Rhesus factor Health Dictionary

One of two proteins secreted from the lining of the stomach whose sole purpose is (it seems) to cradle B12 in a pre-fitted styrofoam mold and (A) carry it through the Seven Levels of Digestive Hell until it reaches those few absorption sites in the last foot of small intestine that understand its “Special Needs” (sounds either sexually kinky or the airplane dinner label on kosher food for flying Hassidim jewelers) and finally (B) slip it from one protein to the other, and thence into the cell membranes where its is turn handed over to (C) the specialized blood protein that can carry it safely to the final target tissues (3 times out of 4, the bone marrow). Cyanocobalamin (B12) has parts that fall off, radicals that twirl around in five directions on three charge potentials, and is as durable as a 49¢ water pistol. And, if we have an ulcer, chronic enteritis or long-standing steatorrhea, we either get B12 shots (and hope the liver still makes that blood carrier) or walk around with pernicious anemia and a hematocrit of 16.... intrinsic factor

An aspect of personal behaviour or lifestyle, an environmental exposure, or an inborn or inherited characteristic, which, on the basis of scientific evidence, is known to be associated with health-related condition(s) considered important to prevent.... risk factor

A coagulative blood protein that is a constituent of the COAGULATION cascade – an essential component in the clotting of blood. Those people with the inherited disorder, HAEMOPHILIA, have abnormally low amounts of factor VIII and so bleed more when cut. They are treated with a concentrated version to reduce the tendency to bleed.... factor viii

See BLOOD GROUPS.... rh factor

A protein in blood that plays an important role in the clotting mechanism. A deficiency of factor causes a rare genetic bleeding disorder known as Christmas disease.... factor ix

Any of various chemicals involved in stimulating new cell growth and maintenance.

Some growth factors, such as vascular endothelial growth factor, which stimulates the formation of new blood vessels, are important in the growth and spread of cancers.... growth factor

A chemical, psychological, physiological, social, environmental or genetic factor or conditions that predisposes an individual to the development of a disease or injury.... health risk factor

The study of the interrelationships between humans, the tools they use, and the environment in which they live and work.... human-factor research

An agent involved in the clotting mechanism of the blood. It helps in the activation of THROMBOPLASTIN in the blood PLASMA (see COAGULATION).... lipoid factor

Various compounds and processes that enable the liver to metabolize fats properly or prevent the formation of cholesterolic stones in the gall bladder by supporting the continued emulsification of gall bladder bile. EXAMPLES: Lecithin, choline, Aristolochia... lipotropic factors

One of the blood proteins that maintains the balance between the blood clotting too easily or too slowly after an injury.

About 5 per cent of the population have an inherited mutation in the gene controlling factor V production, known as factor V Leiden.

They are at increased risk of deep-vein thrombosis (see thrombophilia), particularly if they are taking the oral contraceptive pill or go on long aircraft journeys.... factor v

Factors that lead to increased susceptibility to a disease.... predisposing factors

A group of hormones, produced by the hypothalamus in the brain, that stimulates the release of other hormones.

Luteinizing hormone-releasing hormone is one such releasing factor.... releasing factors

See anti-D(Rh) immunoglobulin.... rhesus immunoglobulin

The development of antibodies against Rhesus (Rh)-positive blood in a person who has Rh-negative blood (see haemolytic disease of the newborn; Rhesus incompatibility).... rhesus isoimmunization

a group of *growth factors that promote new bone formation. Bone morphogenic protein (BMP), a naturally occurring substance that induces *osteoblast formation, has been genetically synthesized to form bone morphogenetic protein, which stimulates new bone formation and assists with fracture healing. Other bone growth factors include a type of transforming growth factor (TGF?) and insulin-like growth factor II (IGF-II), which encourage collagen formation.... bone growth factors

see coagulation factors.... clotting factors

(clotting factors) a group of substances present in blood plasma that, under certain circumstances, undergo a series of chemical reactions leading to the conversion of blood from a liquid to a solid state (see blood coagulation). Although they have specific names, most coagulation factors are referred to by an agreed set of Roman numerals (e.g. *Factor VIII, *Factor IX). Lack of any of these factors in the blood results in the inability of the blood to clot. See also haemophilia.... coagulation factors

(CSF) one of a group of substances (haemopoietic growth factors or hormones) that are produced in the bone marrow and stimulate the production of specific blood cells. Genetically engineered granulocyte colony-stimulating factor (G-CSF) stimulates neutrophil production and also limits bone marrow toxicity from chemotherapy.... colony-stimulating factor

A mismatch between the blood group of a Rhesus (Rh)-negative pregnant woman and that of her baby. In certain circumstances, this mismatch leads to haemolytic disease of the newborn.

The Rh system is based on the presence or absence in the blood of several factors, the most important of which is a substance called D antigen. Rh-positive blood contains D antigen, whereas Rhnegative blood does not. The blood type is determined by genes.Rhesus incompatibility results if a Rhnegative woman is exposed to the blood of her Rh-positive baby while it is being born. There are usually no problems during the first pregnancy with a Rh-positive baby. However, the woman may produce antibodies against the D antigen; in a subsequent pregnancy with a Rh-positive baby, these antibodies may cross the placenta and attack the red blood cells of the fetus. A Rhnegative woman can also be sensitized if she has had a miscarriage, abortion, or amniocentesis, in which the fetus’s Rhpositive blood enters her circulation.

Rhesus incompatibility is now uncommon because injections of anti-D(Rh0) immunoglobulin are given routinely to Rh-negative women during pregnancy and at delivery. They are also given after miscarriage, abortion, amniocentesis, or any procedure that might result in exposure of the mother to fetal blood cells.... rhesus incompatibility

(EGFR) a protein on the surface of cells (see receptor) that binds with epidermal *growth factor and is therefore involved in cell division. EGFR is expressed at increased levels in numerous tumours, particularly of the head and neck, and in colorectal cancer, in which it can be a target for antibody therapy with *cetuximab. *Tyrosine kinase inhibitors acting specifically on the EGFR include gefitinib and erlotinib in lung and pancreatic cancer.... epidermal growth factor receptor

n. (in biochemistry) a substance that is essential to a physiological process, often a substance the nature of which is unknown. See also coagulation factors; growth factor.... factor

an inherited mutation in the gene coding for coagulation Factor V, which results in an increased susceptibility to develop venous *thrombosis.... factor v leiden

a *coagulation factor normally present in blood. Deficiency of the factor is inherited, but rarely causes spontaneous bleeding. However, bleeding does occur after surgery or trauma to the blood vessels.... factor xi

(NGF) a protein (see growth factor), consisting of two polypeptide chains, that is required for the development and longevity of some neurons, including those in the sympathetic nervous system and some central nervous system and sensory neurons. Nerve growth factor is necessary for axon growth and also for initiating new neuronal connections with other cells. The role of NGFs in preventing the degeneration of brain cells is being explored in research into Alzheimer’s disease.... nerve growth factor

(PDGF) see growth factor.... platelet-derived growth factor

see anti-D immunoglobulin; haemolytic disease of the newborn.... rhesus prophylaxis

(TGF) a protein – a *cytokine – that controls growth, proliferation, and other functions in most cells. It plays a role in asthma and other respiratory diseases and is also involved in diseases elsewhere in the body. There are two classes: TGF-? and TGF-?.... transforming growth factor

(TNF) either of two proteins, TNF-? or TNF-?, that function as *cytokines. Produced by macrophages, monocytes, T lymphocytes, and various other cells, they mediate many responses, including inflammation, and have a marked action against tumour cells. Anti-TNF drugs (see cytokine inhibitor) are used in the treatment of several disorders, especially rheumatoid arthritis and ankylosing spondylitis.... tumour necrosis factor

(VEGF) a *growth factor made by both normal cells and their abnormal or malignant counterparts to stimulate new blood vessel formation (see angiogenesis). It can be targeted by a family of drugs known as *angiogenesis inhibitors, which include *bevacizumab.... vascular endothelial growth factor