Ribozyme Health Dictionary

Sections of deoxyribonucleic acid (DNA) – the principal molecule in a cell carrying genetic information – that act as enzymes (see ENZYME). The function of a ribozyme is to transform the messages encoded in DNA into proteins (see PROTEIN), using its property of catalysing chemical reactions in a cell. Most ribozymes act only on other pieces of ribonucleic acid (RNA), editing the messenger type that carries instructions to the parts of the cell that makes proteins. This editing ability is being used by scientists researching ways of correcting faulty GENES which can cause inherited disorders. The aim is to persuade the ribozyme to inhibit the messenger RNA to prevent production of the faulty gene. Ribozymes might also be used to disrupt infectious agents, such as viruses, which rely on RNA to invade body cells.

n. an RNA molecule that can act as an enzyme, catalysing changes to its own molecular structure (before its discovery it was assumed that all enzymes were proteins). Research into the ability of genetically engineered ribozymes to destroy the RNA of HIV (the AIDS virus) is ongoing.