Sterility Health Dictionary

Sterility: From 3 Different Sources


The state either of being germfree or of permanent infertility.
Health Source: BMA Medical Dictionary
Author: The British Medical Association
The state of (1) being free of infectious agents or (2) permanent INFERTILITY.
Health Source: Medical Dictionary
Author: Health Dictionary
n. inability to have children, either due to *infertility or (in someone who has been fertile) deliberately induced by surgical procedures as a means of contraception (see sterilization). Sterility may also be an incidental result of an operation or drug treatment undertaken for other reasons, such as removal of the uterus (*hysterectomy) because of cancer.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Gonorrhoea

Gonorrhoea is an in?ammatory disease caused by Neisseria gonococcous, affecting especially the mucous membrane of the URETHRA in the male and that of the VAGINA in the female, but spreading also to other parts. It is the most common of the SEXUALLY TRANSMITTED DISEASES (STDS). According to the WHO, 200 million new cases are noti?ed annually in the world. In the UK the incidence has been declining since 1991; in 1999 the rate per million of population was 385 for males (599.4 in 1991) and 171.3 for females (216.5 in 1991).

Causes The disease is directly contagious from another person already suffering from it – usually by sexual intercourse, but occasionally conveyed by the discharge on sponges, towels or clothing as well as by actual contact. The gonococcus is found in the discharge expressed from the urethra, which may be spread as a ?lm on a glass slide, suitably stained, and examined under the microscope; or a culture from the discharge may be made on certain bacteriological media and ?lms from this, similarly examined under the microscope. Since discharges resembling that of gonorrhoea accompany other forms of in?ammation, the identi?cation of the organism is of great importance. A gram-stained smear of urethral discharge enables rapid identi?cation of the gonococcus in around 90 per cent of men.

Symptoms These di?er considerably, according to whether the disease is in an acute or a chronic stage.

MEN After an incubation period of 2–10 days, irritation in the urethra, scalding pain on passing water, and a viscid yellowish-white discharge appear; the glands in the groin often enlarge and may suppurate. The urine when passed is hazy and is often found to contain yellowish threads of pus visible to the eye. After some weeks, if the condition has become chronic, the discharge is clear and viscid, there may be irritation in passing urine, and various forms of in?ammation in neighbouring organs may appear – the TESTICLE, PROSTATE GLAND and URINARY BLADDER becoming affected. At a still later stage the in?ammation of the urethra is apt to lead to gradual formation of ?brous tissue around this channel. This contracts and produces narrowing, so that urination becomes di?cult or may be stopped for a time altogether (the condition known as stricture). In?ammation of some of the joints is a common complication in the early stage – the knee, ankle, wrist, and elbow being the joints most frequently affected – and this form of ‘rheumatism’ is very intractable and liable to lead to permanent sti?ness. The ?brous tissues elsewhere may also develop in?ammatory changes, causing pain in the back, foot, etc. In occasional cases, during the acute stage, SEPTICAEMIA may develop, with in?ammation of the heart-valves (ENDOCARDITIS) and abscesses in various parts of the body. The infective matter occasionally is inoculated accidentally into the eye, producing a very severe form of conjunctivitis: in the newly born child this is known as ophthalmia neonatorum and, although now rare in the UK. has in the past been a major cause of blindness (see EYE, DISORDERS OF). WOMEN The course and complications of the disease are somewhat di?erent in women. It begins with a yellow vaginal discharge, pain on urination, and very often in?ammation or abscess of the Bartholin’s glands, situated close to the vulva or opening of the vagina. The chief seriousness, however, of the disease is due to the spread of in?ammation to neighbouring organs, the UTERUS, FALLOPIAN TUBES, and OVARIES, causing permanent destructive changes in these, and leading occasionally to PERITONITIS through the Fallopian tube with a fatal result. Many cases of prolonged ill-health and sterility or recurring miscarriages are due to these changes.

Treatment The chances of cure are better the earlier treatment is instituted. PENICILLIN is the antibiotic of choice but unfortunately the gonococcus is liable to become resistant to this. In patients who are infected with penicillin-resistant organisms, one of the other antibiotics (e.g. cefotaxime, cipro?oxacin or spectinomycin) is used. In all cases it is essential that bacteriological investigation should be carried out at weekly intervals for three or four weeks, to make sure that the patient is cured. Patients attending with gonorrhoea are asked if they will agree to tests for other sexually transmitted infections, such as HIV (see AIDS/HIV) and for assistance in contact tracing.... gonorrhoea

Vasectomy

The surgical operation performed to render men sterile, or infertile. It consists of ligating, or tying, and then cutting the ductus, or vas, deferens (see TESTICLE). It is quite a simple operation carried out under local anaesthesia, through a small incision or cut (or sometimes two) in the upper part of the SCROTUM. It has no e?ect on sexual drive or ejaculation, and does not cause impotency. It is not immediately e?ective, and several tests, spread over several months, must be carried out before it is safe to assume that sterility has been achieved. Fertility can sometimes be restored by a further operation, to restore the continuity of the vas; this cannot be guaranteed, and only seems to occur in about 20 per cent of those who have had the operation.... vasectomy

Mumps

Parotitis. Inflammation of the salivary glands with painful swelling in front of the ears, caused by a virus. Common, children. In adults, mumps may include inflammation of the testicles in men which may lead to sterility; or of the ovaries in women; or of the pancreas in both sexes. A notifiable disease. Symptoms: fever, malaise, headache, one or two days before sudden rise in temperature to about 40°C (104°F).

Treatment. Maintain adequate fluid intake.

Tea. Formula. Angelica 2; Centuary 1; Marigold 1. 2 teaspoons to each cup boiling water; infuse 15 minutes. Add pinch Cayenne. Quarter-1 cup every 2 hours, according to age. Where recovery is tardy, add 3-4 drops Spearmint oil.

With nervousness: add 1 part skullcap.

With swollen testicles or ovarian involvement: Agnus Castus.

Absence of urine: Yarrow.

Alternative formula:– Echinacea 2; Poke root 1; Yarrow 2. Dose: Liquid Extracts: one 5ml teaspoon. Tinctures: two 5ml teaspoons. Powders: 500mg (two 00 capsules or one-third teaspoon). Children: 1 drop for each year to age of 5; 2 drops thereafter to age of 10. Thrice daily.

Tablets/capsules. Poke root. Echinacea.

Malecite Indians: Cramp bark. Echinacea. Decoction.

European traditional. Balm tea, internally, half-1 cup freely. Externally to bathe face and genitals. Tinctures: Formula. Equal parts: Pulsatilla, Ginkgo, Vinca major. Adults: 1-2 teaspoons in water thrice daily. Children: 1 drop for each year to 5 years; thereafter 2 drops each year to 12.

Metastasis. Equal parts, Liquid Extracts. Pulsatilla (testes and mammae); Skullcap (Brain); Vinca major (pancreas). Dosage as Liquid Extract.

Gargle. 5-10 drops Tincture Myrrh in glass of water freely.

Hot compress. St John’s Wort oil to neck or face (Dr A. Vogel).

Poultice to reduce swelling: fresh Mullein leaves.

Vitamins. A. B-complex, C. D. E.

Minerals. Calcium. Iodum. Zinc. Dolomite.

To be treated by or in liaison with a qualified medical practitioner. ... mumps

Andrographis Panicultata

Wall. ex Nees

Family: Acanthaceae.

Habitat: Throughout India, from Himachal Pradesh to Assam and Mizoram, and all over southern India.

English: Creat.

Ayurvedic: Kaalmegha, Bhuunimba, Bhuuminimbaka, Vishwambharaa, Yavtikta, Kalpanaatha, Kiraata-tikta (var.).

Unani: Kiryaat.

Siddha/Tamil: Nilavembu.

Action: Hepatoprotective, cholin- ergic, antispasmodic, stomachic, anthelmintic, alterative, blood purifier, febrifuge. It acts well on the liver, promoting secretion of bile. Used in jaundice and torpid liver, flatulence and diarrhoea of children, colic, strangulation of intestines and splenomegaly; also for cold and upper respiratory tract infections.

Key application: As bitter tonic, febrifuge and hepatoprotective. (Indian Herbal Pharmacopoeia.)

Kaalmegha, officinal in IP, consists of dried leaves and tender shoots, which yield not less than 1% andro- grapholide on dry-weight basis.

Several active constituents have been identified from the leaf and rhizome, including andrographolide, deoxyan- drographolide and other diterpenes.

Andrographolide exhibited strong choleretic action when administered i.p. to rats. It induces increase in bile flow together with change in physical properties of bile secretion. It was found to be more potent than sily- marin.

Andrographolide was found to be almost devoid of antihepatitis-B virus surface antigen-like activity (when compared with picroliv.)

The leaf and stem extracts of Kaal- megha/andrographolide given s.c. or orally did not change blood sugar level of normal or diabetic rats.

Alcoholic extract of the plant exhibited antidiarrhoeal activity against E. coli enterotoxins in animal models.

Clinical evidence of effectiveness of andrographis in humans is limited to the common cold. Preliminary evidence suggests that it might increase antibody activity and phagocytosis by macrophages, and might have mast cell-stabilizing and antiallergy activity. (Natural Medicines Comprehensive Database, 2007.)

The herb is contraindicated inbleed- ing disorders, hypotension, as well as male and female sterility (exhibited infertility in laboratory animals).

Dosage: Whole plant—5-10 ml juice; 50-100 ml decotion; 1-3 g powder. (CCRAS.)... andrographis panicultata

Asplenium Adiantum-nigrum

Linn.

Family: Aspleniaceae.

Habitat: Kashmir at 1500-2000 m and extending to Dalhousie and Chamba in Himachal Pradesh.

English: Black Spleenwort.

Folk: Krishna fern.

Action: Fond—expectorant, pectoral, emmenagogue. Rhizome— anthelmintic. Plant—bitter, diuretic, laxative, anti-inflammatory. It is used for diseases of spleen and in jaundice; produces sterility in women.

The fonds contain aliphatic hydrocarbons, the chief one being hentri- acontane, non-acosane and triterpe- noid hydrocarbons, mainly of 22 (29)- hopene.

Alcohols, sterols and fatty acids are also reported.

Related sp. include: A. laciniatum D. Don (vitamin K3 and phthiocol have been isolated for the first time from the plant); A. adiantoides (L.) C. Chr., synonym A. falcatum Lam. (used in the treatment of enlarged spleen, in in- contenence of urine, in calculus, jaundice and malaria); A. nidus Linn. synonym Thamnopteris nidus (L.) C. Presl., known as Bird's Nest Fern (used as a depurative and sedative).... asplenium adiantum-nigrum

Epididymis

An oblong body attached to the upper part of each TESTICLE, composed of convoluted vessels and ducts, that connects the VASA EFFERENTIA to the VAS DEFERENS. Sperm cells produced in the testis pass along the epididymis, maturing as they go, to be stored in the seminal vesicles until EJACULATION occurs. The epididymis may be damaged by trauma or infection resulting sometimes in sterility. Cysts may also occur.... epididymis

Ipomoea Marginata

(Desr.) Verdc.

Family: Convolvulaceae.

Habitat: Throughout India in the plains, especially on the bank of stream and rivers.

Ayurvedic: Lakshmanaa (Also equated with Ipomoea obscura (Linn.) Ker-Gawler.), Putradaa, Putrajanani.

Folk: Tirutaalli (Kerala).

Action: Used as a single drug for curing sterility in women, and for promoting fertility and virility.

The seeds of Ipomoea obscura contain non-ergolin type indole alkaloids, ipobscurine A and B and serotonin also alkaloid ipobscurine C.... ipomoea marginata

Post-coital Test

A test for INFERTILITY. A specimen of cervical mucus, taken up to 24 hours after coitus (during the post-ovulatory phase of the menstrual cycle), is examined microscopically to assess the motility of the sperms. If motility is above a certain level, then sperms and mucus are not interacting abnormally – thus eliminating one cause of sterility.... post-coital test

Uterus, Diseases Of

Absence or defects of the uterus

Rarely, the UTERUS may be completely absent as a result of abnormal development. In such patients secondary sexual development is normal but MENSTRUATION is absent (primary amennorhoea). The chromosomal make-up of the patient must be checked (see CHROMOSOMES; GENES): in a few cases the genotype is male (testicular feminisation syndrome). No treatment is available, although the woman should be counselled.

The uterus develops as two halves which fuse together. If the fusion is incomplete, a uterine SEPTUM results. Such patients with a double uterus (uterus didelphys) may have fertility problems which can be corrected by surgical removal of the uterine septum. Very rarely there may be two uteri with a double vagina.

The uterus of most women points forwards (anteversion) and bends forwards (ante?exion). However, about 25 per cent of women have a uterus which is pointed backwards (retroversion) and bent backwards (retro?exion). This is a normal variant and very rarely gives rise to any problems. If it does, the attitude of the uterus can be corrected by an operation called a ventrosuspension.

Endometritis The lining of the uterine cavity is called the ENDOMETRIUM. It is this layer that is partially shed cyclically in women of reproductive age giving rise to menstruation. Infection of the endometrium is called endometritis and usually occurs after a pregnancy or in association with the use of an intrauterine contraceptive device (IUCD – see CONTRACEPTION). The symptoms are usually of pain, bleeding and a fever. Treatment is with antibiotics. Unless the FALLOPIAN TUBES are involved and damaged, subsequent fertility is unaffected. Very rarely, the infection is caused by TUBERCULOSIS. Tuberculous endometritis may destroy the endometrium causing permanent amenorrhoea and sterility.

Menstrual disorders are common. Heavy periods (menorrhagia) are often caused by ?broids (see below) or adenomyosis (see below) or by anovulatory cycles. Anovulatory cycles result in the endometrium being subjected to unopposed oestrogen stimulation and occasionally undergoing hyperplasia. Treatment is with cyclical progestogens (see PROGESTOGEN) initially. If this form of treatment fails, endoscopic surgery to remove the endometrium may be successful. The endometrium may be removed using LASER (endometrial laser ablation) or electrocautery (transcervical resection of endometrium). Hysterectomy (see below) will cure the problem if endoscopic surgery fails. Adenomyosis is a condition in which endometrial tissue is found in the muscle layer (myometrium) of the uterus. It usually presents as heavy and painful periods, and occasionally pain during intercourse. Hysterectomy is usually required.

Oligomenorhoea (scanty or infrequent periods) may be caused by a variety of conditions including thyroid disease (see THYROID GLAND, DISEASES OF). It is most commonly associated with usage of the combined oral contraceptive pill. Once serious causes have been eliminated, the patient should be reassured. No treatment is necessary unless conception is desired, in which case the patient may require induction of ovulation.

Primary amenorrhoea means that the patient has never had a period. She should be investigated, although usually it is only due to an inexplicable delay in the onset of periods (delayed menarche) and not to any serious condition. Secondary amenorrhoea is the cessation of periods after menstruation has started. The most common cause is pregnancy. It may be also caused by endocrinological or hormonal problems, tuberculous endometritis, emotional problems and severe weight loss. The treatment of amenorrhoea depends on the cause.

Dysmenorrhoea, or painful periods, is the most common disorder; in most cases the cause is unknown, although the disorder may be due to excessive production of PROSTAGLANDINS.

Irregular menstruation (variations from the woman’s normal menstrual pattern or changes in the duration of bleeding or the amount) can be the result of a disturbance in the balance of OESTROGENS and PROGESTERONE hormone which between them regulate the cycle. For some time after the MENARCHE or before the MENOPAUSE, menstruation may be irregular. If irregularity occurs in a woman whose periods are normally regular, it may be due to unsuspected pregnancy, early miscarriage or to disorders in the uterus, OVARIES or pelvic cavity. The woman should seek medical advice.

Fibroids (leiomyomata) are benign tumours arising from the smooth muscle layer (myometrium) of the uterus. They are found in 80 per cent of women but only a small percentage give rise to any problems and may then require treatment. They may cause heavy periods and occasionally pain. Sometimes they present as a mass arising from the pelvis with pressure symptoms from the bladder or rectum. Although they can be shrunk medically using gonadorelin analogues, which raise the plasma concentrations of LUTEINISING HORMONE and FOLLICLE-STIMULATING HORMONE, this is not a long-term solution. In any case, ?broids only require treatment if they are large or enlarging, or if they cause symptoms. Treatment is either myomectomy (surgical removal) if fertility is to be retained, or a hysterectomy.

Uterine cancers tend to present after the age of 40 with abnormal bleeding (intermenstrual or postmenopausal bleeding). They are usually endometrial carcinomas. Eighty per cent present with early (Stage I) disease. Patients with operable cancers should be treated with total abdominal hysterectomy and bilateral excision of the ovaries and Fallopian tubes. Post-operative RADIOTHERAPY is usually given to those patients with adverse prognostic factors. Pre-operative radiotherapy is still given by some centres, although this practice is now regarded as outdated. PROGESTOGEN treatment may be extremely e?ective in cases of recurrence, but its value remains unproven when used as adjuvant treatment. In 2003 in England and Wales, more than 2,353 women died of uterine cancer.

Disorders of the cervix The cervix (neck of the womb) may produce an excessive discharge due to the presence of a cervical ectopy or ectropion. In both instances columnar epithelium – the layer of secreting cells – which usually lines the cervical canal is exposed on its surface. Asymptomatic patients do not require treatment. If treatment is required, cryocautery – local freezing of tissue – is usually e?ective.

Cervical smears are taken and examined in the laboratory to detect abnormal cells shed from the cervix. Its main purpose is to detect cervical intraepithelial neoplasia (CIN) – the presence of malignant cells in the surface tissue lining the cervix – since up to 40 per cent of women with this condition will develop cervical cancer if the CIN is left untreated. Women with abnormal smears should undergo colposcopy, a painless investigation using a low-powered microscope to inspect the cervix. If CIN is found, treatment consists of simply removing the area of abnormal skin, either using a diathermy loop or laser instrument.

Unfortunately, cervical cancer remains the most common of gynaecological cancers. The most common type is squamous cell carcinoma and around 4,000 new cases (all types) are diagnosed in England and Wales every year. As many as 50 per cent of the women affected may die from the disease within ?ve years. Cervical cancer is staged clinically in four bands according to how far it has extended, and treatment is determined by this staging. Stage I involves only the mucosal lining of the cervix and cone BIOPSY may be the best treatment in young women wanting children. In Stage IV the disease has spread beyond the cervix, uterus and pelvis to the URINARY BLADDER or RECTUM. For most women, radiotherapy or radical Wertheim’s hysterectomy – the latter being preferable for younger women – is the treatment of choice if the cancer is diagnosed early, both resulting in survival rates of ?ve years in 80 per cent of patients. Wertheim’s hysterectomy is a major operation in which the uterus, cervix, upper third of vagina and the tissue surrounding the cervix are removed together with the LYMPH NODES draining the area. The ovaries may be retained if desired. Patients with cervical cancer are treated by radiotherapy, either because they present too late for surgery or because the surgical skill to perform a radical hysterectomy is not available. These operations are best performed by gynaecological oncologists who are gynaecological surgeons specialising in the treatment of gynaecological tumours. The role of CHEMOTHERAPY in cervical and uterine cancer is still being evaluated.

Prolapse of the uterus is a disorder in which the organ drops from its normal situation down into the vagina. First-degree prolapse is a slight displacement of the uterus, second-degree a partial displacement and third-degree when the uterus can be seen outside the VULVA. It may be accompanied by a CYSTOCOELE (the bladder bulges into the front wall of the vagina), urethrocoele (the urethra bulges into the vagina) and rectocoele (the rectal wall bulges into the rear wall of the vagina). Prolapse most commonly occurs in middle-aged women who have had children, but the condition is much less common now than in the past when prenatal and obstetric care was poor, women had more pregnancies and their general health was poor. Treatment is with pelvic exercises, surgical repair of the vagina or hysterectomy. If the woman does not want or is not ?t for surgery, an internal support called a pessary can be ?tted – and changed periodically.

Vertical section of female reproductive tract (viewed from front) showing sites of common gynaecological disorders.

Hysterectomy Many serious conditions of the uterus have traditionally been treated by hysterectomy, or removal of the uterus. It remains a common surgical operation in the UK, but is being superseded in the treatment of some conditions, such as persistent MENORRHAGIA, with endometrial ablation – removal of the lining of the uterus using minimally invasive techniques, usually using an ENDOSCOPE and laser. Hysterectomy is done to treat ?broids, cancer of the uterus and cervix, menorrhagia, ENDOMETRIOSIS and sometimes for severely prolapsed uterus. Total hysterectomy is the usual type of operation: it involves the removal of the uterus and cervix and sometimes the ovaries. After hysterectomy a woman no longer menstruates and cannot become pregnant. If the ovaries have been removed as well and the woman had not reached the menopause, hormone replacement therapy (HRT – see MENOPAUSE) should be considered. Counselling helps the woman to recover from the operation which can be an emotionally challenging event for many.... uterus, diseases of

Gland Balancer

There are times when the endocrine orchestra fails to strike its normal note; when energies of life flow slowly and body tone is low. Such is when stimulation of the thyroid, pancreas, and adrenals by natural precursors of their hormones is helpful. The following has a hormone- effect and proves useful for general weakness, change of life, persistent fatigue, sterility, puberty and adolescence, frigidity, metabolic disorders:

Formula. Ginseng 2; Liquorice 1; Sarsaparilla 1; Ginger half; Kelp half. Dose – powders: half a teaspoon; tinctures 1-3 teaspoons; liquid extracts: 1-2 teaspoons; in water or honey thrice daily. ... gland balancer

Prostatectomy

An operation to remove part or all of the prostate gland.

It is performed to treat enlargement of the gland (see prostate, enlarged), cancer of the prostate (see prostate, cancer of), or prostatitis.

The most common method is trans-urethral prostatectomy, performed during cystoscopy.

If the prostate gland is very enlarged, retropubic prostatectomy may be performed.

An incision exposes the prostate and the tissue is removed.

Prostatectomy may affect potency or sexual sensation, though this is not common.

The operation usually causes sterility.... prostatectomy

Brahmi

Bacopa monnieri

Scrophulariaceae

San: Brahmi, Sarasvati;

Hin: Barami, Jalnim;

Ben: Boihim-sak;

Mal: Brahmi , Nirbrahmi;

Tam: Nirpirami, Piramiyapundu; Kan, Mar: Nirbrahmi

Importance: Brahmi or Thyme leaved gratiola is an important drug in Ayurveda for the improvement of intelligence and memory and revitalisation of sense organs. It clears voice and improves digestion. It is suggested against dermatosis, anaemia, diabetes, cough, dropsy, fever, arthritis, anorexia, dyspepsia, emaciation, and insanity. It dispels poisonous affections, splenic disorders and impurity of blood. It is useful in vitiated conditions of kapha and vata, biliousness, neuralgia, ascites, flatulence, leprosy, leucoderma, syphilis, sterility and general debility. The whole plant is used in a variety of preparations like Brahmighrtam, Sarasvataristam., Brahmitailam, Misrakasneham, etc. In unani Majun Brahmi is considered as a brain tonic.

Distribution: The plant grows wild on damp places and marshy lands in the major part of the plains of India, Pakistan, Afghanistan, Nepal, Sri Lanka and other tropical countries.

Botany: Bacopa monnieri (Linn.) Pennell. syn. Monniera cuneifolia Michx., Herpestis monniera (Linn.) H.B. & K. belongs to the family Scrophulariaceae. It is a prostrate, juicy, succulent, glabrous annual herb rooting at the nodes with numerous ascending branches. Leaves are simple, opposite, decussate, sessile, obovate-oblong or spatulate, entire, fleshy, obscurely veined and punctate. Flowers are pale blue or whitish, axillary, solitary, arranged on long slender pedicels. Fruits are ovoid, acute, 2-celled, 2-valved capsules and tipped with style base. Seeds are minute and numerous (Warrier et al, 1993).

Agrotechnology: The plant grows throughout the warm humid tropics upto 1200m elevation. Brahmi gets established well in water logged fields. The plant is propagated vegetatively by stem cuttings. Land is prepared by ploughing 2 or 3 times. Two to three tonnes/ha of cowdung or compost is applied and the field is again ploughed and levelled. Stem cuttings, 10cm long are spread at a spacing of 20cm. Waterlogging to height of 30cm is always required. Rooting may start within 15-20 days. It will spread over the field within 6 months. Regular application of organic manure will take care of the manurial requirement. Weeding once in a month is required. Care should be taken to maintain water level at a height of 30cm during the growth period. No serious pests or diseases are noted in this crop. Harvesting commences from sixth months onwards. Brahmi leaves can be collected once a month. After 3 years, the whole crop is harvested and removed. Fresh cultivation can be carried out in the same field.

Properties and activity: Earlier workers have reported the isolation of the alkaloids brahmine and hespestine and a mixture of 3 alkaloids from the leaves. Mannitol and saponins were reported later. Subsequent work described isolation of some C27, C29, and C31 hydrocarbons and betulic acid from this plant material. A systematic examination has resulted in the isolation and identification of two saponins designated as bacosides A and B. Bacoside A has chemical structure represented as 3-(-L-arabinopyranosyl)-O- - D-glucopyranoside-10, 20-dihydroxy-16-ketodammar-24-ene. The mixture of bacosides A and B on hydrolysis give four sapogenins, glucose and arabinose. The constitution of bacogenin A, has been established as 3 -30-dihydroxy-20(5)-25-epoxy-22-methyl-24-nor-dammar-22-en-16-one. Bacogenin A2 has been shown to be an isomer of bacogenin A, differing in configuration at C-20. Bacogenin A4 has been identified as ebelin lactone.

The plant is reported to have shown barbiturate hypnosis potentiation effect. The plant is anticancerous and improves learning ability. It is used as a tranquilliser. The plant is astringent, bitter, sweet, cooling, laxative, intellect promoting, anodyne, carminative, digestive, antiinflammatory, anticonvulsant, depurative, cardiotonic, bronchodialator, diuretic, emmenagogue, sudorfic, febrifuge and tonic (Basu et al, 1947; Rastogi et al 1960).... brahmi

Madhuca Longifolia

(Koen.) Macb.

Synonym: Bassia longifolia Koenig.

Family: Sapotaceae.

Habitat: Cultivated in Uttar Pradesh, Bihar, Andhara Pradesh, Karnataka, Bengal and Maharas- tra.

English: South Indian Mahua.

Siddha/Tamil: Illupei, Elupa, Naatu Iluppai, Iruppai.

Folk: Madhuulaka, Jala-Madhuuka, Jala-Mahuaa.

Action: Same as that of Madhuca indica.

Seed kernel gave protobassic acid (a sapogenol) and two major sapo- nins named Mi-saponins A and B and a minor one Mi-saponin C—all bis- desmosides of protobassic acid. Mi- saponins exhibit anti-inflammatory and antiulcerogenic activities.

Mahua oil causes total but reversible sterility in male rats as it shows testicu- lar atrophy with degeneration of seminiferous tubules.

A related species, Madhuca neri- ifolia (Moon) H. J. Lam., synonym Bassia neriifolia Moon, Bassia mal- abarica Bedd. (known as Atta Illuppei in Tamil), is found in Western Ghats and coastal region of South India.

The flowers are used in renal diseases; fruits in rheumatism, cough, asthma and consumption; seed oil is used in rheumatism.... madhuca longifolia

Alkylating Agents

a class of chemotherapy drugs that includes *cyclophosphamide, *ifosfamide, and *melphalan. These drugs bind to DNA and prevent complete separation of the two DNA chains during cell division. Side-effects are those of other *cytotoxic drugs; in addition, alkylating agents interfere with *gametogenesis and may cause sterility in men.... alkylating agents

Castration

n. removal of the sex glands (the testes or the ovaries). Castration in childhood causes failure of sexual development but when done in adult life (usually as part of hormonal treatment for cancer) it produces less marked physical changes in both sexes. Castration inevitably causes sterility but it need not cause impotence or loss of sexual desire.... castration

Follicle-stimulating Hormone

(FSH) a hormone (see gonadotrophin) synthesized and released by the anterior pituitary gland. FSH stimulates ripening of the follicles in the ovary and formation of sperm in the testes. It is administered by injection to treat sterility due to lack of ovulation, amenorrhoea, and decreased sperm production. Stimulation of ovulation by FSH may, in some cases, lead to multiple pregnancy.... follicle-stimulating hormone

Dill Tea And Its Amazing Benefits

Dill is one of the oldest culinary herbs. Most people use it for cooking but few are familiar with the benefits of dill tea. About dill tea Scientifically called Anethum graveolens, dill is an annual aromatic plant with a special therapeutic value. Its cultivation begun in ancient times and today it is popular throughout the globe. It is also used for manufacturing many herbal remedies and medicines. Dill tea can be made from seeds or fresh dill leaves, often called “dill weed” to differentiate it from the seeds. The seeds are viable for couple of years. Dill tea has a sweetly pungent, cooling feeling and it is sharp after taste and has a heavy and lasting flavor. Dill tea has a tender green color. The plant is a source of proteins, carbohydrates, phosphorus, iron, magnesium, sodium and potassium. It also contains a small amount of riboflavin, niacin and zinc. Dill tea offers help in cough, cold and flu. Its seeds were believed to benefit various digestive problems. The seed essential oil may relieve intestinal spasms and griping. Dill seeds contain volatile oil, flavonoids, coumarins and triterpenes. Dill leaves (weed), on the other hand, are rich in carvone, limonene and monoterpenes, carbohydrates, fibers, proteins, vitamins A, C, B complex, calcium, iron, magnesium, manganese, phosphorus, potassium, zinc and copper. In traditional medicine, the seeds are recommended for feminine health in order to correct problems related to estrogen level. Dill seeds favors the growth of female secondary features (breast augmentation, pilosity hair growth rate, skin softness) extending the biological female health. How to brew dill tea To make dill tea from seeds, use 2 teaspoons of mashed dill seeds in 1 cup of boiling water and let it infuse for 10 minutes. Filter the seeds and your tea is ready to be served - fast and easy. For therapeutic purposes, you can drink 3 cups a day with 30 min before meals. To prepare dill weed tea, take 2 teaspoons of dill weed for 1 cup and let it boil in water for approximately 10 minutes. The longer you let the dill tea boil, the more medical benefits you will get. Benefits of dill tea Whether it is made from seeds or fresh leaves, dill tea has a long list of health benefits : Dill tea is popular for controlling flatulence especially when prepared from seeds This kind of tea is suitable for infants against colic or other ailments such as cough, flu, indigestion, gas, stomachache or insomnia. It also stimulates milk production in nursing mothers. Dill tea has many other benefits for women. It alleviates menstrual symptoms and pain, sterility or premature menopause. It is also diuretic and antispasmodic and can be used with success for treating hemorrhoids, jaundice, scurvy, diarrhea, dysentery or respiratory disorders. Dill tea enhances the bone and dental health being a good source of calcium. It also ensures oral freshness. Antioxidants in the dill’s tea essential oils contribute to fight against free radicals and cancer. Dill tea warnings Dill tea has only few warnings especially in hyperestrogenism, hypermenorea, ovarian cysts, breast lump, benign and malignant tumors or other allergies associated with dill. Dill tea is suitable for regular consumption, is relaxant and strength giving, but take into consideration the warnings before you drink it.... dill tea and its amazing benefits

Non-specific Urethritis (nsu)

An in?ammatory condition of the URETHRA due to a cause or causes other than GONORRHOEA. The most common is CHLAMYDIA trachomatis – there has been a rise of over 75 per cent in the incidence in the UK over the past ?ve years to around 70,000 a year. It produces pelvic in?ammatory disease in women, which often results in sterility, the risk of ECTOPIC PREGNANCY, and recurrent pelvic pain. Most cases respond well to TETRACYCLINES. Abstinence from sexual intercourse should be observed during treatment and until cure is complete. Children born to infected mothers may have their eyes infected during birth, producing the condition known as ophthalmia neonatorum. This is treated by the application to the eye of chlortetracycline eye ointment. The lungs of such a child may also be infected, resulting in pneumonia.... non-specific urethritis (nsu)

Orchidectomy

n. surgical removal of a testis. A radical orchidectomy, using an incision in the inguinal region, is performed for malignant tumours within the testis (usually germ-cell tumours, such as *seminoma or *teratoma). Orchidectomy may also be performed for *infarction of the testis. Removal of both testes (bilateral orchidectomy: see castration) causes sterility and reduces levels of testosterone by 90%, which is an effective treatment for advanced prostate cancer.... orchidectomy

Orchitis

n. inflammation of the testis. This causes pain, redness, and swelling of the scrotum, and may be associated with inflammation of the epididymis (epididymo-orchitis). The condition may affect one or both testes; it is usually caused by infection spreading down the vas deferens but can develop in mumps. Mumps orchitis affecting both testes after puberty may result in reduced testicular size and abnormalities in semen analysis, although sterility is rare. Treatment of epididymo-orchitis is by local support and by administration of analgesics and antibiotics; mumps orchitis often responds to *corticosteroids.... orchitis

Sterile

adj. 1. (of a living organism) barren; unable to reproduce its kind (see sterility). 2. (of inanimate objects) completely free from bacteria, fungi, viruses, or other microorganisms that could cause infection.... sterile

Chlamydial Infection

One of the many sexually transmitted diseases. Caused by the micro- organism Chlamydial trachomatis. Common among birds and animals and responsible for psittacosis, trachoma and urethritis. May be acquired by children at childbirth when it causes an eye disorder that may not be serious. Sexually acquired reactive arthritis in men may follow infection. Around 70 per cent PID cases in young women are due to the infection.

Symptoms. Irregular bleeding and moderate pain. Women can still have the infection but no symptoms. Damage to the fallopian tubes possible. Sterility may follow neglect.

Treatment. Formula. Echinacea 2; Goldenseal 1; Myrrh half. Mix. Dose: Powders: 250mg (one 00 capsule or one-sixth teaspoon). Liquid extracts: 15-30 drops. Tinctures: 30-60 drops. Thrice daily in water, honey or fruit juice.

Topical. Douche: 10 drops Liquid extract or Tincture Goldenseal in an ounce (30ml) Rosewater or Distilled extract Witch Hazel. If the condition persists for more than a month, add 10 drops Kava Kava. Diet. Dandelion coffee.

On retiring at night. 2-3 Garlic tablets/capsules.

Treatment by a general medical practitioner or hospital specialist. ... chlamydial infection

Tephrosia Purpurea

(L.) Pers.

Synonym: T. hamiltonii Drumm.

Family: Papilionaceae; Fabaceae.

Habitat: All over India; also grown as green manure and as cover crop.

English: Purple Tephrosia, Wild Indigo.

Ayurvedic: Sharapunkhaa, Vishikha-punkhaa, Sarphokaa.

Unani: Sarponkhaa, Sarphukaa.

Siddha/Tamil: Kattu-kolingi, Kolingi, Paavali, Mollukkay, Kollukkayvelai.

Action: The drug is considered specific for the treatment of inflammation of spleen and liver (is known as Plihaa-shatru, Plihaari in Indian medicine).

Dried herb—diuretic, deobstruent, laxative. Given for the treatment of cough, bronchitis, bilious febrile attacks, insufficiency of the liver, jaundice (not effective in infantile cirrhosis), kidney disorders and for the treatment of bleeding piles, boils, pimples. Also used as a gargle. Root—decoction used in dyspepsia, diarrhoea, cough, bronchitis, adenoids, asthma and rheumatism. Juice is applied to skin eruptions. A liniment prepared from the root is employed in elephantiasis. Oil from seeds—specific against eruptions of the skin, eczema, scabies, leprosy. Seed extract—hypoglycaemic.

Powdered aerial parts prevented elevation of SGOP, SGPT and bilirubin levels.

Hepatoprotective effect of aerial parts was evaluated against (+)-galac- tosamine-induced and carbon tetra- chloride-induced hepatotoxicity in rats.

The leaves contain rutin and rote- noids (0.65-0.80% on dry basis). Rote- noid content is highest in the seed (1.60-1.80%).

The leaves also contain a triterpe- noid, lupeol, and beta-sitosterol.

Seeds contain a diketone-pongamol; a dimethylchromene flavanone iso- lonchocarpin; furanoflavones karan- jin and kanjone; a flavanone purpurin; and sitosterol. A flavonoid, lanceolarin B, is also present in seeds.

The plant extract led to marked lowering of blood glucose level in normal and alloxan-induced diabetic rabbits. In diabetic rabbits the extract exerted 60-70% hypoglycaemic effect as compared to tolbutamide.

Shveta Sharapunkhaa (stems: covered with white hair; flowers: pale pink or pale violet) is equated with T. villosa Pers.

The roots gave a prenylated fla- vanone 7-methylglabranin; pods contain rotenoids—villosin, villon, vil- losol, villosinol, villinol and villosone.

The fresh root is credited with hy- poglycaemic properties, but leaves did not show any such effect. The juice of the leaf is given in dropsy. Ayurve- dic classical texts describe it as a special drug for treating sterility in women.

Boiled leaves of T. uniflora subspecies petrosa (Kant-punkhaa) are used for the treatment of syphilis. The medicinal properties of the plant are more or less similar to those of T. purpurea, but to a milder degree.

T. spinosa Pers. (South India, ascending to 400 m in hills) is also known as Kant-punkhaa (Mulukolingi in Tamil Nadu).

The root is applied to inflammations and swellings of joints; a decoction is given in rheumatism.

Chalcones, spinochalones A and B and flemistrictin A have been isolated from the root. Spinochalone C and spinoflavonones A and B, and fulvin- ervin A have been isolated from the plant.

Dosage: Plant, root, seed—3-5 g powder. (CCRAS.)... tephrosia purpurea

Damiana

Curzon. Turnera diffusa Willd. Leaves and stems.

Constituents: flavonoids, volatile oil, arbutin.

Action: aphrodisiac, antidepressant, diuretic, stomachic, thymoleptic BHP (1983), stimulating tonic to the central nervous system and reproductive organs.

Uses: To enhance sexual performance, especially in the male. Impotence, frigidity, sterility, prostatitis, physical weakness and nervous exhaustion. Depression, anxiety states.

Combines well with Skullcap and Oats for senile dementia and feeble constitution. Traditional combination: (equal parts), Damiana, Saw Palmetto and Kola.

Preparations: Thrice daily.

Tea. 1 teaspoon to each cup boiling water; infuse 15 minutes. Half-1 cup.

Liquid extract. Half-1 teaspoon.

Tincture. 1-2 teaspoons, in water.

Tablets/capsules. One 300mg capsule or capsules after meals thrice daily. ... damiana

Helonias

False Unicorn root. Blazing Star root. Chamaelirium luteum LA Gray. Parts used: roots, rhizome. Keynote: female reproductive system.

Constituents: helonin, saponins, chamaelirin.

Action. Powerful uterine tonic. Emmenagogue. Adaptogen. (Simon Mills) Precursor of oestrogen. Anthelmintic, diuretic, emetic.

Uses: Weakness of female reproductive organs. Absent or painful periods. Endometriosis, leucorrhoea, morning sickness, female sterility, inflammation of the Fallopian tubes, vaginitis, pruritus. Symptoms of the menopause: hot flushes, heavy bloated feeling, headache, depression, and to maintain normal fluid balance. Ovarian neuralgia. Spermatorrhoea in the male. Threatened abortion: miscarriage.

Preparations: Thrice daily. Average dose: 1-2g.

Combines well with Beth root. (F. Fletcher Hyde)

Tea. Does not yield its properties to simple infusion.

Decoction. Half-1 teaspoon to each cup water gently simmered 20 minutes. Dose: half-1 cup.

Liquid extract BHC Vol 1. 1:1 in 45 per cent ethanol. Dose: 1-2ml.

Tincture BHC Vol 1. 1:5 in 45 per cent alcohol. Dose: 2-5ml.

Powder. Equal parts Helonias and Beth root: 500mg (two 00 capsules or one-third teaspoon).

Popular combination. Tablets/capsules. Powdered Helonias BHP (1983) 120mg; powdered Parsley BHP (1983) 60mg; powdered Black Cohosh BHP (1983) 30mg; powdered extract Raspberry leaves 3:1 – 16.70mg. (Gerard House)

Note: Large doses may cause vomiting. ... helonias

Hansen’s Disease

A chronic bacterial infection, also called leprosy, that damages nerves, mainly in the limbs and facial area, and may cause skin damage. The disease is caused by a bacterium,MYCOBACTERIUM LEPRAE, which is spread in droplets of nasal mucus. Hansen’s disease is not highly contagious, and a person is infectious only in the early stages. Prolonged close contact puts people at risk. The disease is most prevalent in Asia, Central America, South America, and Africa.

Hansen’s disease has a long incubation period – about 3–5 years. There are 2 main types: the lepromatous type, in which damage is widespread, progressive, and severe; and the tuberculoid type, which is milder. In both types, damage is initially confined to peripheral nerves supplying the skin and muscles. Skin areas supplied by affected nerves become lighter or darker and sensation and sweating are reduced. As the disease progresses, the peripheral nerves swell and become tender. Hands, feet, and facial skin eventually become numb and muscles become paralysed, leading to deformity. Other possible features include blindness, destruction of bone, and sterility.

The presence of the causative bacteria is confirmed by a skin biopsy. Drug treatment may be with a combination of dapsone, rifampicin, and clofazimine, which kills most of the bacteria in a few days. Any damage that has occurred before treatment, however, is irreversible. Plastic surgery may be necessary to correct deformities; and nerve and tendon transplants may improve the function of damaged limbs.... hansen’s disease

Infertility

n. inability in a woman to conceive or in a man to induce conception after regular unprotected sexual intercourse for two years. Female infertility may be due to failure to ovulate, to obstruction of the *Fallopian tubes, or to disease of the lining of the uterus (endometrium). Possible treatments (depending on the cause) include administration of drugs (such as *clomifene or *gonadorelin analogues), surgery (see salpingography; salpingostomy; salpingolysis) to restore patency of the Fallopian tubes, *gamete intrafallopian transfer (GIFT), and *in vitro fertilization. Causes of male infertility include decreased numbers or motility of spermatozoa (see oligospermia) and total absence of sperm (see azoospermia). See also andrology; sterility.... infertility

Sterilization

n. 1. a surgical operation or any other process that induces *sterility in men or women. In women, hysterectomy and bilateral oophorectomy (surgical removal of both ovaries) are 100% effective and permanent. Alternatively, the Fallopian tubes may be removed (see salpingectomy) or divided and/or ligated. These operations can be performed through the abdomen or the vagina. The modern technique (tubal occlusion) is to occlude (close) permanently the inner (lower) half of the Fallopian tube through a *laparoscope. The occluding device is usually a clip (the Hulka-Clemens or Filshie clips) or a small plastic ring (Falope ring); *diathermy coagulation carries greater dangers (e.g. bowel burns) and is now little used. A more recent method is the use of a rapid-setting plastic introduced into the tubes through a hysteroscope (see hysteroscopy). Men are usually sterilized by *vasectomy. See also castration. 2. the process by which all types of microorganisms (including spores) are destroyed. This is achieved by the use of heat, radiation, chemicals, or filtration. See also autoclave.... sterilization

Deertongue

Carphephorus odoratissimus

FAMILY: Asteraceae (Compositae)

SYNONYMS: Trilisa odoratissima, Liatris odoratissima, Frasera speciosa, hound’s tongue, deer’s tongue, Carolina vanilla, vanilla leaf, wild vanilla, vanilla trilisa, whart’s tongue, liatrix (oleoresin or absolute).

GENERAL DESCRIPTION: A herbaceous perennial plant distinguished by a naked receptacle and feathery pappus, with large, fleshy, dark green leaves, clasped at the base. When fresh, the leaves have little odour but when dried they acquire a vanilla-like odour, largely due to the coumarin that can be seen in crystals on the upper sides of the leaves.

DISTRIBUTION: Native to eastern USA; gathered on the savannah land between North Carolina and Florida.

OTHER SPECIES: There are several species of deertongue native to America, for example blazing star or prairie pine (Liatris squarrosa), and gayfeather (L. spicata). Not to be confused with the common vanilla (Vanilla planifolia) or with the European hound’s tongue (Cynoglossum officinale), all of which have been used in herbal medicine.

HERBAL/FOLK TRADITION: The roots have been used for their diuretic effects, and applied locally for sore throats and gonorrhoea. It has also been used as a tonic in treating malaria. In folklore the plant is associated with contraception and sterility in women.

ACTIONS: Antiseptic, demulcent, diaphoretic, diuretic, febrifuge, stimulant, tonic.

EXTRACTION: Oleoresin by solvent extraction from the dried leaves.

CHARACTERISTICS: A dark green, heavy, viscous liquid with a rich, herbaceous, new-mown hay scent. It blends well with oakmoss, labdanum, lavandin, frankincense, clove, patchouli and oriental-type fragrances.

PRINCIPAL CONSTITUENTS: Mainly coumarin (1.6 per cent), with dihydrotoumarin and terpenes, aldehydes and ketones.

SAFETY DATA: ‘Coumarin has toxic properties including liver injury and haemorrhages.’. (There is also the possibility of dermal irritation and phototoxicity due to the lactones present.)

AROMATHERAPY/HOME: USE None.

OTHER USES: The oleoresin is used as a fixative and fragrance component in soaps, detergents and perfumery work. Used for flavouring tobacco and; also employed for the isolation of coumarin.... deertongue

Sage, Spanish

Salvia lavendulaefolia

FAMILY: Lamiaceae (Labiatae)

SYNONYMS: Lavender-leaved sage.

GENERAL DESCRIPTION: An evergreen shrub, similar to the garden sage but with narrower leaves and small purple flowers. The whole plant is aromatic with a scent reminiscent of spike lavender.

DISTRIBUTION: Native to the mountains in Spain, it also grows in south west France and Yugoslavia. The oil is mainly produced in Spain.

OTHER SPECIES: A very similar oil is distilled in Turkey from a Greek variety, S. triloba, which is used for pharmaceutical purposes. See also entries on clary sage and common sage for other types of sage.

HERBAL/FOLK TRADITION: In Spain it is regarded as something of a ‘cure-all’. Believed to promote longevity and protect against all types of infection (such as plague). Used to treat rheumatism, digestive complaints, menstrual problems, infertility and nervous weakness.

ACTIONS: Antidepressant, anti-inflammatory, antimicrobial, antiseptic, antispasmodic, astringent, carminative, deodorant, depurative, digestive, emmenagogue, expectorant, febrifuge, hypotensive, nervine, regulator (of seborrhoea), stimulant (hepatobiliary, adrenocortical glands, circulation), stomachic, tonic (nerve and general).

EXTRACTION: Essential oil by steam distillation from the leaves.

CHARACTERISTICS: A pale yellow mobile liquid with a fresh-herbaceous, camphoraceous, slightly pinelike odour. It blends well with rosemary, lavandin, lavender, pine, citronella, eucalyptus, juniper, clary sage and cedarwood.

PRINCIPAL CONSTITUENTS: Camphor (up to 34 per cent), cineol (up to 35 per cent), limonene (up to 41 per cent), camphene (up to 20 per cent), pinene (up to 20 per cent) and other minor constituents.

SAFETY DATA: Relatively non-toxic, non-irritant, non-sensitizing. Avoid during pregnancy; use in moderation.

AROMATHERAPY/HOME: USE

Skin care: Acne, cuts, dandruff, dermatitis, eczema, excessive sweating, hair loss, gingivitis, gum infections, sores.

Circulation muscles and joints: Arthritis, debility, fluid retention, muscular aches and pains, poor circulation, rheumatism. Respiratory system: Asthma, coughs, laryngitis.

Digestive system: Jaundice, liver congestion.

Genito-urinary system: Amenorrhoea, dysmenorrhoea, sterility.

Immune system: Colds, fevers, ’flu.

Nervous system: Headaches, nervous exhaustion and stress-related conditions.

OTHER USES: Extensively used as a fragrance component in soaps, cosmetics, toiletries and perfumes, especially ‘industrial’ type fragrances. Extensively employed in foods (especially meat products), as well as alcoholic and soft drinks.... sage, spanish




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