Thallium-technetium Isotope Subtraction Imaging: From 1 Different Sources
a technique to image the parathyroid glands. Technetium is taken up only by the thyroid gland, but thallium is taken up by both the thyroid and parathyroid glands. *Digital subtraction of the two isotopes leaves an image of the parathyroid glands alone. It is an accurate technique (90%) for the identification of adenomas of the parathyroid glands secreting excess hormone.
This is a form of a chemical element with the same chemical properties as other forms, but which has a di?erent atomic mass. It contains an identical number of positively charged particles called protons, in the nucleus, giving it the same atomic number, but the numbers of neutrons di?er. A radioactive isotope, or radionuclide, is one that decays into other isotopes, and in doing so emits alpha, beta or gamma radiation.
Applications of radionuclides to diagnosis The use of radionuclides in diagnosis is based on the fact that it is possible to tag many of the substances normally present in the body with a radioactive label. Certain synthetic radioactive elements, such as technetium, can also be used. Because it is possible to detect minute quantities of radioactive material, only very small doses are needed, making the procedure a safe one. Furthermore the body pool of the material is therefore not appreciably altered, and metabolism is not disturbed. Thus in studies of iodine metabolism the ratio of radioactive atoms administered to stable atoms in the body pool is of the order of 1:1,000 million. By measuring radioactivity in the body, in blood samples, or in the excreta it is possible to gain information about the fate of the labelled substance, and hence of the chemically identical inactive material. Therefore it is theoretically possible to trace the absorption, distribution and excretion of any substance normally present in the body, provided that it can be tagged with a suitable radioactive label.
If the investigation necessitates tracing the path of the material through the body by means of external counting over the body surface, it is obviously essential to use an isotope that emits gamma radiation or positrons. If, however, only measurements on blood sample or excreta are required, it is possible to use pure beta emitters. Whole-body counters measure the total radioactivity in the body, and these are of great value in absorption studies.
Moving images can provide information on body functions such as the movements of the heart, blood ?ow, bile ?ow in the liver, and urine in the kidneys. The development of COMPUTED TOMOGRAPHY or CT scanning has replaced radionuclide scanning for some imaging procedures.
Five main groups of diagnostic uses may be de?ned:
(1) METABOLIC STUDIES The use of radioactive materials in metabolic studies is based on the fundamental property that all isotopes of an element are chemically identical. The radioactive isotope is used as a true isotope tracer – that is, when introduced into the body (in whatever form) it behaves in the same way as the inactive element. For example, isotopes of iodine are used to measure thyroid function (see THYROID GLAND), and isotopes of calcium enable kinetic studies of bone formation and destruction to be performed.... isotope
See MRI.... magnetic resonance imaging
See MRI.... magnetic resonance imaging(mri)
An ISOTOPE of the arti?cial element technetium. It emits gamma rays and is used as a tracer in building up a scintigraphic radioactive image of organs such as the brain.... technetium-99
See angiography.... digital subtraction angiography
See barium X-ray examinations.... intestinal imaging
See radionuclide scanning.... isotope scanning
See barium X-ray examinations.... stomach imaging
Techniques for visualizing the kidneys, usually performed for diagnosis. Ultrasound scanning can be used to identify kidney enlargement, a cyst or tumour, and the site of any blockage. Conventional X-rays show the outline of the kidneys and most kidney stones. Intravenous urography shows the internal anatomy of the kidney and ureters. Angiography is used to image blood circulation through the kidneys. CT scanning and MRI provide detailed cross-sectional images and can show abscesses or tumours. Two types of radionuclide scanning are used for the kidney: DMSA and DTPA scanning. DMSA is a substance given by intravenous injection that binds to cells in the kidney tubule, giving a single, static picture of the kidneys. DTPA, also given intravenously, is filtered in the kidneys and passes out in the urine. Pictures taken at intervals record its passage through the urinary tract and show kidney function. ... kidney imaging
A radioactive element used in radionuclide scanning.... technetium
see Doppler ultrasound.... colour flow ultrasound imaging
any technique that produces an image in the form of a section through the body with the structures cut across. The main techniques are *ultrasonography, *computerized tomography, *magnetic resonance imaging, and some *nuclear medicine techniques (see positron emission tomography; SPECT scanning). If a series of thin-section images is stacked they can be ‘cut’ through to show other planes or allow reconstruction of three-dimensional images.... cross-sectional imaging
a variant of *diffusion weighted imaging in which both the direction and the amount of diffusion of water molecules in a tissue are coded in the image. This MRI technique can be valuable in linear structures, such as nerves and muscle fibres. In the brain the major tracts and their communications can be studied with this technique (see tractography).... diffusion tensor imaging
a method of creating images by *magnetic resonance imaging that relies on the amount of available space that individual water molecules have to move in, which depends on the local microstructure. Pathological tissues generally are less organized, with more space for diffusion and a higher signal.... diffusion weighted imaging
(DSI) the production of static images using an *image intensifier, usually during a fluoroscopic examination. The images can be stored digitally (see digitization) and either transferred to photographic film or viewed on a TV monitor.... digital spot imaging
see Doppler ultrasound.... duplex imaging
(fMRI) a type of *magnetic resonance imaging that measures the increased hemodynamic response seen with neural activity in the brain or spinal cord. fMRI has allowed major advances in brain mapping (i.e. matching sections of the brain with particular behaviours, thoughts, or emotions).... functional magnetic resonance imaging
see co-registration.... fusion imaging
n. (in radiology) the production of images of organs or tissues by a range of techniques. These images are used by physicians in diagnosis and in monitoring the effects of treatment. They can also be used to guide *interventional radiology techniques. See also computerized tomography; magnetic resonance imaging; ultrasonography.... imaging
a radiological technique that enhances visualization of blood vessels (see angiography). A digitized image is taken before the contrast medium (a ‘mask’) is injected, and this is subtracted by computer from the images taken after contrast injection. Only the blood vessels remain on the image. The technique enables blood-vessel anatomy and blood supply to an organ to be demonstrated more clearly. The quality of the image is very dependent on the patient remaining still, since movement causes severe loss of image (movement *artifact). The technique can also be used in nuclear medicine using two different tracers to look for parathyroid gland tumours.... digital subtraction
an emerging area of imaging that exploits recent developments of molecular and cell biology to create new markers. Most molecular imaging uses versions of these markers labelled with radioactive isotopes, which – after administration – are localized in the body and can be detected using such techniques as *positron emission tomography, *SPECT scanning, *magnetic resonance imaging, and optical imaging.... molecular imaging
the rapid acquisition and manipulation of ultrasound information from a scanning probe by electronic circuits to enable images to be produced on TV screens almost instantaneously. The operator can place the scanning probe accurately on the region of interest in order to observe its structure and appreciate moving structures within it (see Doppler ultrasound). Using similar techniques, the instantaneous display of other imaging modalities, such as *computerized tomography scanning and *magnetic resonance imaging, can now be achieved. Real-time imaging is useful in guiding *interventional radiology procedures, for example, allowing a needle to be guided accurately as it is passed into the body. It is also useful for observing dynamic physiological activity.... real-time imaging
n. an isotope of the artificial radioactive element technetium. It emits gamma radiation only, with no beta particles, at a convenient energy for detection by a *gamma camera and has a short half-life. For these reasons it is widely used in nuclear medicine as a *tracer for the examination of many organs (see scintigram). Symbol: Tc-99m.... technetium-99m
see myocardial perfusion scan.... thallium scan
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