n. a *protein kinase inhibitor used for the treatment of advanced renal cell carcinoma. It targets a serine threonine kinase that regulates a signalling cascade controlling cell proliferation. Side-effects include hypersensitivity reactions (flushing, chest pain, breathlessness).
an enzyme that catalyses the transfer of a phosphate group from ATP to a specific amino acid residue of an intracellular protein (usually serine, threonine, or tyrosine), thereby affecting the biological activity of the protein. Protein kinase inhibitors are drugs that block the action of protein kinases in tumour cells and are used in the treatment of cancer. They include *sorafenib, *sunitinib, and *temsirolimus. See also tyrosine kinase inhibitor.... protein kinase
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