Streptomycin Health Dictionary

A group of antibiotics usually reserved for use in patients with severe infections. They are e?ective against a wide range of BACTERIA including some gram-positive and many gram-negative organisms (see GRAM’S STAIN). Aminoglycosides must be used cautiously because they can damage the inner ear – thus affecting hearing – and the kidneys. Examples of this group are AMIKACIN and GENTAMICIN (e?ective against Pseudomonas aeuriginosa), NEOMYCIN (used only for topical administration for skin infections), and STREPTOMYCIN (e?ective in combination with other drugs against Mycobacterium tuberculosis).... aminoglycosides

A disease of rodents such as rabbits and rats, caused by the bacillus, Francisella tularense, and spread either by ?ies or by direct inoculation – for example, into the hands of a person engaged in skinning rabbits. In humans the disease takes the form of a slow fever lasting several weeks, with much malaise and depression, followed by considerable emaciation. It was ?rst described in the district of Tulare in California, and is found widely spread in North America and in Europe, but not in Great Britain. STREPTOMYCIN, the TETRACYCLINES and CHLORAMPHENICOL o?er e?ective treatment.... tularaemia

Also known as undulant fever, or Malta fever.

Causes In Malta and the Mediterranean littoral, the causative organism is the bacterium Brucella melitensis which is conveyed in goat’s milk. In Great Britain, the US and South Africa, the causative organism is the Brucella abortus, which is conveyed in cow’s milk: this is the organism which is responsible for contagious abortion in cattle. In Great Britain brucellosis is largely an occupational disease and is now prescribed as an industrial disease (see OCCUPATIONAL DISEASES), and insured persons who contract the disease at work can claim industrial injuries bene?t. The incidence of brucellosis in the UK has fallen from more than 300 cases a year in 1970 to single ?gures.

Symptoms The characteristic features of the disease are undulating fever, drenching sweats, pains in the joints and back, and headache. The liver and spleen may be enlarged. The diagnosis is con?rmed by the ?nding of Br. abortus, or antibodies to it, in the blood. Recovery and convalescence tend to be slow.

Treatment The condition responds well to one of the tetracycline antibiotics, and also to gentamicin and co-trimoxazole, but relapse is common. In chronic cases a combination of streptomycin and one of the tetracyclines is often more e?ective.

Prevention It can be prevented by boiling or pasteurising all milk used for human consumption. In Scandinavia, the Netherlands, Switzerland and Canada the disease has disappeared following its eradication in animals. Brucellosis has been eradicated from farm animals in the United Kingdom.... brucellosis

A serious infectious disease that is caused by the bacterium YERSINIA PESTIS. It mainly affects rodents but can be transmitted to humans by flea bites. There are 2 main types: bubonic and pneumonic plague. Bubonic plague is characterized by swollen lymph glands (called “buboes”). Symptoms usually start 2–5 days after infection, with fever, shivering, and severe headache. Soon, the smooth, red, intensely painful buboes appear, usually in the groin. There may be bleeding into the skin around the buboes, causing dark patches.Pneumonic plague affects the lungs and can spread from person to person in infected droplets expelled during coughing. Symptoms are severe coughing that produces a bloody, frothy sputum and laboured breathing. Without early treatment, death is almost inevitable.

A sample of fluid from a bubo, or a sputum sample, is taken to confirm the diagnosis.

Possible treatments include streptomycin and tetracycline drugs.... plague

auct non L.

Synonym: A. pilosa Hook.f. non Ledeb.

A. pilosa Ledeb. var. nepalensis (D. Don) Nakai

Family: Rosacae.

Habitat: The Himalayas from Kashmir to West Bengal at 9003,000 m, and in Arunachal Pradesh, Nagaland and Meghalaya.

English: Agrimony, Stickle Wort.

Unani: Ghaafis.

Folk: Belu.

Action: Astringent, anti- inflammatory, hepatic, cholagogue, diuretic, mild haemostatic, antibacterial. Used for irritations and infections of the intestinal tract, gallbladder diseases, hyperacidity, colic, urinary disorders (bed- wetting, incontinence), sluggish liver, mucus membrane inflammations; externally for ulcerated and discharging skin, psoriasis and seborrhoic eczemas.

Key application: In mild, nonspecific, acute diarrhoea and in inflammation of oral and pharyngeal mucosa; as astringent. (German Commission E, The British Herbal Pharmacopoeia.)

The herb contains condensed tannins up to 8%, coumarins, flavonoids (glucosides of luteolin, apigenin and quercetin), polysaccharides, volatile oil. Luteolin 7-glucoside shows a chole- gogic action. Aqueous extracts inhibited Mycobacterium tuberculosis, also strains resistant to streptomycin and p-aminosalicylate. Essential oil is antibacterial, active against Bacillus sub- tilis.

The ethanolic extracts of the herb are used for their antiviral properties. (Natural Medicines Comprehensive Database, 2007.)

Coumarins interact with anticoagulants, and drugs that increase the risk of bleeding Furanocoumarin content increase photosensitivity. (Sharon M. Herr.)... agrimonia eupatoria

Antibiotic is the term used to describe any antibacterial agent derived from micro-organisms, although most of them are now prepared synthetically. Such agents destroy or inhibit the growth of other micro-organisms: examples are penicillin, cephalosporin, amino-glycosides, streptomycin, and tetracycline.

Penicillin was the ?rst antibiotic to be discovered and used in the 1940s. The discovery and isolation in 1958 of the penicillin nucleus, 6-amino penicillanic acid (6-PNA), allowed many new penicillins to be synthesised. These are now the largest single group of antibiotics used in clinical medicine. Most staphylococci (see STAPHYLOCOCCUS) have now developed resistance to benzylpenicillin, the early form of the drug, because they produce penicillinases – enzymes which break down the drug. Other types of penicillin such as cloxacillin and ?ucoxacillin are not affected and are used against penicillin-resistant staphylococci.

The cephalosporins are derived from the compound cephalosporin C, which is obtained by fermentation of the mould cephalosporium.

The cephalosporin nucleus 7 amino cephalosporanic (7-ICA) acid has been the basis for the production of the semi-synthetic compounds of the cephalosporin nucleus. The ?rst semi-synthetic cephalosporin, cephalothin, appeared in 1962; it was followed by cephaloridine in 1964. The original cephalosporins had to be given by injection, but more recent preparations can be given by mouth. The newer preparations are less readily destroyed by betalactamases and so they have a much broader spectrum of antibacterial activity. The newer cephalosporins include cephalexin, cefazolin, cephacetrile, cephapirin, cefamandole, cefuroxine, cephrodine, cefodroxil and cefotaxine. Inactivation of beta-lactamase is the basis of bacterial resistance both to the penicillins and to the cephalosporins, so that attempts to prepare these antibiotics with resistance to betalactamase is of great importance. A synthetic inhibitor of beta-lactamase called clavulanic acid has been synthesised; this is used in combination with the penicillins and cephalosporins to prevent resistance. The cephamycins are a new addition to the beta-lactam antibiotics. They are similar in structure to the cephalosporins but are produced, not by fungi, but by actinomycetes.

Overuse and misuse of antibiotics have resulted in many bacteria becoming resistant to them. Hospitals, in particular, have problems with METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA). Combinations of antibiotics are needed to combat resistant strains of bacteria, another example being Mycobacterium tuberculosis.... antibiotics

One of the anti-tuberculous drugs. It has the advantages of being relatively non-toxic and of being active when taken by mouth. Unfortunately, like streptomycin, it may render the Mycobacterium tuberculosis resistant to its action. This tendency to produce resistance is considerably reduced if it is given in conjunction with RIFAMPICIN and PYRAZINAMIDE.... isoniazid

A hypersensitivity reaction due to circulating antigen-antibody complexes (see ANTIGEN; ANTIBODIES), so-called because it was a not uncommon reaction to the administration of foreign SERUM which used to be given as a form of passive IMMUNITY before the days of antibiotics. By de?nition, it is a manifestation of sensitivity to serum – but the same clinical and pathological picture can occur 1–3 weeks after the administration of drugs such as PENICILLIN and STREPTOMYCIN. It is characterised by fever, ARTHRALGIA and LYMPHADENOPATHY and is usually self-limiting as it resolves when the supply of antigen is used up.... serum sickness

Linn.

Family: Amaranthaceae.

Habitat: A common weed, occurring throughout India.

English: Wild Cock's Comb.

Ayurvedic: Shitivaaraka, Vitunna.

Siddha/Tamil: Pannaikeerai.

Folk: Shveta-murga, Sarvari, Sarvali, Surali.

Action: Flowers—used in menor- rhagia, blood-dysentery. Seeds— antidiarrhoeal, also used in stomatitis. Whole plant—antibacterial, antiscorbutic and cooling.

Tender leaves are rich in potassium and in B1 and B6. An alcoholic extract of the leaves and its flavonoids showed antibacterial activity, which was comparable to ampicillin and streptomycin.

The seeds contain 11.6-17% of protein and 6.4-10.9% of a fatty oil. The seeds and roots yield triterpenoid sapo- nins. An alcoholic extract of the seeds possess significant diuretic activity.... celosia argentea

The prevention or treatment of disease by chemical substances. The term is generally used in two senses: the use of antibacterial and other drugs to treat infections; and the administration of ANTIMETABOLITES and other drugs to treat cancer. The discovery by Paul Ehrlich in 1910 of the action of Salvarsan in treating syphilis led to the introduction of sulphonamides in 1935, followed by PENICILLIN during World War II, which revolutionised the treatment of common infections. Many ANTIBACTERIAL DRUGS have been developed since then: these include CEPHALOSPORINS, cephamycins, TETRACYCLINES, AMINOGLYCOSIDES, MACROLIDES and CLINDAMYCIN as well as antituberculous drugs such as STREPTOMYCIN and METRONIDAZOLE. Unfortunately, overuse of chemotherapeutic drugs in medicine and in animal husbandry has stimulated widespread resistance among previously susceptible pathogenic microorganisms. Chemotherapy also plays an important role in treating tropical diseases, especially MALARIA, SLEEPING SICKNESS and LEPROSY.

Recently chemotherapy has become increasingly e?ective in the treatment of cancer. Numerous drugs, generally CYTOTOXIC, are available; great care is required in their selection and to minimise side-effects. Certain tumours are highly sensitive to chemotherapy

– especially testicular tumours, LEUKAEMIA, LYMPHOMA and various tumours occurring in childhood (e.g. Wilm’s tumour – see NEPHROBLASTOMA) – and may even be cured.... chemotherapy

Stuntz.

Synonym: Prosopis juliflora DC.

Family: Mimosaceae.

Habitat: Argentine, Arid, Mexican, Peruvian and Australian species have been introduced into India.

English: Mesquite.

Folk: Khejaraa, Vilaayati Kikar, Kaabuli Kikar.

Action: Gum—inferior to Gum arabic. The dry wood contains 0.9, bark 3.0-8.4, and roots 6-7% tannin.

The leaves contain piperidine alkaloids, juliprosinene, juliflorinine and N-methyljuliforidine. Other alkaloids present in the leaves are juliprosine, isojuliprosine, juliflorine, julifloricine and julifloridine.

A mixture of alkaloids containing mainly juliprosine and isojuliprosine showed significant antifungal activity against dermatophytes (comparable to griseofulvin).

The alkaloid fraction also showed broad spectrum bactericidal action against both Gram-positive and Gramnegative bacteria (comparable to antibiotics like penicillin, streptomycin, ampicillin, sulphamethoxazole and te- tracycline).

Significant activity of juliflorine against fungi and bacteria, and that of julifloricine against bacteria has also been reported.

The fruit gave a flavone glycoside, patulitrin which exhibited cytotoxic activity.... prosopis chilensis

A type of antibiotic drug. Aminoglycoside drugs are given by injection and are generally reserved for the treatment of serious infections because their use can damage the inner ear or kidneys. Important examples are gentamicin and streptomycin, which are also used topically for eye and ear infections.... aminoglycoside drugs

The 8th cranial nerve. It consists of 2 branches: the vestibular nerve (concerned with balance) and the cochlear nerve (concerned with hearing). Each vestibulocochlear nerve (1 on each side) carries sensory impulses from the inner ear to the brain, which it enters between the pons and medulla oblongata (in the brainstem).

A tumour of the cells that surround the vestibulocochlear nerve (see acoustic neuroma) may cause loss of balance, tinnitus, and deafness.

Deafness may also result from damage to the nerve, which may be due to an infection, such as meningitis or encephalitis, or to a reaction to a drug such as streptomycin.... vestibulocochlear nerve

been recognised from earliest times. Evidence of the condition has been found in Egyptian mummies; in the fourth century BC Hippocrates, the Greek physician, called it phthisis because of the lung involvement; and in 1882 Koch announced the discovery of the causative organism, the tubercle bacillus or Mycobacterium tuberculosis.

The symptoms depend upon the site of the infection. General symptoms such as fever, weight loss and night sweats are common. In the most common form of pulmonary tuberculosis, cough and blood-stained sputum (haemoptysis) are common symptoms.

The route of infection is most often by inhalation, although it can be by ingestion of products such as infected milk. The results of contact depend upon the extent of the exposure and the susceptibility of the individual. Around 30 per cent of those closely exposed to the organism will be infected, but most will contain the infection with no signi?cant clinical illness and only a minority will go on to develop clinical disease. Around 5 per cent of those infected will develop post-primary disease over the next two or three years. The rest are at risk of reactivation of the disease later, particularly if their resistance is reduced by associated disease, poor nutrition or immunosuppression. In developed countries around 5 per cent of those infected will reactivate their healed tuberculosis into a clinical problem.

Immunosuppressed patients such as those infected with HIV are at much greater risk of developing clinical tuberculosis on primary contact or from reactivation. This is a particular problem in many developing countries, where there is a high incidence of both HIV and tuberculosis.

Diagnosis This depends upon identi?cation of mycobacteria on direct staining of sputum or other secretions or tissue, and upon culture of the organism. Culture takes 4–6 weeks but is necessary for di?erentiation from other non-tuberculous mycobacteria and for drug-sensitivity testing. Newer techniques involving DNA ampli?cation by polymerase chain reaction (PCR) can detect small numbers of organisms and help with earlier diagnosis.

Treatment This can be preventative or curative. Important elements of prevention are adequate nutrition and social conditions, BCG vaccination (see IMMUNISATION), an adequate public-health programme for contact tracing, and chemoprophylaxis. Radiological screening with mass miniature radiography is no longer used.

Vaccination with an attenuated organism (BCG – Bacillus Calmette Guerin) is used in the United Kingdom and some other countries at 12–13 years, or earlier in high-risk groups. Some studies show 80 per cent protection against tuberculosis for ten years after vaccination.

Cases of open tuberculosis need to be identi?ed; their close contacts should be reviewed for evidence of disease. Adequate antibiotic chemotherapy removes the infective risk after around two weeks of treatment. Chemoprophylaxis – the use of antituberculous therapy in those without clinical disease – may be used in contacts who develop a strong reaction on tuberculin skin testing or those at high risk because of associated disease.

The major principles of antibiotic chemotherapy for tuberculosis are that a combination of drugs needs to be used, and that treatment needs to be continued for a prolonged period – usually six months. Use of single agents or interrupted courses leads to the development of drug resistance. Serious outbreaks of multiply resistant Mycobacterium tuberculosis have been seen mainly in AIDS units, where patients have greater susceptibility to the disease, but also in developing countries where maintenance of appropriate antibacterial therapy for six months or more can be di?cult.

Streptomycin was the ?rst useful agent identi?ed in 1944. The four drugs used most often now are RIFAMPICIN, ISONIAZID, PYRAZINAMIDE and ETHAMBUTOL. Three to four agents are used for the ?rst two months; then, when sensitivities are known and clinical response observed, two drugs, most often rifampicin and isoniazid, are continued for the rest of the course. Treatment is taken daily, although thrice-weekly, directly observed therapy is used when there is doubt about the patient’s compliance. All the antituberculous agents have a range of adverse effects that need to be monitored during treatment. Provided that the treatment is prescribed and taken appropriately, response to treatment is very good with cure of disease and very low relapse rates.... nature of the disease tuberculosis has

Herbs that stimulate the body’s immune system to withstand infection. Alternatives to anti-bacterial substances obtained from micro-organisms as penicillin, streptomycin etc. Those from herbs do not destroy beneficial bacteria normally present in the intestines, neither does the body get used to them.

Some essential oils are natural antibiotics. Others: Blue Flag root, Buchu, Chaparral, Butterbur, Echinacea, Feverfew, Garlic, Goldenseal, Holy Thistle, Horse Radish (Vogel), Juniper berries, Myrrh, Nasturtium, Poke root, Red Clover, Watercress (Vogel), Wild Indigo, Wild Thyme.

Vitamin C is a powerful antibiotic (1-2g daily).

ANTI-INFLAMMATORIES. A group of agents known to reduce inflammation. Action is not to suppress but to enable tissue to return to normal on the strength of its own resources. Some members of the group are helpful for chronic conditions such as polyarthritis and rheumatism caused by a sub-acute inflammation going on quietly over a long time. Others work by blocking prostaglandin synthesis. General. Chamomile (German, Roman), Cowslip root, Fennel, Feverfew, Heartsease, Mistletoe, Turmeric, Yellow Dock.

Specific. Bistort (bowel). Comfrey (bones). Devil’s Claw (muscles). St John’s Wort (nerve tissue). Lignum vitae (rheumatic joints). Poke root (lymph vessels). Eyebright (conjunctivitis: topical as an eye lotion). Horsechestnut (anus). Bogbean (liver and gall bladder).

Steroid-like action. Ginseng, Black Cohosh, Black Haw, Liquorice, Wild Yam.

Aspirin-like action. Birch, Black Willow bark, Meadowsweet, White Poplar bark, White Willow bark, Wintergreen.

Some types of inflammation may be reduced by herbs that stimulate the eliminatory organs – lungs, bowel, skin and kidneys. A timely enema may reduce a high temperature with inflammation, to expel toxins and unload an over-loaded bowel; (Dandelion root, Parsley root, Sarsaparilla).

ANTI-INFLAMMATION FORMULA. (Biostrath). Drops containing cultures combined with extracts derived from medicinal plants possessing known therapeutic properties: Arnica, Bryony, Balm, Chamomile, Horseradish, Marigold, Hypericum, Echinacea.

Indications: colic, inflammation of the alimentary tract. ... anti-infectives

an infectious disease caused by Calymmatobacterium granulomatis, which is transmitted during sexual intercourse. A pimply rash on and around the genital organs develops into a granulomatous ulcer. The disease responds to treatment with tetracyclines and streptomycin.... granuloma inguinale

Though the Black Death is supposed to have passed into medical history, occasional cases are recorded which give rise to the question: “Could it really come again?”

In an atomic age the collapse of medical services provided by governments is not far removed from the bounds of possibility. Wars come and go, medical fashions change, what is regarded as scientific today, may be neglected to tomorrow’s superstition. It is possible this book may be consulted long after 20th century medicine has had its day.

The preventative remedy of history is Garlic. It was given to workers on the Great Pyramid of Cheops as a known antiseptic and prophylactic against infection. A riot ensued when supplies ran out. During the Great Plague under Charles II a colony of people escaped death, living to reveal their secret – all were in the habit of eating Garlic. It was later confirmed that the plague was not found in houses in which Garlic had been consumed.

The disease is spread by fleas from the black rat by the organism: bacillus pestis. Incubation period is two to five days, followed by severe headache, shivering, dizziness, fever and rapid pulse. Before delirium, the patient may have the ‘staggers’ and confused speech.

Glands of the body enlarge and may suppurate. Suppuration is a welcome sign indicating speedy elimination of pus. Haemorrhagic spots break out on the skin.

The most dangerous type is that which affects the lungs, known as ‘pneumonic’ and which is highly infectious; characterised by cyanosis (blueness of the face).

Occasionally there are human cases of Bubonic Plague in California and the West but today they seldom prove fatal. Public health officials point out that the incidence of the disease in China and Vietnam is lower than for centuries because of vaccine therapy. Wild animals still spread sporadic cases of the Plague.

Treatment: Health Authorities to be notified immediately and patient isolated. All bedding and personal effects to be destroyed or disinfected. Specialised nursing necessary. If hospital care is not available, the patient should receive treatment for collapse (Capsicum, Ginger or other circulatory stimulants).

In the absence of streptomycin and tetracycline, to which the organism yersinia is sensitive, powerful alternatives may assist: Echinacea, Wild Indigo, Poke root, Queen’s Delight, Sarsaparilla, Yellow Parilla, Goldenseal, Prickly Ash.

Topical. Poultice of Slippery Elm, Marshmallow, or both combined to promote suppuration. History records pulped fresh Plantain leaves.

To be treated by general medical practitioner or Infectious Diseases consultant. ... bubonic plague

n. a genus of aerobic mouldlike bacteria. Most species live in the soil, but some are parasites of animals, humans, and plants; in humans they cause *Madura foot. They are important medically as a source of such antibiotics as *streptomycin, *neomycin, *dactinomycin, and *chloramphenicol.... streptomyces

(TB) n. an infectious disease caused by the bacillus Mycobacterium tuberculosis (first identified by Koch in 1882) and characterized by the formation of nodular lesions (tubercles) in the tissues.

In pulmonary tuberculosis – formerly known as consumption and phthisis (wasting) – the bacillus is inhaled into the lungs where it sets up a primary tubercle and spreads to the nearest lymph nodes (the primary complex). Natural immune defences may heal it at this stage; alternatively the disease may smoulder for months or years and fluctuate with the patient’s resistance. Many people become infected but show no symptoms. Others develop a chronic infection and can transmit the bacillus by coughing and sneezing. Symptoms of the active disease include fever, night sweats, weight loss, and the spitting of blood. In some cases the bacilli spread from the lungs to the bloodstream, setting up millions of tiny tubercles throughout the body (miliary tuberculosis), or migrate to the meninges to cause tuberculous *meningitis. Bacilli entering by the mouth, usually in infected cows’ milk, set up a primary complex in abdominal lymph nodes, leading to *peritonitis, and sometimes spread to other organs, joints, and bones (see Pott’s disease).

Tuberculosis is curable by various combinations of the antibiotics *streptomycin, *ethambutol, *isoniazid (INH), *rifampicin, and *pyrazinamide. Preventive measures in the UK include the detection of cases by X-ray screening of vulnerable populations and vaccination with *BCG vaccine of those with no immunity to the disease (the *tuberculin test identifies which people require vaccination). The childhood immunization schedule no longer includes BCG vaccination at 10–14 years of age; vaccination now targets high-risk groups, such as immigrants from countries with a high incidence of TB. There has been a resurgence of tuberculosis in recent years in association with HIV infection. The number of patients with multidrug resistant TB has also increased due to patients not completing drug courses. Many centres have introduced directly observed therapy (DOT), in which nurse practitioners watch patients taking their drugs or administer the drugs.... tuberculosis