n. 1. (in psychoanalysis) the replacement of one idea by another: a form of *defence mechanism. 2. (symptom substitution) (in psychology) the supposed process whereby removing one psychological symptom leads to another symptom appearing if the basic psychological cause has not been removed. It is controversial whether this happens. 3. the replacement of one addictive and dangerous drug with another that is better controlled and easier to manage, with the aim of harm reduction.