Scrofula Health Dictionary

Linn.

Synonym: A. acuminata Wall. ex Royle

Family: Ranunculaceae.

Habitat: Native to Europe; grows in temperate Himalayas from Hazara to Bhutan.

English: Baneberry Grapewort.

Folk: Visha-phale (Kannada).

Action: Root—antirheumatic, anti-inflammatory, nerve sedative, emetic, purgative; used in the treatment of rheumatic fever, lumbago, scrofula, nervous disorders, chorea.

The plant is reported to contain trans-aconitic acid, which shows a strong cytostatic action. Its Me ether is active against Ehrlich's ascites tumours.

In folk medicine, roots are used in cases of ovarian neuralgia, uterine tenderness and sub-involution. They are adulterant of the roots of Helleborus niger. Berries are poisonous; used topically for skin diseases. The toxic constituent is protoanemonin (lactone). It is irritant to mucous membrane.... actaea spicata

Linn.

Family: Agavaceae.

Habitat: Native to America; grown in gardens for ornamentation.

English: Century Plant, American Aloe.

Ayurvedic: Kaantala (related sp.).

Siddha/Tamil: Alagai.

Folk: Ban-Kevaraa.

Action: Leaf juice—used for warts, cancerous ulcers and putrid tumours. Leaves are also used as a resolvant in syphilis and scrofula.

The leaves contain ten steroidal sa- ponins (six of these are spirostanolic and four furostanolic), also hecogenin (0.20%) and piscidic acid. The seeds contain steroid sapogenins including hecogenin. The plant exhibits significant antibacterial activity.... agave americana

Linn.

Family: Amaranthaceae.

Habitat: Grown as vegetable in northern India.

English: Love-Lies-Bleeding, Tassel Flower.

Ayurvedic: Raam-daanaa (grain).

Siddha/Tamil: Pungikeerai, Siru- keerai.

Folk: Chuko.

Action: Blood-purifier, diuretic; used in piles, strangury, dropsy and anasarca; tea has been used for relieving pulmonary conditions; also given in scrofula and applied to scrofulous sores. Antimicrobial peptides have been isolated from seeds.

In Western herbal medicine, LoveLies-Bleeding is equated with Amaranthus hypochondriacus, and is used for ulcers, diarrhoea, as well as inflammation of the mouth and throat.

Preliminary evidence suggests that Amaranth seed can reduce total cholesterol and LDL, while increasing HDL, but Amaranth muffins failed to reduce cholesterol levels in hypercholes- terolemic adults beyond the reduction achieved by low-fat diet. (Natural Medicines Comprehensive Database, 2007.)... amaranthus caudatus

Treating scrofula or tubercular swellings of the lymph glands... antiscrofulous

Linn.

Synonym: B. candida Roxb.

Family: Caesalpiniaceae.

Habitat: Punjab, Western Peninsula and Assam. Also cultivated in gardens.

English: Mountain Ebony, Buddhist Bauhinia.

Ayurvedic: Kaanchanaara, Kaan- chanaaraka, Kanchanak, Kaan- chana, Gandhaari, Sonapushpaka, Ashmantaka.

Siddha/Tamil: Sivappumanchori.

Action: Buds—a decoction is given in piles (also used against tumours), haematuria, menorrhagia. Dried buds are used in diarrhoea, dysentery, worm infestation, piles and tumours. Root— carminative, used in dyspepsia and flatulence (a decoction is reported to prevent obesity). Bark—astringent, anthelmintic; used externally in scrofula and skin diseases. Seeds—possess human blood agglutinating activity. Leaf— antifungal.

Along with other therapeutic applications, The Ayurvedic Pharmacopoeia of India indicated the use of the stem bark in lymphadenitis and goitre. (Ka- anchnaar Guggulu is prescribed for glandular swellings and goitre.)

Water-soluble portion of alcoholic extract of the plant showed preventive effect against goitre in rats.

Flowers gave flavonoids, kaempfe- rol-3-galactoside and kaempferol-3- rhamnoglucoside. The stem bark yields hentriacontane, octacosanol and stigmasterol. Stem contains beta-sitos- terol, lupeol and a flavanone glyco- side.

Dosage: Stem bark—20-30 g for decoction. (API Vol. I.)... bauhinia variegata

Curcuma spp.

Zingiberaceae

The genus Curcuma belonging to the family Zingiberaceae comprises of a number of species which are medicinally very important. Among them, the most important species are described below.

1. C. amada Roxb.

English: Mango ginger San: Amrardrakam, Karpuraharida Hin: Ama -haldi

Mal: Mangainchi

Tam: Mankayinci

Tel: Mamidi Allam

Mango ginger is cultivated in Gujarat and found wild in parts of West Bengal, U. P, Karnataka and Tamil Nadu. It is a rhizomatous aromatic herb with a leafy tuft and 60-90cm in height. Leaves are long, petiolate, oblong-lanceolate, tapering at both ends, glabrous and green on both sides. Flowers are white or pale yellow, arranged in spikes in the centre of tuft of the leaves. Lip is semi -elliptic, yellow, 3-lobbed with the mid lobe emarginate. The rhizomes are useful in vitiated conditions of pitta, anorexia, dyspepsia, flatulence, colic, bruises, wounds, chronic ulcers, skin diseases, pruritus, fever, constipations, strangury, hiccough, cough, bronchitis, sprains, gout, halitosis, otalgia and inflammations (Warrier et al, 1994). The fresh root possesses the smell of green mango and hence the name mango ginger. The rhizomes are used externally in the form of paste as an application for bruises and skin diseases generally combined with other medicines. Tubers rubbed with the leaf- juice of Caesalpinia bonduc is given for worms (Nadkarni, 1982).

The essential oil contains -pinene, -and -curcumene, camphor, cuminyl alcohol, myristic acid and turmerone. Car-3-ene and cis-ocimene contribute the characteristic mango odour of the rhizome. Rhizome is CNS active, hypothermic and it shows potentiation of amphetamine toxicity. Tuber is trypsin inhibitor and is effective against Vibrio cholerae (Husain et al, 1992). The rhizomes are bitter, sweet sour, aromatic, cooling, appetiser, carminative, digestive, stomachic, demulcent, vulnerary, febrifuge, alexertic, aphrodisiac, laxative, diurectic, expectorant, antiinflammatory and antipyretic (Warrier et al, 1994).

2. C. aromatica Salisb.

Eng: Wild turmeric; San: Aranyaharidra, Vanaharidra;

Hin: Ban-haridra, Jangli-haldi;

Ben: Ban Haland; Mal,

Tam: Kasturimanjal, Kattumanjal;

Tel: Adavi-pasupu;

Kan: Kadarasina

Wild turmeric or Cochin turmeric or Yellow zeodoary is found wild throughout India and cultivated in Bengal and Kerala. It is a perennial tuberous herb with annulate, aromatic yellow rhizome which is internally orange-red in colour. Leaves are elliptic or lanceolate- oblong, caudate-acuminate, 30-60cm long, petioles as long or even longer, bracts ovate, recurved, more or less tinged with red or pink. Flowers are pink, lip yellow, obovate, deflexed, sub-entire or obscurely three lobed. Fruits are dehiscent, globose, 3-valved capsules. Rhizomes are used in combination with astringents and aromatics for bruises, sprains, hiccough, bronchitis, cough, leucoderma and skin eruptions (Warrier et al, 1994). The rhizomes have an agreeable fragrant smell and yield a yellow colouring matter like turmeric, and the fresh root has a camphoraceous odour. The dried rhizome is used as a carminative and aromatic adjunctant to other medicines (Nadkarni, 1998).

Essential oil contains -and - -curcumene, d-camphene and p-methoxy cinnamic acid. The colouring matter is curcumin. Numerous sesquiterpenoids of germacrone and guaiane skeletons have been identified recently. Rhizome has effect on respiration. It is spasmolytic and shows antagonism of amphetamine hyperactivity. Rhizome is an anti-dote for snakebite and carminative (Husain et al, 1992).

3. C. longa Linn. syn. C. domestica Valeton.

Eng: Turmeric; San: Haridra, Varavarnini;

Hin: Haldi, halda;

Ben: Haldi;

Mal: Manjal, Pachamanjal, Varattumanjal;

Tam: Mancal;

Kan: Haldi, Arasina;

Tel: Pasapu

Turmeric is cultivated all over India, particularly in W. Bengal, T. N and Maharashtra. It is a perennial herb, 60-90cm in height, with a short stem and tufts of erect leaves. Rhizome is cylindric, ovoid, orange coloured and branched. Leaves are simple, very large, petiole as long as the blade, oblong-lanceolate, tapering to the base upto 45cm long. Flowers are pale yellow, arranged in spikes concealed by the sheathing petioles and flowering bracts are pale green (Warrier et al, 1994). Turmeric occupies an important position in the life of Indian people as it forms an integral part of the rituals, ceremonies and cuisine. Due to the strong antiseptic properties, turmeric has been used as a remedy for all kinds of poisonous affections, ulcers and wounds. It gives good complexion to the skin and so it is applied to face as a depilatory and facial tonic. The drug cures diseases due to morbid vata, pitta and kapha, diabetes, eye diseases, ulcers, oedema, anaemia, anorexia, leprosy and scrofula. It purifies blood by destroying the pathogenic organisms. A paste of turmeric alone, or combined with a paste of neem (Azadirachta indica) leaves, is used to cure ringworm, obstinate itching, eczema and other parasitic skin diseases and in chicken pox and small pox. The drug is also useful in cold, cough, bronchitis, conjunctivitis and liver affections (Nadkarni, 1954; Kurup et al,1979; Kolammal, 1979). The rhizome is the officinal part and is an important ingredient of formulations like Nalpamaradi taila, Jatyadi taila, Narayana gula, etc. (Sivarajan et al, 1994).

Turmeric paste mixed with a little limejuice and saltpetre and applied hot is a popular application to sprains and bruises. In smallpox and chickenpox, a coating of turmeric is applied to facilitate the process of scabbing. The smoke produced by sprinkling powdered turmeric over burnt charcoal will relieve scorpion sting when the part affected is exposed to the smoke for a few minutes. Turmeric and alum powder in the proportion of 1:20 is blown into the ear in chronic otorrhoea (Nadkarni, 1998). “Haridra Khand”, a compound containing powdered turmeric, sugar and many other ingredients is a well-known preparation for cold, cough and flu, and for skin diseases. In Unani system, roasted turmeric is an ingredient of “Hab Narkachur”, used as antidysenteric for children (Thakur et al, 1989).

Essential oil contains ar-turmerone, and ar-curcumene as ma jor constituents. Some of the other compounds are -and -pinene, sabinene, myrcene, -terpinene, limonene, p- cymene, perillyl alcohol, turmerone, eugenol, iso-eugenol, eugenol methyl ether and iso- eugenol methyl ether. Curcumin and related compounds have also been reported as major constituents of the rhizomes. Recently a number of sesquiterpenes have been reported from C. longa, viz., the sesquiterpenoids of germacrane, bisabolane and guainane skeletons (Husain et al, 1992). The study of sesquiterpenes has revealed a new compound curlone (Kisoy et al, 1983). The crystalline colouring matter curcumin (0. 6%) is diferuloyl methane (Mathews et al, 1980). Stigmasterol, cholestrol, -sitosterol and fatty acids, mainly straight chain dienoic acids are reported (Moon et al, 1977). Curcumin, the colouring agent and major constituent of C. longa, is said to possess local as well as systemic antiinflammatory property which has been found to compare favourably with phenylbutazone (Srimal and Dhawan, 1973). An extract of the crude drug ‘akon’ containing the rhizomes exhibited intensive preventive activity against carbon tetrachloride induced liver injury invivo and invitro. The liver protecting effects of some analogs of ferulic acid and p-coumaric acid, probable metabolites of the curcuminoids have been also evaluated (Kiso et al, 1983). Curcumin is antiinflammatory. Rhizome is antiprotozoal, spasmolytic, CNS active, antiparasitic, antispasmodic, antibacterial, antiarthritic, anthelmintic, carminative, antiperiodic, emo llient, anodyne, laxative, diruretic, expectorant, alterative, alexertive, febrifuge, opthalmic and tonic.

4. C. zedoaria (Berg.) Rosc. syn. C. zerumbet Roxb; Amomum zedoaria

Christm.vEng: Round zedoary; San: Kachura, Shati;

Hin: Kakhur;

Ben: Sati;

Kan: Kachora

Mal: Manjakoova, Adavi-kacholam;

Tam: Kichilikizhangu, Nirvisham;

Tel: Kacheramu

The round zedoary or Zerumbet is mostly found in India and S. E. Asia. The plant has 4-6 leaves with 20-60cm long lamina. The leaf lami na is oblong-lanceolate, finely acuminate and glabrous on both the surfaces. Flower stalk is 20-25cm long, emerging before the leaves. Flowers are yellow, while the flowering bract is green tinged with red. Calyx is 8mm long, corolla tube is twice as long as the calyx. Capsule is ovoid, trigonous, thin smooth and bursting irregularly. Tubers are palmately branched and camphoraceous (Thakur et al, 1989). The identity of the plant sources of the drug Karcura is a matter of debate. There is difference of opinion among men of Ayurveda, as to whether Sati and Karcura are the same drug or different. Many authors consider them different and equate Sati with Hedychium spicatum Smith. and Karcura with C. zedoaria, both belonging to Zingiberaceae (Kurup et al,1979; Chunekar 1982; Sharma, 1983). Some others treat them to be the same and equate it with C. zedoaria (Kirtikar and Basu, 1918; Vaidya, 1936; Nadkarni, 1954; Kapoor and Mitra, 1979). However, the source of Karcura in Kerala in the recent times has been Kaempferia galanga of the same family. The rhizome of C. zedoaria is used as appetiser and tonic, particularly prescribed to ladies after childbirth. In case of cold, a decoction of long pepper (Piper longum), cinnamon (Cinnamomum verum), zedoary and honey is given. In Ayurveda it is an ingredient of “Braticityadi kwatha”, used in high fever (Thakur et al, 1989). Root is useful in flatulence and dyspepsia, and as a corrector of purgatives. Fresh root checks leucorrhoeal and gonorrhoeal discharges. Root powder is a good substitute for many foreign foods for infants. For worms, the juice from the tubers is given to children. Juice of the leaves is given in dropsy (Nadkarni, 1982). It is an odoriferous ingredient of the cosmetics used for the cure of chronic skin diseases caused by impure or deranged blood (Nadkarni, 1998).

Essential oil from rhizomes contains -pinene, d-camphene, cineole, d-camphor, sesquiterpenes and sesquiterpene alcohols (Husain et al, 1992). The novel sesquiterpenoids which have been isolated and characterised are cuzerenone, epi-cuzerenone, iso- furanogermerene, curcumadiol, curcumol, curcumenol, iso-curcumenol, procurcumenol, dehydrocurdione (Hikino et al, 1968, 1971, 1972), germacrone-4, 5-epoxide, germacrone, germacrone furanodienone, curcumenol, iso-curcumenol, curcumanolides A and B and curcumenone (Shiobara et al, 1985). The starch left after the extraction is purified and sold as a commodity of cottage industry in West-Bengal under the name ‘Shoti’ (Rao et al, 1928). Ethyl-p methoxy-cinnamate has been isolated from the alcoholic extract of the plant (Gupta et al, 1976). Rhizome is stomachic, diuretic, and carminative and gastrointestinal stimulant.

Other important species of Curcuma genus are

C. angustifolia Roxb. (Vellakoova)

C. caesia Roxb. (Black ginger)

C. leucorhiza Roxb.

C. pseudomontana Grah.

C. rubescens Roxb.

Agrotechnology: Curcuma species are tropical herbs and can be grown on different types of soils both under irrigated and rainfed conditions. Rich loamy soils having good drainage are ideal for the crop. The plant is propagated by whole or split mother rhizomes. Well developed, healthy and disease free rhizomes are to be selected. Rhizomes are to be treated with copper oxychloride fungicides and stored in cool, dry place or earthen pits plastered with mud and cowdung. The best season of planting is during April with the receipt of pre-monsoon showers. The land is to be prepared to a fine tilth during February-March. On receipt of pre- monsoon showers in April, beds of size 3x1.2m with a spacing of 40cm between beds are to be prepared. Small pits are to be taken in the beds in rows with a spacing of 25-40cm.

Finger rhizomes are to be planted flat with buds facing upwards and covered with soil or dry powdered cattle ma nure. The crop is to be mulched immediately after planting and 50 days after first mulching. Cattle manure or compost is to be applied as basal dose at 20-40t/ha at the time of land preparation or by spreading over the beds after planting. Application of NPK fertilizers is beneficial and found to increase the yield considerably. Weeding is to be done twice at 60 and 120 days after planting, depending upon weed intensity. Earthing up is to be done after 60 days. No major incidence of pest or disease is noticed in this crop. Leaf blotch and leaf spot can be controlled by spraying Bordeaux mixture or 0.2% Mancozeb. Shoot borers can be controlled by spraying 0.05% Dimethoate or 0.025% Quinalphos. Time of harvest usually extends from January-March. Harvesting is generally done at about 7-10 months after planting depending upon the species and variety. Harvested rhizomes are to be cleaned of mud and other materials adhering to them. Good fingers separated are to be used for curing (KAU, 1996).... curcuma

Kern.

Synonym: F. monostachya Hassk.

Family: Cyperaceae.

Habitat: Throughout warmer regions of India, as a weed.

Ayurvedic: Ibha-muulaka. (Also equated with F. annua.)

Action: Used in adenitis, scrofula, syphilis; also in cough, bronchitis and asthma.... fimbristylis ovata

Ging.

Family: Violaceae.

Habitat: The Himalayas, Eastern and Western Ghats.

Unani: Banafashaa (related species).

Action: Dried flowers—used for coughs and colds. Herb— bruised and applied to ulcers; also prescribed in syphilis and scrofula. (In Chinese medicine, recommended against cancerous growths.)... viola patrinii

Bauhinia variegata

Caesalpiniaceae

San: Kancanarah, Kovidarah;

Hin: Kancanar;

Ben: Rakta Kanchan;

Tam: Sigappu-mandarai

Mal: Mandaram, Chuvannamandaram, Malayakatti, Kongu, Kongumandaram;

Tel: Daeva Kanchanamu, Mandara;

Kan: Ullipe, Kanchavala, Kempu Mandara

Importance: In traditional medicine, Bauhinia is extensively used in glandular diseases and as an antidote to poison. The drug is also reported to be useful in dysentery, diarrhoea, piles and worms (Kurup et al, 1979; Sharma et al, 1983). They are useful in vitiated conditions of kapha and pitta, diarrhoea, dysentery, skin diseases, leprosy, intestinal worms, tumours, wounds, ulcers, inflammations, scrofula, protoptosis, haemorrhoids, haemoptysis, cough, menorrhagia and diabetics. Usirasavam and Candanasavam are some of the preparations using the drug. An important Ayurvedic preparation, “Kanchnar Guggal” contains bark of this plant. In Unani system, the flowers are used in “Hab Mussafi Khun”, for skin diseases, the bark is used in “Sufuf Kalan”-an aphrodisiac.

Distribution: The plant is distributed in the Sub-Himalayan tracts from the Indus eastwards and throughout the dry forests of India, ascending to 1300m. It is also cultivated throughout the plains.

Botany: Bauhinia variegata Linn. syn. B.

candida Roxb. belonging to the family Caesalpiniaceae is a moderate sized deciduous tree with vertically cracked grey bark, wood moderately hard, greyish brown with irregular darker patches. Leaves are of 2 leaflets, connate for about two-thirds up. Leaflets are ovate with rounded apex, 10-15cm long, pubescent beneath when young and coriaceous. Flowers are white or pink, the uppermost petal darker and variegated usually appearing before the leaves in short axillary or terminal racemes. Stamens are 5 and stamenodes absent. Fruits are flat dehiscent pods with 10-15 seeds (Warrier et al, 1993).

Other important species of the genus Bauhinia are as follows.

1. B. tomentosa Linn.

It is the yellow or golden flowered one, commonly known as Manja Mandaram. It is found in Africa and Asia. In India it is found wild in dry deciduous forests and often cultivated. The plant is antidysenteric, antidote for snakebite and scorpion sting and also used in liver complaints. The bark is astringent. Root bark is vermifuge. Fruit is diuretic. Seed is tonic, wound healing and aphrodisiac.

2. B. purpurea Linn.

Pink Bauhinia or Camel’s Foot tree is found in South and S. E. Asia. In India, it is found in deciduous forests. Root is carminative and tonic. Bark is astringent and antidiarrhoeal and is used in ulcer and goitre. Flowers are laxative. The experimental studies conducted by Sijoria and Prasad (1979) on animals indicate that B. purpurea is very effective in normalising the thyroid gland.

3. B. racemosa Lam.

The plant is found in Sub-Himalayan tracts, in U.P, West Bengal, Central and South India. The leaf is anticephalalgic and antimalarial. Bark is astringent, antidiarrhoeal. The seeds are antibacterial. Stem-bark is CVS and CNS active, hypothermic and anticancerous.

4. B. malabarica Roxb.

Malabar Mountain Ebony is found in Sub-Himalayan tracts, from Kumaon to West Bengal, ascending to 1350m, Assam, Bihar and South India. The flowers of this plant are antidysenteric.

5. B. retusa Roxb.

The plant is distributed in north-western Himalayas from the Beas eastwards, Himachal Pradesh, U.P., Orissa, M.P. and A.P. The gum of the plant is emmenagogue, diuretic and can be used externally in sores. The seed is hypoglycaemic and hypocholesterolaemic. The aerial part is CVS active and has effect on respiration.

6. B. vahlii W.&A.

Camel’s Foot climber is found in Punjab, Bihar, Assam, Madhy Pradesh, Andra Pradesh and Tamil Nadu. Leaf is demulcent. Seed is tonic and aphrodisiac. Stem is CVS active, antiarrhythmic and spasmolytic.

Agrotechnology: Well drained hilly areas are ideal for the cultivation of Bauhinia. The plant is seed propagated. Seeds are formed in February-March. Seeds are to be collected from the dried pods, soaked in water for 12 hours before sowing in seedbeds. At four-leaved stage they are to be transferred to polybags. Two month old seedlings from polybags are used for field planting. Pits of size 60cm cube are to be taken and filled with 10kg dried cowdung mixed with topsoil and formed into a mound. On these seedlings are to be planted at a distance of 6-7.5m. Irrigation is to be given in the first year. Two weedings and application of organic manure once is required in a year. The plant is not attacked by any serious pests and diseases. The plant flowers on the third year. At the end of tenth year the tree can be cut and wood used for medicinal purposes (Prasad et al, 1997).

Properties and activity: Flowers contain flavanoids-kaempferol-3-galactoside and kaempferol-3- rhamnoglucoside. Stem bark yields hentriacontane, octacosanol and stigmasterol. Stem yields -sitisterol, lupiol and a flavanone glycoside-5, 7-dimethoxy flavanone 4-O- -L- rhamnopyranoside- -D-glucopyranoside. Seeds possess human blood agglutinating activity. Stem bark is hypothermic, CNS active and depressant. Bud, flower, leaf and stembark are antibacterial. Stem possesses juvenoid activity. Bark is alterative, tonic, antileprotic and antirheumatic. Bud is antidysenteric. Root is carminative and antidote for snakebite. Bark, flower and root promote suppuration. Bark and bud are astringent and vermifuge (Husain et al, 1992).... bauhinia

combats the development of tuberculosis of lymph nodes (scrofula).... antiscrofula

(Linn.) Urban.

Hydro cotyle asiatica

Family: Umbelliferae; Apiaceae.

Habitat: In marshy places throughout India up to 200 m.

English: Asiatic Pennywort, Indian Pennywort.

Ayurvedic: Manduukaparni, Manduukaparnikaa, Maanduuki, Saraswati, Brahma-manduuki.

Siddha/Tamil: Vallaarai.

Action: Adaptogen, central nervous system relaxant, peripheral vasodilator, sedative, antibiotic, detoxifier, blood-purifier, laxative, diuretic, emmenagogue. Used as a brain tonic for improving memory and for overcoming mental confusion, stress, fatigue, also used for obstinate skin diseases and leprosy.

Key application: Extracts orally to treat stress-induced stomach and duodenal ulcers; topically to accelerate healing, particularly in cases of chronic postsurgical and post trauma wounds; also to treat second and third degree burns. Patients suffering from venous insufficiency were treated with a titrated extract of the drug. (WHO.)

Used in Indian medicine as a brain tonic and sedative. (Indian Herbal Pharmacopoeia.)

Major constituents of the plant are: triterpenoid saponins—brahmoside, asiaticoside, thankuniside; alkaloids (hydrocotyline); bitter principles (vel- larin).

Brahmoside, present in the plant, is reported to exhibit tranquilizing and anabolic activity. Raw leaves are eaten or plant decoction is drunk to treat hypertension.

Asiaticoside, extracted from leaves, gave encouraging results in leprosy. It dissolves the waxy covering of Bacillus leprae. Centelloside has also been found useful in leprosy. Asiaticoside reduced the number tubercular lesions in the liver, lungs, nerve ganglia and spleen in experimental animals. Another derivative of asiaticoside, oxyasi- aticoside, inhibits growth of Tubercle bacillus at a concentration of 0.15 ml/ml Asiaticosides are also hyperglycaemic.

The asiatic acid acts against resistant bacteria, particularly Mycobacterium tuberculosis and M. leprae as well as Gram-positive cocci.

Asiaticosides elevate blood glucose, triglycerides and cholesterol levels. They seem to decrease blood urea nitrogen and acid phosphatase levels. (Pharmacological findings. Natural Medicines Comprehensive Database, 2007.)

Boiled leaves are eaten for urinary tract infections, and unfiltered juice for scrofula and syphilis.

Extract of the fresh plant significantly inhibits gastric ulceration by cold restraint stress in rats.

In research, using rats, the herb exhibited protective effect against alcohol-induced and aspirin-induced ulcers. (JExp Biol, 2001, Feb, 39(2), 13742.)

Dosage: Whole plant—3-6 g (API Vol. IV.)... centella asiatica

Walp.

Family: Papaveraceae.

Habitat: The Himalayas from Kumaon to Khasia Hills. Cultivated in Indian gardens.

English: Squirrel Corn. (A related species, Corydalis cucullaria, known as Turkey Pea, occurs in Canada and the USA.)

Action: Diuretic, alterative, anti- scrofula. Used for torpid and sluggish conditions, menstrual disorders and diseases due to vitiated blood. Also employed as a sedative for the relief of paralysis agitans and other muscular tremors.

A large number of physiologically active isoquinoline alkaloids have been isolated from the tubers of many species of Dicentra, but the use of Corydalis is not linked with the alkaloids they contain, only bulbocapnine, present in the tubers, exhibits therapeutic activity. It produces catalepsy in mammals and possesses sympathetic as well as parasympathetic central effects.

It has been employed for the relief of paralysis agitans and other muscular tremors, vesticular nystagmus and similar conditions.

The root contains protopine, cory- deline, bulbocapnine, cancentrine, de- hydrocancentrines A and B. Bicucul- line (an isoquinoline alkaloid) isolated from the tuber of Dicentra cucullaria, is a centrally-acting, spasmogenic antagonist of GABA.... dicentra canadensis

Roxb.

Family: Compositae; Asteraceae.

Habitat: Throughout India.

English: Globe-Thistle, Camel's Thistle.

Ayurvedic: Utkantaka, Uttundaka, Brahmadandi.

Folk: Uunta-Kateraa.

Action: Alterative, diuretic, nerve tonic (used in hoarse cough, dyspepsia, scrofula, hysteria.)

Aerial parts of the plant contain alkaloids, echinopsine, echinopsidine and echinozolinone. Taraxasterol acetate, isolated from the plant, is a potent anti-inflammatory constituent; the ethanolic extract of the whole plant is more effective when administered parenterally than orally. Api- genin and its derivatives, echinacin and echinaticin show antifungal activity.... echinops echinatus

Mostly known as a cleansing herb, figwort tea was used in the past to treat tuberculosis. Some of the benefits of figwort tea are the detoxifying properties and the capacity to treat skin conditions. About Figworth tea Botanically called Scrophularia nodosa, figwort is also known as carpenter’s square, knotted figwort, throatwort or rose noble. Figwort is a perennial plant with thick square fleshy stems and green or purple flowers, commonly found in the cooler woodlands of Europe, North America and Central Asia. It is harvested in the summer when it is in bloom. It was used in the past to treat tuberculosis commonly called scrofula. It is commonly known as a powerful diuretic and a detoxifier. In China it is associated with salt and taken as a yin tonic. Figwort is typically prepared as a tea infusion, a tincture or as a compress. Figwort tea is prepared from the aerial parts and the roots. Figwort tea contains saponins, cardioactive, glycosides, flavonoids, resin, sugar and organic acids. Ho to prepare figwort tea To make figwort tea, use two teaspoons of dried figwort herbs in a cup of boiling water. Take it out of the heat, and let the mix infuse for about 10 - 15 minutes. It is recommended to be taken not more than twice a day. Benefits of figwort tea Figwort tea is used externally to treat skin conditions, such as eczema and psoriasis. It may also help heal wounds, ulcers, burns, and hemorrhoids. In homeopathic medicine, figwort tea is used to treat decreased resistance, tonsillitis, and lymph edema. It is used internally for its mild laxative effect and its mild diuretic and heart strengthening properties. Figwort tea may stimulate the lymphatic system. Some people believe that figwort Tea may have anti tumor properties. Side effects of figwort tea Pregnant and breastfeeding women should also avoid use, as well as those with cardiac conditions or diabetes, as it might create cardiac disturbances or slow the heart beatings or interfere with some medication. Figwort tea is mainly considered safe for regular consumption but do not ignore it’s precautions before deciding to drink it regularly.... figwort tea

R.Br.

Synonym: Hydnocarpus odorata Landl.

Family: Flacourtiaceae.

Habitat: Eastern Himalayas, Khasi Hills and Sikkim.

Ayurvedic: Chaalmograa (substitute). Tuvaraka (var.) (Controversial synonyms.)

Unani: Tukhm-e-Biranj Mograa.

Folk: Chaaval-mungari.

Action: Oil from seed used in psoriasis, eczema, scrofula, gout, rheumatic affections.

A triterpenoid ketolactone, odolac- tone, has been isolated from the plant. The fruit pulp is used as piscic. The seeds of G. odorata were formerly, erroneously, thought to be the source Chaalmograa oil of commerce obtained from the seeds of Hydnocar- pus kurzii, used in leprosy. Gynocardia oil does not contain chaulmoogric or hydnocarpic acid.... gynocardia odorata

C. B. Clarke non Linn.

Synonym: Onosma hispidum Wall. ex D. Don.

Family: Boraginaceae.

Habitat: Kashmir and Kumaon up to 1,000-1,500 m.

Unani: Ratanjot (equated with Onosma echioides Linn., according to National Formularly ofUnani Medicine).

Action: Astringent and styptic. Root—bruised and used as application to eruptions. An ingredient of ointments for ulcers, scrofula, burns. Flowers—stimulant, cardiac tonic.

Ursolic acid and naphthoquinones, onosone A and B have been isolated from the root. Shikonin acetate is obtained from callus cultures of the plant.

The species, distributed in western Himalayas, is Onosma echioides C. B. Clarke non Linn.; Onosma echioides Linn. is an European species. A variety of this species, var. kashmiricum Johnson, is found in Kashmir. Onosma hookeri C. B. Clarke occurs in Sikkim and Bhutan.

Maharanga emodi (Wall.) DC., synonym Onosma emodi (Wall.) DC. (the Himalayas from Garhwal to Bhutan at altitudes of 3,500-4,000 m) is also known as Ratanjot and Shankhuli.

(Ratanjot is used in a generic sense to cover a range of red dye-yielding roots, rather than the root of a single species. As many as 15 plant species belonging to four different families are known as Ratanjot; five of them do not yield red dye. General properties and colour reactions attributed to Ratanjot resemble Alkanet from Alkanna tinctoria Tausch.)... onosma echioides

Gloriosa superba

Liliaceae

San: Langali, Visalya, Agnishika,Shakrapushpi, Garbhaghatini

Hin: Kalihari

Mal: Menthonni

Tam: Akkinichilam

Pan: Kariari

Guj: Dudhiya vachnag

Kan: Nangulika Mar: Nagakaria

Ben: Bishalanguli Ori: Dangogahana

Tel: Adavinabhi

Importance: Glory lily is a glabrous herbaceous climber which yields different types of troplone alkaloids of medicinal importance. The major alkaloids are colchicine , 3-demethyl colchicine and colchicoside. There is another alkaloid gloriosine which promises to be even more effective than colchicine in plant breeding for inducing polyploidy. The genus has importance in the ornamental horticulture due to its bright flowers and wiry climbing stem.

The roots and rhizomes are used in traditional system of medicine. Its abortifacient and antipyretic properties have been mentioned in ancient classics “Charaka”. The name Garbhaghatini is due to this abortifacient activity. They are useful in the treatment of inflammations, ulcers, scrofula, hemorrhoids, pruritus, dyspepsia, helminthiasis, flatulence, intermittent fevers and debility. The root is given internally as an effective antidote against cobra poison. A paste of the root is also used as an anodyne; applications in bites of poisonous insects, snake bites, scorpion sting, parasitic skin diseases and leprosy (Nadkarni,1954; Chaudhuri and Thakur; 1994).

Distribution: The plant is distributed throughout tropical India upto an altitude of 2500m and in Andaman islands. It is also cultivated in tropical and South Africa, Madagaskar, Indonesia and Malasia. It is reported to be cultivated in some parts of Europe. In India it was cultivated in RRL, Jammu in 1960s. Recently it was taken up by Indian Council of Agricultural Research(ICAR). Cultivation of the plant is mostly confined to the Southern states of India besides its collection from wild sources.

Botany: Gloriosa superba Linn. belongs to Liliaceae family. It is a glabrous climbing herb with tuberous root stock grows over hedges and small trees. Stem is 6m long which grows to a height of 1.2-1.5m before the stem branches. Leaves are simple, alternate or whorled, sessile, ovate-lanceolate, 17x4.5cm, tip elongating into a spirally coiled tendril, base cordate and margin entire. Flowers are large in terminal racemes; perianth segments 6, linear, flexuosus and deflexed, basal half bright yellow, upper half red; stamens 6; ovary glabrous, 3-celled. Fruits are capsules, linear-oblong, upto 6.8cm long, 3 equal lobes, one or two lobes shorter in malformed fruits; green dried to pale and then black colour, dehisced into three sections. Seeds are oval in shape, testa spongy, embryo cylindric, 30-150 seeds per capsule, pale orange attached to the sutures. Tubers are cylindric, large, simple, ‘V’ shaped with the two limps equal or unequal in lenth pointed towards end brownish externally and yellowish internally. (Narain, 1977)

Agrotechnology: This is a rainy season plant and sprouts well in warm, humid and tropical conditions. It should be grown in sun as the plants in shade become weedy and thin and move towards light. G. superba is a shallow rooted plant and grows well in a variety of soils either clay or sand through out India. It grows well in a light porous soil with good drainage. For vigorous growth, greater blooms and strong tuber, a mixture of soil, sand and compost manure is recommended. The propagation is mainly by tubers, by division of rhizomes. Seeds remain dormant for 6-9 months and due to hard seed coat, about 20-30 days are required for germination and seeds may take 3-4 years before it matures to flower. Treatment of seeds by gibberellin(1-3 ppm) resulted in higher yield of colchicine in the plant and higher production of tubers. In tissue culture, young sprouts are cultured on Murashige and Skoog’s medium (Msb) supplemented with kinetin (1-4 mg/l). Direct regeneration of the explants are obtained.

The seeds and rhizomes are sown usually in the last week of June to mid July. The rhizomes are planted by splitting carefully into two from their ‘V’ shaped joints (two buds being at the extreme end of each rhizome) in lines 20cm apart at a distance of 20cm (while seeds are sown in lines at a distance of 4-6cm apart). They are watered regularly when the plants are growing. After green shoots appear 2-3 showers are weekly. The irradiation of the plant at 42% natural sunlight intensity increased the production of tuber and colchicine. They usually takes 6-10 weeks to flower after sprouting and then set on fruits. The fruits ripen at the end of October and after that aerial shoot eventually dies, leaving the fleshy tubers underground. The tubers are dug out with great care. An individual plant produces 50g tubers on an average. The average yield is approximately 4000-5000kg of rhizomes and 1000 kg of seed per hectare. The content of colchicine is usually 0.358% and 1.013% in tubers and seeds, respectively.

Post harvest technology: Lixivation of the material is done with 70% ethyl alcohol. Concentrated under vacuum to one third of its volume and extracted with chloroform for colchicine and related substances-concentration of the aqueous phase to syrup which is extracted 6-8 times with a mixture of CHCl3 - alcohol (4:1) to yield colchicoside.

Properties and activity: The flowers, leaves and tubers contain colchicine, superbin, N-formyl deacetyl colchicine, demethyl colochicine and lumicolchicine. Tubers also contain gloriosine. Leaves in addition, contain chelidonic acid, 2-hydroxy 6-methoxy benzoic acid and -sitosterol glucoside. Colchicine, demethyl colchicine and colchicoside have been reported from seeds. Rhizome is oxytocic, anticancerous, antimalarial, stomachic, purgative, cholagogue, anthelmintic, alterative, febrifuge and antileprotic. Leaf is antiasthmatic and antiinflammatory. Root shows antigonorrhoeic and antibiotic activity. This plant has poisonous effect to enviroment and livestock. The toxic properties are due to presence of alkaloids chiefly colchicine (Clewer et al, 1915).... glory lily

Linn.

Family: Polygonaceae.

Habitat: Native to Europe; found in Mt. Abu.

English: Yellow Dock, Curled Dock.

Ayurvedic: Chukra, Chukrikaa, Patraamla, Rochani, Shatvedhani.

Action: Root—used as a laxative in rheumatism, bilious disorders, and as an astringent in piles and haemorrhagic affections; also used for skin eruptions, chronic skin diseases, scrofula, scurvy, congested liver and jaundice. Acts like Sarsaparilla when used for scrofulous skin affections and glandular swellings. Seeds— astringent. Used for dysentery.

The root contains anthraquinones (about 2.17-4%) including nepodin, and other glycosides based on chryso- phanol, physcion and emodin; also tannins, rumicin and oxalates. Large doses should be avoided. Disturbances caused by the plant are attributed to rumicin. The root and rhizome are reported to stimulate bile production. (Natural Medicines Comprehensive Database, 2007.)

The leaves contain 30 mg/100 g ascorbic acid.

R. crispus is pharmacologically more active than rhubarb, because the extracts of the roots of the former contain more quantity of anthraquinones (2.17%) than the extracts of the latter (1.42%).

It has been suggested that Amlavetas should be equated with R. crispus.... rumex crispus

Linn.

Family: Caryophyllaceae.

Habitat: Native to temperate region of Europe; introduced in Indian gardens.

English: Bouncing Bet, Soapwort.

Action: Roots—blood purifier, cholagogue, expectorant, diuretic, diaphoretic. Roots and leaves— used for scrofula and skin diseases. Sap used as a depurative for scabies, furuncles, hepatic eruptions and venereal ulcers (as a lotion). Plant— employed for jaundice (to increase bile flow); also in respiratory disorders (bronchitis, sore throat).

Key application: Root—in catarrhs of the upper respiratory tract. (German Commission E.)

The plant contains saponin, sapo- toxin and saponarin. The root contains sapotoxin (4-5%) and saporubrinic acid. Saponin content of the root is highest (7.7-8.2%) just before flowering stage and the lowest (about 3%) during the flowering period. The bark yield 0.8% of saponin. The leaves contain saponarin. Youngest leaves show the highest haemolytic activity.

Aqueous extract of the plant exhibit antibacterial activity.... saponaria officinalis

Linn.

Family: Cruciferae; Brassicaeae.

Habitat: Kashmir, Punjab, Haryana and from Rajasthan to Uttar Pradesh in moist soils.

English: London Rocket.

Ayurvedic: Khaaksi.

Unani: Khuubkalaan.

Action: Seeds—expectorant, restorative, febrifuge, rubefacient, antibacterial. Used in asthma.

Leaves—rich in vitamin C (176 mg/ 100 g), beta-carotene (10,000 IU/100 g) and minerals. Used in throat and chest infections.

Aerial parts yield beta-sitosterol, 3 beta-D-glucoside, isorhamnetin and quercetin.

The seed contains a flavonoid, iso- rhamnetin. Fatty oil from seeds contain linolenic and oleic acids (as chief constituents), along with erucic, palmitic and stearic acids.

Ethanolic extract of seeds exhibited marked antibacterial action, also antipyretic and analgesic effects.

S. loeselii Linn. (Kashmir and Hi- machal Pradesh) is used in scrofula and as an antiscorbutic. The seed oil contains erucic acid and larger amounts of tetracosenoic acid. The plant contains alkaloids, organic acids, tannins, glycosides, saponins, coumarins and flavonoids.... sisymbrium irio

Strobilanthes ciliatus

Acanthaceae

San: Sahacarah, Sairyakah;

Hin: Karvi, Kara;

Mal: Karimkurunji, Kurunji;

Tam: Kurunji, Sinnakurunji

Importance: Strobilanthes is an important shrub used in the treatment of rheumatism. The roots are useful in rheumatalgia, lumbago, siatica, limping, chest congestion, strangury, fever, leucoderma, skin diseases, inflammations, cough, bronchitis, odontalgia and general debility. The leaves and bark are useful in whooping cough, fever, bronchitis, dropsy, leucoderma, leprosy, pouritus, inflammations, scrofula and fever (Warrier et al, 1995).

Distribution: It is distributed in tropical countries, such as India, Sri Lanka, Pakistan and in a few subtropical countries. It is observed in India, throughout the evergreen forests of Western Ghats upto 1200m. It is also cultivated.

Botany: The genus Strobilanthes belonging to the family Acanthaceae consists of 3 species namely,

S. ciliatus Nees.,syn. Nilgirianthus ciliatus (Nees) Bremek

S. auriculatus Nees. and

S. callisus Nees.

S. ciliatus is a slender shrub with subquandrangular white dotted dark green or purple stems and branches. Leaves are dark green, elliptic, accuminate at both ends, serrate, glabrous with 6-7 pairs of main nerves. Flowers are white to lilac, arranged in axillary slender glabrous spikes. Fruits are very rarely formed. Adventitious roots arise from a few basal nodes also. The main roots as well as the nodal roots are used as raw drugs (Warrier et al, 1995).

Agrotechnology: Strobilanthes prefers silty loam soil, mixed with sand, for good growth. It grows abundantly in river banks, lowlands and plains. The best season of planting is May-June. The field is to be ploughed to a fine tilth and mixed with 5-7t/ha of FYM/compost/dried cowdung. Seed beds of size 3m length, 0.5m width and 15cm height are to be made in which 10cm long stem cuttings are to be planted at a spacing of 30cm between plants. Rooting occurs within 20 days. Two weedings should be carried out at 2 months and 4 months after planting, followed by organic manure application. Irrigation is not a must but during summer months it is beneficial. The plant is not attacked by any serious pests or diseases. Harvesting can be done at the end of the second year. For this the plants are to be cut, roots dug out and collected. Roots are to be washed well, dried in sun and marketed. Roots, leaves and bark constitute the economic parts (Prasad et al, 1997).

Properties and activity: The leaves and stem yield essential oil which is of good medicinal value. The roots are bitter, sweet, thermogenic, emollient, diuretic, febrifuge, diaphoretic, depurative, antiinflammatory and tonic. Leaves and bark are diaphoretic, expectorant, depurative and febrifuge.... strobilanthes

Linn.

Family: Tropaeolaceae.

Habitat: Native to South America; grown as an ornamental and salad herb.

English: Garden Nasturtium, Indian Cress, Climbing-Nasturtium.

Action: Leaves—an infusion increases resistance to bacterial infections, reduces catarrh formation and expels phlegm. Juice of the plant—given internally for treating scrofula. Flowers—used for healing wounds. Seeds— purgative.

Common Nasturtium contains glu- cocyanates (including glycotropeo- line), spilanthol, myrosin (an enzyme), oxalic acid and vitamin C. The leaves from the young plant showed greater antibiotic activity than the stems; roots were inactive.

Extracts and preparations of T. majus are found efficacious in the infections of urinary and respiratory tract, but have no effect on infections of the biliary tract or in typhoid fever.... tropaeolum majus

Tuberculosis results form infection with Mycobacterium tuberculosis. The lungs are the site most often affected, but most organs in the body can be involved in tuberculosis. The other common sites are LYMPH NODES, bones, gastrointestinal tract, kidneys, skin and MENINGES.

The weight loss and wasting associated with tuberculosis before treatment was available led to the disease’s popular name of consumption. Enlargement of the glands in the neck, formerly called scrofula, was known also as the ‘king’s evil’ from the supersition that a touch of the royal hand could cure the condition. Lupus vulgaris (see under LUPUS) is another of the skin manifestations of the disease.

The typical pathological change in tuberculosis involves the formation of clusters of cells called granulomas (see GRANULOMA) with death of the cells in the centre producing CASEATION.

It is estimated that there are 7–8 million new cases of tuberculosis worldwide each year, with 2–3 million deaths. The incidence of tuberculosis in developed countries has shown a steady decline throughout the 20th century, mainly as a result of improved nutrition and social conditions and accelerated by the development of antituberculous chemotherapy in the 1940s. Since the mid-1980s the decline has stopped, and incidence has even started to rise again in inner-city areas. In 2002, 7,239 cases of tuberculosis were noti?ed in the UK compared with 6,442 a decade earlier; more than 390 deaths in 2003 were attributed to the disease. Factors involved in this rise are immigration from higher-prevalence areas, poorer social conditions and homelessness in some urban centres and the association with HIV infection and drug abuse. The incidence of tuberculosis is also rising in many developing countries because of the emergence of resistant strains of the tubercle bacillus (see below). In the UK recently there have been serious outbreaks in a handful of urban-based schools.... tuberculosis

Linn.

Synonym: V. malabarica Bl.

Family: Dipterocarpaceae.

Habitat: Peninsular India, from Kanara to Trivandrum and in Coorg.

English: White Damar, Indian Copal-Tree, Malabar Tallow tree, Piney Varnish-Tree.

Ayurvedic: Sarja, Sarjaka, Karsya, Sasyasumbara, Devdhuupa, Marich-patraka. Chhaagakar- na. Ajakarna and Shaala (related species) are also equated with V indica.

Unani: Raal.

Siddha/Tamil: Kungiliyam, Vellai Kundarakam.

Action: Resin—astringent, antibacterial, antidiarrhoeal, emmena- gogue. Used for chronic bronchitis, piles, skin eruptions, ringworm, scrofula, tubercular glands, ulcers, wounds, boils; urinary discharges; amenorrhoea; gonorrhoea and syphilis. Bark—antidysenteric. Oil and resin—antirheumatic. Resin enters into a number of antiseptic and anti-inflammatory ointments. Leaves—juice is applied to cure burns. Orally administered to prevent vomiting.

The Ayurvedic Pharmacopoeia ofIn- dia recommends the resinous exudate internally (1-2 g) in lipid disorders, anaemia, genitourinary diseases, diarrhoea and diseases due to vitiated blood; externally in gout, abscesses, skin diseases, burns, eruptions.

The bark contains polyphenols—dl- epi-catechin, levorotatory isomers of fisetinidol, fzelechin; and bergenin.

Resin is a complex mixture of several triterpene hydrocarbons, ketones, alcohols and acids, along with small amounts of sesquiterpenes. On distillation, the oleoresin gave an essential oil (76%), consisting of phenolic constituents and azulenes. The essential oil shows marked antibacterial activity against Gram-positive and Gramnegative micro-organism.

The leaves and roots contain berge- nin and hope phenol. The seed also contain bergenin. Hope phenol showed fungicidal activity. The plant exhibited anti-ulcerogenic activity in rats.

The fruit shell contains 25% tannins.

Dosage: Resinous exudate—1-2 g (API, Vol. IV.)... vateria indica

Kaul (cultivated var.)

W somnífera (Linn.) Dunal (Chemo- type I, II, III: Israele.) Family: Solanaceae.

Habitat: Throughout the drier and subtropical parts of India.

English: Winter Cherry. (Physalis alkekengi is also known as Winter Cherry.)

Ayurvedic: Ashwagandhaa, Haya- gandhaa, Ashwakanda, Gandharva- gandhaa, Turaga, Turagagandhaa, Turangagandhaa, Vaajigandhaa, Gokarnaa, Vrishaa, Varaahakarni, Varadaa, Balyaa, Vaajikari. (A substitute for Kaakoli and Kshira- kaakoli.) Cultivated var.: Asgandh Naagori. (Indian botanists consider the cultivated plants distinct from the wild ones.)

Unani: Asgandh.

Siddha: Amukkuramkizhangu.

Action: Root—used as an antiinflammatory drug for swellings, tumours, scrofula and rheumatism; and as a sedative and hypnotic in anxiety neurosis. Leaf— anti-inflammatory, hepatopro- tective, antibacterial. Fruits and seeds—diuretic. Withanine— sedative, hypnotic. Withaferin A—major component of biologically active steroids; as effective as hydrocortisone dose for dose. Antibacterial, antitumour, an- tiarthritic, significantly protective against hepatotoxicity in rats.

The root contains several alkaloids, including withanine, withananine, withananinine, pseudo-withanine, somnine, somniferine, somniferinine. The leaves of Indian chemotype contain 12 withanolides, including withaferin A. Steroidal lactones ofwithano- lide series have been isolated.

Withanine is sedative and hypnotic. Withaferin A is antitumour, an- tiarthritic and antibacterial. Anti-inflammatory activity has been attributed to biologically active steroids, of which withaferin A is a major component. The activity is comparable to that of hydrocortisone sodium succinate.

Withaferin A also showed significantly protective effect against CCl4- induced hepatotoxicity in rats. It was as effective as hydrocortisone dose for dose.

The root extract contains an ingredient which has GABA mimetic activity

The free amino acids present in the root include aspartic acid, glycine, tyrosine, alanine, proline, tryptophan, glutamic acid and cystine.

The Ayurvedic Pharmacopoeia ofIn- dia recommends Ashwagandha in im- potency. This claim could not be sustained in a recent experiment and raises a doubt about the equation of classical Ashwagandha with Withania somnifera. A methanolic extract of With- ania somnifera root induced a marked impairment in libido, sexual performance, sexual vigour and penile dysfunction in male rats. (Llayperuma et al, Asian J Androl, 2002, 295-298.)

The total alkaloids of the root exhibited prolonged hypotensive, brady- cardiac and depressant action of the higher cerebral centres in several experimental animals.

A withanolide-free aqueous fraction isolated from the roots of Withania somnifera exhibited antistress activity in a dose-dependent manner in mice. (Phytother Res 2003, 531-6.)

(See also Simon Mills; American Herbal Pharmacopoeia, 2000; Natural Medicines Comprehensive Database, 2007.)

Dosage: Root—3-6 g powder. (API, Vol. I.)... withania ashwagandha

Linn.

Synonym: X. indicum Koenig. ex Roxb.

Family: Compositae; Asteraceae.

Habitat: Tropical India.

English: Cocklebur, Burweed.

Ayurvedic: Shankheshwara, Arishta, Aartagala.

Siddha/Tamil: Maruloomatham, Marlumutta.

Folk: Bana-okraa.

Action: Plant—used for leucoderma, ulcers, abscesses, strumous and malignant diseases.

Root—antitumour. Leaves and shoots—applied externally on venereal sores, herpes and scrofula.

Leaves contain seaquiterpene lac- tones—xanthinin, xanthumin, xan- thanol and iso-xanthanol. Leaves also contain isohexacosane, chlorobu- tanol, stearyl alcohol, beta-sitosterol and palmitic acid. A highly toxic compound, carboxyatractyloside, has been isolated from the plant.

Beta-sitosterol glucoside is anti-inflammatory, xanthumin is a central nervous system depressant. Alcoholic solution of xanthinin shows strong antibacterial activity against Gramnegative bacteria and fungi. A cy- totoxic compound, xanthatin (a seco- 4,5-guaianolide) has been detected in the resin.

The root gave n-heptacosanol, stig- masterol, 3,4,-dihydro oxycinnamic acid, beta-sitosterol and its D-gluco- side, and campesterol.

Xanthium spinosum Linn. (introduced from Europe into West Bengal and Assam), known as Spiny Clotbur, is used as a diuretic, antiperiodic (also in intermittent fevers), sudorific, antidiarrhoeal and styptic.

The whole plant gave several xan- thanolides. The sesquiterpene lac- tones, xanthinin, solstitialin and sti- zolicin, isolated from the plant, demonstrated limited antitumour action in vitro. Xanthatin has also been isolated.... xanthium strumarium

Throatwort. Scrophularia nodosa L. German: Kno?tige. French: Schofulaire des bois. Spanish: Scrophularia nudoso. Italian: Scrofularia maggiore.

Constituents: flavonoids, iridoids, phenolic acids.

Action: relaxing alterative, anodyne (mild – as applied to piles), diuretic (mild), laxative, anti- inflammatory, vulnerary, lymphatic, cardiac stimulant.

Uses: Skin eruptions that exude matter: scrofulous eczema, psoriasis, pemphigus. Severe itching. Swollen glands. Piles: hard, swollen and painful. Appendicitis. Lumps in the breast (traditional). It is called scrofula plant because of its reputation for discharging abscesses, boils, infected wounds, etc.

Combines well with Yellow Dock. Figwort 2; Yellow Dock 1.

Preparations: Thrice daily.

Tea. 1 heaped teaspoon to each cup boiling water; infuse 15 minutes; dose – half-1 cup. Powder. 500mg (two 00 capsules or one-third teaspoon).

Liquid extract. Dose: 1-2ml.

Tincture BHP (1983) 1:10 in 45 per cent alcohol; dose – 2-4ml.

Note: Contra-indicated in tachycardia (rapid heart beat). ... figwort

Wild Pansy. Viola tricolor L. French: Pensee. German: Dreifarbiges Veilchen. Spanish: Pensamiento. Italian: Pensiero. Leaves and flowers. Keynotes: skin and mucous membranes. Constituents: mucilage, gum, saponin, flavonoids.

Action: anti-inflammatory, antirheumatic, expectorant, diuretic. Alterative. Depurative. Laxative. Rich in zinc. Anti-allergic. Anti-acne.

Uses: Chronic skin disorders with purulent sticky discharge. Moist eczema, milk crust, ringworm. Some success reported by Dr Schlegel, Moscow, for sexually transmitted diseases generally, with ulceration. A daily tea made from the herb is still taken in Russia by those with a tendency to tuberculosis, scrofula. Capillary fragility BHP (1983). To prevent capillary haemorrhage when under corticosteroid therapy. Rheumatism. Acute bronchitis, whooping cough and respiratory distress in children.

Action is enhanced with Mouse Ear (equal parts) for whooping cough; and with Red Clover (equal parts) for skin disorders.

Preparations: Average dose: 2-4 grams. Thrice daily. Chiefly used as a tea made from the dried or fresh herb: 2 teaspoons to each cup boiling water; infuse 15 minutes. 1 cup. Liquid Extract BHP (1983). 2-4ml.

Tablets/capsules. Two 250mg. ... heartsease