Pseudohypertrophy Health Dictionary

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Pseudohypertrophy: From 1 Different Sources

n. increase in the size of an organ or structure caused by excessive growth of cells that have a packing or supporting role but do not contribute directly to its functioning. The result is usually a decline in the efficiency of the organ although it becomes larger. —pseudohypertrophic adj.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Duchenne Muscular Dystrophy

An X-linked recessive disorder (that is, the abnormal gene is carried on the X chromosome). This means that the disease occurs almost exclusively in males, as its presence in a female is counteracted by the normal gene likely to be in her other X chromosome. The disorder is characterised by progressive muscular weakness and wasting. It is the most common form of muscular dystrophy, ocurring in 30 per 100,000 live male births, often – but not always – in families with other members having the disorder.

The disease usually appears within the ?rst three years of life, beginning in the pelvic girdle and lower limbs and later spreading to the shoulder girdle. The calf muscles become bulky (pseudohypertrophy). The weakness gives rise to a characteristic waddling gait and, when rising from the supine position, the child rolls on to his face and then uses his arms to push himself up. Death usually occurs by the middle of the second decade from respiratory infections. Prenatal screening of female carriers using gene probes is increasingly available. (See DYSTROPHY; MUSCLES, DISORDERS OF – Myopathy.)... duchenne muscular dystrophy


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