Sona Health Dictionary

Cassia senna

Caesalpiniaceae

San: Svarnapatri;

Hin: Sanay, Sana Ka Patt;

Ben: Sonamukhi;

Mal: Sunnamukki, Chonnamukki, Nilavaka;

Tam: Nilavirai, Nilavakai;

Tel: Netatangedu

Importance: Indian Senna or Tinnevelly senna is a shrub very highly esteemed in India for its medicinal value. The leaves are useful in constipation, abdominal disorders, leprosy, skin diseases, leucoderma, splenomegaly, hepatopathy, jaundice, helminthiasis, dyspepsia, cough, bronchitis, typhoid fever, anaemia, tumours and vitiated conditions of pitta and vata (Warrier et al,1994). It is used in Ayurvedic preparations; “Pancha Sakara Churna”, “Shat Sakara Churna” and “Madhu Yastyadi Churna” used for constipation. Its use is widespread in Unani system and some of the important products of this system containing senna are “Itrifal Mulayyin”, “Jawarish Ood Mulayyin”, “Hab Shabyar”, “Sufuf Mulliyin”, “Sharbat Ahmad Shahi”, etc. used as a mild laxative (Thakur et al, 1989).

Distribution: The plant is of Mediterranean origin. It is found in Somalia, Saudi Arabia, parts of Pakistan and Kutch area of Gujarat. It is largely cultivated in Tirunelveli, Ramanathapuram, Madurai and Salem districts of Tamil Nadu.

Botany: The genus Cassia, belonging to the family Caesalpiniaceae, comprises of a number of species, namely,

C. senna Linn. syn. C. angustifolia Vahl.

C. absus Linn.

C. alata Linn.

C. auriculata Linn.

C. burmanni Wight. syn. C. obovata (Linn.) Collad.

C. glauca Lam.

C. javanica Linn.

C. mimosoides Linn.

C. obtusifolia Linn. syn. C. tora Linn.

C. occidentalis Linn.

C. pumila Lam.

C. slamea Lam.

C. acutifolia Delile.

C. sophera Linn.

C. senna is a shrub or undershrub, 60-75cm in height with pale subterete or obtusely angled erect or spreading branches. Leaves are paripinnate. Leaflets are 5-8 in number, ovate-lanceolate and glabrous. Flowers are yellowish, many and arranged in axillary racemes. Fruits are flat legumes, greenish brown to dark brown and nearly smooth (Chopra et al,1980, Warrier et al,1994).

In commerce, the leaves and pods obtained from C. senna are known as “ Tinnevelly Senna” and those from C. acutifolia Delile. as “Alexandrian Senna”. The leaves of C. acutifolia are narrower than C. senna, otherwise both resemble to a large extent (Thakur et al, 1989). All the true Sennas have the portions of their leaves unequally divided. In some kinds the lower part of one side is reduced to little more than a line in breadth, while the other is from a quarter to half an inch in breadth. The drug known under the name of East Indian Senna is nearly free from adulteration; and as its properties appear identical with those of the Alexandrian and the price being less, it probably will supersede it in general practice. Its size and shape readily identify it (Graves, 1996).

Agrotechnology: The plant requires a mild subtropical climate with warm winters which are free from frost for its growth. Semiarid areas with adequate irrigation facilities are ideal for cultivation. Areas having high rainfall, humidity and poor drainage are not suitable. Light or medium loamy soils with adequate drainage and pH varying from 7.0-8.2 are preferable. In South India both summer and winter crops are possible. The plant is propagated by seeds. The seed rate required is 15-20kg/ha. Seeds are sown in October-November (winter rainfed crop) or in February-March (irrigated crop). Higher seed rate is required for unirrigated crop. Seeds are sown in lines 30cm apart. Application of 5-10t of FYM/ha before planting or raising a green manure crop is beneficial. About 40kg N and 25-50kg P2O5/ha applied as basal dressing and 40kg N/ha applied in 2 split dozes as top dressing gave better yield. While the rainfed crop is grown without irrigation, the irrigated crop requires 5-8 light irrigations during the entire growing season. The crop requires 2-3 weedings and hoeings in order to keep it free from weeds. Alternaria alternata causes leaf spot and dieback but the disease is not serious. In North India, the plant is attacked by the larvae of butterfly Catopsilia pyranthe which can be controlled by planting the crop in March-April instead of June-July. Under irrigated conditions, the first crop is obtained after 90 days of planting. The leaves are stripped by hand when they are fully green, thick and bluish-green in colour. The second crop is taken 4 weeks after the first harvest and the third 4-6 weeks after the second one. The last harvest of leaves is done when the entire crop is harvested along with the pods. Yield under irrigated conditions is nearly1.4t of leaves and 150kg pods/ha and under unirrigated conditions is 500-600kg leaves and 80-100kg pods/ha. The leaves are dried in thin layers under shade so as to retain the green colour and the pods are hung for 10-12 days to get dried. The leaves and pods are cleaned, graded and marketed (Husain et al, 1993).

Properties and Activity: Leaves contain glucose, fructose, sucrose and pinnitol. Mucilage consists of galactose, arabinose, rhamnose and galacturonic acid. Leaves also contain sennoside-C(8,8’- diglucoside of rhein-aloe-emodin-dianthrone). Pods contain sennosides A and B, glycoside of anthraquinones rhein and chrysophanic acid. Seeds contain -sitosterol (Husain et al, 1992). Leaves and pods also contain 0.33% -sterol and flavonols-kaempferol, kaempferin, and iso-rhamnetin. Sennoside content of C. acutifolia is higher ranging from 2.5% to 4.5% as compared to C. angustifolia ranging from 1.5 % to 2.5%.

The purgative activity of Senna is attributed to its sennosides. The pods cause lesser griping than the leaves. Leaf and pod is laxative. The leaves are astringent, bitter, sweet, acrid, thermogenic, cathartic, depurative, liver tonic, anthelmintic, cholagogue, expectorant and febrifuge.... indian senna

Linn.

Synonym: B. candida Roxb.

Family: Caesalpiniaceae.

Habitat: Punjab, Western Peninsula and Assam. Also cultivated in gardens.

English: Mountain Ebony, Buddhist Bauhinia.

Ayurvedic: Kaanchanaara, Kaan- chanaaraka, Kanchanak, Kaan- chana, Gandhaari, Sonapushpaka, Ashmantaka.

Siddha/Tamil: Sivappumanchori.

Action: Buds—a decoction is given in piles (also used against tumours), haematuria, menorrhagia. Dried buds are used in diarrhoea, dysentery, worm infestation, piles and tumours. Root— carminative, used in dyspepsia and flatulence (a decoction is reported to prevent obesity). Bark—astringent, anthelmintic; used externally in scrofula and skin diseases. Seeds—possess human blood agglutinating activity. Leaf— antifungal.

Along with other therapeutic applications, The Ayurvedic Pharmacopoeia of India indicated the use of the stem bark in lymphadenitis and goitre. (Ka- anchnaar Guggulu is prescribed for glandular swellings and goitre.)

Water-soluble portion of alcoholic extract of the plant showed preventive effect against goitre in rats.

Flowers gave flavonoids, kaempfe- rol-3-galactoside and kaempferol-3- rhamnoglucoside. The stem bark yields hentriacontane, octacosanol and stigmasterol. Stem contains beta-sitos- terol, lupeol and a flavanone glyco- side.

Dosage: Stem bark—20-30 g for decoction. (API Vol. I.)... bauhinia variegata

Vahl.

Synonym: C. senna Linn. var. senna.

Family: Caesalpiniaceae.

Habitat: Native to Sudan and Arabia. Now cultivated mainly in Tirunelveli and Ramnathpuram districts and to a lesser extent in Madurai, Salem and Tiruchirapalli districts of Tamil Nadu. Also grown on a small scale in Cuddapah district of Andhra Pradesh and certain parts of Karnataka.

English: Indian Senna, Tinnevelly Senna.

Ayurvedic: Svarna-pattri, Maarkandikaa, Maarkandi.

Unani: Sannaa, Sanaa-makki, Senaai, Sonaamukhi, Sanaa-Hindi.

Siddha/Tamil: Nilaavaarai.

Folk: Sanaai.

Action: Purgative (free from astringent action of rhubark type herbs, but causes gripe), used in compounds for treating biliousness, distention of stomach, vomiting and hiccups. Also used as a febrifuge, in splenic enlargements, jaundice, amoebic dysentery. Contraindicated in inflammatory colon diseases.

Key application: Leaf and dried fruit—in occasional constipation. (German Commission E.) As a stimulant laxative. (The British Herbal Pharmacopoeia.) 1,8- dihydoxy-anthracene derivatives have a laxative effect. This effect is due to the sennosides, specifically, due to their active metabolite in the colon, rheinanthrone. The effect is primarily caused by the influence on the motility of the colon by inhibiting stationary and stimulating propulsive contractions. (German Commission E, ESCOP, WHO.) Seena has been included in I.P. as a purgative.

Most of the Senna sp. contain rhein, aloe-emodin, kaempferol, isormam- netin, both free and as glucosides, together with mycricyl alcohol. The purgative principles are largely attributed to anthraquinone derivatives and their glucosides.

Senna is an Arabian name. The drug was brought into use by Arabian physicians for removing capillary congestion (pods were preferred to leaves).

The active purgative principle of senna was discovered in 1866.

Cassia acutifolia Delile is also equated with Maarkandikaa, Svarna-pattri, Sanaai.

Dosage: Leaves—500 mg to 2 g (API Vol. I.)... cassia angustifolia

(L.) Collad.

Synonym: C. obtusa Roxb.

Family: Calsalpiniaceae.

Habitat: Punjab, Delhi, Rajasthan, Madhya Pradesh, Gujarat, Maharashtra, Karnataka, Kerala and Tamil Nadu.

English: Spanish, Sudan Senna.

Ayurvedic: Maarkandikaa, Svarna- pattri. (related species)

Folk: Sonaamukhi, Sanaai.

Action: An adulterant of the true senna. Leaves and seeds—purgative and anthelmintic.... cassia obovata

Vent.

Family: Bignoniaceae.

Habitat: Throughout the greater part of India.

English: Indian Trumpet Flower.

Ayurvedic: Shyonaaka, Shoshana, Tuntuka, Kutannata, Madhukparna, Patrorna, Bhalluka, Prthushimba, Nata. ^Q

Siddha/Tamil: Peruvaagai.

Folk: Sonaa-paathaa.

Action: Tender fruit—carminative, stomachic, spasmolytic. Seed— purgative. Root bark—astringent, antidiarrhoeal. Used for amoebic dysentery. Bark—antirheumatic, diuretic.

The leaves contained flavones and their glycosides including baicalein and scutellarein; also anthraquinone, aloe-emodin. Bark of the root gave chrysin, baicalein and oroxylin A. Bark also gave dihydrobaicalein. Heart- wood yielded beta-sitosterol and an iso-flavone, prunetin.

Dosage: Root—5-10 g powder; 2550 g for decoction. (API, Vol. III.)... oroxylum indicum

(Linn.) H. B. & K.

Synonym: Stenolobium stans (L.) D. Don.

Bignonia stans Linn.

Family: Bignoniaceae.

Habitat: Cultivated in gardens.

English: Yellow Elder, Yellow Bells.

Siddha/Tamil: Sonapaati, Thanga Arali, Naga Sambagam.

Action: Leaves—hypoglycaemic (tecomine and tecostanine are hypoglycaemic alkaloids).

Root—diuretic, vermifuge. The flowers contain beta-carotene and zeaxanthin. The plant gave phenolic acids, beta-sitosterol and triterpe- noids—ursolic acid, oleanolic acid and alpha-amarine. An indole-metaboli- zing enzyme, indole-oxygenase, has been isolated from the leaves. Antidiabetic activity of the plant was tested on streptozotocin-induced diabetic rats.... tecoma stans

Bunge.

Synonym: V. officinalis auct. non Linn.

Family: Valerianacea.

Habitat: Western Himalayas, Kashmir at Sonamarg at 2,4002,700 m.

English: Common Valerian.

Action: Rhizome and roots— sedative, hypotensive, cardiotonic; depressant on CNS, antispasmodic; used for hysteria, neurosis, nervousness, hypochondriasis.

The roots and rhizomes yielded alkaloids—dipyridylmethylketone, ac- tinidine, iso-valeramide and valerian- ine; sesquiterpene ketone-valeranone. Bornyl acetate is the major constituent of the root oil, 31.5%, whereas it is only 6.6% in leaf oil. Bornyl isovalerate is reported from the root oil.

Baalaka is a confusing synonym of Tagara. It should be equated with Pavo- nia odorata Willd. (Malvaceae).

Baalaka (syns: Ambu, Baala, Barhi- shtha, Hrivera, Jala, Kacha, Muurd- haja, Udichi, Udichya) is known as Sugandhabaalaa in Northern markets. In South India Coleus vettiveroides K. C. Jacob (Labiateae) is preferred as Baalaka. Delphinium brunonianum Royle (Ranunculaceae), with synonyms Kutila, Nata, Vakra, is also used as Tagara.

Valeriana leschenaultii DC. var. brunoniana C. B. Clarke.

Family: Valerianaceae.

Habitat: The temperate Himalayas from Kashmir to Bhutan at altitudes of 1,200-3,60 m and in the Khasi and Jaintia hills between 1,500 and 1,800 m.

Folk: Sugandhabaalaa, Tagger, Taggar-ganthodaa. Asaarun (Ku- maon).

Action: Used as V. jatamansi and V officinalis.

Valeriana hardwickii is known as Taggar-ganthodaa in Mumbai and Asaarun in Kumaon. In Unani medicine, Asaarun is equated with Asarum europaeum Linn. (Aristolochiaceae). It is known as Subul-e-barri, Naardin- barri and Persian Tagar; Wild Nard, Hazel Wort and Asarabacca in English. Though sedative and brain tonic, Asaarun should not be equated with Tagara.

Family: Valerianaceae.

Habitat: Karnakata and the Nilgiris.

Ayurvedic: Tagara (related species).

Folk: Sugandhabaalaa, Taggar, Baalaka.

Action: Used as a substitute for valerian.... valeriana dubia

Linn.

Family: Valerianaceae.

Habitat: Native to Eurasia. (V officinalis auct. non Linn. is found in Kashmir at Sonamarg at 2,4002,700 m)

English: Valerian, Garden Heliotrope, Common Valerian.

Ayurvedic: Tagara, Nata. Baalaka (syn. Udichya, Jala, Barhishtha) is also equated with Valeriana sp.

Folk: Sugandhabaalaa, taggar.

Action: Tranquillizer, hypnotic, a natural relaxant to higher nerve centres. Used for nervous tension, sleeplessness, restlessness, palpitation, tension, headache, migraine, menstrual pain, intestinal cramps, bronchial spasm.

Key application: Internally for restlessness and sleeping disorders based on nervous conditions (German Commission E). (See Expanded Commission E, ESCOP and WHO monographs.)

Constituents of the root include val- trates, didrovaltrates and isovalerates. Other constituents include 0.4-1.4% monoterpenes and sesquiterpenes, caf- feic, gamma-aminobutyric (GABA) and chlorogenic acids, beta-sitosterol, methyl, 2-pyrrolketone, choline, tannins, gums alkaloids and resin. (Expanded Commission E Monographs.)

The volatile oil (0.5-2%) contains bornyl acetate and bornyl isovalerate as the principal components. Other constituents include beta-caryophyllene, valeranone, valerenal, valerenic acid and other sesquiterpenoids and mono- terpenes.

The co-occurrence of three cyclo- pentane-sesquiterpenoids (valerenic acid, acetoxyvalerenic acid and valere- nal) is confined to Valeriana officinalis L. and permits its distinction from V edulis and V. Wallichii. (WHO.)

The important active compounds of valerian are the valepotriates (iridoid molecules) and valeric acid. Originally it was thought that valepotriates were responsible for the herbs sedative effect, but, later on, an aqueous extract of the root has also been shown to have a sedative effect. Since valepotriates are not soluble in water, it was concluded that valerenic acid is also the chemical factor responsible for the sedative effect of the herb. Most commercial extracts in Western herbal are water-soluble extracts standardized for valerenic acids.

Large doses ofvalepotriates from the herb decreased benzodiazepines and diazepam withdrawl symptoms in rats. At low doses valerian enhances binding of flunitrazepam, but at high doses it inhibits binding of the drug. Valerenic acid inhibits breakdown of GABA, and hydroxypinoresinol binds to benzodi- azepine receptor. (Sharon M. Herr.)

The safety of valepotriates has been questioned.

Currently valerian is an approved over-the-counter medicine in Germany, Belgium, France, Switzerland and Italy. (The British Herbal Compendium.)

See Valeriana dubia Bunge, syn. V. officinalis auct. non Linn., known as Common Valerian.... valeriana officinalis