a bite by the female mosquito, one or more sporozoites – a stage in the life-cycle of the parasite – are injected into the human circulation; these are taken up by the hepatocytes (liver cells). Following division, merozoites (minute particles resulting from the division) are liberated into the bloodstream where they invade red blood cells. These in turn divide, releasing further merozoites. As merozoites are periodically liberated into the bloodstream, they cause the characteristic fevers, rigors, etc.
Malaria occurs in many tropical and subtropical countries; P. falciparum is, however, con?ned very largely to Africa, Asia and South America. Malaria is present in increasingly large areas; in addition, the parasites are developing resistance to various preventative and treatment drugs. The disease constitutes a signi?cant problem for travellers, who must obtain sound advice on chemoprophylaxis before embarking on tropical trips – especially to a rural area where intense transmission can occur. Transmission has also been recorded at airports, and following blood transfusion.
The World Health Organisation (WHO) has listed malaria as one of Europe’s top ten infectious diseases. In 1992, 20,000 cases were reported: this had risen to more than 200,000 by the late 1990s. The resurgence of malaria has been worldwide, in part the result of the development of resistant strains of the disease, and in part because many countries have failed (or been unable) to implement environmental measures to eliminate mosquitoes. Nearly 40 years ago the WHO forecast that by 1980 only four million people would be affected worldwide; now, at the beginning of the 21st century, around 500 million people a year are contracting malaria with about 3,000 people a day dying from the infection – as many as 70 per cent of them children under the age of ?ve, according to WHO ?gures. The apparently steady advance of global warming means that countries with temperate climates may well warm up su?ciently to enable malaria to become established as an ENDEMIC disease. In any case, the great increase in international air travel has exposed many more people to the risk of malaria, and infected individuals may not exhibit symptoms until they are back home. Doctors seeing a recent traveller with unexplained pyrexia and illness should consider the possibility of malarial infection.
Diagnosis is by demonstration of trophozoites – a stage in the parasite’s life-cycle that takes place in red blood cells – in thick/thin blood-?lms of peripheral blood. Serological tests are of value in deciding whether an individual has had a past infection, but are of no value in acute disease.
P. vivax and P. ovale infections cause less severe disease than P. falciparum (see below), although overall there are many clinical similarities; acute complications are unusual, but chronic ANAEMIA is often present. Primaquine is necessary to eliminate the exoerythrocytic cycle in the hepatocyte (liver cell).
P. falciparum Complications of P. falciparum infection include cerebral involvement (see BRAIN – Cerebrum), due to adhesion of immature trophozoites on to the cerebral vascular endothelium; these lead to a high death rate when inadequately treated. Renal involvement (frequently resulting from HAEMOGLOBINURIA), PULMONARY OEDEMA, HYPOTENSION, HYPOGLYCAEMIA, and complications in pregnancy are also important. In complicated disease, HAEMODIALYSIS and exchange TRANSFUSION have been used. No adequate controlled trial using the latter regimen has been carried out, however, and possible bene?ts must be weighed against numerous potential side-effects – for instance, the introduction of a wide range of infections, overload of the circulatory system with infused ?uids, and other complications.
P. malariae usually produces a chronic infection, and chronic renal disease (nephrotic syndrome) is an occasional sequel, especially in tropical Africa.
Gross SPLENOMEGALY (hyper-reactive malarious splenomegaly, or tropical splenomegaly syndrome) can complicate all four human Plasmodium spp. infections. The syndrome responds to long-term malarial chemoprophylaxis. BURKITT’S LYMPHOMA is found in geographical areas where malaria infection is endemic; the EPSTEIN BARR VIRUS is aetiologically involved.
Prophylaxis Malaria specialists in the United Kingdom have produced guidance for residents travelling to endemic areas for short stays. Drug choice takes account of:
risk of exposure to malaria;
extent of drug resistance;
e?cacy of recommended drugs and their side-effects;
criteria relevant to the individual (e.g. age, pregnancy, kidney or liver impairment). Personal protection against being bitten by
mosquitoes is essential. Permethrinimpregnated nets are an e?ective barrier, while skin barrier protection and vaporised insecticides are helpful. Lotions, sprays or roll-on applicators all containing diethyltoluamide (DEET) are safe and work when put on the skin. Their e?ect, however, lasts only for a few hours. Long sleeves and trousers should be worn after dark.
Drug prophylaxis should be started at least a week before travelling into countries where malaria is endemic (two or three weeks in the case of me?oquine). Drug treatment should be continued for at least four weeks after leaving endemic areas. Even if all recommended antimalarial programmes are followed, it is possible that malaria may occur any time up to three months afterwards. Medical advice should be sought if any illness develops. Chloroquine can be used as a prophylactic drug where the risk of resistant falciparum malaria is low; otherwise, me?oquine or proguanil hydrochloride should be used. Travellers to malaria-infested areas should seek expert advice on appropriate prophylactic treatment well before departing.
Treatment Various chemoprophylactic regimes are widely used. Those commmonly prescribed include: chloroquine + paludrine, me?oquine, and Maloprim (trimethoprim + dapsone); Fansidar (trimethoprim + sulphamethoxazole) has been shown to have signi?cant side-effects, especially when used in conjunction with chloroquine, and is now rarely used. No chemotherapeutic regimen is totally e?ective, so other preventive measures are again being used. These include people avoiding mosquito bites, covering exposed areas of the body between dusk and dawn, and using mosquito repellents.
Chemotherapy was for many years dominated by the synthetic agent chloroquine. However, with the widespread emergence of chloroquine-resistance, quinine is again being widely used. It is given intravenously in severe infections; the oral route is used subsequently and in minor cases. Other agents currently in use include me?oquine, halofantrine, doxycycline, and the artemesinin alkaloids (‘qinghaosu’).
Researchers are working on vaccines against malaria.... malaria
Habitat: Western ghats from Maharashtra southwards up to an altitude of 1,200 m.
Siddha/Tamil: Pulichan.Action: Root and leaves—used in intermittent fevers, biliousness, jaundice; also in rheumatic affections; bruised in salt water, used in skin diseases. A decoction of the root bark is given to women to control fits at the time of delivery.
Acetogenins, including stereoiso- mers, are important constituents of the root bark. Glutinone, glutinol, taraxerol, beta-sitosterol and benzyl benzoate have also been isolated. The essential oil of the root bark of Kerala plant contains bornyl acetate 15.2% and patchoulenone 8.1%.A decoction and roots of Uvaria gandiflora Roxb., synonym U. purpurea Blume (Indian Botanic Garden, Kolkata) is used for flatulence, stomachache; also after childbirth. A decoction of U. micrantha (A. DC.) Hook. f. & Thoms. (tropical forests of the Andamans) is also administered after childbirth as a prophylactic.... uvaria narumClinically, yellow fever is characterised by jaundice, fever, chills, headache, gastrointestinal haemorrhage(s), and ALBUMINURIA. The incubation period is 3–6 (up to 10) days. Differentiation from viral hepatitides, other viral haemorrhagic fevers, severe Plasmodium falciparum malaria, and several other infections is often impossible without sophisticated investigative techniques. Infection carries a high mortality rate. Liver histology (biopsy is contraindicated due to the haemorrhagic diathesis) shows characteristic changes; a fulminating hepatic infection is often present. Acute in?ammation of the kidneys and an in?amed, congested gastric mucosa, often accompanied by haemorrhage, are also demonstrable; myocardial involvement often occurs. Diagnosis is primarily based on virological techniques; serological tests are also of value. Yellow fever should be suspected in any travellers from an endemic area.
Management consists of instituting techniques for acute hepatocellular (liver-cell) failure. The affected individual should be kept in an isolation unit, away from mosquitoes which could transmit the disease to a healthy individual. Formerly, laboratory infections were occasionally acquired from infected blood samples. Prophylactically, a satisfactory attenuated VACCINE (17D) has been available for around 60 years; this is given subcutaneously and provides an individual with excellent protection for ten years; international certi?cates are valid for this length of time. Every traveller to an endemic area should be immunised; this is mandatory for entry to countries where the infection is endemic.... yellow fever
Action: antiseptic, antifungal, gastric tonic, nutritive, mild sedative. Oil has mild bactericidal and anti- fungal properties. Anti-dandruff, Carminative, Cholagogue, Vermifuge.
Uses: Weak digestion, poor appetite; hot and soothing to a ‘cold’ stomach. Urinary infections (decoction). Chest infections (berries). Rheumatic pains (seed oil, externally).
Reportedly used in cancer. (J.L. Hartwell, Lloydia, 32, 247, 1969)
Boosts insulin activity. (American Health, 1989, Nov 8, p96)
Preparations: Average dose: 2-4 grams. Thrice daily.
Decoction. 1oz crushed leaves to 1 pint water simmered down to three-quarters of its volume. Dose. Half a cup thrice daily.
Bay bath. Place crushed leaves in a small muslin bag and steep in hot water.
Diet: taken as a culinary herb with potatoes, salads, soups, etc. A source of oleic acid and linoleic acid.
Contact dermatitis may sometimes occur as an allergy on handling the oil. ... bay leaves
In an atomic age the collapse of medical services provided by governments is not far removed from the bounds of possibility. Wars come and go, medical fashions change, what is regarded as scientific today, may be neglected to tomorrow’s superstition. It is possible this book may be consulted long after 20th century medicine has had its day.
The preventative remedy of history is Garlic. It was given to workers on the Great Pyramid of Cheops as a known antiseptic and prophylactic against infection. A riot ensued when supplies ran out. During the Great Plague under Charles II a colony of people escaped death, living to reveal their secret – all were in the habit of eating Garlic. It was later confirmed that the plague was not found in houses in which Garlic had been consumed.
The disease is spread by fleas from the black rat by the organism: bacillus pestis. Incubation period is two to five days, followed by severe headache, shivering, dizziness, fever and rapid pulse. Before delirium, the patient may have the ‘staggers’ and confused speech.
Glands of the body enlarge and may suppurate. Suppuration is a welcome sign indicating speedy elimination of pus. Haemorrhagic spots break out on the skin.
The most dangerous type is that which affects the lungs, known as ‘pneumonic’ and which is highly infectious; characterised by cyanosis (blueness of the face).
Occasionally there are human cases of Bubonic Plague in California and the West but today they seldom prove fatal. Public health officials point out that the incidence of the disease in China and Vietnam is lower than for centuries because of vaccine therapy. Wild animals still spread sporadic cases of the Plague.
Treatment: Health Authorities to be notified immediately and patient isolated. All bedding and personal effects to be destroyed or disinfected. Specialised nursing necessary. If hospital care is not available, the patient should receive treatment for collapse (Capsicum, Ginger or other circulatory stimulants).
In the absence of streptomycin and tetracycline, to which the organism yersinia is sensitive, powerful alternatives may assist: Echinacea, Wild Indigo, Poke root, Queen’s Delight, Sarsaparilla, Yellow Parilla, Goldenseal, Prickly Ash.
Topical. Poultice of Slippery Elm, Marshmallow, or both combined to promote suppuration. History records pulped fresh Plantain leaves.
To be treated by general medical practitioner or Infectious Diseases consultant. ... bubonic plague
Alternatives. Internal. Prickly Ash, Hawthorn, Cayenne, Blue Flag, Ginger.
Tinctures. To tone the skin. Mix, equal parts: Yarrow, Blue Flag root, Prickly Ash. Few drops tincture Capsicum (Cayenne). One 5ml teaspoon in water before meals thrice daily.
Topical. Oak bark hand or foot baths: handful bark to each 1 pint (500ml) water simmered 20 minutes. Capsicum or Black Bryony (Tamus): cream or lotion.
Friar’s balsam: soak cotton wool and apply.
Traditional. Rub with raw onion. Bathe with potato water. Infusion of Wild Thyme wash (Dr Alfred Vogel). Cider vinegar.
Prophylactic measures: adequate footwear (socks and shoes) before winter comes.
Supplementation. 2 × 300mg Calcium lactate tablets at meals thrice daily. Vitamin E (400iu daily). Vitamin B-complex (500mg daily). ... chilblains
Symptoms: low grade fever, malaise, sore throat, massive swelling of cervical lymph glands, thick white exudate from tonsils, false membrane forms from soft palate to larynx with brassy cough and difficult breathing leading to cyanosis and coma. Toxaemia, prostration, thin rapid pulse. Throat swabs taken for laboratory examination. See: NOTIFIABLE DISEASES.
Treatment. Bedrest. Encourage sweating.
Recommendations are for those parts of the world where medical help is not readily available and may save lives. Alternatives:–
1. Combine: Tincture Echinacea 3; Tincture Goldenseal 2; Tincture Myrrh 1. Dose: 30-60 drops in water, two-hourly.
2. Combine equal parts: Tincture Lobelia; Tincture Echinacea. Dose: 30-60 drops in water, two-hourly.
3. Combine Tincture Poke root 2; Tincture Echinacea 3. Dose: 30-60 drops in water, two hourly.
4. G.L.B. Rounseville, MD, Ill., USA. I have treated diphtheria since 1883. I have treated diphtheria until I am sure the number of cases treated run into four digits. I have never given a hypodermic of antitoxin on my own initiative, nor have I ever lost a case early enough to inhibit conditions. I have depended upon Echinacea not only prophylactic but also as an antiseptic . . . In the line of medication the remedies are: Aconite, Belladonna, Poke root and Cactus grand, according to indications. But remember, if you are to have success, Echinacea must be given internally, externally and eternally! Do not fear any case of diphtheria with properly selected remedies as the symptoms occur. Echinacea will also be your stimulant, diaphoretic, diuretic, sialogogue, cathartic and antipyretic. (Ellingwood’s Physiomedicalist, Vol 13, No 6, June, 1919, 202)
5. Alexander M. Stern MD, Palatka, Florida, USA. Combine: tinctures Echinacea 1oz, Belladonna 10 drops, Aconite 10 drops. Water to 4oz. 1 teaspoon 2-hourly.
6. F.H. Williams, MD, Bristol, Conn., USA. I took a case which had been given up to die with tracheal diphtheritic croup. I gave him old-fashioned Lobelia (2) seed and Capsicum (1) internally and externally and secured expulsion of a perfect cast of the trachea without a tracheotomy.
7. Gargle, and frequent drink. To loosen false membrane. Raw lemon juice 1, water 2. Pineapple juice. Teas: Red Sage, fresh Poke root. Cold packs – saturated with Echinacea (Tincture, Liquid Extract or decoction) to throat.
Note: Capsicum and Lobelia open up the surface blood flow of the body thus releasing congestion on the inner mucous membranes.
Diet. Complete lemon-juice and herb tea fast with no solid foods as long as crisis lasts.
To be treated by a general medical practitioner or hospital specialist. ... diphtheria
Treatment. Circulatory stimulants. Vaso-dilators.
Alternatives. BHP (1983) – Prickly Ash bark, Cramp bark, Black Cohosh, Angelica root, Hawthorn, Wild Yam. Prophylactic – Garlic.
Decoction. Mix, equal parts: Black Cohosh, Prickly Ash bark, Hawthorn berries. One teaspoon to each cup of water simmered gently 20 minutes. Half-1 cup thrice daily.
Formula. Hawthorn 2; Black Cohosh 1; Prickly Ash 1. Dose: Powders: 500mg (two 00 capsules or one- third teaspoon). Liquid Extracts: one 5ml teaspoon. Tinctures: two 5ml teaspoons. Thrice daily in water or honey.
Tablets/capsules. Prickly Ash. Hawthorn. Black Cohosh. Garlic, 2 at night. Cramp bark. Ginkgo.
Life Drops. 3-10 drops in cup of tea to relieve spasm.
Ginkgo biloba. “Walking distance is definitely increased.” (Rudolf F. Weiss MD. Herbal Medicine, Beaconsfield Publishers)
Garlic. 80 patients with symptomatic state II occlusive disease (claudication), randomised, to take either Garlic powder 800mg a day in tablet form (equivalent to Kwai) or placebo for 12 weeks. A significantly greater improvement in walking distance, apparent after just 4 weeks, occurred in the Garlic-treated group compared with the placebo group. (Professor H. Kiesewetter, Department of Clinical Haemostasiology, University of Saarland, Germany)
Diet. Lacto-vegetarian.
Supplements. Vitamin E, 400iu morning and evening.
General. Venesection sometimes necessary. No smoking or alcohol. See: BUERGER’S DISEASE, RAYNAUD’S DISEASE, ARTERIOSCLEROSIS, PHLEBITIS, THROMBOSIS. ... intermittent claudication
Rash: blotchy and orange-red. Commencing behind the ears, it rapidly invades the whole body. Complications: inflammation of the middle ear, brain, and eyes.
Prophylactic: Pulsatilla.
A Danish study confirms that suppression of measles with drugs and vaccines can contribute to dermatitis, arthritis and cancer later in life.
Treatment by or in liaison with a general medical practitioner.
Alternatives. Marigold petal tea popular: 2-6 teaspoons to 1 pint boiling water. Make in vacuum flask. Consume 1-2 flaskfuls daily.
Other teas. Lime flowers, Chamomile, Elderflowers and Peppermint, Vervain. Formula (France): equal parts, German Chamomile, Catmint, Thyme. 2 teaspoons to each cup boiling water; infuse 15 minutes. 1 cup freely. Children: 2-5 teaspoons each year to 5 years; quarter to half cup to 10 years.
Jethro Kloss. 1 teaspoon Pleurisy root; quarter of a teaspoon powdered Ginger. Steep in 1 pint boiling water. For hyperactive child, add 1 teaspoon Skullcap. Infuse 20 minutes. Dose: half-1 cup freely. Children: 2-5 teaspoons each year to 5 years; quarter to half cup to 10 years.
Traditional. First give laxative to clear stomach and bowels. Then, bruise Houseleek, adding equal weight of honey. Dessertspoon every 2 hours. Cup of Balm tea assists reduction of temperature.
Topical. Wash with warm Elderflowers or Chamomile tea. Aloe Vera juice.
Aromatherapy. To inhale or for bath: Lavender essential oil.
Enema. Constipation. Injection of warm Chamomile tea.
Eyes. Impairment of sight possible. For inflamed eyes and lids bathe with warm Elderflowers or Chamomile tea.
Note: There is always debility and chilliness followed by a throwing out of the skin morbific materials. Diaphoretic drinks are important so that no undue stress is placed on the kidneys. These include teas of Yarrow, Lemon Balm, Lime flowers, Hyssop, Ginger, Elderflowers and Peppermint.
Tincture. Echinacea. Adults: 1 teaspoon. Child: 1 drop each year to 5; thereafter 2 drops each year to 12 years.
Diet. 3-day fast, if possible. No solid food. Abundant Vitamin C drinks, fruit juices. All cases should receive Vitamin A supplements, halibut liver oil. Foods rich in beta-carotene (carrots). ... measles
Symptoms: legs and hands cold, pale face, alternate heats and chills, loss of appetite, nervous exhaustion, pain in the back and loins.
General use. Uterine astringents.
Alternatives. Bayberry bark, Beth root, Black Haw, Blue Cohosh, Broom, Cranesbill (American), Goldenseal, Lady’s Mantle, Life root, Periwinkle (greater), Raspberry leaves, Rhatany root, Shepherd’s Purse, Yarrow. For reduction of menstrual flow without arrest.
Raspberry leaves. A gentle astringent tea for mild cases.
Agnus Castus. Heavy bleeding between periods.
Formula. Tea. Equal parts: Lady’s Mantle, Raspberry leaves, Shepherd’s Purse. 2 teaspoons to each cup boiling water; infuse 15 minutes. 1 cup freely.
Formula. Powders. Black Haw 3; Bayberry bark 3; Cinnamon 1. Dose: 750mg (three 00 capsules or half a teaspoon) 3-4 times daily.
For the severe case. Formula. Bur-marigold 2; Lady’s Mantle 2; Beth root 1. Dose: Liquid Extracts: 1-2 teaspoons; Tinctures: 2-3 teaspoons; every 2 hours.
Prophylactic: Mistletoe, taken at least 14 days before period. For prolonged heavy loss, refer patient to a gynaecologist.
Diet. Vitamin K foods. Iron foods. Prunes. Kelp. Irish Moss.
Supplements. Daily. Vitamin A, 7,500iu, Vitamin C, 1g. Vitamin E, 200iu. Vitamin K, 5mcg. Bioflavonoids. Calcium. Iodine. Iron – Floradix.
Sitz bath. Has a toning effect upon the pelvic organs, arresting high blood loss. See: SITZ BATH. ... menorrhagia
Constituents: flavonoids, volatile oil, allicin, vitamins, sterols, phenolic acids.
Action: hypoglycaemic, antibiotic, anticoagulant, expectorant, hypotensive, antibacterial, antisclerotic, anti-inflammatory, diuretic. Shares some of the properties of Garlic. Mild bacterical (fresh juice). Promotes bile flow, reduces blood sugar, stimulates the heart, coronary flow and systolic pressure.
Uses: Oedema, mild dropsy, high blood pressure. Inclusion in daily diet for those at risk from heart attack or stroke through low HDLs (high-density lipoprotein) levels.
“An Onion a day keeps arteriosclerosis at bay.” (Dr Victor Gurewich, Professor of Medicine, Tuft’s University, Boston, USA)
Onions clear arteries of fat which impedes blood flow. Of value for sour belching, cystitis, chilblains, insect bites, freckles. Two or three drops juice into the auditory meatus for earache and partial deafness. Burns and scalds (bruised raw Onion). Claimed that juice rubbed into the scalp arrests falling hair.
“I have observed that families using Onions freely as an article of diet have escaped epidemic diseases, although their neighbours might be having scarlet fever, etc. I believe Onions are reliable prophylactics. I have prevented the spread of contagious disease in the same household by their timely use.” (Dr L. Covert)
The traditional roasted Onion is still used as a poultice for softening hard tumours and pains of acute gout.
Preparations: Decoction. Water in which Onions are boiled is a powerful diuretic and may also be used for above disorders.
Home tincture. Macerate Onions for 8 days in Holland’s gin, shake daily; strain, bottle. 2-3 teaspoons in water, thrice daily for oedema, dropsy or gravel.
Note: A research team at the National Cancer Institute, China, has shown that the Onion family (Chives, Onions, Leeks and Garlic) can significantly reduce the risk of stomach cancer. ... onion
Symptoms. Upper abdominal pain, fever, nausea, backache, low blood pressure, high white cell count. Tre atme nt: anti-inflammatories, herbal antibiotics for bacterial infection. Allspice, Bearberry, Elecampane, Goldenseal, Liquorice root, Mullein, Nettles, Wahoo. Others as follows:–
Teas: Haronga Tree, Chamomile, Mullein, Uva Ursi, Burdock leaves, Marigold petals, Liquorice. Cup every 3 hours.
Decoctions: Sarsaparilla (hot). Barberry (cold). See: DECOCTION.
Tablets/capsules. Blue Flag root, Chamomile, Sarsaparilla, Kelp.
Formula. Echinacea 2; Blue Flag root 1; Liquorice root 1. Dose – Liquid extracts: 1 teaspoon. Tinctures: 2 teaspoons. Powders: 500mg (two 00 capsules or one-third teaspoon); every 3 hours for acute cases, otherwise thrice daily.
Goldenseal, tincture: 10 drops once daily maintenance prophylactic dose.
External. Poultice over upper abdomen: Mullein, Chamomile or Castor oil.
Diet. Abundant citrus fruits.
Supplements. Vitamin C, methionine and selenium to mop up free radicals. Without the supplements toxins strike the pancreas, leading to severe pain. In this way they can be used as an alternative to pain-killers. (Researchers, Manchester Royal Infirmary)
Vitamin C. Lack of Vitamin C may trigger acute pancreatitis in susceptible patients. (Mr Patrick Scott, Manchester Royal Infirmary) ... pancreatitis
respiratory distress syndrome (RDS; hyaline membrane disease) the condition of a newborn infant in which the lungs are imperfectly expanded. Initial inflation and normal expansion of the lungs requires the presence of a substance (*surfactant) that reduces the surface tension of the air sacs (alveoli) and prevents collapse of the small airways. Without surfactant the airways collapse, leading to inefficient and ‘stiff’ lungs. The condition is most common and serious among preterm infants, in whom surfactant may be deficient. It lasts 5–10 days, with worsening on days 2–3. Breathing is rapid, laboured, and shallow, and microscopic examinations of lung tissue in fatal cases has revealed the presence of *hyalin material in the collapsed air sacs. The condition is treated by careful nursing, intravenous fluids, and oxygen, with or without positive-pressure ventilation (see noninvasive ventilation). Early surfactant replacement therapy has been shown to reduce the severity of RDS and when given prophylactically it has been demonstrated to improve clinical outcome. See also adult respiratory distress syndrome.... respiratory distress
FAMILY: Lamiaceae (Labiatae)
SYNOYNMS Common basil, joy-of-the-mountain, ‘true’ sweet basil, European basil.
GENERAL DESCRIPTION: A tender annual herb, with very dark green, ovate leaves, greyish-green beneath, an erect square stem up to 60 cms high, bearing whorls of two-lipped greenish or pinky-white flowers. The whole plant has a powerful aromatic scent.
DISTRIBUTION: Native to tropical Asia and Africa, it is now widely cultivated throughout Europe, the Mediterranean region, the Pacific Islands, North and South America. The European, French or ‘true’ sweet basil oil is produced in France, Italy, Egypt, Bulgaria, Hungary and the USA.
OTHER SPECIES: There are many varieties of basil occurring all over the world, used both for their culinary and medicinal applications, such as bush basil (O. minimum), holy basil (O. sanctum), both from India, camphor basil (O. kilimanjaricum) from East Africa (also grown in India), and the fever plant (O. viride) from West Africa. However, there are two principal chemotypes most commonly used for the extraction of essential oil: the so-called ‘French basil’ and the ‘exotic basil’ – see separate entry.
HERBAL/FOLK TRADITION: Widely used in Far Eastern medicine especially in the Ayurvedic tradition, where it is called tulsi. It is used for respiratory problems such as bronchitis, coughs, colds, asthma, ’flu and emphysema but is also used as an antidote to poisonous insect or snake bites. It has also been used against epidemics and fever, such as malaria. It improves blood circulation and the digestive system and in China it is used for stomach and kidney ailments.
In the West it is considered a ‘cooling’ herb, and is used for rheumatic pain, irritable skin conditions and for those of a nervous disposition. It is a popular culinary herb, especially in Italy and France.
ACTIONS: Antidepressant, antiseptic, antispasmodic, carminative, cephalic, digestive, emmenagogue, expectorant, febrifuge, galactagogue, nervine, prophylactic, restorative, stimulant of adrenal cortex, stomachic, tonic.
EXTRACTION: Essential oil by steam distillation from the flowering herb.
CHARACTERISTICS: ‘True’ sweet basil oil is a colourless or pale yellow liquid with a light, fresh sweet-spicy scent and balsamic undertone. It blends well with bergamot, clary sage, lime, opopanax, oakmoss, citronella, geranium, hyssop and other ‘green’ notes.
PRINCIPAL CONSTITUENTS: Linalol (40–45 per cent), methyl chavicol (23.8 per cent) and small amounts of eugenol, limonene and citronellol, among others.
SAFETY DATA: Relatively non-toxic, non-irritant, possible sensitization in some individuals. Avoid during pregnancy.
AROMATHERAPY/HOME: USE
Skin Care: Insect bites (mosquito, wasp), insect repellent.
Circulation, Muscles and Joints: Gout, muscular aches and pains, rheumatism.
Respiratory Syste: Bronchitis, coughs, earache, sinusitis.
Digestive System: Dyspepsia, flatulence, nausea.
Genito-Urinary System: Cramps, scanty periods.
Immune System: Colds, fever, ’flu, infectious disease.
Nervous System: Anxiety, depression, fatigue, insomnia, migraine, nervous tension: ‘Oil of Basil is an excellent, indeed perhaps the best, aromatic nerve tonic. It clears the head, relieves intellectual fatigue, and gives the mind strength and clarity.’8
OTHER USES: The oil is used in soaps, cosmetics and perfumery; it is also used extensively in major food categories, especially savouries.... basil, french
FAMILY: Myrtaceae
SYNONYMS: Gum tree, southern blue gum, Tasmanian blue gum, fever tree, stringy bark.
GENERAL DESCRIPTION: A beautiful, tall, evergreen tree, up to 90 metres high. The young trees have bluish-green oval leaves while the mature trees develop long, narrow, yellowish leaves, creamy-white flowers and a smooth, pale grey bark often covered in a white powder.
DISTRIBUTION: Native to Tasmania and Australia. Mainly cultivated in Spain and Portugal, also Brazil, California, Russia and China. Very little of this oil now comes from its native countries.
OTHER SPECIES: There are over 700 different species of eucalyptus, of which at least 500 produce a type of essential oil. Many have been extracted simply for experimental purposes, and research is still being carried out with regard to the different constituents of each oil. In general, they can be divided into three categories. 1. The medicinal oils containing large amounts of cineol (or eucalyptol), such as the blue gum, but increasingly the blue malee (E. polybractea), the narrow-leaved peppermint (E. radiata var. australiana) and the gully gum (E. smithii). 2. The industrial oils containing mainly piperitone and phellandrene, such as the peppermint eucalyptus (E. piperita), grey peppermint (E. radiata var. phellandra) and increasingly the broad-leaved peppermint (E. dives var. Type). 3. The perfumery oils containing mainly citronellal, such as the lemon-scented eucalyptus (E. citriodora). See also Botanical Classification section.
HERBAL/FOLK TRADITION: A traditional household remedy in Australia, the leaves and oil are especially used for respiratory ailments such as bronchitis and croup, and the dried leaves are smoked like tobacco for asthma. It is also used for feverish conditions (malaria, typhoid, cholera, etc.) and skin problems like burns, ulcers and wounds. Aqueous extracts are used for aching joints, bacterial dysentery, ringworms, tuberculosis, etc. and employed for similar reasons in western and eastern medicine. The wood is also used for timber production in Spain.
ACTIONS: Analgesic, antineuralgic, antirheumatic, antiseptic, antispasmodic, antiviral, balsamic, cicatrisant, decongestant, deodorant, depurative, diuretic, expectorant, febrifuge, hypoglycaemic, parasiticide, prophylactic, rubefacient, stimulant, vermifuge, vulnerary.
EXTRACTION: Essential oil by steam distillation from the fresh or partially dried leaves and young twigs.
CHARACTERISTICS: A colourless mobile liquid (yellows on ageing), with a somewhat harsh camphoraceous odour and woody-sweet undertone. It blends well with thyme, rosemary, lavender, marjoram, pine, cedarwood and lemon. (The narrow-leaved eucalyptus (E. radiata var. australiana) is often used in preference to the blue gum in aromatherapy work, being rich in cineol but with a sweeter and less harsh odour.)
PRINCIPAL CONSTITUENTS: Cineol (70–85 per cent), pinene, limonene, cymene, phellandrene, terpinene, aromadendrene, among others.
SAFETY DATA: Externally non-toxic, non-irritant (in dilution), non-sensitizing. ‘When taken internally eucalyptus oil is toxic and as little as 3.5ml has been reported as fatal’..
AROMATHERAPY/HOME: USE
Skin Care: Burns, blisters, cuts, herpes, insect bites, insect repellent, lice, skin infections, wounds.
Circulation Muscles And Joints: Muscular aches and pains, poor circulation, rheumatoid arthritis, sprains, etc.
Respiratory System: Asthma, bronchitis, catarrh, coughs, sinusitis, throat infections.
Genito-Urinary System: Cystitis, leucorrhoea.
Immune System: Chickenpox, colds, epidemics, ’flu, measles.
Nervous System: Debility, headaches, neuralgia.
OTHER USES: The oil and cineol are largely employed in the preparation of liniments, inhalants, cough syrups, ointments, toothpaste and as pharmaceutical flavourings also used in veterinary practise and dentistry. Used as a fragrance component in soaps, detergents and toiletries – little used in perfumes. Used for the isolation of cineol and employed as a flavour ingredient in most major food categories.... eucalyptus, blue gum
FAMILY: Lamiaceae (Labiatae)
SYNONYMS: L. spica, aspic, broad-leaved lavender, lesser lavender, spike.
GENERAL DESCRIPTION: An aromatic evergreen sub-shrub up to 1 metre high with lance-shaped leaves, broader and rougher than true lavender. The flower is more compressed and of a dull grey-blue colour.
DISTRIBUTION: Native to the mountainous regions of France and Spain; also found in North Africa, Italy, Yugoslavia and the eastern Mediterranean countries. It is cultivated internationally; the oil is mainly produced in France and Spain.
OTHER SPECIES: There are many different chemotypes of lavender in general, and this also applies to spike lavender. The French spike oil is reputed to be a more delicate, aromatic scent than the Spanish variety. For other varieties, see entries on lavandin, true lavender and the Botanical Classification section.
HERBAL/FOLK TRADITION: Culpeper recommends spike lavender for a variety of ailments including ‘pains of the head and brain which proceed from cold, apoplexy, falling sickness, the dropsy, or sluggish malady, cramps, convulsions, palsies, and often faintings’. He also warns that ‘the oil of spike is of a fierce and piercing quality, and ought to be carefully used, a very few drops being sufficient for inward or outward maladies’.. The preparation ‘oleum spicae’ was made by mixing ¼ spike oil with ¾ turpentine, and used for paralysed limbs, old sprains and stiff joints (it was also said to encourage hair growth).
Spike lavender is current in the British Herbal Pharmacopoeia, indicated for flatulent dyspepsia, colic, depressive headaches, and the oil (topically) for rheumatic pain.
ACTIONS: See true lavender.
EXTRACTION: Essential oil by water or steam distillation from the flowering tops.
CHARACTERISTICS: A water-white or pale yellow liquid with a penetrating, fresh herbaceous, camphoraceous odour. It blends well with rosemary, sage, lavandin, eucalyptus, rosewood, lavender, petitgrain, pine, cedarwood, oakmoss, patchouli and spice oils, particularly clove.
PRINCIPAL CONSTITUENTS: Mainly cineol and camphor (40–60 per cent), with linalol and linalyl acetate, among others.
SAFETY DATA: Non-toxic, non-irritant (except in concentration), non-sensitizing.
AROMATHERAPY/HOME: USE See true lavender.
OTHER USES: It is used in some pharmaceutical preparations and especially in veterinary practice as a prophylactic, in incipient paralysis, for rheumatism and arthritis and to get rid of lice. It is extensively employed as a fragrance component especially in soaps and industrial perfumes such as deodorants, disinfectants and cleaning agents, as well as insecticides and room sprays, etc. It is also used in the food industry and in the production of fine varnishes and lacquers.... lavender, spike
FAMILY: Lamiaceae (Labiatae)
SYNONYMS: P. patchouly, patchouly, puchaput.
GENERAL DESCRIPTION: A perennial bushy herb up to 1 metre high with a sturdy, hairy stem, large, fragrant, furry leaves and white flowers tinged with purple.
DISTRIBUTION: Native to tropical Asia, especially Indonesia and the Philippines. It is extensively cultivated for its oil in its native regions as well as India, China, Malaysia and South America. The oil is also distilled in Europe and America from the dried leaves.
OTHER SPECIES: Closely related to the Java patchouli (P. heyneanus), also known as false patchouli, which is also occasionally used to produce an essential oil.
HERBAL/FOLK TRADITION: The oil is used in the East generally to scent linen and clothes, and is believed to help prevent the spread of disease (prophylactic). In China, Japan and Malaysia the herb is used to treat colds, headaches, nausea, vomiting, diarrhoea, abdominal pain and halitosis. In Japan and Malaysia it is used as an antidote to poisonous snakebites.
ACTIONS: Antidepressant, anti-inflammatory, anti-emetic, antimicrobial, antiphlogistic, antiseptic, antitoxic, antiviral, aphrodisiac, astringent, bactericidal, carminative, cicatrisant, deodorant, digestive, diuretic, febrifuge, fungicidal, nervine, prophylactic, stimulant (nervous), stomachic, tonic.
EXTRACTION: Essential oil by steam distillation of the dried leaves (usually subjected to fermentation previously). A resinoid is also produced, mainly as a fixative.
CHARACTERISTICS: An amber or dark orange viscous liquid with a sweet, rich, herbaceous earthy odour – it improves with age. It blends well with labdanum, vetiver, sandalwood, cedarwood, oakmoss, geranium, clove, lavender, rose, neroli, bergamot, cassia, myrrh, opopanax, clary sage and oriental-type bases.
PRINCIPAL CONSTITUENTS: Patchouli alcohol (40 per cent approx.), pogostol, bulnesol, nor patchoulenol, bulnese, patchoulene, among others.
SAFETY DATA: Non-toxic, non-irritant, non-sensitizing.
AROMATHERAPY/HOME: USE
Skin care: Acne, athlete’s foot, cracked and chapped skin, dandruff, dermatitis, eczema (weeping), fungal infections, hair care, impetigo, insect repellent, sores, oily hair and skin, open pores, wounds, wrinkles.
Nervous system: Frigidity, nervous exhaustion and stress-related complaints.
OTHER USES: Extensively used in cosmetic preparations, and as a fixative in soaps and perfumes, especially oriental types. Extensively used in the food industry, in alcoholic and soft drinks. It makes a good masking agent for unpleasant tastes and smells.... patchouli
Health Encyclopedia