The SYNOVITIS usually starts acutely and is frequently asymmetrical, with the knees and ankles most commonly affected. Often there are in?ammatory lesions of tendon sheaths and entheses (bone and muscle functions) such as plantar fasciitis (see FASCIITIS). The severity and duration of the acute episode are extremely variable. Individuals with the histocompatibility antigen HLA B27 are particularly prone to severe attacks.
Causes There is a major immunogenetic predisposition to rheumatoid arthritis in people carrying the HLA-DR4 antigen (see HLA SYSTEM). Other minor immunogenetic factors have also been implicated. In addition, there is a degree of familial clustering which suggests other unidenti?ed genetic factors. Genetic factors cannot alone explain aetiology, and environmental and chance factors must be important, but these have yet to be identi?ed.
Epidemiology Rheumatoid arthritis more commonly occurs in women from the age of 30 onwards, the sex ratio being approximately 4:1. Typical rheumatoid arthritis may occur in adolescence, but in childhood chronic SYNOVITIS usually takes one of a number of di?erent patterns, classi?ed under juvenile chronic arthritis.
Pathology The primary lesion is an in?ammation of the synovial membrane of joints. The synovial ?uid becomes diluted with in?ammatory exudate: if this persists for months it leads to progressive destruction of articular CARTILAGE and BONE. Cartilage is replaced by in?ammatory tissue known as pannus; a similar tissue invades bone to form erosions. Synovitis also affects tendon sheaths, and may lead to adhesion ?brosis or attrition and rupture of tendons. Subcutaneous and other bursae may be involved. Necrobiotic nodules also occur at sites outside synovium, including the subcutaneous tissues, the lungs, the pericardium and the pleura.
Clinical features Rheumatoid arthritis varies from the very mild to the severely disabling. Many mild cases probably go undiagnosed. At least 50 per cent of patients continue to lead a reasonably normal life; around 25 per cent are signi?cantly disabled in terms of work and leisure activities; and a minority become markedly disabled and are limited in their independence. There is often an early acute phase, followed by substantial remission, but in other patients gradual step-wise deterioration may occur, with progressive involvement of an increasing number of joints.
The diagnosis of rheumatoid arthritis is largely based on clinical symptoms and signs. Approximately 70 per cent of patients have rheumatoid factor ANTIBODIES in the SERUM but, because of the large number of false positives and false negatives, this test has very little value in clinical practice. It may be a useful pointer to a worse prognosis in early cases if the level is high. X-RAYS may help in diagnosing early cases and are particularly helpful when considering surgery or possible complications such as pathological fracture. Patients commonly develop ANAEMIA, which may be partly due to gastrointestinal blood loss from antiin?ammatory drug treatment (see below).
Treatment involves physical, pharmacological, and surgical measures, together with psychological and social support tailored to the individual patient’s needs. Regular activity should be maintained. Resting of certain joints such as the wrist with splints may be helpful at night or to assist prolonged manual activities. Sound footwear is important. Early use of antirheumatic drugs reduces long-term disability. Drug treatment includes simple ANALGESICS, NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS), and slow-acting drugs including GOLD SALTS (in the form of SODIUM AUROTHIOMALATE), PENICILLAMINE, SULFASALAZINE, METHOTREXATE and AZATHIOPRINE.
The non-steroidal agents are largely e?ective in reducing pain and early-morning sti?ness, and have no e?ect on the chronic in?ammatory process. It is important, especially in the elderly, to explain to patients the adverse effects of NSAIDs, the dosage of which can be cut by prescribing paracetamol at the same time. Combinations of anti-rheumatic drugs seem better than single agents. The slow-acting drugs take approximately three months to act but have a more global e?ect on chronic in?ammation, with a greater reduction in swelling and an associated fall in erythrocyte sedimentation rate (ESR) and rise in the level of HAEMOGLOBIN. Local CORTICOSTEROIDS are useful, given into individual joints. Systemic corticosteroids carry serious problems if continued long term, but may be useful under special circumstances. Much research is currently going on into the use of tumour necrosis factor antagonists such as INFLIXIMAB and etanercept, but their precise role remains uncertain.... rheumatoid arthritis
Clinical features There are various types. The oligoarthritic type involves 1–4 joints (usually knee or ankle) which become hot, swollen and painful. One complication is an in?ammation of the eyes – UVEITIS. The condition often ‘burns out’, but may reappear at any time, even years later.
The polyarthritic type is more like RHEUMATOID ARTHRITIS in adults, and the child may have persistent symptoms leading to major joint deformity and crippling.
The systemic type, previously called Still’s disease, presents with a high fever and rash, enlarged liver, spleen and lymph nodes, and arthritis – although the latter may be mild. In some children the illness becomes recurrent; in others it dies down only to return as polyarthritis.
Complications These include uveitis, which can lead to loss of vision; a failure to thrive; osteoporosis (see under BONE, DISORDERS OF); joint deformity; and psychosocial diffculties.
Treatment This includes ANTIPYRETICS and ANALGESICS, including NON-STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS), intra-articular steroid injections, anti-tumour necrosis factor drugs and steroids.
Physiotherapy is vital, and children may need to wear splints or other orthotic devices to alleviate deformity and pain. Orthopaedic operative procedures may be necessary.... juvenile idiopathic arthritis (jia)
Chronic bowel conditions are frequently responsible for heavy drainage of vitamins and minerals via excessive stool. Calcium may be pillaged from the bones to make up blood calcium levels which, if prolonged, may lead to rigid spine.
Treatment. Treatment of arthritis would be secondary, the primary object being to normalise the bowel. Alternatives:–
Teas or decoctions. Comfrey leaves, Calamus, Chamomile, Avens, Agrimony, Marshmallow root, Meadowsweet, Slippery Elm bark, Wild Yam.
Tea. Formula. Equal parts: Agrimony, Balm, Chamomile. 1 heaped teaspoon to each cup boiling water; infuse 5-10 minutes; 1 cup freely.
Fenugreek seeds. Decoction. 1 cup freely.
Tablets/capsules. Calamus, Fenugreek, Goldenseal, Wild Yam.
Formula. Fenugreek 2; Wild Yam 1; Goldenseal quarter; Ginger quarter. Mix. Dose: Powders: 500mg (two 00 capsules or one-third teaspoon). Liquid extracts: 1 teaspoon. Tinctures: 2 teaspoons.
Bamboo powder. Two 320mg capsules thrice daily. (Dr Max Rombi)
Biostrath Willow Formula.
Diet. Slippery Elm food. Vitamin B12. Low fat. Cider vinegar.
Supportive: high enemas. Natural lifestyle. Outlook good. ... arthritis – bowel related
See: INFECTIVE HEPATITIS.
Treatment. To include liver agents: Barberry, Fringe Tree, Balmony or Milk Thistle. ... arthritis – of infective hepatitis
Treatment by general medical practitioner or infectious diseases specialist. ... arthritis – of leprosy
Formula. Echinacea 1; Goldenseal half; Poke root quarter. Mix. Dose: Powders: 500mg (two 00 capsules or one-third teaspoon). Liquid extracts: 1 teaspoon. Tinctures: 2 teaspoons. Thrice daily, in water.
Poke root tablets/capsules. As recommended. ... arthritis – from attack of mumps
Treatment. BHP (1983) recommends: Meadowsweet, Balm of Gilead, Poke root, Bogbean, Hart’s Tongue fern, Mountain Grape.
Teas: Singly or in combination (equal parts): Chamomile, Bogbean, Nettles, Yarrow. 1-2 teaspoons to each cup boiling water; infuse 5-10 minutes. 1 cup thrice daily before meals.
Tablets/capsules. Blue Flag root, Dandelion root, Poke root, Prickly Ash bark.
Formula. White Poplar bark 2; Black Cohosh half; Poke root quarter; Valerian quarter; Liquorice quarter. Mix. Dose: Powders: 500mg (two 00 capsules or one-third teaspoon) (children 5-12 years: 250mg – one 00 capsule or one-sixth teaspoon). Liquid extracts: 1 teaspoon: (children 5-12: 3-10 drops). Tinctures: 2 teaspoons: (children 5-12: 5-20 drops).
Evening Primrose oil. Immune enhancer.
Topical. Hot poultice: Slippery Elm, Mullein or Lobelia.
Diet: Lacto vegetarian. Kelp. Comfrey tea. Molasses. Low fat.
General. Adequate rest, good nursing, gentle manipulation but no massage to inflamed joints. Natural lifestyle. Parental emotional support.
Oily fish. See entry. ... arthritis, juvenile, chronic
Tinctures. Balm of Gilead 1; Kava Kava 1; Black Cohosh half; Juniper quarter. Mix. Dose: 30-60 drops, thrice daily.
Topical. Tea Tree oil (if too strong may be diluted many times. Analgesic cream.
Treatment by or in liaison with a general medical practitioner or infectious disease specialist. ... arthritis, gonococcal
Infective arthritis may be associated with German Measles against which conventional antibiotics may be of little value. Infective organisms include: streptococcus, E. coli, staphylococcus, or others. May follow surgical operation, steroid therapy, rheumatoid arthritis or diabetes.
Symptoms. Joint hot, feverish, enlarged and painful.
Differential diagnosis: distinguish from gout and synovitis. Herbal treatment must needs be persevered with for 3 to 6 months, even longer. Good nursing is necessary. Natural life-style. Bedrest.
Treatment. For all microbial infections include Echinacea. (Hyde)
Teas. Nettles. Red Clover. Yarrow. 2 teaspoons to each cup boiling water; infuse 15 minutes. 1 cup 3-4 times daily.
Tablets/capsules. Devil’s Claw, Alfalfa, Echinacea, Horsetail.
Alternative formulae:– Powders. Echinacea 2; Burdock 1; Devil’s Claw 1; Guaiacum quarter. Mix. Dose: 750mg (three 00 capsules or half a teaspoon). Thrice daily.
Liquid Extracts. Echinacea 2; Juniper half; Black Cohosh half; Guaiacum quarter. Mix. Dose: 30-60 drops. Thrice daily.
Tinctures. Dandelion 2; Echinacea 2; Poke root half; Peppermint quarter. mix. Dose: 1-2 teaspoons. Thrice daily.
Above powders, liquid extracts and tinctures – effects are enhanced when each dose is taken in half-1 cup Fennel tea; otherwise, to be taken in water.
Topical. Analgesic cream. Comfrey poultice, Comfrey ointment. Tea Tree oil, Castor oil packs.
Diet. High Vitamin C foods. Dandelion coffee. ... arthritis, infective
Symptoms: Joint pains with feverishness, loss of weight, anaemia and red raised patches of skin on nose and face (butterfly rash). Swelling of the joints resembles rheumatoid arthritis. Chest and kidney disease possible. Personality changes with depression followed by mania and possible convulsions.
Treatment. Standard orthodox treatments: aspirin, steroids. Alternatives: Echinacea (rash), Valerian (mental confusion), Lobelia (chest pains), Parsley Piert (kidney function).
Tablets/capsules. Echinacea. Poke root. Dandelion. Valerian. Wild Yam. Prickly Ash bark.
Powders. Echinacea 2; Dandelion 1; Wild Yam half; Poke root quarter; Devil’s Claw half; Fennel half. Mix. Dose: 500mg (two 00 capsules or one-third teaspoon) thrice daily. In water or cup of Fenugreek tea. Tinctures. Dandelion 4; Valerian 1; Prickly Ash half; Poke root half; Peppermint quarter. Mix. Dose: 1 teaspoon thrice daily, in water or cup Fenugreek tea.
Tincture. Queen’s Delight BHP (1983) 1:5 in 45 per cent alcohol. Dose 1-4ml (15-60 drops).
Topical. Plantain Salvo. Castor oil. Oil Cajeput or Sassafras. Comfrey or Chickweed cream.
Diet. Young girls may require diet for anaemia.
Supplementation. Daily. Vitamins A, B6, B12, C, D. Dolomite (1500mg). Calcium Pantothenate (500mg). Iron: Men (10mg), women (18mg). ... arthritis, lupus
Alternatives. Agnus Castus, Alfalfa, Black Cohosh, Blue Cohosh, Cramp bark, Hawthorn, Hops, Liquorice, Sage, Sarsaparilla, Wild Yam, Yarrow.
Tea. Formula. Equal parts: Alfalfa, Hops, Sage. 1 heaped teaspoon to each cup boiling water; infuse 5-10 minutes; 1 cup freely.
Chinese medicine: Sage tea.
Formula. Agnus castus 2; Black Cohosh 1; Valerian half; Juniper quarter. Mix. Dose: Powders: 500mg (two 00 capsules or one-third teaspoon). Liquid Extracts: 1 teaspoon. Tinctures: 2 teaspoons, in water, or cup of Nettle tea.
Nettle tea. Favourable results reported.
Evening Primrose oil.
Diet. Oily fish. Low fat, Low salt. High fibre.
Supplements. Vitamins A, B6, B-complex, C, E. Calcium, Magnesium, Zinc. ... arthritis – menopausal
Common in the elderly and menopausal women. Calcium salts may be laid down in a joint believed to be due to errors of diet. Small crystals of calcium hydroxyapatite have been observed to form in cartilage and synovial fluid. (Research group: St Bartholomew’s Hospital, London)
The aged sometimes suffer from diminished supply of hydrochloric acid in the stomach, and which is necessary for normal calcium metabolism. An effective substitute is 2 teaspoons cider vinegar in a glass of water sipped before or during meals.
Alte rnative s. Black Cohosh and Meadowsweet (natural sources of salicylic acid), Asafoetida (inflammation of connective tissue), Hawthorn (efficient circulation of the blood), Poke root, Bladderwrack, Guaiacum, Devil’s Claw, Bogbean, White Poplar bark, Yucca leaves.
Tea. Celery seeds. 1 teaspoon to each cup boiling water. Infuse 15 minutes. Half-1 cup, 2-3 times daily, before meals. Comfrey tea.
Alternative formulae:– Powders. White Willow 2; Devil’s Claw 1; Black Cohosh half; Guaiacum quarter. Mix. Dose: 500mg (two 00 capsules or one-third teaspoon). Thrice daily in water or Nettle tea. Liquid extracts. White Willow 2; Devil’s Claw 1; Bogbean 1; Fennel 1; Tincture Capsicum quarter. Mix. 1 teaspoon thrice daily in water or Nettle tea.
Tinctures. Bogbean 2; Meadowsweet 2; Black Cohosh 1; Guaiacum quarter; Peppermint quarter. Mix. Dose: 2 teaspoons thrice daily.
Tablets/capsules: Devil’s Claw, Wild Yam, Ligvites.
Cod liver oil. Chief of the iodised oils. Can reach and nourish cartilage by the process of osmosis. Its constituents filter into cartilage, imparting increased elasticity which prevents degeneration. Known to soften-up fibrous tissue. 2 teaspoons once daily. Also helps correct uric acid metabolism.
Topical. Physiotherapy. Osteopathy. Jojoba oil packs. Capsicum Cream. Hot and cold compresses twice daily – followed by a cold compress at night, leaving on when in bed. Hot Epsom salt bath twice weekly. Diet. Oily fish: see entry. Low fat. Low salt. High fibre. Avoid lemons and other citrus fruits. Lemon juice may remove some calculi from the body but later begins to remove calcium from the bones. Supplementation. Pantothenic acid 10mg; Vitamin A 7500iu; Vitamin B6 25mg; Vitamin E 400iu; Zinc 25mg.
General. Warm dry climate often relieves. Surgery may be necessary. Herbs Pleurisy root, Comfrey root and Bryonia, sustain the constitution and promote tissue healing after joint replacements with ceramic substitute after the famous Charnley operation. The condition is disabling but it is possible to manage successfully, maintaining normal activities with minimum difficulty. ... arthritis – osteo
Alternatives:– Teas. Gotu Kola, Red clover flowers, Chickweed. Singly or in combination. 1 heaped teaspoon to each cup boiling water: infuse 5-10 minutes. 1 cup thrice daily.
Decoction. Fine cut: Burdock 2; Horsetail 1; Echinacea 1; Thuja quarter. Mix. 1oz to 1 pint water gently simmered 15 minutes. Wineglassful (or half a cup) thrice daily, before meals.
Tablets/capsules. Echinacea, Poke root, Prickly Ash bark.
Powders. Formula. Sarsaparilla 1; Echinacea 1; Boneset half; Thuja quarter. Dose: 500mg (two 00 capsules or one-third teaspoon) thrice daily.
Liquid extracts. Formula. Equal parts: Echinacea, Devil’s Claw, Gotu Kola. Dose: 30-60 drops thrice daily before meals.
Tinctures. Formula. Burdock 2; Echinacea 1; Boneset 1; Sarsaparilla 1; Thuja quarter. Fennel quarter. Mix. Dose: 1-2 teaspoons thrice daily.
Cod Liver oil.
Topical. Comfrey poultice, Chickweed cream, Oils of Mullein, Jojoba or Evening Primrose.
Diet. Oily fish (or fish oils). Low salt, low fat.
Supplements. Vitamins A, B-complex, C, D, E, Magnesium, Sulphur, Zinc. ... arthritis – psoriatic
Symptoms. Morning stiffness and pain wearing off later. Easy fatigue and decline in health. Nodules on surface of bones (elbows, wrists, fingers). Joint fluids (synovia) appear to be the object of attack for which abundant Vitamin C is preventative. Anaemia and muscle wasting call attention to inadequate nutrition, possibly from faulty food habits for which liver and intestine herbs are indicated.
Treatment. Varies in accord with individual needs. May have to be changed many times before progress is made. Whatever treatment is prescribed, agents should have a beneficial effect upon the stomach and intestines to ensure proper absorption of active ingredients. (Meadowsweet)
It is a widely held opinion that the first cause of this condition is a bacterial pathogen. An anti- inflammatory herb should be included in each combination of agents at the onset of the disease. See: ANTI-INFLAMMATORY HERBS. Guaiacum (Lignum vitae) and Turmeric (Curcuma longa) have a powerful anti-inflammatory action and have no adverse effects upon bone marrow cells or suppress the body’s immune system. Breast feeding cuts RA death rate.
Of therapeutic value according to the case. Agrimony, Angelica root, Balmony, Black Cohosh (particularly in presence of low back pain and sciatica), Bogbean, Boldo, Burdock, Celery, Cramp bark, Devil’s Claw, Echinacea (to cleanse and stimulate lymphatic system), Ginseng (Korean), Ginseng (Siberian), Liquorice, Meadowsweet, Poke root, Prickly Ash bark, White Poplar bark, White Willow bark, Wild Yam.
Tea. Formula. Equal parts. Alfalfa, Bogbean, Nettles. 1 heaped teaspoon to each cup boiling water; infuse 5-10 minutes, 1 cup thrice daily.
Decoction. Prickly Ash bark 1; Cramp bark 1; White Willow bark 2. Mix. 1oz to 1 pint water gently simmered 20 minutes. Dose: Half-1 cup thrice daily.
Tablets/capsules. Black Cohosh, Celery, Cramp bark, Devil’s Claw, Feverfew, Poke root, Prickly Ash, Wild Yam, Ligvites.
Alternative formulae:– Powders. White Willow bark 2; Devil’s Claw 1; Black Cohosh half; Ginger quarter. Mix. Dose: 750mg (three 00 capsules or half a teaspoon) thrice daily.
Liquid extracts. White Willow bark 2; Wild Yam half; Liquorice half; Guaiacum quarter. Mix. Dose: 1-2 teaspoons thrice daily.
Tinctures. Cramp bark 1; Bogbean 1; Prickly Ash half; Meadowsweet 1; Fennel half. Mix. Dose: 1-3 teaspoons thrice daily.
Ligvites. (Gerard House)
Cod Liver oil. Contains organic iodine, an important factor in softening-up fibrous tissue, to assist metabolism of uric-acid, help formation of haemoglobin, dilate blood vessels; all related to arthritics. The oil, taken internally, can reach and nourish cartilage by the process of osmosis; its constituents filter into cartilage and impart increased elasticity.
Topical. Evening Primrose oil, Wintergreen lotion, Comfrey poultice. Hydrotherapy: hot fomentations of Hops, Chamomile or Ragwort. Cold water packs: crushed ice or packet of frozen peas in a damp towel applied daily for 10 minutes for stiffness and pain. See: MASSAGE OIL.
Aromatherapy. Massage oils, any one: Cajeput, Juniper, Pine or Rosemary. 6 drops to 2 teaspoons Almond oil.
Supportives: under-water massage, brush baths, sweat packs, Rosemary baths, exposure of joints to sunlight.
Diet. Low salt, low fat, oily fish, Mate tea, Dandelion coffee. On exacerbation of the disease cut out all dairy products.
Supplements. Daily. Evening Primrose capsules: four 500mg; Vitamin C (1-3g); Bromelain 250mg between meals; Zinc 25mg.
General. Residence in a warm climate. Yoga. Disability and deformity may be avoided by a conscientious approach to the subject. ... arthritis – rheumatoid
Elecampane (Inula) has a direct effect on TB bacilli, controlling night sweats and localising the disease. Agents yielding salicylates (mild analgesics) Meadowsweet, White Willow, etc are of value. Echinacea increases phagocytic power of the leucocytes and may normalise percentage count of neutraphiles. To meet individual needs, it will be necessary to vary treatment many times during the course of the disease.
Alternatives. Echinacea, Elecampane, Balm of Gilead buds (Hyde), Gotu Kola, Comfrey root, Iceland Moss. Rupturewort promotes elasticity of lung tissue.
Decoction. Equal parts: Iceland Moss, Comfrey root, Elecampane root, Liquorice. Mix. 1oz to 1 pint water gently simmered 20 minutes in a covered vessel. Dose: Half a cup thrice daily.
Alternative formulae:– Powders. White Willow 2; Comfrey 1; Echinacea 1; Ginger quarter. Mix. Dose: 750mg (three 00 capsules or half a teaspoon) thrice daily.
Tinctures. White Willow 2; Echinacea 1; Blue Cohosh half; White Poplar half; Tincture Capsicum quarter. Mix. 1 teaspoon thrice daily before meals.
Tincture Krameria (Rhatany root), Dose: 30-60 drops in water thrice daily.
Fenugreek seed tea.
Comfrey. Potential benefit of Comfrey root outweighs risk.
Topical. Compresses: Mullein leaves, Lobelia, Comfrey root or Fenugreek. Evening Primrose oil. No massage to affected joints.
Diet. Low carbohydrate. Oily fish.
Supplements. Vitamins A, B6, B12, D, Niacin, Calcium, Iron, Phosphorus.
General. Tuberculosis is a notifiable disease for which specific medical treatment is available. Failure to comply may expose a practitioner to a charge of negligence. ... arthritis – tuberculous
Possible complications include short stature, anaemia, pleurisy, pericarditis, and enlargement of the liver and spleen. Uveitis may develop, which, if untreated, may damage vision. Rarely, amyloidosis may occur or kidney failure may develop. Diagnosis is based on the symptoms, together with the results of X-rays and blood tests, and is only made if the condition lasts for longer than 3 months.
Treatment may include antirheumatic drugs, corticosteroid drugs, nonsteroidal anti-inflammatory drugs, or aspirin. Splints may be worn to rest inflamed joints and to reduce the risk of deformities. Physiotherapy reduces the risk of muscle wasting and deformities.
The arthritis usually clears up after several years. However, in some children, the condition remains active into adult life.
– kala-azar A form of leishmaniasis that is spread by insects. Kala-azar occurs in parts of Africa, India, the Mediterranean, and South America.... juvenile chronic arthritis