Psoralea corylifolia Health Dictionary

Psoralea Corylifolia: From 1 Different Sources


Linn.

Family: Papilionaceae; Fabaceae.

English: Babchi, Purple Fleabane.

Habitat: Rajasthan., eastern districts of Punjab and adjoining areas of Uttar Pradesh.

Ayurvedic: Somaraaji, Somavalli, Somavallik, Soma, Chaandri, Vaakuchi, Baakuchi, Avalguja. (Somaraaji and Avalguja have also been equated with Centratherum anthelminticum.)

Unani: Baabchi, Bakuchi.

Siddha/Tamil: Karpoogaarisi.

Action: Seed—used in leucoderma, vitiligo, leprosy, psoriasis and inflammatory diseases of the skin, both orally and externally. (The Ayurvedic Pharmacopoeia of India.)

The seed and roots contain chal- cones, flavones, isoflavones, furano- coumarins and coumesterol group of compounds. These include psoralen, isopsoralen, bavachinin.

A mixture of psoralen and isopso- ralen, in a ratio of 1:3, is recommended for topical application in leucoderma. These furanocoumarins initiate transformation of DOPA to melanin under the influence of UV light. Seeds are powdered and administered orally with warm water (5 g/day) in cases of eczema.

Psoralen was found to be cytotoxic in vitro. The combination therapy of psoralen and UV irradiation has been shown to inhibit the growth of tumours in vivo.

Bavachinin-A, isolated from the fruits, exhibited marked anti-inflammatory, antipyretic and mild analgesic properties similar to those of oxyphenylbutazone and hydrocortisone. It demonstrated better antipyretic activity than paracetamol experimentally.

Oral administration of the powdered seeds has generally resulted in side reactions (nausea, vomiting, purging); external application generally proved highly irritant to the skin.

Dosage: Seed—1-3 g powder (CCRAS.); 3-6 g powder (API, Vol. I).
Health Source: Indian Medicinal Plants
Author: Health Dictionary

Centratherum Anthelminticum

Kuntze.

Synonym: Vernonia anthelmintica Willd.

Family: Asteraceae.

Habitat: Throughout India up to 2,000 m in the Himalayas and Khasi Hills.

English: Purple Flea-bane, Achenes.

Ayurvedic: Aranya-Jiraka, Vanajira- ka, Kaalijiri, Karjiri. Somaraaji (also equated with Psoralea corylifolia Linn., Papilionaceae).

Unani: Kamoon barri.

Siddha/Tamil: Kaattu seerakam.

Action: Anthelmintic (against earthworms and tapeworms), stomachic, diuretic; used in skin diseases.

Delta-7-avenasterol is the main active principle of seeds. Seed oil contains vernasterol. Seeds bitter principle is a demanolide lactone. Centratherin and germacranolide from the leaves and stem have been isolated. Leaves contain abscisic acid. EtOH extract of achenes exhibited good results in giar- diasis. Various plant parts are used in syphilis. Clinical studies on vircarcika eczema validated the use of the drug in skin diseases.

The drug exhibited smooth muscle- relaxant and hypotensive activity in animals.

Dosage: Seed—1-3 g powder. (CCRAS.)

Dosage: Seed—1-3 g powder. (CCRAS.)... centratherum anthelminticum

Hydnocarpus Kurzii

(King) Warb.

Synonym: H. heterophylla auct. non-Bl. Taractogenos Kurzii King.

Family: Flacourtiaceae.

Habitat: Assam and Tripura.

English: Chalmogra.

Ayurvedic: Tuvaraka (related species, substitute for H. laurifolia.)

Unani: Chaalmograa, Tukhm-e- Biranj Mograa.

Siddha/Tamil: Niradi-muttu.

Action: Antileprotic, dermatic, febrifuge, sedative. Used parenter- ally for leprosy; also for psoriasis, eczema and dermatitis.

The plant is a source of chaulmoogra oil (Oleum Chaulmoograe which contains hydnocarpic, chaulmoogric, gor- lic, oleic, palmitic acids and lower homologues of hydnocarpic acid. The oil mixed with neem oil or oil of Psoralea corylifolia is used in leprosy.

In mice, intraperitoneal and subcutaneous administration of chaul- moogra fatty acids demonstrated antimicrobial activity against Mycobac- terium leprae. (PDR.)... hydnocarpus kurzii

Hansen’s Disease

Leprosy. Progressive infection by Mycobacterium leprae. Two forms: (1) tuberculoid; infection of the nerve endings and membranes of the nose, with loss of feeling and pale patches on the body. (2) Lepromatous; with inflamed thickened painful red skin exacerbated by ulceration, fever, neuritis and orchitis. Distorted lips and loss of nasal bone as infection progresses.

Symptoms: numbness, nerves may swell like iron rods. Infected nerves kill all sensation. In endemic areas, pins and needles in hands may call attention to it. A disease of nerves rather than skin. NOTIFIABLE DISEASE.

Many laymen and practitioners will never have seen a case. In the absence of modern medicine some good can be achieved by traditional remedies. Ancient Hindu and Chinese records refer to the use of Gotu Kola (internally and externally). Dr C.D. de Granpre? (1888) refers. (Martindale 27; p.441)

Oil of Chaulmoogra was used up to one hundred years ago before introduction of modern drugs. It fell into dis-use until discovered by a Director of Health in the Philippine Islands during World War I when he used it successfully in combination with camphor. In South America, where the disease is still active, Sarsaparilla has a long traditional reputation. Walnut oil is used as a dressing, in China. An anti- staphylococcal fraction has been isolated from the seeds of Psoralea corylifolia for use in leprosy. (Indian Journal of Pharmacy 26: 141, 1964)

Tea. Gotu Kola. Half a teaspoon to each cup boiling water; infuse 15 minutes. Drink freely. Stronger infusions may be used externally to cleanse ulceration.

Decoction. Combine: Sarsaparilla 1; Gotu Kola 1; Echinacea 2. Half an ounce to 1 pint water gently simmered 20 minutes. Dose: Half a cup 3 times daily.

Formula. Echinacea 2; Sarsaparilla 1; Gotu Kola 2. Dose. Powders 500mg. Liquid Extracts 3-5ml. Tinctures 5-10ml. Thrice daily.

Note: Antibody-positive cases of AIDS are vulnerable to leprosy, both diseases being caused by a similar bacterium.

To be treated by infectious diseases specialist. ... hansen’s disease

Leukoderma

Pale patches on skin due to loss of pigmentation. May follow a skin disease or from handling chemicals. Vitiligo is a modified form of the disease. There is no known cure, although Dr Wm Burton (Ellingwood) found Butternut useful. Seeds of Psoralea corylifolia appear to be indicated. (Indian Journal of Pharmacy 26:141.1964)

See entry: HIMALAYAN COW PARSLEY. ... leukoderma




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