Schistosomiasis Health Dictionary

Schistosomiasis: From 4 Different Sources


A parasitic tropical disease, caused by any of 3 species of flukes called schistosomes, and acquired from bathing in infested water. The larval form penetrates the bather’s skin and develops in the body into adult flukes, which settle in the veins of the bladder and intestines. Eggs laid by adults provoke inflammatory reactions; there may be bleeding and ulceration in the bladder and intestinal walls, and the liver may also be affected. The first symptom is usually tingling and an itchy rash where the flukes have penetrated the skin. An influenza-like illness may develop weeks later, when the adults produce eggs. Subsequent symptoms include blood in the urine or faeces, abdominal or lower back pain, and enlargement of the liver or spleen. Complications of long-term infestation include liver cirrhosis, bladder tumours, and kidney failure. Treatment is with the drug praziquantel.
Health Source: BMA Medical Dictionary
Author: The British Medical Association
A disease caused by parasites o f the genus Schistosoma , also known as bilharzia, which has an aquatic snail intermediate host.
Health Source: Dictionary of Tropical Medicine
Author: Health Dictionary
Also known as BILHARZIASIS. This infection results from one of the human Schistosoma species. It is common in Africa, South America, the Far East, Middle East, and, to a limited extent, the Caribbean. The life-cycle is dependent on fresh-water snails which act as the intermediate host for the ?uke; the cercarial stage of the ?uke enters via intact human skin and matures in the portal circulation. Clinically, ‘swimmers’ itch’ may occur at the site of cercarial skin penetration. Acute schistosomiasis (Katayama fever) can result in fever, an urticarial rash (see URTICARIA), and enlargement of LIVER and SPLEEN. The adult male is about 12 mm and the female 24 mm in length.

S. haematobium causes CYSTITIS and haematuria – passage of blood in the urine; bladder cancer and ureteric obstruction, giving rise to hydronephrosis and kidney failure, are long-term sequelae in a severe case. S. mansoni can cause colonic symptoms and in a severe case, POLYPOSIS of the COLON; diarrhoea, which may be bloody, can be a presenting feature. In a heavy infection, eggs surrounded by granulomas are deposited in the liver, giving rise to extensive damage (pipe-stem ?brosis) associated with PORTAL HYPERTENSION, oesophageal varices, etc. However, unlike in CIRRHOSIS, hepatocellular function is preserved until late in the disease. S. japonicum (which is con?ned to the Far East, especially Indonesia) behaves similarly to S. mansoni infection; liver involvement is often more severe.

Diagnosis can be made by microscopic examination of URINE or FAECES. The characteristic eggs are usually detectable. Alternatively, rectal or liver BIOPSY are of value. Serological tests, including an ELISA (see ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA)), have now largely replaced invasive procedures used in making a parasitological diagnosis.

Treatment CHEMOTHERAPY has been revolutionised by the introduction of praziquantel (administered orally); this compound has no serious side-effects, although its cost may limit its use in developing countries. Oxamniquine is cheaper and e?ective in S. mansoni infection, although evidence of resistance has been recorded in several countries. Metriphonate is also relatively cheap and is of value in S. haematobium infection. Prevention is by complete avoidance of exposure to contaminated water; all travellers to infected areas should know about this disease. It is increasing in frequency as new expanses of fresh water appear as a result of irrigation schemes and dam projects. Molluscicides can be employed for snail-control.

Health Source: Medical Dictionary
Author: Health Dictionary
(bilharziasis) n. a tropical disease caused by blood flukes of the genus *Schistosoma. Eggs present in the stools or urine of infected people undergo part of their larval development within freshwater snails living in water contaminated with human sewage. The disease is contracted when *cercaria larvae, released from the snails, penetrate the skin of anyone bathing in infected water. Adult flukes eventually settle in the blood vessels of the intestine (S. mansoni and S. japonicum) or the bladder (S. haematobium); the release of their spiked eggs causes anaemia, inflammation, and the formation of scar tissue. Additional intestinal symptoms are diarrhoea, dysentery, enlargement of the spleen and liver, and cirrhosis of the liver. If the bladder is affected, blood is passed in the urine and cystitis and cancer of the bladder may develop. The disease is treated with praziquantel.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Bilharzia

Schistosomiasis; a diseases caused by a parasitic trematode and acquired by contact with water infected with cercariae shed by the snail intermediate host.... bilharzia

Bilharziasis

Bilharziasis is another name for SCHISTOSOMIASIS.... bilharziasis

Praziquantel

A broad spectrum anthelmintic very effective against many human trematodiases (including all forms of schistosomiasis) and some cestode infections (e.g. hymenolepiasis; cysticercosis).... praziquantel

Tropical Medicine

The diagnosis and treatment of diseases that occur most commonly in tropical zones of the world. Examples are LEPROSY, MALARIA, SCHISTOSOMIASIS and TRYPANOSOMIASIS. With the great increase in international travel in the past 30 or so years, TROPICAL DISEASES are appearing more often in temperate climates. Global warming may also be enlarging the areas in which tropical disorders naturally occur.... tropical medicine

Ascites

An accumulation of a serous effusion in the abdominal cavity seen in a number of conditions such as cirrhosis and schistosomiasis.... ascites

Bather’s Itch

Bather’s itch, also called schistosome DERMATITIS, is the term given to a blotchy rash on the skin occurring in those bathing in water which is infested with the larvae of certain trematode worms known as schistosomes (see SCHISTOSOMIASIS). The worm is parasitic in snails. The skin rash is caused by penetration of the skin by the free-swimming larval cercaria. Bather’s itch is common in many parts of the world.... bather’s itch

Drink Pau D’arco Tea From South America

Get a taste of South America by drinking pau d’arco tea. It has a pleasant, earthy taste, astringent and just a bit bitter. Find out more about its health benefits and side effects! About Pau D’Arco Tea Pau D’Arco tea uses the inner bark of the Pink Ipê tree, also known as Pink Lapacho. The tree can be found in many South American countries. The Pink Lapacho is a large tree which can grow up to 30m tall. Usually, the trunk represents a third of that height, while the rest is used by the tree’s branches. The bark is dark brown, tough and hard to peel, and its branches spring up with opposite and petiolate leaves, and large, tubular-shaped pink flowers which bloom between July and September. How to make Pau D’Arco Tea To enjoy some pau d’arco tea, add 3 tablespoons to a pot containing 1 liter of water and bring it to boiling point. Once it reaches boiling point, lower the heat to medium-low and leave it like this for about 20 minutes. Once that’s done, strain the tea and pour it into cups. Pau d’arco tea can be served both hot and cold. If you want to, you can sweeten it with honey, stevia or fruit juice. Pau D’Arco Tea Benefits The inner bark of the Pink Lapacho tea has important active constituents, such as lapachol, lapachone and isolapachone, as well as various flavonoids and tannins. They are transferred to the pau d’arco tea; this way, the beverage helps us stay healthy. Pau d’arco tea plays an important role in the help against cancer. Cancer patients who have consumed this tea have shown progress, from alleviation of chemotherapy symptoms to complete remission of the cancerous tumors. Pau d’arco tea is also useful in the treatment of other diseases, such as diabetes, fibromyalgia, and lupus. Drinking pau d’arco tea can help if you’ve got a cold or the flu. It is also useful as a remedy for smoker’s cough, and acts as an expectorant, stimulating coughing in order to get rid of mucus. It was also discovered that pau d’arco tea increases the production of red blood cells. Although researches are still being made in this area, it is recommended in the treatment for leukemia, anemia and other blood disorders. Pau d’arco tea is also useful in fighting fungi. It is used to treat yeast infection and candida, due to its antifungal nature. It can help in the treatment for stomach ulcers, tuberculosis, pneumonia, and dysentery. It also protects you against tropical diseases (malaria, schistosomiasis). Pau D’Arco Tea Side Effects Pau d’arco tea may act like a blood thinner. Don’t drink this tea at least two weeks before a surgery, otherwise it might increase the risk of bleeding both during and after the surgery, and can decrease the blood clotting speed. You also shouldn’t drink pau d’arco tea if you’ve got a bleeding disorder (hemophilia) or if you’re taking anticoagulants. If you’re taking any medication, talk to your doctor first before drinking pau d’arco tea. It may interfere with various medications, for example aspirin, enoxaparin, warfarin, and dalteparin. It is also recommended that you not drink pau d’arco tea if you’re pregnant or breastfeeding. During pregnancy, it can lead to child defects or even death of the baby. It can also affect the baby during breastfeeding. Be careful with the amount of pau d’arco tea you drink a day. The maximum amount of tea you can drink a day is 1 liter. If you drink more, it might lead to nausea, vomiting or bleeding (in which case you should consult a doctor). Other symptoms include headaches, dizziness and diarrhea. Pau d’arco tea has lots of important health benefits, but it also has a few side effects which you should remember. If you make sure it’s safe to drink this tea, you can enjoy it with no worries!... drink pau d’arco tea from south america

Katayama Syndrome

A syndrome characterised by allergic symptoms and involving the respiratory tract (i.e. fever, cough, rash and marked eosinophilia) sometimes seen in patients who have had exposure to a large number of schistosome cercariae, especially Schistosoma japonicum, sometimes S. mansoni, rarely S. haematobium. Sydrome occurs during the invasive stage of schistosomiasis from the time of cercarial penetration of the skin to the time of early egg laying in the veins.... katayama syndrome

Schistomicide

A drug used to treat SCHISTOSOMIASIS. Praziquantel is the drug of choice, with a combination of e?ectiveness, broad-activity spectrum and few side-effects.... schistomicide

Cashew Tree Fruit

Anacardium occidentale L. Active ingredient: anacardic acid – an inhibitor of prostaglandin synthetase. Kills laval mosquitoes and water snails. Dumped by natives into ponds where mosquitoes and snails breed. The apple-like fruit serves as a pesticide to control malaria, schistosomiasis and other parasitic diseases from drinking water. (Dr Isao Kubo, University of California-Berkeley, USA)

Leaves used by natives of West Africa for malaria. ... cashew tree fruit

Dysentery

A clinical state arising from invasive colo-rectal disease; it is accompanied by abdominal colic, diarrhoea, and passage of blood/mucus in the stool. Although the two major forms are caused by Shigella spp. (bacillary dysentery) and Entamoeba histolytica (amoebic dysentery), other organisms including entero-haemorrhagic Escherichia coli (serotypes 0157:H7 and 026:H11) and Campylobacter spp. are also relevant. Other causes of dysentery include Balantidium coli and that caused by schistosomiasis (bilharzia) – Schistosoma mansoni and S. japonicum infection.

Shigellosis This form is usually caused by Shigella dysenteriae-1 (Shiga’s bacillus), Shigella ?exneri, Shigella boydii, and Shigella sonnei; the latter is the most benign and occurs in temperate climates also. It is transmitted by food and water contamination, by direct contact, and by ?ies; the organisms thrive in the presence of overcrowding and insanitary conditions. The incubation is between one and seven days, and the severity of the illness depends on the strain responsible. Duration of illness varies from a few days to two weeks and can be particularly severe in young, old, and malnourished individuals. Complications include perforation and haemorrhage from the colo-rectum, the haemolytic uraemic syndrome (which includes renal failure), and REITER’S SYNDROME. Diagnosis is dependent on demonstration of Shigella in (a) faecal sample(s) – before or usually after culture.

If dehydration is present, this should be treated accordingly, usually with an oral rehydration technique. Shigella is eradicated by antibiotics such as trimethoprimsulphamethoxazole, trimethoprim, ampicillin, and amoxycillin. Recently, a widespread resistance to many antibiotics has developed, especially in Asia and southern America, where the agent of choice is now a quinolone compound, for example, cipro?oxacin; nalidixic acid is also e?ective. Prevention depends on improved hygiene and sanitation, careful protection of food from ?ies, ?y destruction, and garbage disposal. A Shigella carrier must not be allowed to handle food.

Entamoeba histolytica infection Most cases occur in the tropics and subtropics. Dysentery may be accompanied by weight loss, anaemia, and occasionally DYSPNOEA. E. histolytica contaminates food (e.g. uncooked vegetables) or drinking water. After ingestion of the cyst-stage, and following the action of digestive enzymes, the motile trophozoite emerges in the colon causing local invasive disease (amoebic colitis). On entering the portal system, these organisms may gain access to the liver, causing invasive hepatic disease (amoebic liver ‘abscess’). Other sites of ‘abscess’ formation include the lungs (usually right) and brain. In the colo-rectum an amoeboma may be di?cult to di?erentiate from a carcinoma. Clinical symptoms usually occur within a week, but can be delayed for months, or even years; onset may be acute – as for Shigella spp. infection. Perforation, colo-rectal haemorrhage, and appendicitis are unusual complications. Diagnosis is by demonstration of E. histolytica trophozoites in a fresh faecal sample; other amoebae affecting humans do not invade tissues. Research techniques can be used to di?erentiate between pathogenic (E. dysenteriae) and non-pathogenic strains (E. dispar). Alternatively, several serological tests are of value in diagnosis, but only in the presence of invasive disease.

Treatment consists of one of the 5nitroimidazole compounds – metronidazole, tinidazole, and ornidazole; alcohol avoidance is important during their administration. A ?ve- to ten-day course should be followed by diloxanide furoate for ten days. Other compounds – emetine, chloroquine, iodoquinol, and paromomycin – are now rarely used. Invasive disease involving the liver or other organ(s) usually responds favourably to a similar regimen; aspiration of a liver ‘abscess’ is now rarely indicated, as controlled trials have indicated a similar resolution rate whether this technique is used or not, provided a 5-nitroimidazole compound is administered.... dysentery

Guanábana

Soursop (Annona muricata).

Plant Part Used: Leaf, fruit.

Dominican Medicinal Uses: Leaf: tea, orally, for common cold, flu, musculoskeletal injury, menopausal symptoms, nervousness/anxiety; externally as a bath for fever in children. Fruit: eaten, diuretic and fever-reducing.

Safety: Fruits are commonly consumed; reports of toxicity from ingestion of leaves in humans; contradictory results from animal toxicity studies; possibly implicated in atypical parkinsonism in the Caribbean.

Laboratory & Preclinical Data: In vivo: antioxidant (stem bark alcohol extract).

In vitro: human serotonin receptor binding activity, antiviral (HSV-1), cytotoxic in cancer cells, molluscicidal in schistosomiasis vector (plant extracts and constituents).

* See entry for Guanábana in “Part 3: Dominican Medicinal Plant Profiles” of this book for more information, including references.... guanábana

Flatworm

Any species of worm that has a flattened shape.

Two types of flatworm are parasites of humans: cestodes (tapeworms) and trematodes (flukes, schistosomes; see liver fluke; schistosomiasis).... flatworm

Fluke

A type of flattened worm, also known as a trematode, that may infest humans or animals.

The 2 main diseases caused by flukes are liver fluke infestation, which occurs worldwide, and schistosomiasis, a debilitating tropical disease.... fluke

Platyhelminth

A flat or ribbon-shaped parasitic worm. (See liver fluke, schistosomiasis, tapeworm)... platyhelminth

Proctitis

Inflammation of the rectum, causing soreness and bleeding, sometimes with a mucus and pus discharge. Proctitis commonly occurs as a feature of ulcerative colitis, Crohn’s disease, or dysentery. In cases where inflammation is confined to the rectum, the cause is often unknown. In male homosexuals, proctitis is sometimes due to gonorrhoea or another sexually transmitted infection. Rare causes include tuberculosis, amoebiasis, and schistosomiasis.

Diagnosis is made by proctoscopy. A biopsy is sometimes needed. Treatment of the underlying cause usually clears the problem. Corticosteroid drugs may relieve symptoms.... proctitis

Schistosome

A type of fluke.

Three types of schistosome are parasites of humans, causing different forms of schistosomiasis.... schistosome

Schistosoma

(Bilharzia) n. a genus of blood *flukes, three species of which are important parasites of humans causing one of the most serious of tropical diseases (see schistosomiasis). S. japonicum is common in the Far East; S. mansoni is widespread in Africa, the West Indies, and South and Central America; and S. haematobium occurs in Africa and the Middle East.... schistosoma

Liver Disease In The Tropics

ACUTE LIVER DISEASE The hepatitis viruses (A– F) are of paramount importance. Hepatitis E (HEV) often produces acute hepatic failure in pregnant women; extensive epidemics – transmitted by contaminated drinking-water supplies – have been documented. HBV, especially in association with HDV, also causes acute liver failure in infected patients in several tropical countries: however, the major importance of HBV is that the infection leads to chronic liver disease (see below). Other hepatotoxic viruses include the EPSTEIN BARR VIRUS, CYTOMEGALOVIRUS (CMV), the ?avivirus causing YELLOW FEVER, Marburg/Ebola viruses, etc. Acute liver disease also occurs in the presence of several acute bacterial infections, including Salmonella typhi, brucellosis, leptospirosis, syphilis, etc. The complex type of jaundice associated with acute systemic bacterial infection – especially pneumococcal PNEUMONIA and pyomiositis – assumes a major importance in many tropical countries, especially those in Africa and in Papua New Guinea. Of protozoan infections, plasmodium falciparum malaria, LEISHMANIASIS, and TOXOPLASMOSIS should be considered. Ascaris lumbricoides (the roundworm) can produce obstruction to the biliary system. CHRONIC LIVER DISEASE Long-term disease is dominated by sequelae of HBV and HCV infections (often acquired during the neonatal period), both of which can cause chronic active hepatitis, cirrhosis, and hepatocellular carcinoma (‘hepatoma’) – one of the world’s most common malignancies. Chronic liver disease is also caused by SCHISTOSOMIASIS (usually Schistosoma mansoni and S. japonicum), and acute and chronic alcohol ingestion. Furthermore, many local herbal remedies and also orthodox chemotherapeutic compounds (e.g. those used in tuberculosis and leprosy) can result in chronic liver disease. HAEMOSIDEROSIS is a major problem in southern Africa. Hepatocytes contain excessive iron – derived primarily from an excessive intake, often present in locally brewed beer; however, a genetic predisposition seems likely. Indian childhood cirrhosis – associated with an excess of copper – is a major problem in India and surrounding countries. Epidemiological evidence shows that much of the copper is derived from copper vessels used to store milk after weaning. Veno-occlusive disease was ?rst described in Jamaica and is caused by pyrrolyzidine alkaloids (present in bush-tea). Several HIV-associated ‘opportunistic’ infections can give rise to hepatic disease (see AIDS/HIV).

A localised (focal) form of liver disease in all tropical/subtropical countries results from invasive Entamoeba histolytica infection (amoebic liver ‘abscess’); serology and imaging techniques assist in diagnosis. Hydatidosis also causes localised liver disease; one or more cysts usually involve the right lobe of the liver. Serological tests and imaging techniques are of value in diagnosis. Whilst surgery formerly constituted the sole method of management, prolonged courses of albendazole and/or praziquantel have now been shown to be e?ective; however, surgical intervention is still required in some cases.

Hepato-biliary disease is also a problem in many tropical/subtropical countries. In southeast Asia, Clonorchis sinensis and Opisthorchis viverini infections cause chronic biliary-tract infection, complicated by adenocarcinoma of the biliary system. Praziquantel is e?ective chemotherapy before advanced disease ensues. Fasciola hepatica (the liver ?uke) is a further hepato-biliary helminthic infection; treatment is with bithionol or triclabendazole, praziquantel being relatively ine?ective.... liver disease in the tropics

Tropical Diseases

Technically, those diseases occurring in the area of the globe situated between the Tropic of Cancer and the Tropic of Capricorn: pertaining to the sun. They include many ‘exotic’ infections – many of them parasitic in origin – which fall under the umbrella of ‘TROPICAL MEDICINE’. However, disease in the tropics is far broader than this and includes numerous other infections, many of them with a viral or bacterial basis: for example, the viral hepatidises, streptococcal and pneumococcal infections, and tuberculosis. The prevalence of other diseases, such as rheumatic cardiac disease, cirrhosis, heptocellular carcinoma (‘hepatoma’), and various nutrition-related problems, is also much increased in most areas of the tropics. With people from developed countries increasingly travelling to worldwide destinations for business and holiday, the ‘importation’ of tropical diseases to temperate climates should be borne in mind when people fall ill.

The following diseases and conditions are treated under their separate dictionary entries: ANCYLOSTOMIASIS; BERIBERI; BLACKWATER FEVER; CHOLERA; DENGUE; DRACONTIASIS; DYSENTERY; ELEPHANTIASIS; FILARIASIS; HEAT STROKE; LEISHMANIASIS; LEPROSY; LIVER, DISEASES OF; MALARIA; ORIENTAL SORE; PLAGUE; PRICKLY HEAT; SCHISTOSOMIASIS; SLEEPING SICKNESS; STRONGYLOIDIASIS; SUNBURN; YAWS; YELLOW FEVER.... tropical diseases

Splenomegaly

n. enlargement of the spleen. It most commonly occurs in *malaria, *schistosomiasis, and other disorders caused by parasites; in infections; in blood disorders, including some forms of anaemia and lack of platelets (*thrombocytopenia); in *leukaemia; and in *Hodgkin’s disease. See also hypersplenism.... splenomegaly

Wigandia Caracasana

Kunth.

Family: Hydrophyllaceae.

Habitat: Native to tropical America; introduced into Indian gardens.

Action: Leaves and branch tips— a decoction is used in rheumatism; also for whooping cough and respiratory problems.

Solvent extracts of the leaves (etha- nol, acetone and M-hexane) were found active against Gram-positive bacteria.

Synonym: W. viridiflora Meissn. W. indica var. virdiflora Hook. f.

Family: Thymelaeaceae.

Habitat: Eastern Assam; as a weed in Tamil Nadu.

English: Small-Leaf Salago.

Folk: Salago.

Action: Root bark—diuretic, vesicant, purgative and piscicidal.

The root bark is reported to contain a flavone glycoside, wikstroemin, which exhibited diuretic activity.

In Chinese folk medicine, the bark is used for schistosomiasis.

The stem contains wikstromol, a lig- nin prototype which exhibited anti- neoplastic activity. Daphnoretin, isolated from the plant, caused platelet aggregation in the blood of rabbits. A polysaccharide, comprising glucose, arabinose, galacturonic acid, galactose and xylose, protected mice against radiation and enhanced the formation of macrophages.... wigandia caracasana

Coriander

Coriandrum sativum, L. German: Koriander. French: Coriandre. Spanish: Cilantro. Italian: Coriandro. Russian: Coriandro. The Persians grew Coriander as a mild antiseptic and spice over 3000 years ago. It added fragrance to the Hanging Gardens of Babylon. Contains volatile oil, coumarins, phenolic acids, sterols, etc.

Action: stimulant, carminative. The aromatic herb contains a volatile oil, warming to the stomach and dispelling wind. Aromatherapists discover its use as an anti-rheumatic.

Uses: Well-known Chinese remedy for measles. Schistosomiasis. Hypoglycaemic and of value in diabetes. Aerophagy (air-swallowing). Gastroenteritis.

Preparations: The tea serves as a gripe water for infant’s colic. Half-1 teaspoon bruised seeds to each cup boiling water: cover with saucer to prevent escape of volatile oil. Drink before meals or as necessary for flatulence.

Powder: Half-1 gram, thrice daily.

Liquid Extract: Half-2ml in water thrice daily.

Aromatherapy. For rheumatic muscles and joints, lotion: 1 part oil of Coriander to 10 parts Almond oil. ... coriander

Carcinogen

Any agent capable of causing cancer. Chemicals are the largest group of carcinogens. Major types include polycyclic aromatic hydrocarbons (PAHs), which occur in tobacco smoke, pitch, tar fumes, and soot. Exposure to PAHs may lead to cancer of the respiratory system or skin. Certain aromatic amines used in the chemical and rubber industries may cause bladder cancer after prolonged exposure.

The best-known physical carcinogen is high-energy radiation, such as nuclear radiation and X-rays. Exposure may cause cancerous changes in cells, especially in cells that divide quickly: for example, changes in the precursors of white blood cells in the bone marrow causes leukaemia. The risk depends on the dosage and duration of exposure. Over many years, exposure to ultraviolet radiation in sunlight can cause skin cancer. Another known physical carcinogen is asbestos (see asbestos-related diseases).

Only a few biological agents are known to cause cancer in humans.

SCHISTOSOMA HAEMATOBIUM, one of the blood flukes responsible for schistosomiasis, can cause cancer of the bladder; and ASPERGILLUS FLAVUS, a fungus that produces the poison aflatoxin in stored peanuts and grain, is believed to cause liver cancer.

Viruses associated with cancer include strains of the human papilloma virus, which are linked to cancer of the cervix; the hepatitis B virus, which is linked to liver cancer; and a type of herpes virus which is associated with Kaposi’s sarcoma.... carcinogen

Glomerulonephritis

Inflammation of the glomeruli (see glomerulus), affecting both kidneys. Damage to the glomeruli hampers the removal of waste products, salt, and water from the bloodstream, which may cause serious complications.

Some types of glomerulonephritis are caused by immune complexes (components of the immune system produced in response to infection) becoming trapped in the glomeruli. The condition occurs in some autoimmune disorders. Infectious diseases such as malaria and schistosomiasis are important causes of glomerulonephritis in tropical countries.

Mild glomerulonephritis may produce no symptoms. Some sufferers experience a dull ache over the kidneys. The urine may become bloodstained. Loss of protein into the urine may cause oedema (see nephrotic syndrome). Hypertension is a potentially serious complication. Long-term glomerulonephritis is a common cause of chronic kidney failure.

Diagnosis involves kidney function tests, urinalysis, and kidney biopsy. Treatment depends on the cause and severity of the disease. Children with nephrotic syndrome usually respond to corticosteroid drugs. In adults, kidney failure can sometimes be prevented or delayed by drug treatment and dietary control to reduce the work of the kidneys.glomerulosclerosis Scarring caused by damage to the glomeruli (see glomerulus). Mild glomerulosclerosis occurs normally with age. Glomerulosclerosis may occur in some severe types of glomerulonephritis. It is also sometimes associated with diabetes mellitus, hypertension, AIDS, or intravenous drug abuse. glomerulus A filtering unit of the kidney that consists of a cluster of capillaries enclosed in a capsule and supplied with blood from the renal artery. Each glomerulus is a part of a larger filtering unit called a nephron. Filtered blood eventually leaves the kidney via the renal vein.

(See also glomerulonephritis.)... glomerulonephritis

Liver, Disorders Of

The liver is a common site of disease. The most significant liver conditions include alcohol-related disorders (see liver disease, alcoholic), hepatitis, and liver cancer. Disorders can also result from infection. Certain viruses cause hepatitis (see hepatitis, viral). Bacteria may spread up the biliary system to the liver, causing cholangitis or liver abscess. Parasitic diseases affecting the liver include schistosomiasis, liver fluke, and hydatid disease. Certain metabolic disorders, such as haemochromatosis and Wilson’s disease, may involve the liver. Other types of liver disorder include Budd–Chiari syndrome, in which the veins draining the liver become blocked. Occasionally, defects of liver structure are present at birth. Such defects principally affect the bile ducts; one example is biliary atresia, in which the bile ducts are absent. Because the liver breaks down drugs and toxins, damage to liver cells can also be caused through overdose or drug allergy. (See also jaundice; liver failure; portal hypertension.)... liver, disorders of

Water-borne Infection

A disease caused by infective or parasitic organisms transmitted via water. Infections can be contracted if infected water is drunk, if it contaminates food, or if individuals swim or wade in it. Worldwide, contamination of drinking water is an important mode of transmission for various diseases including hepatitis A, many viral and bacterial causes of diarrhoea, typhoid fever, cholera, amoebiasis, and some types of worm infestation.

Swimming in polluted water should be avoided because, if swallowed, there is a risk of contracting disease. In addition, a form of leptospirosis is caused by contact with water contaminated by rat’s urine. In tropical countries, there is also a risk of contracting schistosomiasis (bilharzia), which is a serious disease caused by a fluke that can burrow through the swimmer’s skin.... water-borne infection

Worm Infestation

Several types of worm, or their larvae, existing as parasites of humans. They may live in the intestines, blood, lymphatic system, bile ducts, or in organs such as the liver. In many cases, they cause few or no symptoms, but some can cause chronic illness. There are 2 main classes: roundworms and platyhelminths, which are subdivided into cestodes (tapeworms) and trematodes (flukes).

Worm diseases found in developed countries include threadworm infestation, ascariasis, whipworm infestation, toxocariasis, liver-fluke infestation, and various tapeworm infestations. Those occurring in tropical regions include hookworm infestation, filariasis, guinea worm disease, and schistosomiasis.

Worms may be acquired by eating undercooked, infected meat, by contact with soil or water containing worm larvae, or by accidental ingestion of worm eggs from soil contaminated by infected faeces.

Most infestations can be easily eradicated with anthelmintic drugs.... worm infestation




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