Habitat: The temperate Himalayas, from Kashmir, Sikkim to Bhutan at altitudes of 600-2,500 m.
English: Japanese Wax tree, Wild Varnish tree.Ayurvedic: Karkatashringee. (Used as a substitute for Pistacia integerrima galls.).Unani: Kaakraasingi.Siddha/Tamil: Karkatakasringi, Kadukapoo (galls).Action: Thorn-like excrescences on the branches—astringent, expectorant; prescribed in diarrhoea, dysentery and vomiting. Fruits— expectorant (used as an adjuvant in tuberculosis).
The sapwood and heartwood contain polyphenols. The sapwood contains gallo tannin; the heartwood gave fisetin, and its -7-glucoside, fustin, gar- banzol, 3,7,4'-trihydroxyflavone, gallic and ellagic acid. The bark is reported to contain 10% of tannin.The juice from the leaves causes blisters. Leaves contain 20% tannin (dry basis), a flavone glycoside rhoifolin, co- rilagin and shikimic acid. Ethanolic extract of the leaves is reported to exhibit anticancer and antiviral activities. Latex from the stem also causes blisters.Mesocarp of the fruit contains el- lagic acid. An acid isolated from the fruit is reported to be cardiotonic and sympathomimetic. It was found to be toxic to rabbits. However, the fruits are used in the treatment of tuberculosis. Hinokiflavone, isolated from the fruits, showed cytotoxic activity in vitro against KB culture cells.Drupes are rich in biflavones.The wax obtained from the pulpy mesocarp of the fruit contains palmitic 77, stearic 5, dibasic 6, oleic 12%, and linoleic acid (a trace). It is used as a substitute for beeswax.