The framework upon which the rest of the body is built up. The bones are generally called the skeleton, though this term also includes the cartilages which join the ribs to the breastbone, protect the larynx, etc.

Structure of bone Bone is composed partly of ?brous tissue, partly of bone matrix comprising phosphate and carbonate of lime, intimately mixed together. The bones of a child are about two-thirds ?brous tissue, whilst those of the aged contain one-third; the toughness of the former and the brittleness of the latter are therefore evident.

The shafts of the limb bones are composed of dense bone, the bone being a hard tube surrounded by a membrane (the periosteum) and enclosing a fatty substance (the BONE MARROW); and of cancellous bone, which forms the short bones and the ends of long bones, in which a ?ne lace-work of bone ?lls up the whole interior, enclosing marrow in its meshes. The marrow of the smaller bones is of great importance. It is red in colour, and in it red blood corpuscles are formed. Even the densest bone is tunnelled by ?ne canals (Haversian canals) in which run small blood vessels, nerves and lymphatics, for the maintenance and repair of the bone. Around these Haversian canals the bone is arranged in circular plates called lamellae, the lamellae being separated from one another by clefts, known as lacunae, in which single bone-cells are contained. Even the lamellae are pierced by ?ne tubes known as canaliculi lodging processes of these cells. Each lamella is composed of very ?ne interlacing ?bres.

GROWTH OF BONES Bones grow in thickness from the ?brous tissue and lime salts laid down by cells in their substance. The long bones grow in length from a plate of cartilage (epiphyseal cartilage) which runs across the bone about 1·5 cm or more from its ends, and which on one surface is also constantly forming bone until the bone ceases to lengthen at about the age of 16 or 18. Epiphyseal injury in children may lead to diminished growth of the limb.

REPAIR OF BONE is e?ected by cells of microscopic size, some called osteoblasts, elaborating the materials brought by the blood and laying down strands of ?brous tissue, between which bone earth is later deposited; while other cells, known as osteoclasts, dissolve and break up dead or damaged bone. When a fracture has occurred, and the broken ends have been brought into contact, these are surrounded by a mass of blood at ?rst; this is partly absorbed and partly organised by these cells, ?rst into ?brous tissue and later into bone. The mass surrounding the fractured ends is called the callus, and for some months it forms a distinct thickening which is gradually smoothed away, leaving the bone as before the fracture. If the ends have not been brought accurately into contact, a permanent thickening results.

VARIETIES OF BONES Apart from the structural varieties, bones fall into four classes: (a) long bones like those of the limbs; (b) short bones composed of cancellous tissue, like those of the wrist and the ankle; (c) ?at bones like those of the skull; (d) irregular bones like those of the face or the vertebrae of the spinal column (backbone).

The skeleton consists of more than 200 bones. It is divided into an axial part, comprising the skull, the vertebral column, the ribs with their cartilages, and the breastbone; and an appendicular portion comprising the four limbs. The hyoid bone in the neck, together with the cartilages protecting the larynx and windpipe, may be described as the visceral skeleton.

AXIAL SKELETON The skull consists of the cranium, which has eight bones, viz. occipital, two parietal, two temporal, one frontal, ethmoid, and sphenoid; and of the face, which has 14 bones, viz. two maxillae or upper jaw-bones, one mandible or lower jaw-bone, two malar or cheek bones, two nasal, two lacrimal, two turbinal, two palate bones, and one vomer bone. (For further details, see SKULL.) The vertebral column consists of seven vertebrae in the cervical or neck region, 12 dorsal vertebrae, ?ve vertebrae in the lumbar or loin region, the sacrum or sacral bone (a mass formed of ?ve vertebrae fused together and forming the back part of the pelvis, which is closed at the sides by the haunch-bones), and ?nally the coccyx (four small vertebrae representing the tail of lower animals). The vertebral column has four curves: the ?rst forwards in the neck, the second backwards in the dorsal region, the third forwards in the loins, and the lowest, involving the sacrum and coccyx, backwards. These are associated with the erect attitude, develop after a child learns to walk, and have the e?ect of diminishing jars and shocks before these reach internal organs. This is aided still further by discs of cartilage placed between each pair of vertebrae. Each vertebra has a solid part, the body in front, and behind this a ring of bone, the series of rings one above another forming a bony canal up which runs the spinal cord to pass through an opening in the skull at the upper end of the canal and there join the brain. (For further details, see SPINAL COLUMN.) The ribs – 12 in number, on each side – are attached behind to the 12 dorsal vertebrae, while in front they end a few inches away from the breastbone, but are continued forwards by cartilages. Of these the upper seven reach the breastbone, these ribs being called true ribs; the next three are joined each to the cartilage above it, while the last two have their ends free and are called ?oating ribs. The breastbone, or sternum, is shaped something like a short sword, about 15 cm (6 inches) long, and rather over 2·5 cm (1 inch) wide.

APPENDICULAR SKELETON The upper limb consists of the shoulder region and three segments – the upper arm, the forearm, and the wrist with the hand, separated from each other by joints. In the shoulder lie the clavicle or collar-bone (which is immediately beneath the skin, and forms a prominent object on the front of the neck), and the scapula or shoulder-blade behind the chest. In the upper arm is a single bone, the humerus. In the forearm are two bones, the radius and ulna; the radius, in the movements of alternately turning the hand palm up and back up (called supination and pronation respectively), rotating around the ulna, which remains ?xed. In the carpus or wrist are eight small bones: the scaphoid, lunate, triquetral, pisiform, trapezium, trapezoid, capitate and hamate. In the hand proper are ?ve bones called metacarpals, upon which are set the four ?ngers, each containing the three bones known as phalanges, and the thumb with two phalanges.

The lower limb consists similarly of the region of the hip-bone and three segments – the thigh, the leg and the foot. The hip-bone is a large ?at bone made up of three – the ilium, the ischium and the pubis – fused together, and forms the side of the pelvis or basin which encloses some of the abdominal organs. The thigh contains the femur, and the leg contains two bones – the tibia and ?bula. In the tarsus are seven bones: the talus (which forms part of the ankle joint); the calcaneus or heel-bone; the navicular; the lateral, intermediate and medial cuneiforms; and the cuboid. These bones are so shaped as to form a distinct arch in the foot both from before back and from side to side. Finally, as in the hand, there are ?ve metatarsals and 14 phalanges, of which the great toe has two, the other toes three each.

Besides these named bones there are others sometimes found in sinews, called sesamoid bones, while the numbers of the regular bones may be increased by extra ribs or diminished by the fusion together of two or more bones.... bone

An adjective that relates to muscle and/or bone. The musculoskeletal system comprises the bones of the skeleton and all the muscles attached to them.... musculoskeletal

The branch of surgery concerned with disorders of the bones and joints and their associated muscles, tendons, and ligaments. Procedures include setting broken bones and applying casts; treating dislocations, slipped discs, arthritis, and back problems; treating bone tumours and birth defects of the skeleton; and repairing or replacing hip, knee, or finger joints.... orthopaedics

The bony skeleton of the head, which rests on the 1st cervical vertebra. The skull protects the brain, houses the special sense organs, provides points of attachment for muscles, and forms part of the respiratory and digestive tracts.

The 8 bones of the cranium encase the brain.

The skull’s facial skeleton includes the nasal and cheek bones, maxilla, and mandible.

All except the mandible are fixed together by immovable joints.... skull

A hard but pliant substance forming parts of the skeleton – for example, the cartilages of the ribs, of the larynx and of the ears. Microscopically, cartilage is found to consist of cells arranged in twos or in rows, and embedded in a ground-glass-like material devoid of blood vessels and nerves. The end of every long bone has a smooth layer of hyaline cartilage on it where it forms a joint with other bones (articular cartilage), and in young persons up to about the age of 16 there is a plate of cartilage (epiphyseal cartilage) running right across the bone about 12 mm (half an inch) from each end. The latter, by constantly thickening and changing into bone, causes the increase in length of the bone. (See also BONE.) In some situations there is found a combination of cartilage and ?brous tissue, as in the discs between the vertebrae of the spine. This ?bro-cartilage, as it is known, combines the pliability of ?brous tissue with the elasticity of cartilage. (For cartilages of the knee, see KNEE.)... cartilage

A carbohydrate substance forming the skeleton of most plant structures. It is colourless, transparent, insoluble in water and is practically unaffected by digestion. In vegetable foods it therefore adds to the bulk, but it is of no value as a food-stu?. It is found in practically a pure state in cotton-wool.... cellulose

Curcuma spp.

Zingiberaceae

The genus Curcuma belonging to the family Zingiberaceae comprises of a number of species which are medicinally very important. Among them, the most important species are described below.

1. C. amada Roxb.

English: Mango ginger San: Amrardrakam, Karpuraharida Hin: Ama -haldi

Mal: Mangainchi

Tam: Mankayinci

Tel: Mamidi Allam

Mango ginger is cultivated in Gujarat and found wild in parts of West Bengal, U. P, Karnataka and Tamil Nadu. It is a rhizomatous aromatic herb with a leafy tuft and 60-90cm in height. Leaves are long, petiolate, oblong-lanceolate, tapering at both ends, glabrous and green on both sides. Flowers are white or pale yellow, arranged in spikes in the centre of tuft of the leaves. Lip is semi -elliptic, yellow, 3-lobbed with the mid lobe emarginate. The rhizomes are useful in vitiated conditions of pitta, anorexia, dyspepsia, flatulence, colic, bruises, wounds, chronic ulcers, skin diseases, pruritus, fever, constipations, strangury, hiccough, cough, bronchitis, sprains, gout, halitosis, otalgia and inflammations (Warrier et al, 1994). The fresh root possesses the smell of green mango and hence the name mango ginger. The rhizomes are used externally in the form of paste as an application for bruises and skin diseases generally combined with other medicines. Tubers rubbed with the leaf- juice of Caesalpinia bonduc is given for worms (Nadkarni, 1982).

The essential oil contains -pinene, -and -curcumene, camphor, cuminyl alcohol, myristic acid and turmerone. Car-3-ene and cis-ocimene contribute the characteristic mango odour of the rhizome. Rhizome is CNS active, hypothermic and it shows potentiation of amphetamine toxicity. Tuber is trypsin inhibitor and is effective against Vibrio cholerae (Husain et al, 1992). The rhizomes are bitter, sweet sour, aromatic, cooling, appetiser, carminative, digestive, stomachic, demulcent, vulnerary, febrifuge, alexertic, aphrodisiac, laxative, diurectic, expectorant, antiinflammatory and antipyretic (Warrier et al, 1994).

2. C. aromatica Salisb.

Eng: Wild turmeric; San: Aranyaharidra, Vanaharidra;

Hin: Ban-haridra, Jangli-haldi;

Ben: Ban Haland; Mal,

Tam: Kasturimanjal, Kattumanjal;

Tel: Adavi-pasupu;

Kan: Kadarasina

Wild turmeric or Cochin turmeric or Yellow zeodoary is found wild throughout India and cultivated in Bengal and Kerala. It is a perennial tuberous herb with annulate, aromatic yellow rhizome which is internally orange-red in colour. Leaves are elliptic or lanceolate- oblong, caudate-acuminate, 30-60cm long, petioles as long or even longer, bracts ovate, recurved, more or less tinged with red or pink. Flowers are pink, lip yellow, obovate, deflexed, sub-entire or obscurely three lobed. Fruits are dehiscent, globose, 3-valved capsules. Rhizomes are used in combination with astringents and aromatics for bruises, sprains, hiccough, bronchitis, cough, leucoderma and skin eruptions (Warrier et al, 1994). The rhizomes have an agreeable fragrant smell and yield a yellow colouring matter like turmeric, and the fresh root has a camphoraceous odour. The dried rhizome is used as a carminative and aromatic adjunctant to other medicines (Nadkarni, 1998).

Essential oil contains -and - -curcumene, d-camphene and p-methoxy cinnamic acid. The colouring matter is curcumin. Numerous sesquiterpenoids of germacrone and guaiane skeletons have been identified recently. Rhizome has effect on respiration. It is spasmolytic and shows antagonism of amphetamine hyperactivity. Rhizome is an anti-dote for snakebite and carminative (Husain et al, 1992).

3. C. longa Linn. syn. C. domestica Valeton.

Eng: Turmeric; San: Haridra, Varavarnini;

Hin: Haldi, halda;

Ben: Haldi;

Mal: Manjal, Pachamanjal, Varattumanjal;

Tam: Mancal;

Kan: Haldi, Arasina;

Tel: Pasapu

Turmeric is cultivated all over India, particularly in W. Bengal, T. N and Maharashtra. It is a perennial herb, 60-90cm in height, with a short stem and tufts of erect leaves. Rhizome is cylindric, ovoid, orange coloured and branched. Leaves are simple, very large, petiole as long as the blade, oblong-lanceolate, tapering to the base upto 45cm long. Flowers are pale yellow, arranged in spikes concealed by the sheathing petioles and flowering bracts are pale green (Warrier et al, 1994). Turmeric occupies an important position in the life of Indian people as it forms an integral part of the rituals, ceremonies and cuisine. Due to the strong antiseptic properties, turmeric has been used as a remedy for all kinds of poisonous affections, ulcers and wounds. It gives good complexion to the skin and so it is applied to face as a depilatory and facial tonic. The drug cures diseases due to morbid vata, pitta and kapha, diabetes, eye diseases, ulcers, oedema, anaemia, anorexia, leprosy and scrofula. It purifies blood by destroying the pathogenic organisms. A paste of turmeric alone, or combined with a paste of neem (Azadirachta indica) leaves, is used to cure ringworm, obstinate itching, eczema and other parasitic skin diseases and in chicken pox and small pox. The drug is also useful in cold, cough, bronchitis, conjunctivitis and liver affections (Nadkarni, 1954; Kurup et al,1979; Kolammal, 1979). The rhizome is the officinal part and is an important ingredient of formulations like Nalpamaradi taila, Jatyadi taila, Narayana gula, etc. (Sivarajan et al, 1994).

Turmeric paste mixed with a little limejuice and saltpetre and applied hot is a popular application to sprains and bruises. In smallpox and chickenpox, a coating of turmeric is applied to facilitate the process of scabbing. The smoke produced by sprinkling powdered turmeric over burnt charcoal will relieve scorpion sting when the part affected is exposed to the smoke for a few minutes. Turmeric and alum powder in the proportion of 1:20 is blown into the ear in chronic otorrhoea (Nadkarni, 1998). “Haridra Khand”, a compound containing powdered turmeric, sugar and many other ingredients is a well-known preparation for cold, cough and flu, and for skin diseases. In Unani system, roasted turmeric is an ingredient of “Hab Narkachur”, used as antidysenteric for children (Thakur et al, 1989).

Essential oil contains ar-turmerone, and ar-curcumene as ma jor constituents. Some of the other compounds are -and -pinene, sabinene, myrcene, -terpinene, limonene, p- cymene, perillyl alcohol, turmerone, eugenol, iso-eugenol, eugenol methyl ether and iso- eugenol methyl ether. Curcumin and related compounds have also been reported as major constituents of the rhizomes. Recently a number of sesquiterpenes have been reported from C. longa, viz., the sesquiterpenoids of germacrane, bisabolane and guainane skeletons (Husain et al, 1992). The study of sesquiterpenes has revealed a new compound curlone (Kisoy et al, 1983). The crystalline colouring matter curcumin (0. 6%) is diferuloyl methane (Mathews et al, 1980). Stigmasterol, cholestrol, -sitosterol and fatty acids, mainly straight chain dienoic acids are reported (Moon et al, 1977). Curcumin, the colouring agent and major constituent of C. longa, is said to possess local as well as systemic antiinflammatory property which has been found to compare favourably with phenylbutazone (Srimal and Dhawan, 1973). An extract of the crude drug ‘akon’ containing the rhizomes exhibited intensive preventive activity against carbon tetrachloride induced liver injury invivo and invitro. The liver protecting effects of some analogs of ferulic acid and p-coumaric acid, probable metabolites of the curcuminoids have been also evaluated (Kiso et al, 1983). Curcumin is antiinflammatory. Rhizome is antiprotozoal, spasmolytic, CNS active, antiparasitic, antispasmodic, antibacterial, antiarthritic, anthelmintic, carminative, antiperiodic, emo llient, anodyne, laxative, diruretic, expectorant, alterative, alexertive, febrifuge, opthalmic and tonic.

4. C. zedoaria (Berg.) Rosc. syn. C. zerumbet Roxb; Amomum zedoaria

Christm.vEng: Round zedoary; San: Kachura, Shati;

Hin: Kakhur;

Ben: Sati;

Kan: Kachora

Mal: Manjakoova, Adavi-kacholam;

Tam: Kichilikizhangu, Nirvisham;

Tel: Kacheramu

The round zedoary or Zerumbet is mostly found in India and S. E. Asia. The plant has 4-6 leaves with 20-60cm long lamina. The leaf lami na is oblong-lanceolate, finely acuminate and glabrous on both the surfaces. Flower stalk is 20-25cm long, emerging before the leaves. Flowers are yellow, while the flowering bract is green tinged with red. Calyx is 8mm long, corolla tube is twice as long as the calyx. Capsule is ovoid, trigonous, thin smooth and bursting irregularly. Tubers are palmately branched and camphoraceous (Thakur et al, 1989). The identity of the plant sources of the drug Karcura is a matter of debate. There is difference of opinion among men of Ayurveda, as to whether Sati and Karcura are the same drug or different. Many authors consider them different and equate Sati with Hedychium spicatum Smith. and Karcura with C. zedoaria, both belonging to Zingiberaceae (Kurup et al,1979; Chunekar 1982; Sharma, 1983). Some others treat them to be the same and equate it with C. zedoaria (Kirtikar and Basu, 1918; Vaidya, 1936; Nadkarni, 1954; Kapoor and Mitra, 1979). However, the source of Karcura in Kerala in the recent times has been Kaempferia galanga of the same family. The rhizome of C. zedoaria is used as appetiser and tonic, particularly prescribed to ladies after childbirth. In case of cold, a decoction of long pepper (Piper longum), cinnamon (Cinnamomum verum), zedoary and honey is given. In Ayurveda it is an ingredient of “Braticityadi kwatha”, used in high fever (Thakur et al, 1989). Root is useful in flatulence and dyspepsia, and as a corrector of purgatives. Fresh root checks leucorrhoeal and gonorrhoeal discharges. Root powder is a good substitute for many foreign foods for infants. For worms, the juice from the tubers is given to children. Juice of the leaves is given in dropsy (Nadkarni, 1982). It is an odoriferous ingredient of the cosmetics used for the cure of chronic skin diseases caused by impure or deranged blood (Nadkarni, 1998).

Essential oil from rhizomes contains -pinene, d-camphene, cineole, d-camphor, sesquiterpenes and sesquiterpene alcohols (Husain et al, 1992). The novel sesquiterpenoids which have been isolated and characterised are cuzerenone, epi-cuzerenone, iso- furanogermerene, curcumadiol, curcumol, curcumenol, iso-curcumenol, procurcumenol, dehydrocurdione (Hikino et al, 1968, 1971, 1972), germacrone-4, 5-epoxide, germacrone, germacrone furanodienone, curcumenol, iso-curcumenol, curcumanolides A and B and curcumenone (Shiobara et al, 1985). The starch left after the extraction is purified and sold as a commodity of cottage industry in West-Bengal under the name ‘Shoti’ (Rao et al, 1928). Ethyl-p methoxy-cinnamate has been isolated from the alcoholic extract of the plant (Gupta et al, 1976). Rhizome is stomachic, diuretic, and carminative and gastrointestinal stimulant.

Other important species of Curcuma genus are

C. angustifolia Roxb. (Vellakoova)

C. caesia Roxb. (Black ginger)

C. leucorhiza Roxb.

C. pseudomontana Grah.

C. rubescens Roxb.

Agrotechnology: Curcuma species are tropical herbs and can be grown on different types of soils both under irrigated and rainfed conditions. Rich loamy soils having good drainage are ideal for the crop. The plant is propagated by whole or split mother rhizomes. Well developed, healthy and disease free rhizomes are to be selected. Rhizomes are to be treated with copper oxychloride fungicides and stored in cool, dry place or earthen pits plastered with mud and cowdung. The best season of planting is during April with the receipt of pre-monsoon showers. The land is to be prepared to a fine tilth during February-March. On receipt of pre- monsoon showers in April, beds of size 3x1.2m with a spacing of 40cm between beds are to be prepared. Small pits are to be taken in the beds in rows with a spacing of 25-40cm.

Finger rhizomes are to be planted flat with buds facing upwards and covered with soil or dry powdered cattle ma nure. The crop is to be mulched immediately after planting and 50 days after first mulching. Cattle manure or compost is to be applied as basal dose at 20-40t/ha at the time of land preparation or by spreading over the beds after planting. Application of NPK fertilizers is beneficial and found to increase the yield considerably. Weeding is to be done twice at 60 and 120 days after planting, depending upon weed intensity. Earthing up is to be done after 60 days. No major incidence of pest or disease is noticed in this crop. Leaf blotch and leaf spot can be controlled by spraying Bordeaux mixture or 0.2% Mancozeb. Shoot borers can be controlled by spraying 0.05% Dimethoate or 0.025% Quinalphos. Time of harvest usually extends from January-March. Harvesting is generally done at about 7-10 months after planting depending upon the species and variety. Harvested rhizomes are to be cleaned of mud and other materials adhering to them. Good fingers separated are to be used for curing (KAU, 1996).... curcuma

Murraya Koenigii

Rutaceae

San: Kalasakh, Kaidaryah

Hin: Mithinim, Katnim

Ben: Barsunga

Mal: Kariveppu, Karuveppu

Tam: Kariveppilai, Karuveppu

Kan: Kari Baeva

Tel: Karivepaku

Ass: Narasingha, Bishahari

Importance: Curry leaf, a plant of homestead gardens has gained importance as a commercial crop and is cultivated for its culinary and medicinal value. The plant is highly esteemed for its leaves which promote appetite and digestion and destroy pathogenic organisms. It is reported to be useful in emaciation, skin diseases, hemopathy, worm troubles, neurosis and poisons. They are useful in vitiated conditions of kapha and pitta, hyperdipna, colic, flatulence, diarrhoea, dysentery, vomiting, inflammations and foul ulcers. “Kaidaryah” drug is prepared using this plant which improves voice, stimulates digestion and destroys concocted poisons in the system. The important preparations using the drug are Kalasadi kasayam, Pamantaka tailam, Jatyadi tailam, Jatyadi ghrtam, etc (Sivarajan et al,1994).

Distribution: Curry leaf is seen in the foot of the Himalaya and Bashahi eastwards to Sikkim and Peninsular India, upto 1700m. It is also found in Sri Lanka, Burma, Indo-China, South China and Hainan. Commercial cultivation in India is limited to Tamil Nadu and Karnataka states.

Botany: The genus Murraya of the family Rutaceae includes the following species:

M. Koenigii (Linn.) Spreng. syn. Bergera koenigii Linn.

M. Exotica Linn. syn. M. paniculata (Linn.) Jack.

Murraya koenigii is a small aromatic tree with dark grey bark and closely crowded spreading dark green foliage. Leaves are imparipinnate and alternate. Leaflets are alternate, obliquely ovate or somewhat rhomboid, gland dotted and strongly aromatic. Flowers are white, arranged in much branched terminal corymbose cymes and fragrant. Fruits are subglobose or ellipsoid berries, purplish black when ripe and 2-seeded (Warrier et al, 1995).

Agrotechnology: Curry leaf tree does not choose a specific climate and can come up even in dry climate too. In places where minimum temperature goes below 13 C, the growth of the shoot will be slightly affected. It comes up well in light textured red soils. DWD-1 and DWD-2 are two improved varieties released from UAS, Dharwad. Curry leaf is propagated by seed. Main field is to be ploughed repeatedly. A spacing of 90-120cm is followed on either side. Pits of size 30cm3 are dug out one month before planting and filled with top soil mixed with well decomposed FYM at the time of planting. Healthy seedlings are planted in the centre of the pits. Then long furrows are formed connecting all the pits to facilitate easy irrigation. The seedlings are irrigated once in 5-7 days upto 3 years and once in 15 days afterwards. The field should be kept free from weeds. Plants may be trained and pruned to maintain a bush of 1m in height. For better growth and yield, each plant is fertilised with 20kg of FYM besides 150:25:50g of N, P2O5, K2O/ year. Attack of aphids in the vegetative stage can be controlled by spraying of dimethoate at 2ml/l of water. Leaves from such sprayed plants should be harvested only after 10 days. Spraying carbendazim at 1g/l can take care of leaf spot diseases. The crop comes to first harvest at the end of first year. The yield of leaves account to 400kg/ha at the end of first year, 2000 to 2200kg/ha in the second and third year harvested at an interval of four months and 2500kg/ha in the fourth year harvested at three months interval. From fifth year onwards it is harvested at 2.5-3 months interval giving an yield of 3500-5000kg/ha (Kumar et al, 1997).

Properties and activity: All parts of the plant, especially the leaves are rich in carbazole alkaloids. These include members with (i) C13 - skeleton -murrayanin, mukoeic acid, mukonine and mukonidine; (ii) C18 - skeleton including gerinimbine, koenimbine, murrayacine, koenigine and koenigicine (koenidine); and (iii) C23- skeleton containing mahanimbine, mahanimbicine, iso- mahanimbicine, mahanine, mahanimbinine, murrayayazoline, murrayazolinine, murrayazolidine, cyclomahanimbine and bicyclomahanimbicine. Other carbazole bases include mukoline, mukolidine (C13 group, from roots), mukonicine (C18 from leaves), the biogenetically significant mukonal (C13, stem-bark), mahanimboline (C23, root-bark), iso- murrayazoline (C23, stem-bark). The leaves gave a coumarin glucoside, scopolin also. Essential oil from leaves contained -caryophylline, -gurjunene, -elemene, - phellandrene, -thujene as major constituents.

The roots, bark and leaves are bitter, acrid, astringent, cooling, aromatic, demulcent, depurative, anthelmintic, febrifuge, stomachic, appetising, carminative, antiinflammatory and antiseptic. Aerial part is spasmolytic and antiprotozoal. Root is antiprotozoal, CVS active and has effect on nictitating membrane. Leaf is hypoglycaemic (Hussain et al,1992).... curry leaf

An inherited disorder affecting about one person in 50,000 in which the CONNECTIVE TISSUE is abnormal. The result is defects of the heart valves, the arteries arising from the heart, the skeleton and the eyes. The victims are unusually tall and thin with a particular facial appearance (the US President Abraham Lincoln was said to have Marfan’s) and deformities of the chest and spine. They have spider-like ?ngers and toes and their joints and ligaments are weak. Orthopaedic intervention may help, as will drugs to control the heart problems. As affected individuals have a 50 per cent chance of passing on the disease to their children, they should receive genetic counselling.... marfan’s syndrome

A joint is the articulation point between di?erent parts of the skeleton, whether bone or cartilage. Joints are divided into those which are ?xed or relatively ?xed (?brous and cartilaginous joints), and those which allow free movement (synovial joints). In the former, exempli?ed by the sutures between the bones of the skull, a layer of cartilage or ?brous tissue lies between the bones, binding them ?rmly together. Amphiarthrodial joints, exempli?ed by the joints between the vertebral bodies (see SPINAL COLUMN), have a thick disc of ?brocartilage between the bones. Although the individual joint is capable of very little movement, a series of these gives to the spinal column, as a whole, a ?exible character.

All movable joints involve four structures: the bones whose junction forms the joint; a layer of cartilage covering the ends of these, making them smooth; a ?brous sheath, the capsule, thickened at various points into bands or ligaments, which hold the bones together; and, ?nally, the synovial membrane, which lines the capsule and produces a synovial ?uid, lubricating the movements of the joint. In addition, the bones are kept in position at the joints by the various muscles passing over them and by atmospheric pressure. Where the ends of the bones do not quite correspond, a subsidiary disc of ?bro-cartilage may help to adapt the ends of the bones more perfectly to each other. Larger cavities may be ?lled by movable pads of fat under the synovial membrane, giving additional protection to the joint.

Varieties After this main division of joints into those which are ?xed and those movable, the movable joints may be further subdivided. In gliding joints, such as the wrist and ankle, the bones have ?at surfaces capable of only a limited amount of movement. In hinge joints, such as the elbow and knee, movement takes place around one axis. Ball-and-socket joints, exempli?ed by the shoulder and hip, allow free movement in any direction. Subsidiary varieties are named according to the shape of the bones which enter the joint.... joints

A hereditary disease due to an inherited abnormality of COLLAGEN. It is characterised by extreme fragility of the skeleton, resulting in fractures and deformities. It may be accompanied by blue sclera (the outermost, normally white coat of the eyeball), transparent teeth, hypermobility (excessive range of movement) of the joints, deafness, and dwar?sm (shortness of stature). The exact cause is not known, although there is some evidence that it may be associated with collagen formation. Parents of affected children can obtain help and advice from the Brittle Bone Society.... osteogenesis imperfecta

4 weeks pregnancy

"Pregnancy calendar" at 4th week: A miracle begins! Your baby, now consisting of a cell stack, is clinging to the walls of your uterus and starting to grow rapidly. Early pregnancy in this period, for example, nausea in pregnancy is extremely normal. Birth is a beautiful yet remote dream.

Your baby in 4 weeks pregnancy

Your baby is a seed of poppy seeds. By the end of the week your baby will be about 1 mm long. Once the fertilized egg is placed on the side of your uterus, it divides into cell layers and becomes an embryo from official care. These cells turn into the body of your baby during pregnancy, forming the nervous system, skeleton, muscles and organs.

Support system in formation

The disc-like organ, which connects your body systems to the baby's systems, begins to form and attaches to the uterine wall where the egg is placed. The umbilical cord comes out of one of the placenta. Amniotic fluid, which will stretch your baby during pregnancy, has begun to form in a circumscribing membrane sac.

Your 4th week pregnancy

As the fertilized egg gets into your uterus, you may experience some bleeding. This is known as implantation hemorrhage and is completely normal.

The results came

Thanks to the brand-new placenta-attacked hCG hormone and a pregnancy test at home after the first period you missed, you will get a positive result, but false negative results can also be seen. This hormone is the greatest cause of nausea or morning sickness that many pregnant women experience in the first three months. If you are not pregnant, but your pregnancy test at home is negative, you may need a doctor.... pregnancy calendar - week 4 of your pregnancy

Repair of the NOSE or modi?cation of its shape by operation. This operation is performed by reconstructive and ENT (ear, nose and throat) surgeons alike. It may involve alteration of the bony skeleton of the nose and/or alteration of the SEPTUM (septorhinoplasty). It is mostly performed for cosmetic reasons; however, any disease process or injury which has caused a defect in the nose may be repaired as well. The latter problem would usually involve the utilisation of some form of skin ?ap, whereas this would not be required for cosmetic surgical purposes.... rhinoplasty

Salve for rheumatic joints, stiff muscles, lumbago, backache and to prepare the spine or skeleton for manipulation as in osteopathy.

Ingredients: Cayenne pods 2oz (or Tincture Capsicum 60 drops); Camphor flowers quarter of an ounce; Peppermint oil 20 drops; Cajuput oil 50 drops; Eucalyptus oil 20 drops; Beeswax 2oz. Sunflower seed oil 16oz.

Method: Gently heat Sunflower seed oil. If Cayenne pods, are used: add pods, steep for one and a half hours. Stir. Strain. Over gentle heat add wax stirring gently until dissolved. Add other ingredients (including Tincture Capsicum if used), stirring well. Pour into jars while fluid. ... golden fire

The collarbone. The 2 clavicles, 1 on each side, form joints with the top of the sternum (breastbone) and the scapula (shoulderblade). The clavicles support the arms and transmit forces from the arms to the central skeleton.... clavicle

One of 5 long, cylindrical bones within the foot. The bones make up the central skeleton of the foot and are held in an arch by the surrounding ligaments.... metatarsal bone

Also known as the spine, this forms an important part of the skeleton, acting both as the rigid pillar which supports the upper parts of the body and as a protection to the SPINAL CORD and nerves arising from it. The spinal column is built up of a number of bones placed one upon another, which, in consequence of having a slight degree of turning-movement, are known as the vertebrae. The possession of a spinal cord supported by a vertebral column distinguishes the higher animals from the lower types, and is why they are called vertebrates. Of the vertebrates, humans alone stand absolutely erect, and this erect carriage of the body gives to the skull and vertebral column certain distinctive characters.

The human backbone is about 70 cm (28

inches) in length, and varies little in full-grown people; di?erences in height depend mainly upon the length of the lower limbs. The number of vertebrae is 33 in children, although in adult life ?ve of these fuse together to form the sacrum, and the lowest four unite in the coccyx, so that the number of separate bones is reduced to 26. Of these there are seven in the neck, known as cervical vertebrae; 12 with ribs attached, in the region of the thorax known as thoracic or dorsal vertebrae; ?ve in the loins, called lumbar vertebrae; ?ve fused to form the sacrum; and four joined in the coccyx. These numbers are expressed in a formula thus: C7, D12, L5, S5, Coc4=33.

Although the vertebrae in each of these regions have distinguishing features, all the vertebrae are constructed on the same general plan. Each has a thick, rounded, bony part in front, known as the body, and these bodies form the main thickness of the column. Behind the body of each is a ring of bone, the neural ring, these rings placed one above another forming the bony canal which lodges the spinal cord. From each side of the ring a short process of bone known as the transverse process stands out, and from the back of the ring a larger process, the spinous process, projects. These processes give attachment to the strong ligaments and muscles which unite, support, and bend the column. The spines can be seen or felt beneath the skin of the back lying in the centre of a groove between the muscular masses of the two sides, and they give to the column its name of the spinal column. One of these spines, that of the seventh cervical vertebra, is especially large and forms a distinct bony prominence, where the neck joins the back. Between the bodies of the vertebrae lies a series of thick discs of ?brocartilage known as intervertebral discs. Each disc consists of an outer portion, known as the annulus ?brosus, and an inner core, known as the nucleus pulposus. These 23 discs provide the upper part of the spine with pliability and resilience.

The ?rst and second cervical vertebrae are specially modi?ed. The ?rst vertebra, known as the atlas, is devoid of a body, but has a specially large and strong ring with two hollows upon which the skull rests, thus allowing forward and backward movements (nodding). The second vertebra, known as the axis, has a pivot on its body which ?ts into the ?rst vertebra and thus allows free rotation of the head from side to side. The spinal column has four natural curves (see diagram) which help to cushion the shocks of walking and running.

The neural rings of the vertebrae form a canal, which is wide in the neck, smaller and almost round in the dorsal region, and wide again in the lumbar vertebrae. Down the canal runs the spinal cord, and the nerves leaving the cord do so through openings between the vertebrae which are produced by notches on the upper and lower margins of each ring. The intervertebral foramina formed by these notches are so large in comparison with the nerves passing through them that there is no chance of pressure upon the latter, except in very serious injuries which dislocate and fracture the spine.... spinal column

Luxations. Displacement of a structure, usually bone, as in an osteopathic lesion. May occur spontaneously as a result of weak ligaments or from injury, posture. Common in the shoulder. Many dislocations of the spine and skeleton are resolved by osteopathy.

Alternatives. To strengthen ligaments: Comfrey (topical). Wild Yam, Irish Moss, Slippery Elm bark, Horsetail, Fenugreek seeds. St John’s Wort, Ginseng.

Supplementation. Calcium and Zinc, Vitamin C (1 gram thrice daily).

DISMUTASE ENZYMES (SOD). A dismutase enzyme is a biologically active enzyme complex present in most human cells and capable of converting tissue-damaging oxygen free radicals (highly reactive cellular toxins) into less harmful chemical substances that can be excreted from the body through the usual eliminatory channels.

Evidence shows that a number of chronic diseases including MS, diabetes, arthritis, even cancer, are the result of free radical damage. SOD is derived from a natural wheat sprout extract from specially cultured wheat that is hypoallergenic. It stimulates and supports the immune system, neutralises toxins, and minimises tissue damage in wasting diseases and organ transplantation. Protecting oxygen levels in body cells, it allays the ageing process and alleviates circulatory disorders. ... dislocations

adj. 1. relating to or affecting the vermiform appendix. 2. relating to the limbs: the appendicular skeleton comprises the bones of the limbs.... appendicular

n. any member of a large group of animals that possess a hard external skeleton and jointed legs and other appendages. Many arthropods are of medical importance, including the *mites, *ticks, and *insects.... arthropod

n. the part of the skeleton that encloses the brain. It consists of eight bones connected together by immovable joints (see skull). —cranial adj.... cranium

n. (pl. sterna) the breastbone: a flat bone, 15–20 cm long, extending from the base of the neck to just below the diaphragm and forming the front part of the skeleton of the thorax. The sternum articulates with the collar bones (see clavicle) and the costal cartilages of the first seven pairs of ribs. It consists of three sections: the middle and longest section – the body or gladiolus – is attached to the *manubrium at the top and the *xiphoid (or ensiform) process at the bottom. The manubrium slopes back from the body so that the junction between the two parts forms an angle (angle of Louis or sternal angle). —sternal adj.... sternum

Shave grass. Pewterwort. Nature’s hoover. Equisetum arvense L. German: Ackerschachtelhalm. French: Equisette. Spanish: Belcho. Italian: rasperella. Chinese: We?n-ching. Dried stems. Keynote: genito-urinary system. A natural source of silicic acid, ashes containing 70 per cent silica soluble in water and alcohol.

Constituents: flavonoids, alkaloids, sterols, silicic acid.

Action: haemostatic for bleeding of genitourinary organs, styptic, a soothing non-irritating diuretic. Increases coagulability of the blood. Remineraliser. Anti-atheroma. Antirheumatic. Astringent. Immune enhancer. White blood cell stimulator.

Uses: Blood in the urine, prostatitis, bed-wetting, dropsy, chronic bladder infections, incontinence in the aged, catarrh of the urinary organs, gravel, urethritis of sexual transmission with bleeding, stricture, severe pain in the bladder unrelieved by passing water, constant desire to pass water without relief. Carcinoma of the womb: cure reported. Foetid discharges of STD. Arteriosclerosis.

Silica, as in Horsetail, preserves elasticity of connective tissue; controls absorption of calcium and is a necessary ingredient of nails, hair, teeth and the skeleton. Its cleansing properties rapidly remove urates, uric acid and cellulites from the system. Hastens repair of tissue after lung damage of tuberculosis or other diseases.

Combinations. (1) With Shepherd’s Purse for blood in the urine. (2) With Pulsatilla to inhibit growth of uterine fibroid. (3) With Buchu for cystitis. (4) With Oats and Goldenseal for renal exhaustion. “Combines well with Hydrangea for non-malignant prostatitis.” (F. Fletcher Hyde) Arteriosclerosis. (Dr Max Rombi)

Preparations: Horsetail has a heavy mineral content (silica, selenium and zinc) therefore treatment is best staggered so as to avoid kidney strain – one month, followed by one week’s break. Average dose: 1 to 4 grams; thrice daily.

Tea: half-1 teaspoon to cup water; bring to boil; simmer 5 minutes; infuse 30 minutes. Dose: half-1 cup, cold.

Liquid extract BHC Vol 1. 1:1 in 25 per cent ethanol. Dose: 1-4ml (15-60 drops).

Home tincture: 1 part herb to 5 parts 25 per cent alcohol (gin, Vodka, etc). Steep 14 days, shake daily. Dose: 2-5ml (30-75 drops) in water.

Poultice: “Place double handful herb in a sieve and place over a pot of boiling water (double boiler, etc). The soft hot herbs are placed between a piece of linen and applied to ulcer, adenoma, cyst or tumour.” (Maria Treben)

Bath. 9oz leaves: bring to boil in 1 gallon water. Simmer 5 minutes; strain. Add to bath water.

Enema: 1 pint weak tea for infants with kidney disorders. ... horsetail

A procedure to obtain a sample of cells from the bone marrow (aspiration biopsy) or a small core of bone with marrow inside (trephine biopsy). The sample is usually taken, under local anaesthesia, from the sternum (breastbone) or iliac crests (upper part of the hip-bones). Microscopic examination gives information on the development of the blood components

surrounding tissues. Radionuclide scanning detects areas throughout the skeleton in which there is high bone-cell activity. This type of scanning and on the presence of cells foreign to the marrow.

It is useful in the diagnosis of many blood disorders, including leukaemia and anaemia.

It can also show whether bone marrow has been invaded by lymphoma or cells from other tumours.... bone marrow biopsy

A rare malignant form of bone cancer. It arises in a large bone, usually the femur, tibia, humerus, or a pelvic bone, and spreads to other areas at an early stage. The condition is most common in children aged 10–15. An affected bone is painful and tender. It may also become weakened and fracture easily. Other symptoms include weight loss, fever, and anaemia.

The sarcoma is diagnosed by X-rays and a biopsy.

If cancer is found, the whole skeleton is examined by X-rays and radionuclide scanning, and the lungs viewed by CT scanning, to determine if, and how far, the cancer has spread.

Treatment is with radiotherapy and anticancer drugs.

If the cancer has not spread, the outlook is good.... ewing’s sarcoma

Bodily movements include skeletal movements and movements of soft tissues and body organs. All movement is brought about by the actions of muscles and may be voluntary, involuntary, or a reflex action.

All voluntary skeletal movements are initiated in the part of the cerebrum (main mass of the brain) called the motor cortex. Signals are sent down the spinal cord along nerve fibres, and from there along separate nerve fibres to the appropriate muscles. Control relies on information supplied by sensory nerve receptors, in the muscles and elsewhere, that record the position of the different parts of the body and the amount of contraction in each muscle. This information is integrated in specific regions of the brain (including the cerebellum and basal ganglia) that control the coordination, initiation, and cessation of movement.

Skeletal movements can also occur as simple reflexes in response to certain sensory warning signals; the movement is automatic and less controlled, involving far fewer nerve connections.

Some body movements do not involve the skeleton. For example, eye and tongue movements are brought about by contractions of muscles that are attached to soft tissues. These movements may be voluntary or reflex.

Movements of the internal organs are involuntary; they include the heartbeat and peristalsis.... movement

n. the chest: the part of the body cavity between the neck and the diaphragm. The skeleton of the thorax is formed by the sternum, costal cartilages, ribs, and thoracic vertebrae of the backbone. It encloses the lungs, heart, oesophagus, and associated structures. Compare abdomen. —thoracic adj.... thorax

“Brittle bones”. The Silent Epidemic. Weakness and softness of the bones due to wastage of minerals, chiefly calcium. Crippling, painful, deforming. ‘Bone-thinning’ leads to hundreds of thousands of crush and spontaneous fractures every year. Vertebra of the spine may collapse with loss of height and stooping. Sufferers show body levels of zinc about 25 per cent lower than normal. May run in families.

Affects women more than men by 10:1 especially after menopause, whether this is natural or due to destruction or removal of ovaries in early adult life.

By means of a calcium-rich diet after 35 years it is a preventable disease. Like so many degenerative diseases a common cause is widespread consumptions of refined, processed, chemicalised foods. It is possible that dental caries is in reality osteoporosis.

In men, alcohol is the chief cause. It wreaks its greatest havoc in women 10-15 years after the menopause. Increased calcium will not restore tissue already lost by wasting. Emphasis is therefore on prevention. It is estimated that a quarter of women over 50 in the West suffer bone loss after the menopause when reduced oestrogen speeds loss of calcium with possible bone damage to wrist, spine and especially hip. The chances of such fractures in women reaching seventy are one in two.

Vitamin D deficiency predisposes, as also does over-prescription of thyroxine for hypothyroid cases. Fat-free diets can break bones.

In menopausal women, increased bone loss is associated with disorders of the ovaries, which organs should receive treatment. Specially at risk are anorexic women with absence of periods. Secondary causes: hyperthyroidism, long-term use of steroids, liver disease, drugs (Tamoxifen, Antacids).

Common fractures are those of hips, spine and wrist. Wrist bone mineral content and grip strength are related. Squeezing a tennis ball hard three times each morning and evening reduces risk of fractures of the wrist.

Drinking of Lemon juice contributes to brittle bones. The habit of daily drinking of the juice causes enamel of teeth to crumble and the removal of calcium from the bones.

Cod Liver oil (chief of the iodised oils) reaches and nourishes cartilage, imparting increased elasticity which prevents degeneration.

Coffee. Two or more cups of coffee a day significantly reduces bone mineral density in women, but drinking milk each day can counter it.

Alternatives. Alfalfa, Black Cohosh, Chamomile, Clivers, Fennel, Dong quai, Fenugreek, Liquorice, Meadowsweet, Mullein, Pimpernel, Helonias, Plantain, Rest Harrow, Shepherd’s Purse, Silverweed, Toadflax, Unicorn root. Nettle tea.

Tea. Equal parts. Alfalfa, Comfrey leaves, Nettles. Mix. 2 teaspoons to each cup boiling water; infuse 5- 15 minutes; 1 cup thrice daily.

Decoction. Equal parts: Comfrey root, Irish Moss (for minerals), Horsetail. Mix. 3 heaped teaspoons to 1 pint (500ml) water gently simmered 20 minutes. Dose: 1 cup thrice daily.

Tablets/capsules. Bamboo gum, Helonias, Iceland Moss, Irish Moss for minerals, Kelp, Prickly Ash. Formula. Horsetail 2; Alfalfa 2; Helonias 1. Mix. Powders: 500mg (two 00 capsules or one-third teaspoon). Liquid extracts: 1 teaspoon. Tinctures: 2 teaspoons. Action is enhanced by taking in a cup of Fenugreek tea.

Comfrey decoction. 1 heaped teaspoon to cup water gently simmered 5 minutes. Strain when cold. Dose: 1 cup, to which is added 10 drops Tincture Helonias, morning and evening. Fenugreek seeds may be used as an alternative to Comfrey root. Comfrey and Fenugreek are osteo-protectives. For this condition the potential benefit of Comfrey outweighs possible risk.

Propolis. Regeneration of bone tissue.

Dr John Christopher. Mix powders: Horsetail 6, de-husked Oats 3; Comfrey root 4; Lobelia 4. Dose: quarter to half a teaspoon 2-3 times daily.

Diet. Fresh raw fruit and green vegetables. Consumption of raw bran (which contains calcium-binding phytic acid) and wholemeal bread should be suspended until recovery is advanced. Natural spring water. Fish and fish oils. Reject high salt intake which aggravates bone loss and places the skeleton at risk by creating increasing loss of calcium and phosphorus through the kidneys. Avoid soft drinks, alcohol. Heavy meat meals inhibit calcium metabolism. Incidence of the disease is lower in vegetarians. High protein. Supplements. Daily. Vitamin A, Vitamin B12 (50mcg); Vitamin C (500mg); Vitamin D, Vitamin E, Folic acid 200mcg; Vitamin B6 (50mg); Calcium citrate 1g; Magnesium citrate 500mg. Boron and Vitamin D. Zinc 15mg.

Calcium helps reduce risk of fracture particularly in menopausal women who may increase their daily intake to 800mg – Calcium citrate malate being more effective than the carbonate. Dried skimmed milk can supply up to 60 per cent of the recommended daily amount of Calcium.

Stop smoking.

Information. National Osteoporosis Society, PO Box 10, Radstock, Bath BA3 3YB, UK. Send SAE. ... osteoporosis

A group of rare inherited metabolic disorders (see metabolism, inborn errors of) of which Hurler’s syndrome is the best known. All mucopolysaccharidoses are genetic disorders in which there is an abnormality of a specific enzyme. This leads to the accumulation within body cells of substances called mucopolysaccharides.

Features may include abnormalities of the skeleton and/or the central nervous system, with learning difficulties and, in some cases, a characteristic facial appearance. There may also be clouding of the cornea, liver enlargement, and joint stiffness. No specific treatment is available. However, a bone marrow transplant may successfully be used to treat Hurler’s syndrome.

Mild forms of mucopolysaccharidoses allow a child to have a relatively normal life.

More severe types usually cause death during childhood or adolescence.... mucopolysaccharidosis

The muscles of the body that are attached to the skeleton. These muscles are responsible for voluntary movement, and also support and stabilize the skeleton. In most cases, a muscle attaches to a bone (usually by means of a tendon) and crosses over a joint to attach to another bone. Muscles can produce movement by contracting and shortening to pull on the bone to which they are attached. They can only pull, not push, and are therefore arranged so that the pull of one muscle or group of muscles is opposed to another, enabling a movement to be reversed. Although most actions of the skeletal muscles are under conscious control, reflex movements of certain muscles occur in response to stimuli.

There are more than 600 muscles in the body, classified according to the type of movement they produce.

An extensor opens out a joint, a flexor closes it; an adductor draws a part of the body inwards, an abductor moves it outwards; a levator raises it, a depressor lowers it; and constrictor or sphincter muscles surround and close orifices.... muscular system

n. a tissue whose cells have the ability to contract, producing movement or force (see illustration). Muscles possess mechanisms for converting energy derived from chemical reactions into mechanical energy. The major functions of muscles are to produce movements of the body, to maintain the position of the body against the force of gravity, to produce movements of structures inside the body, and to alter pressures or tensions of structures in the body. There are three types of muscle: *striated muscle, attached to the skeleton; *smooth muscle, which is found in such tissues as the stomach, gut, and blood vessels; and *cardiac muscle, which forms the walls of the heart.... muscle

n. a curved, slightly twisted, strip of bone forming part of the skeleton of the thorax, which protects the heart and lungs. There are 12 pairs of ribs. The head of each rib articulates with one of the 12 thoracic vertebrae of the backbone; the other end is attached to a section of cartilage (see costal cartilage). The first seven pairs – the true ribs – are connected directly to the sternum by their costal cartilages. The next three pairs – the false ribs – are attached indirectly: each is connected by its cartilage to the rib above it. The last two pairs of ribs – the floating ribs – end freely in the muscles of the body wall. Anatomical name: costa.... rib

a tissue comprising the bulk of the body’s musculature. It is also known as skeletal muscle, because it is attached to the skeleton and is responsible for the movement of bones, and voluntary muscle, because it is under voluntary control. Striated muscle is composed of parallel bundles of multinucleate fibres (each containing many myofibrils), which reveal cross-banding when viewed under the microscope. This effect is caused by the alternation of actin and myosin protein filaments within each myofibril (see illustration). According to the ‘sliding filament’ theory, when muscle contraction takes place, the two sets of filaments slide past each other, so reducing the length of each unit (sarcomere) of the myofibril. The sliding is caused by a series of cyclic reactions, requiring ATP, resulting in a change in orientation of projections on the myosin filaments; each projection is first attached to an actin filament but contracts and releases it to become reattached at a different site.... striated muscle