has been used in combination with TRIMETHOPRIM (as co-trimoxazole) to treat infections of the URINARY TRACT. Increasing bacterial resistance to sulphonamides and the incidence of side-effects means that caution is needed in prescribing co-trimoxazole.
(sulphamethoxazole) n. see co-trimoxazole; sulphonamide.
n. an antibacterial drug that is active against a range of microorganisms; it is used mainly in the treatment of chronic urinary-tract infections and respiratory-tract infections. Long-term treatment may cause anaemia due to deficiency of folate, with which the drug interacts (see dihydrofolate reductase inhibitor). Trimethoprim is also administered in a combined preparation with sulfamethoxazole (see co-trimoxazole) but is now more usually prescribed alone, because of the severity of the side-effects of co-trimoxazole.... trimethoprim