Squamous Cell Carcinoma: From 3 Different Sources
One of the most common types of skin cancer. Squamous cell carcinoma is linked to long-term exposure to sunlight. It is most common in fair-skinned people over 60.
The tumour starts as a small, painless lump or patch (usually on the lip, ear, or back of the hand), which enlarges fairly rapidly, often resembling a wart or ulcer. Left untreated, the cancer may spread to other parts of the body and prove fatal.
Diagnosis is based on a skin biopsy. The tumour is removed surgically or destroyed by radiotherapy.
Malignant tumour of squamous epithelium of skin, which generally spreads and metastasises.
(SCC) any cancer of squamous epithelium, arising from such tissues as the skin and the lining of the upper airways and digestive tract (especially in the head and neck). SCC is the second commonest form of skin cancer (after *basal cell carcinoma), occurring usually in late-middle and old age. Cumulative sun exposure is the commonest cause but other environmental carcinogens may be responsible. Renal transplant patients are at particularly high risk of this tumour. SCC is mainly found on areas exposed to light and is three times more common in men than in women. SCC grows faster than basal cell carcinoma; it spreads locally at first but later may spread to sites distant from its origin (see metastasis). Treatment is usually by surgical excision or radiotherapy.
A malignant epithelial tumour eventually becoming fatal... carcinoma
A generally slow growing malignant epithelial tumour, which has potential to invade and metastasise, especially if untreated.... basal cell carcinoma
The ?rst stage of CARCINOMA in which the malignant tumour is present only in the EPITHELIUM, and when surgical excision of the local growth, with its pathological status con?rmed in the laboratory, should ensure a cure.... carcinoma in situ
The spread of cancer cells from their original site of growth to other tissues in the body. Such a spread of cancer, which takes place mainly via blood and lymph vessels, is usually fatal. CHEMOTHERAPY and RADIOTHERAPY may, however, check the spread or sometimes destroy the cancerous growth.... carcinomatosis
The smallest unit of living material that can function independently.... cell
Those embryonic cells with the potential to develop into ova (see OVUM) or spermatozoa (see SPERMATOZOON).... germ cell
See HYPERNEPHROMA.... renal cell carcinoma
See: ARTERITIS. ... giant cell arteritis
This is the basic cell from which all types of blood cells originate. Its appearance is believed to be similar to that of a LYMPHOCYTE.... haemopoietic stem cell
See NEURON(E).... nerve cell
A type of cell found in one highly malignant form of lung cancer. The cell is small and either oval or round. The nucleus stains darkly and the cytoplasm is sparse and di?cult to identify. Oat-cell, or small-cell, carcinoma of the bronchus is usually caused by smoking, and comprises around 30 per cent of all bronchial cancers. It responds to radiotherapy and chemotherapy but, because the growth has usually spread widely by the time it is diagnosed, the prognosis is poor. Results of surgery are unsatisfactory.... oat cell
That fraction of the blood’s total volume made up of red cells. The packed cell volume is found by centrifuging blood in a tube and measuring the depth of the column of red cells as a fraction of the whole column of blood. (See also HAEMATOCRIT.)... packed cell volume
See ERYTHROCYTES; BLOOD.... red blood cell
See OAT CELL.... small-cell carcinoma
A specialised white cell (lymphocyte) responsible for cell-mediated immunity. See also T-lymphocyte.... t-cell
See LEUCOCYTES.... white blood cell
See lymphocyte.... b-cell
A growth comprised of immature sperm cells in the male testis or of immature ova in the female ovary. A seminoma is one type of germ cell tumour (see testis, cancer of).... germ cell tumour
A type of white blood cell that circulates through the body and is able to detect the presence of the foreign agents. Once exposed to an antigen on the agent, these cells differentiate into plasma cells to produce antibody.... b-lymphocyte (or b-cell)
Poorly differentiated adenocarcinoma.... carcinoma simplex
See TRANSFUSION.... cell salvage transfusion
A defence mechanism involving the coordinated activity of two subpopulations of TLymphocytes, helper T-Cells and killer T-Cells. Helper T-Cells produce a variety of substances that stimulate and regulate other participants in the immune response. Killer T-Lymphocytes destroy cells in the body that bear foreign antigens (e.g. cells that are infected with viruses or other microorganisms).... cell-mediated immunity
Squamous cell carcin oma; cancer of squamous epithelium.... epidermoid carcinoma
A method of autologous blood TRANSFUSION – using a patient’s own blood, salvaged during a surgical operation – instead of conventional blood-bank transfusion.... perioperative cell salvage
The cells that produce the MYELIN sheath of the AXON of a medullated NERVE. They are wrapped around a segment of the axon, forming concentric layers.... schwann cell
See LYMPHOMA.... t-cell lymphoma
A growth composed of cells that produce various hormones. These cells, amine precursor uptake and decarboxylation (APUD) cells, occur in different parts of the body. Some tumours of the thyroid gland, pancreas, and lungs are cell tumours, as are a carcinoid tumour (see carcinoid syndrome) and phaeochromocytoma (a type of adrenal tumour).... apud cell tumour
These have almost completely replaced BONE MARROW TRANSPLANT, used to treat malignancies such as LEUKAEMIA and LYMPHOMA for the past 20 years. The high doses of CHEMOTHERAPY or RADIOTHERAPY used to treat these diseases destroy the bone marrow which contains stem cells from which all the blood cells derive. In 1989 stem cells were found in the blood during recovery from chemotherapy. By giving growth factors (cytokines), the number of stem cells in the blood increased for about three to four days. In a peripheral-blood stem-cell transplant, these cells can be separated from the peripheral blood, without a general anaesthetic. The cells taken by either method are then frozen and returned intravenously after the chemotherapy or radiotherapy is completed. Once transplanted, the stem cells usually take less than three weeks to repopulate the blood, compared to a month or more for a bone marrow transplant. This means that there is less risk of infection or bleeding during the recovery from the transplant. The whole procedure has a mortality risk of less than 5 per cent – half the risk of a bone marrow transplant.... peripheral-blood stem-cell transplants
A form of anaemia growing into an acute social problem, affecting people of African, Asian, and Mediterranean origin. Thalassaemias are caused by defects of a gene that produces the globin part of haemoglobin. Such defects in the DNA can now be detected in the womb before birth. The name derives from sickle-shaped cells instead of circular red blood cells. Few sufferers survive beyond their 40th year.
Symptoms. Unhealthy pallor, listlessness, sore tongue, dizziness, vague aches and pains, rapid pulse and breathing, tinnitus, palpitation. The skull may be disproportionately large, resistance to infection feeble, chances of survival poor. This form of anaemia is linked with defective colour vision. Impaired liver function. Stunted growth, great pain. Sufferers have a higher risk of infection.
Malaria. Sufferers are less likely to die of malaria because their red cells do not support the growth of malaria parasites very well.
Carriers: Carriers of the sickle-cell gene can now be identified by a simple blood test.
Treatment. No specifics exist but supportive herbal treatment has been known to increase output of red cells and raise haemoglobin levels:– Red Clover flowers, Yellow Dock, Echinacea, Burdock, Wild Indigo, Gentian, Nettles, Birch leaves, Sage, Walnut leaves, Centaury, Gota Kola (Indian Pennywort). Alternatives:– Tea. Mix equal parts: Iceland Moss, Nettles, Red Clover flowers. 2 teaspoons to each cup boiling water; infuse 15 minutes; 1 cup morning and evening.
Decoction. Mix equal parts; Echinacea, Walnut leaves, Balm of Gilead buds; 1 teaspoon to each cup water gently simmered for 20 minutes. Half-1 cup, cold, 3 times daily, before meals.
Tablets/capsules. Sarsaparilla. Ginseng. Iceland Moss. Red Clover. Echinacea. Gentian.
Powders. Formula: Echinacea 1; Fringe Tree half; Ginseng half; White Poplar bark 1. Dose: 500mg (two 00 capsules or one-third teaspoon) thrice daily before meals.
Liquid extracts. Formula. Echinacea 2; Dandelion 1; Oat Husk (avena sativa) 1. Mix. Dose, 1-2 teaspoons before meals, in water or one of the above teas or decoctions.
Tinctures. Same combination. Dose: 2-3 teaspoons.
Dong quai. See entry.
Pollen. Claimed to be of value.
Diet. Dandelion coffee. Molasses. Desiccated liver. Calf liver, fresh. Green leafy vegetables contain chlorophyll, iron and folic acid. Cider vinegar. Dried beans, apricots and shellfish. Dandelion leaves in salads. Milk, eggs, meats, Soya. Carrot juice to increase red cells.
Supplements. Daily. Vitamin B12. Vitamin C, 1g; Folic acid 400mcg, Floradix. Of particular value: Vitamin E 400iu. Zinc.
Note: Those at risk should submit themselves for screening. The disease cannot be cured but can be controlled largely by orthodox measures and sometimes by natural medicine. ... anaemia: sickle cell
The most common form of cancer throughout the world. Five year survival: 10 per cent. Its association with cigarette smoking is now established beyond doubt. Other causes include such occupational poisons as asbestos, arsenic, chromium, diesel fumes, etc. The squamous cell carcinoma is the most common of the four types.
Diagnosis is confirmed by sputum test, chest X-ray, bronchoscopy or biopsy. Earliest symptoms are persistent cough, pain in the chest, hoarseness of voice and difficulty of breathing. Physical examination is likely to reveal sensitivity and swelling of lymph nodes under arms.
Symptoms. Tiredness, lack of energy, possible pains in bones and over liver area. Clubbing of finger-tips indicate congestion of the lungs. Swelling of arms, neck and face may be obvious. A haematologist may find calcium salts in the blood. The supportive action of alteratives, eliminatives and lymphatic agents often alleviate symptoms where the act of swallowing has not been impaired.
Broncho-dilators (Lobelia, Ephedra, etc) assist breathing. Mullein has some reputation for pain relief. To arrest bleeding from the lesion (Blood root).
According to Dr Madaus, Germany, Rupturewort is specific on lung tissue. To disperse sputum (Elecampane, Red Clover). In advanced cases there may be swollen ankles and kidney breakdown for which Parsley root, Parsley Piert or Buchu may be indicated. Cough (Sundew, Irish Moss). Soft cough with much sputum (Iceland Moss). To increase resistance (Echinacea).
Alternatives. Secondary to primary treatment. Of possible value.
Teas. Violet leaves, Mullein leaves, Yarrow leaves, Gotu Kola leaves, White Horehound leaves. Flavour with a little Liquorice if unpalatable.
Tablets/capsules. Lobelia, Iceland Moss, Echinacea, Poke root.
Formula. Equal parts: Violet, Red Clover, Garden Thyme, Yarrow, Liquorice. Dose: Powders: 750mg (three 00 capsules or half a teaspoon. Liquid Extracts: 1-2 teaspoons. Tinctures: 1-3 teaspoons. Thrice daily, and during the night if relief is sought.
Practitioner. Tinctures BHP (1983). Ephedra 4; Red Clover 4, Yellow Dock 2; Bugleweed 2; Blood root quarter; Liquorice quarter (liquid extract). Mix. Start low: 30-60 drops in water before meals and at bedtime increasing to maximum tolerance level.
Aromatherapy. Oils: Eucalyptus or Thyme on tissue to assist breathing. Inhale.
Diet. See: DIET – CANCER.
Treatment by a general medical practitioner or hospital specialist. ... cancer - bronchial carcinoma
An inherited blood disease in which the red blood cells contain haemoglobin S, an abnormal type of haemoglobin. This crystallizes in the capillaries, making red cells sickle-shaped and fragile, and leading to haemolytic anaemia. The abnormal cells are unable to pass easily through tiny blood vessels. The blood supply to organs is blocked intermittently, causing sickle cell crises. The disease affects mainly black people.Symptoms usually appear after age 6 months, often beginning with painful swelling of the hands and feet. Chronic haemolytic anaemia causes fatigue, headaches, shortness of breath on exertion, pallor, and jaundice. Sickle cell crises start suddenly; they are sometimes brought on by an infection, cold weather, or dehydration, but may also occur for no apparent reason. The sufferer may experience pains (especially in the bones), blood in the urine (from kidney damage) or damage to the lungs or intestines. If the brain is affected, seizures, a stroke, or unconsciousness may result.
In some affected children, the spleen enlarges and traps red cells at a particularly high rate, causing a life-threatening form of anaemia. After adolescence, the spleen usually stops functioning, increasing the risk of infection in those affected.
Diagnosis is made from examination of a blood smear and electrophoresis.
Supportive treatment may include folic acid supplements, and penicillin and immunization to protect against infection.
Life-threatening crises are treated with intravenous infusions of fluids, antibiotics, oxygen therapy, and analgesic drugs.
If the crisis still does not respond, an exchange blood transfusion may be performed.
This may be done regularly for people who suffer frequent severe crises.... sickle cell anaemia
(APC) a cell, such as a *dendritic cell or a *macrophage, that processes antigen for presentation to a T lymphocytes (see helper T cell).... antigen-presenting cell
(blood corpuscle) any of the cells that are present in the blood in health or disease. The cells may be subclassified into three major categories, namely red cells (*erythrocytes); white cells (*leucocytes), which include granulocytes, lymphocytes, and monocytes; and *platelets (see illustration). The blood cells account for approximately 40% of the total volume of the blood in health; red cells comprise the vast majority.... blood cell
cancer of the bronchus, one of the commonest causes of death in smokers. See also lung cancer; small-cell lung cancer.... bronchial carcinoma
(echinocyte) a red blood cell (erythrocyte) with abnormal small thorny projections. See crenation.... burr cell
(perikaryon) the enlarged portion of a *neuron (nerve cell), containing the nucleus. It is concerned more with the nutrition of the cell than with propagation of nerve impulses.... cell body
a machine that aspirates blood lost during surgery and immediately spins, washes, and filters it for retransfusion back into the patient’s body (see autotransfusion). The process, called intraoperative cell salvage, is used in surgery that has significant blood loss, such as orthopaedic and vascular surgery and Caesarean section, and avoids the costs and risks of *allogeneic transfusion.... cell saver
molecules on the surface of cell membranes that are responsible for most cellular functions directly related to their immediate environment. Many have very precise functions of adhesion (see adhesion molecules), metabolic exchange, hormone reception, respiration, and immune reactions. Cell-to-cell exchanges involve specialized surface structures (junctions), which form a communicating nexus.... cell-surface molecules
(clear-cell adenocarcinoma) a variant of *adenocarcinoma that tends to arise from the kidneys or the female genital tract. In the latter case it is linked to intrauterine exposure to *diethylstilbestrol during the 1950s and 1960s and takes the form of a vaginal cancer, which can be treated by radical surgery followed by radiotherapy.... clear-cell carcinoma
a group of lymphomas in which abnormal T *lymphocytes are concentrated in the skin. The most common form is *mycosis fungoides.... cutaneous t-cell lymphoma
a type of T *lymphocyte that destroys cancerous cells, virus-infected cells, and *allografts. Cytotoxic T cells recognize peptide antigens attached to proteins that are encoded by the *HLA system.... cytotoxic t cell
a type of haemopoietic cell with specialized antigen-presenting functions. The head and neck are common sites for dendritic cell pathology. See antigen-presenting cell.... dendritic cell
(DCIS) the earliest stage of breast cancer, detectable by mammography, which is confined to the lactiferous (milk) ducts of the breast. See carcinoma in situ.... ductal carcinoma in situ
n. any of the gastrin-secreting cells of the stomach lining located predominantly in the gastric *antrum. Gastrin stimulates the production of gastric acid by parietal cells in the stomach. Increased G-cell activity is associated with the formation of duodenal ulcers and the *Zollinger-Ellison syndrome.... g-cell
any large cell, such as a *megakaryocyte. Giant cells may have one or many nuclei.... giant cell
an abnormal white blood cell that has the appearance of an immature lymphocyte with fine hairlike cytoplasmic projections around the perimeter of the cell. It is found in a rare form of leukaemia (hairy-cell leukaemia) most commonly occurring in young men.... hairy cell
a type of T *lymphocyte that plays a key role in cell-mediated immunity by recognizing foreign antigen on the surface of *antigen-presenting cells when this is associated with the individual’s *MHC antigens, having been processed by antigen-presenting cells. Helper T cells stimulate the production of *cytotoxic T cells, which destroy the target cells.... helper t cell
an androgen-producing tumour of the ovary found in older women and often resulting in *virilization. Such tumours are so called as they tend to occur around the area of the ovary where the blood vessels enter (the hilum). They are usually small and are treated by surgical removal, with resolution of most of the symptoms.... hilar cell tumour
a malignant tumour of the thyroid gland that arises from Hürthle (or Askanazy) cells, altered follicular cells of the gland that have large nuclei and stain deeply with eosin (these cells are also found in benign nodules and Hashimoto’s disease). Hürthle cell carcinoma is not as common as papillary, follicular, or anaplastic thyroid carcinomas (see thyroid cancer). [K. W. Hürthle (1860–1945), German histologist]... hürthle cell tumour
see luteinizing hormone.... interstitial-cell-stimulating hormone
a group of autoantibodies directed against components of the insulin-secreting beta cells of the pancreas. They are usually detectable in the blood of people presenting with type 1 diabetes. Antibodies against *glutamic acid decarboxylase (GAD) in the beta cells have become a more specific test for islet cell antibodies, to help confirm a diagnosis of type 1 diabetes.... islet cell antibodies
a new technique still under evaluation for curing type 1 *diabetes mellitus, which involves the injection of donated cells from the pancreatic *islets of Langerhans into the liver, where it is hoped they will seed and survive. The transplanted cells then take over insulin production from the recipient’s diseased pancreas.... islet cell transplantation
any tumour arising in a cell of the pancreatic *islets of Langerhans. These tumours, which include *insulinomas, *glucagonomas, and *somatostatinomas, form one of the two major subclasses of gastrointestinal neuroendocrine tumours, the other being the *carcinoid tumours.... islet cell tumour
overgrowth of cells of the *reticuloendothelial system. This includes disorders previously called histiocytosis X, including eosinophilic granuloma, Hand–Schüller–Christian disease, and Letterer–Siwe disease. [P. Langerhans (1847–88), German physician and anatomist]... langerhans cell histiocytosis
cancer that arises in the lobules (rather than the ducts) of the breast. Like ductal carcinoma, it may be confined to its site of origin but can invade other tissues; however, it has a greater tendency than ductal carcinoma to affect both breasts.... lobular carcinoma
a tumour whose consistency was thought to resemble that of bone marrow. Medullary carcinoma of the thyroid has associations with tumours of other organs (multiple endocrine neoplasia; see MENS) and is often familial: it arises from the *C cells of the thyroid and produces calcitonin, which can often be used as a *tumour marker.... medullary carcinoma
a long-lived lymphocyte that is formed following primary infection. It enables a faster and more robust immune response following a second exposure to the antigen.... memory cell
(NK cell) a type of *lymphocyte that is able to kill virus-infected cells and cancerous cells and mediates rejection of bone-marrow grafts. NK cells are a part of natural (or innate) *immunity. Their function is regulated by a balance between activating receptors, which recognize proteins on cancerous or virus-infected cells, and inhibitory receptors specific for certain molecules encoded by the *HLA system.... natural killer cell
(NSCLC) any type of lung cancer other than *small-cell lung cancer. Such cancers include *adenocarcinoma of the lung, large-cell carcinomas, and squamous-cell carcinoma of the lung.... non-small-cell lung cancer
a posterior ethmoidal sinus air cell (see paranasal sinuses). They are surgically important because of their proximity to the optic nerve and internal carotid artery. [A. Onodi (1857–1919), Hungarian rhinolaryngologist]... onodi cell
a type of neuron found in the *cerebral cortex, with a pyramid-shaped cell body, a branched dendrite extending from the apex towards the brain surface, several dendrites extending horizontally from the base, and an axon running in the white matter of the hemisphere.... pyramidal cell
a large binucleate cell that is characteristic of *Hodgkin’s disease. [D. Reed Mendenhall (1874–1964), US pathologist; C. Sternberg (1872–1935), Austrian pathologist]... reed–sternberg cell
(Treg cell) a type of T *lymphocyte that suppresses immune responses.... regulatory t cell
a cell that is not undergoing division. See interphase.... resting cell
progressive renal disease developing in 5–8% of patients with *sickle-cell disease. Infarcts in the cortex can occur with sickle-cell crises and present with pain and haematuria. Acute or more insidious damage to the medulla will lead to a urinary concentrating defect and later to papillary necrosis and/or fibrosis. Occlusion of vessels within the glomerular capillary tuft leads to a secondary form of *focal segmental glomerulosclerosis and can present with the *nephrotic syndrome.... sickle-cell nephropathy
(SCLC) a type of bronchial carcinoma characterized by small cells (or oat cells), small round or oval cells with darkly staining nuclei and scanty indistinct cytoplasm. Small-cell carcinoma is usually related to smoking and accounts for about one-quarter of bronchial carcinomas; it carries a poor prognosis due to early distant spread, typically to bones, liver, and brain. Treatment is primarily with chemotherapy and radiotherapy and paraneoplastic symptoms (see paraneoplastic syndrome) from *ectopic hormone production are common. Compare non-small-cell lung cancer.... small-cell lung cancer
see temporal bone.... squamous bone
see epithelium.... squamous epithelium
see Reed–Sternberg cell.... sternberg–reed cell
a type of T *lymphocyte that prevents an immune response by B cells or other T cells to an antigen.... suppressor t cell
a form of cancer that affects the urothelium, which lines the urinary collecting system of the kidney, ureters, bladder, and the proximal part of the urethra. It is the most common type of bladder cancer.... transitional cell carcinoma
see regulatory T cell.... treg cell
an *indolent preinvasive wartlike carcinoma typically of the oral cavity, associated with chewing tobacco, and vulva.... verrucous carcinoma
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