Purified Protein Derivative (ppd): From 1 Different Sources
Reagent used by intradermal administration in the Mantoux (tuberculin) test for TB.
Molecular constituent of all cells comprising amino acid building blocks.... protein
A protein produced in the body in response to inflammation.... c-reactive protein
A protein produced in the gut and liver of the FETUS. Abnormality in the fetus, such as neural tube defect, may result in raised levels of alphafeto protein in the maternal blood. In DOWN’S (DOWN) SYNDROME, levels may be abnormally low. In either case, screening of the pregnancy should be carried out, including AMNIOCENTESIS to check the amount of alpha-feto protein in the amniotic ?uid. The protein may also be produced in some abnormal tissues in the adult – in patients with liver cancer, for example.... alpha-feto protein
The formation of protein molecules through the joining of amino acids.... protein synthesis
a protein of low molecular weight found in the urine of patients with multiple *myeloma and rarely in patients with *lymphoma, *leukaemia, and *Hodgkin’s disease. [H. Bence-Jones (1814–73), British physician]... bence-jones protein
(PTH-RP) a protein that is secreted by certain malignant tumours and is the main cause of malignant *hypercalcaemia. PTH-RP, which has effects similar to *parathyroid hormone, stimulates generalized bone resorption and excessive calcium reabsorption in the kidney tubules. It is most commonly produced by lung tumours, squamous-cell carcinomas of other organs, melanomas, and tumours of the breast, liver, pancreas, bladder, and prostate.... parathyroid hormone-related protein
an enzyme that catalyses the transfer of a phosphate group from ATP to a specific amino acid residue of an intracellular protein (usually serine, threonine, or tyrosine), thereby affecting the biological activity of the protein. Protein kinase inhibitors are drugs that block the action of protein kinases in tumour cells and are used in the treatment of cancer. They include *sorafenib, *sunitinib, and *temsirolimus. See also tyrosine kinase inhibitor.... protein kinase
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