Thiamine Health Dictionary

(Singhalese: beri = extreme weakness.) Formerly a major health problem in many Asian countries, beriberi is a nutritional de?ciency disease resulting from prolonged de?ciency of the water-soluble vitamin, THIAMINE (vitamin B1). It is often associated with de?ciencies of other members of the the vitamin B complex (see APPENDIX 5: VITAMINS). A major public-health problem in countries where highly polished rice constitutes the staple diet, beriberi also occurs sporadically in alcoholics (see WERNICKE’S ENCEPHALOPATHY) and in people suffering from chronic malabsorptive states. Clinical symptoms include weakness, paralysis – involving especially the hands and feet (associated with sensory loss, particularly in the legs) – and ‘burning sensations’ in the feet (dry beriberi). Alternatively, it is accompanied by oedema, palpitations and a dilated heart (wet beriberi). Death usually results from cardiac failure. Thiamine de?ciency can be con?rmed by estimating erythrocyte transketolase concentration; blood and urine thiamine levels can be measured by high-pressure liquid chromatography.

Treatment consists of large doses of vitamin B1 – orally or intramuscularly; a diet containing other vitamins of the B group; and rest.

Infantile beriberi This is the result of maternal thiamine de?ciency; although the mother is not necessarily affected, the breast-fed baby may develop typical signs (see above). Optic and third cranial, and recurrent laryngeal nerves may be affected; encephalopathy can result in convulsions, coma and death.... beriberi

A colourless liquid, also called ethanol or ethyl-alcohol, produced by the fermentation of carbohydrates by yeast. Medically, alcohol is used as a solvent and an antiseptic; recreationally it is a widely used drug, taken in alcoholic drinks to give a pleasant taste as well as to relax, reduce inhibitions, and increase sociability. Taken to excess, alcohol causes much mental and physical harm – not just to the individual imbibing it, but often to their family, friends, community and work colleagues.

Alcohol depresses the central nervous system and disturbs both mental and physical functioning. Even small doses of alcohol will slow a person’s re?exes and concentration; potentially dangerous effects when, for example, driving or operating machinery. Drunkenness causes slurred speech, muddled thinking, amnesia (memory loss), drowsiness, erectile IMPOTENCE, poor coordination and dulled reactions – thereby making driving or operating machinery especially dangerous. Disinhibition may lead to extreme euphoria, irritability, misery or aggression, depending on the underlying mood at the start of drinking. Severe intoxication may lead to COMA and respiratory failure.

Persistent alcohol misuse leads to physical, mental, social and occupational problems, as well as to a risk of DEPENDENCE (see also ALCOHOL DEPENDENCE). Misuse may follow several patterns: regular but controlled heavy intake, ‘binge’ drinking, and dependence (alcoholism). The ?rst pattern usually leads to mainly physical problems such as gastritis, peptic ulcer, liver disease, heart disease and impotence. The second is most common among young men and usually leads to mainly social and occupational problems – getting into ?ghts, jeopardising personal relationships, overspending on alcohol at weekends, and missing days o? work because of hangovers. The third pattern – alcohol dependence – is the most serious, and can severely disrupt health and social stability.

Many researchers consider alcohol dependence to be an illness that runs in families, with a genetic component which is probably passed on as a vulnerable personality. But it is hard to disentangle genetic, environmental and social factors in such families. In the UK there are estimated to be around a million people suffering from alcohol dependence and a similar number who have di?culty controlling their consumption (together about 1:30 of the population).

Alcohol causes tolerance and both physical and psychological dependence (see DEPENDENCE for de?nitions). Dependent drinkers classically drink early in the morning to relieve overnight withdrawal symptoms. These symptoms include anxiety, restlessness, nausea and vomiting, and tremor. Sudden withdrawal from regular heavy drinking can lead to life-threatening delirium tremens (DTs), with severe tremor, hallucinations (often visual – seeing spiders and monsters, rather than the pink elephants of romantic myth), and CONVULSIONS. This must be treated urgently with sedative drugs, preferably by intravenous drip. Similar symptoms, plus severe INCOORDINATION and double-vision, can occur in WERNICKE’S ENCEPHALOPATHY, a serious neurological condition due to lack of the B vitamin thiamine (whose absorption from the stomach is markedly reduced by alcohol). If not treated urgently with injections of thiamine and other vitamins, this can lead to an irreversible form of brain damage called Korsako?’s psychosis, with severe amnesia. Finally, prolonged alcohol misuse can cause a form of dementia.

In addition to these severe neurological disorders, the wide range of life-threatening problems caused by heavy drinking includes HEPATITIS, liver CIRRHOSIS, pancreatitis (see PANCREAS, DISEASES OF), gastrointestinal haemorrhage, suicide and FETAL ALCOHOL SYNDROME; pregnant women should not drink alcohol as this syndrome may occur with more than a glass of wine or half-pint of beer a day. The social effects of alcohol misuse – such as marital breakdown, family violence and severe debt – can be equally devastating.

Treatment of alcohol-related problems is only moderately successful. First, many of the physical problems are treated in the short term by doctors who fail to spot, or never ask about, heavy drinking. Second, attempts at treating alcohol dependence by detoxi?cation or ‘drying out’ (substituting a tranquillising drug for alcohol and withdrawing it gradually over about a week) are not always followed-up by adequate support at home, so that drinking starts again. Home support by community alcohol teams comprising doctors, nurses, social workers and, when appropriate, probation o?cers is a recent development that may have better results. Many drinkers ?nd the voluntary organisation Alcoholics Anonymous (AA) and its related groups for relatives (Al-Anon) and teenagers (Alateen) helpful because total abstinence from alcohol is encouraged by intensive psychological and social support from fellow ex-drinkers.

Useful contacts are: Alcoholics Anonymous; Al-Anon Family Groups UK and Eire (including Alateen); Alcohol Concern; Alcohol Focus Scotland; and Alcohol and Substance Misuse.

1 standard drink =1 unit

=••• pint of beer

=1 measure of spirits

=1 glass of sherry or vermouth

=1 glass of wine

Limits within which alcohol is believed not to cause long-term health risks:... alcohol

Aneurine is an alternative name for vitamin B1. (See THIAMINE.)... aneurine

(Cocoa, milk chocolate, sweet chocolate)

Nutritional Profile Energy value (calories per serving): Moderate Protein: Low (cocoa powder) High (chocolate) Fat: Moderate Saturated fat: High Cholesterol: None Carbohydrates: Low (chocolate) High (cocoa powder) Fiber: Moderate (chocolate) High (cocoa powder) Sodium: Moderate Major vitamin contribution: B vitamins Major mineral contribution: Calcium, iron, copper

About the Nutrients in This Food Cocoa beans are high-carbohydrate, high-protein food, with less dietary fiber and more fat than all other beans, excepting soy beans. The cocoa bean’s dietary fiber includes pectins and gums. Its proteins are limited in the essential amino acids lysine and isoleucine. Cocoa butter, the fat in cocoa beans, is the second most highly saturated vegetable fat (coconut oil is number one), but it has two redeeming nutritional qualities. First, it rarely turns rancid. Second, it melts at 95°F, the temperature of the human tongue. Cocoa butter has no cholesterol; neither does plain cocoa powder or plain dark chocolate. Cocoa beans have B vitamins (thiamine, riboflavin, niacin) plus min- erals (iron, magnesium, potassium, phosphorus, and copper). All chocolate candy is made from chocolate liquor, a thick paste pro- duce by roasting and grinding cocoa beans. Dark (sweet) chocolate is made of chocolate liquor, cocoa butter, and sugar. Milk chocolate is made of choc- olate liquor, cocoa butter, sugar, milk or milk powder, and vanilla. White * These values apply to plain cocoa powder and plain unsweetened chocolate. Add- ing other foods, such as milk or sugar, changes these values. For example, there is no cholesterol in plain bitter chocolate, but there is cholesterol in milk chocolate. chocolate is made of cocoa butter, sugar, and milk powder. Baking chocolate is unsweetened dark chocolate. The most prominent nutrient in chocolate is its fat. Fat Content in One Ounce of Chocolate

	Saturated fat (g)	Monounsaturated fat (g)	Polyunsaturated fat (g)	Cholesterol (mg)
Dark (sweet)
chocolate	5.6	3.2	0.3	0
Milk chocolate	5.9	4.5	0.4	6.6
Baking chocolate	9	5.6	0.3	0
White chocolate	5.5	2.6	0.3	0

  Source: USDA Nut rient Data Laborator y. Nat ional Nut rient Database for Standard Reference. Available online. UR L : http://w w w.nal.usda.gov/fnic/foodcomp/search /. Because chocolate is made from a bean, it also contains dietary fiber and measurable amounts of certain minerals. For example, one ounce of dark chocolate, the most nutritious “eating” chocolate, has 1.6 g dietary fiber, 0.78 mg iron (4 percent of the R DA for a woman, 10 percent of the R DA for a man), 32 mg magnesium (11 percent of the R DA for a woman, 8 percent of the R DA for a man), and .43 mg zinc (5 percent of the R DA for a woman, 4 percent of the R DA for a man). Cocoa beans, cocoa, and chocolate contain caffeine, the muscle stimulant theobro- mine, and the mood-altering chemicals phenylethylalanine and anandamide (see below).

The Most Nutritious Way to Serve This Food With low-fat milk to complete the proteins without adding saturated fat and cholesterol. NOTE : Both cocoa and chocolate contain oxalic acid, which binds with calcium to form cal- cium oxalate, an insoluble compound, but milk has so much calcium that the small amount bound to cocoa and chocolate hardly matters. Chocolate skim milk is a source of calcium.

Diets That May Restrict or Exclude This Food Antiflatulence diet Low-calcium and low-oxalate diet (to prevent the formation of calcium oxalate kidney stones) Low-calorie diet Low-carbohydrate diet Low-fat diet Low-fat, controlled-cholesterol diet (milk chocolates) Low-fiber diet Potassium-regulated (low-potassium) diet

Buying This Food Look for: Tightly sealed boxes or bars. When you open a box of chocolates or unwrap a candy bar, the chocolate should be glossy and shiny. Chocolate that looks dull may be stale, or it may be inexpensively made candy without enough cocoa butter to make it gleam and give it the rich creamy mouthfeel we associate with the best chocolate. (Fine chocolate melts evenly on the tongue.) Chocolate should also smell fresh, not dry and powdery, and when you break a bar or piece of chocolate it should break cleanly, not crumble. One exception: If you have stored a bar of chocolate in the refrigerator, it may splinter if you break it without bringing it to room temperature first.

Storing This Food Store chocolate at a constant temperature, preferably below 78°F. At higher temperatures, the fat in the chocolate will rise to the surface and, when the chocolate is cooled, the fat will solidif y into a whitish powdery bloom. Bloom is unsightly but doesn’t change the chocolate’s taste or nutritional value. To get rid of bloom, melt the chocolate. The chocolate will turn dark, rich brown again when its fat recombines with the other ingredients. Chocolate with bloom makes a perfectly satisfactory chocolate sauce. Dark chocolate (bitter chocolate, semisweet chocolate) ages for at least six months after it is made, as its flavor becomes deeper and more intense. Wrapped tightly and stored in a cool, dry cabinet, it can stay fresh for a year or more. Milk chocolate ages only for about a month after it is made and holds its peak flavor for about three to six months, depending on how carefully it is stored. Plain cocoa, with no added milk powder or sugar, will stay fresh for up to a year if you keep it tightly sealed and cool.

What Happens When You Cook This Food Chocolate burns easily. To melt it without mishap, stir the chocolate in a bowl over a pot of hot water or in the top of a double boiler or put the chocolate in a covered dish and melt it in the microwave (which does not get as hot as a pot on the store). Simple chemistry dictates that chocolate cakes be leavened with baking soda rather than baking powder. Chocolate is so acidic that it will upset the delicate balance of acid (cream of tartar) and base (alkali = sodium bicarbonate = baking soda) in baking powder. But it is not acidic enough to balance plain sodium bicarbonate. That’s why we add an acidic sour-milk product such as buttermilk or sour cream or yogurt to a chocolate cake. Without the sour milk, the batter would be so basic that the chocolate would look red, not brown, and taste very bitter.

How Other Kinds of Processing Affect This Food Freezing. Chocolate freezes and thaws well. Pack it in a moistureproof container and defrost it in the same package to let it reabsorb moisture it gave off while frozen.

Medical Uses and/or Benefits Mood elevator. Chocolate’s reputation for making people feel good is based not only on its caffeine content—19 mg caffeine per ounce of dark (sweet) chocolate, which is one-third the amount of caffeine in a five-ounce cup of brewed coffee—but also on its naturally occurring mood altering chemicals phenylethylalanine and anandamide. Phenylethylalanine is found in the blood of people in love. Anandamide stimulates areas of your brain also affected by the active ingredients in marijuana. (NOTE : As noted by the researchers at the Neurosci- ences Institute in San Diego who identified anandamide in chocolate in 1996, to get even the faintest hint of marijuana-like effects from chocolate you would have to eat more than 25 pounds of the candy all at once.) Possible heart health benefits. Chocolate is rich in catechins, the antioxidant chemicals that give tea its reputation as a heart-protective anticancer beverage (see tea). In addition, a series of studies beginning with those at the USDA Agricultural Research Center in Peoria, Illinois, suggest that consuming foods rich in stearic acid like chocolate may reduce rather than raise the risk of a blood clot leading to a heart attack. Possible slowing of the aging process. Chocolate is a relatively good source of copper, a mineral that may play a role in slowing the aging process by decreasing the incidence of “protein glycation,” a reaction in which sugar molecules ( gly = sugar) hook up with protein molecules in the bloodstream, twisting the protein molecules out of shape and rendering them unusable. This can lead to bone loss, rising cholesterol, cardiac abnormalities, and a slew of other unpleasantries. In people with diabetes, excess protein glycation may be one factor involved in complications such as loss of vision. Ordinarily, increased protein glyca- tion is age-related. But at the USDA Grand Forks Human Nutrition Research Center in North Dakota, agricultural research scientist Jack T. Saari has found that rats on copper-deficient diets experience more protein glycation at any age than other rats. A recent USDA survey of American eating patterns says that most of us get about 1.2 mg copper a day, considerably less than the Estimated Safe and Adequate Daily Dietary Intake (ESADDI) or 1.5 mg to 3 mg a day. Vegetarians are less likely to be copper deficient because, as Saari notes, the foods highest in copper are whole grains, nuts, seeds, and beans, including the cocoa bean. One ounce of dark chocolate has .25 mg copper (8 –17 percent of the ESADDI).

Adverse Effects Associated with This Food Possible loss of bone density. In 2008, a team of Australian researchers at Royal Perth Hos- pital, and Sir Charles Gairdner Hospital published a report in the American Journal of Clinical Nutrition suggesting that women who consume chocolate daily had 3.1 percent lower bone density than women who consume chocolate no more than once a week. No explanation for the reaction was proposed; the finding remains to be confirmed. Possible increase in the risk of heart disease. Cocoa beans, cocoa powder, and plain dark chocolate are high in saturated fats. Milk chocolate is high in saturated fats and cholesterol. Eating foods high in saturated fats and cholesterol increases the amount of cholesterol in your blood and raises your risk of heart disease. NOTE : Plain cocoa powder and plain dark chocolate may be exceptions to this rule. In studies at the USDA Agricultural Research Center in Peoria, Illinois, volunteers who consumed foods high in stearic acid, the saturated fat in cocoa beans, cocoa powder, and chocolate, had a lower risk of blood clots. In addition, chocolate is high in flavonoids, the antioxidant chemicals that give red wine its heart-healthy reputation. Mild jitters. There is less caffeine in chocolate than in an equal size serving of coffee: A five- ounce cup of drip-brewed coffee has 110 to 150 mg caffeine; a five-ounce cup of cocoa made with a tablespoon of plain cocoa powder ( 1/3 oz.) has about 18 mg caffeine. Nonetheless, people who are very sensitive to caffeine may find even these small amounts problematic. Allergic reaction. According to the Merck Manual, chocolate is one of the 12 foods most likely to trigger the classic food allergy symptoms: hives, swelling of the lips and eyes, and upset stomach.* The others are berries (blackberries, blueberries, raspberries, strawberries), corn, eggs, fish, legumes (green peas, lima beans, peanuts, soybeans), milk, nuts, peaches, pork, shellfish, and wheat (see wheat cer ea ls).

Food/Drug Interactions Monoamine oxidase (MAO) inhibitors. Monoamine oxidase inhibitors are drugs used to treat depression. They inactivate naturally occurring enzymes in your body that metabolize tyra- mine, a substance found in many fermented or aged foods. Tyramine constricts blood vessels and increases blood pressure. Caffeine is a substance similar to tyramine. If you consume excessive amounts of a caffeinated food, such as cocoa or chocolate, while you are taking an M AO inhibitor, the result may be a hypertensive crisis. False-positive test for pheochromocytoma. Pheochromocytoma, a tumor of the adrenal gland, secretes adrenalin, which the body converts to VM A (vanillylmandelic acid). VM A is excreted in urine, and, until recently, the test for this tumor measured the level of VM A in the urine. In the past, chocolate and cocoa, both of which contain VM A, were eliminated from the patient’s diet prior to the test lest they elevate the level of VM A in the urine and produce a false-positive result. Today, more finely drawn tests usually make this unnecessary. * The evidence link ing chocolate to allergic or migraine headaches is inconsistent. In some people, phenylet hylamine (PEA) seems to cause headaches similar to t hose induced by t yramine, anot her pressor amine. The PEA-induced headache is unusual in t hat it is a delayed react ion t hat usually occurs 12 or more hours after t he chocolate is eaten.... chocolate

The bean of Glycine soja, a leguminous plant related to peas and beans. It has a high protein and fat content. Starch is almost completely absent and there is much mineral matter, for example a variable but large amount of iron: 6·7 to 30 mg per 100 grams of soya ?our compared with 1 mg in white ?our and 3 mg in 100 grams of wholemeal ?our. It is a good source of thiamine and ribo?avine, and of vitamin A in the form of carotene. It is used in infant formulas, especially for those babies thought to have cows’ milk protein intolerance.... soya bean

Also called the Wernicke-Korsako? syndrome, this uncommon disorder is characterised by mental confusion or DELIRIUM that occurs in combination with an unsteady GAIT, nystagmus (see under EYE, DISORDERS OF), and paralysis of the eye muscles and eventually PSYCHOSIS. It is caused by a de?ciency of vitamin B1 (THIAMINE

– see APPENDIX 5: VITAMINS) which affects the brain and nervous system. It occurs in alcoholic individuals and in patients with persistent vomiting. As soon as the condition is diagnosed, it must be treated with large doses of thiamine. Unless the patient has developed symptoms of psychosis, the condition is usually reversible with treatment.... wernicke’s encephalopathy

Loss of ability to memorize information and/or to recall information stored in memory. Possible causes of amnesia are head injury; degenerative disorders such as Alzheimer’s disease and other forms of dementia; infections such as encephalitis; thiamine deficiency in alcoholics, leading to Wernicke– Korsakoff syndrome; brain tumours; strokes; and subarachnoid haemorrhage. Amnesia can also occur in some forms of psychiatric illness.

In retrograde amnesia, the loss of memory extends back for some time before the onset of the disorder.

In anterograde amnesia, there is an inability to store new information in the period following the onset of illness.... amnesia

(Linn.) O. Kuntze.

Family: Ranunculaceae.

Habitat: Western temperate Himalayas from 2,500 to 4,000 m.

English: American cowslip, Marsh Marigold, Water Buttercup.

Folk: Mamiri (Punjab).

Family: Theaceae.

Habitat: Cultivated in Assam, Darjeeling, Travancore, the Nilgiris, Malabar, Bengal, Dehra Dun and Kumaon.

English: Tea.

Unani: Chaai, Shaahi, Shaayi.

Siddha/Tamil: Thaeyilai.

Action: Stimulant, diuretic, astringent. In China, used for diarrhoea and dysentery (causes gastrointestinal upsets and nervous irritability when consumed in excess). Green tea: anticancer effects have been observed in Chinese green tea, Camellia thea, extract; the extract of Japanese green tea showed antihepatotoxic effects.

Important constituents of leaf buds and very young leaves are: caffeine, with a much smaller amount of other xanthines (theophylline and theo- bromine); tannins (the main tannin in green tea is (-)-epigallocatechin); flavonoids, quercetin, kaempferol. The stimulant and diuretic are due to caffeine content, the astringency due to the tannins.

Drinking tea lowers thiamine and thiamine diphosphate losses in urine and blood serum respectively but increases niacin losses. Hot water extract of black tea facilitates Ca absorption in the body experimentally. Tea may decrease zinc bioavailability.

The tea, if added to the meal, significantly lower the availability of iron. Milk is as effective as ascorbic acid in countering the depressing effect of tea on iron availability (in vitro).

The green tea catechin inhibited car- cinogenesis in small intestines when given during or after carcinogen treatment to experimental rats. (-)-epi- gallocatechin gallate and theaflavin di- gallate from green tea inhibited the in- fectivity of both influenza A and B virus (in vitro).

Green tea, when added to a lard- cholesterol diet, decreased the cholesterol and triglyceride levels in fowls. Tea polyphenols exhibit hypocholes- terolaemic activity.

Tea polyphenols—(-)-epicatechin gallate, (-)-epigallocatechine galate, theaflavin monogallate A or B, and or theaflavin digallate—are used for treating hyperglycaemia.

Saponins from tea are used as an- tiulcer agents.

Concurrent use of tea and beta- adrenergic agonists may increase the risk of cardiac arrhythmias. Caffeine, a component of tea, may increase insulin resistance. (Sharon M. Herr.)... camellia sinensis

Linn.

Family: Lauraceae

Habitat: Throughout the greater parts of India.

English: Doddar-Laurel, Love-Vine.

Ayurvedic: Amarvalli, Aakaashbel. (Cuscuta reflexa is also known as Amarvalli.)

Siddha/Tamil: Erumaikkottan.

Action: Astringent, diuretic (given in dropsy and anasarca, also in biliousness, chronic dysentery, haemoptysis and for supressing lactation after still-birth); piscicidal and insecticidal (used as a hair-wash for killing vermin).

The plant contains aporphine alkaloids. calcium, phosphorus, thiamine, riboflavin and niacin; also tocopherols. Nuts, crushed with vinegar and barley flour, are used against indurations of breast. The extract of nuts exhibits possibility of its use as a platelet inhibitor in thrombosis and atherosclerosis. Leaves are inhibitors of pectinolytic enzymes.

American chestnut and European chestnut are equated with Castanea dentata and C. sativa,respectively. Both are used for respiratory ailments.... cassytha filiformis

A state of confusion accompanied by trembling and vivid hallucinations.

It usually arises in alcoholics after withdrawal or abstinence from alcohol.

Early symptoms include restlessness, agitation, trembling, and sleeplessness.

The person may develop a rapid heartbeat, fever, and dilation of the pupils.

Sweating, confusion, hallucinations, and convulsions may also occur.

Treatment consists of rest, rehydration, and sedation.

Vitamin injections, particularly of thiamine (see vitamin B complex), may be given.... delirium tremens

an organic disorder affecting the brain that results in a memory defect in which new information fails to be learnt although events from the past are still recalled; *disorientation in time and place; and a tendency to unintentionally invent material to fill memory blanks (see confabulation). The commonest cause of the condition is untreated *Wernicke’s encephalopathy in the context of alcoholism. Large doses of thiamine are given as treatment. The condition often becomes chronic. [S. S. Korsakoff (1854–1900), Russian neurologist]... korsakoff’s syndrome

Horsetail (Equisetum species).

Plant Part Used: Leaf-stem.

Dominican Medicinal Uses: Leaves and stems: decoction, orally, for bladder, urinary tract or kidney infection, kidney stones, kidney ailments (general), infections (general), vaginal infections, menstrual cramps, to cleanse the blood and as a diuretic.

Safety: Considered safe when used appropriately; must be taken with plenty of water due to diuretic effect; high silica content may be toxic if plant is ingested.

Contraindications: Children, case of heart or kidney disorders.

Drug Interactions: Cardiac glycosides, digitalis (may enhance toxicity); thiamine (breaks down vitamin).

Clinical Data: Human clinical trials: diuretic (aqueous plant extract), metabolism effects and renal excretion (standardized extract).

Laboratory & Preclinical Data: In vivo: diuretic, anti-ulcer, gastroprotective, hypoglycemic (organic plant extracts).

In vitro: anti-platelet-aggregant, antimicrobial, contractile response enhancement, cytogenic, hepatoprotective, radical scavenging (plant extracts and constituents).

* See entry for Cola de caballo in “Part 3: Dominican Medicinal Plant Profiles” of this book for more information, including references.... cola de caballo

Linn.

Family: Iridaceae.

Habitat: Cultivated in Kashmir up to 2,000 m and in Chaubattia in Uttar Pradesh.

English: Saffron, Crocus.

Ayurvedic: Kumkuma, Rudhira, Vadrika, Kaashmira, Kaashmiraka, Vaalhika, Agnishikhaa, Ghrusrrn, Rakta, Kshataja. Keshara (usually Keshara indicates Naagakeshara, Mesuaferrea Linn.)

Unani: Zaafraan.

Siddha/Tamil: Kumgumappoo (dried stigma).

Action: Stigma and style—nervine tonic, sedative, antispasmodic expectorant (in dry cough, whooping cough, bronchitis), stomachic, diaphoretic, emmenagogue.

The Ayurvedic Pharmacopoeia of India indicated the use of the stigma and style in migraine, chronic sinusitis, and in urinary obstruction, inflammation of the urinary tract.

The saffron is used in Chinese medicine for melancholia, depression, shock and menstrual disorders.

Saffron contains a volatile oil composed of terpenes, terpene alcohols and esters. The herb also contains crocin, picrocrocin, crocetin, carotenoids and riboflavin and thiamine.

Preliminary evidence suggests that crocetin may improved atherosclerosis by increasing plasma oxygen diffusion and decreasing cholesterol and triglyceride levels. In addition, cro- cetin binds to albumin, potentially increasing oxygen diffusion and improving atherosclerosis. (Natural Medicines Comprehensive Database, 2007.)

The stigma showed remarkable inhibitory effect on blood coagulation due to the presence of platelet aggregation inhibitor containing adenosine. It accelerated in vitro fibrinolytic activity of urokinase and plasmin.

Small amounts of Saffron stimulate gastric secretion; larger amounts stimulate uterine smooth muscle and exhibit emmenagogue and abortifacient effects.

Saffron extract showed cytotoxic and antimutagenic activity and antitu- mour activity against ascites tumours in mice. Chemical analysis indicated that the naturally occurring crocin may be the active principle responsible for the observed anticancer activity.

A xanthone, carotenoid glycosidic conjugate, mangi-crocin, isolated from saffron, showed significant adapto- genic activity. A natural antioxidant, isolated from saffron stem callus, showed better antioxidant activity than vitamin E. Saffron bulbs are toxic, stigmas in overdoses narcotic.

The dose of stigma and styles at 1.55.0 g is toxic. (Recommended dose : 0.5-1.5 g per day).

Dosage: Dried style and stigma—20-50 mg (API Vol. IV.)... crocus sativus

Mill.

Synonym: C. vulgaris Pers.

Family: Rosaceae.

Habitat: Cultivated in Punjab, Kashmir and the Nilgiri hills.

English: Quince Fruit.

Ayurvedic: Amritaphala, Paatalaa, Simbitikaa.

Unani: Bihi, Bihidaanaa.

Siddha/Tamil: Shimaimathala.

Action: Fruit pulp and seeds— soothing and demulcent; used in irritable bowel syndrome, diarrhoea, dysentery, constipation, and in irritable conditions of the mucous membrane. Leaf, bud and bark—astringent. Fruit— expectorant. Mucilage—used externally for scalds, ulcers and burns.

The seed kernel contains the gly- coside amygdalin, tannin, mucilage (about 22%), ash (1.3%) and fatty oil (l4-19%).

In Greece, a tea prepared by boiling dry seeds in water is given in cystitis. The major water-soluble polysac- charide in the mucilage of seeds contains a high proportion of glucuronic acid residues.

The fruit contains pectin (yield 0.53% fresh weight) and is similar to that of apple. Ionone glycosides, along with octadienoic acid and its diol, have been isolated from the fruit.

Fruit juice contains thiamine, riboflavin, nicotinic acid, vitamin B6, inositol, pantothenic acid, folic acid and biotin.

The essential oil also gave a number of ionone-related compounds. The buds contain a cyanogenetic glycoside. The bark and shoots yield hydrocyanic acid on distillation.... cydonia oblonga

B1 (thiamine, aneurine) a vitamin of the B complex that is active in the form of thiamine pyrophosphate, a coenzyme in decarboxylation reactions in carbohydrate metabolism. A deficiency of vitamin B1 leads to *beriberi. Good sources of the vitamin are cereals, beans, meat, potatoes, and nuts. The adult RNI (see Dietary Reference Values) is 0.4 mg/1000 kcal of dietary calories eaten.... vitamin

mental confusion or delirium occurring in combination with paralysis of the eye muscles, *nystagmus, and an unsteady gait. It is caused by a deficiency of vitamin B1 (thiamine) and is most commonly seen in alcoholics and in patients with persistent vomiting or an unbalanced diet. Treatment with thiamine relieves the symptoms. [K. Wernicke (1848–1905), German neurologist]... wernicke’s encephalopathy

Gaertn.

Family: Gramineae; Poaceae.

Habitat: A grain crop of Karnataka; also grown on large scale in Tamil Nadu, Andhra Pradesh and Maharashtra.

English: Finger Millet, African millet, Ragi.

Ayurvedic: Madhuuli, Markata- hasta-trna.

Siddha/Tamil: Ragi, Kezhvaregu.

Action: Seeds—cooling, astringent. Nutritive value of ragi is higher than that of rice and equal to that of wheat. White ragi is superior to the pigmented type. A nourishing food for infants, growing children, expectant mothers and aged people. Ragi is considered an ideal food for diabetics because of slow release of sugars to the body. A decoction of leaves and stems is drunk to ease vaginal bleeding.

The protein content of ragi is 813%, with P 250, Fe 7.6, thiamine 0.18— and riboflavin 0.1 mg/100 g. Ragi has high glycemic index value. It reduced plasma cholesterol, total serum cholesterol and LDL cholesterol by 9% each, and triglycerides by 15%, and increased HDL cholesterol, thus exhibited a sig- nificantbeneficial effect on plasma profile. The lipemic index for ragi is 55, taking isocaloric wheat-supplemented background diet (control) at 100.... eleusine coracana

Allium sativum

Liliaceae

San: Lasunah, Rasonah;

Hin:Lasun, Lahasun;

Ben: Lashan;

Mal: Vellulli;

Kan: Belluli;

Tam: Vellaipuntu; Mar: Lasunas; Ass: Naharu; Tel:Vellulli, Tella-gadda;

Guj: Lasan

Importance: Garlic is one of the important bulb crops used as a spice or condiment with medicinal value throughout the world. It possesses high nutritive value. Its preparations are useful in vitiated conditions of kapha and vata, cough, whooping cough, bronchitis, asthma, fever, facial paralysis, flatulence, colic, constipation, atonic dyspepsia, helminthiasis, duodenal ulcers, pulmonary and laryngeal tuberculosis, opthalmopathy, cardiopathy, fatigue, leucoderma, leprosy, hysteria, haemorrhoids, sciatica, otalgia, lumbago, swellings, splenopathy, hepatopathy, pneumonopathy, anthralgia, sore eyes, ear ache and dental caries (Kumar et al, 1997).

Distribution: Garlic is a native of Southern Europe and it is cultivated all over the world.. It is grown throughout India; Gujarat and Orissa being the leading states.

Botany: The genus Allium of Liliaceae family comprises a number of species. The important ones are the following:

A. sativum Linn. syn. A. porrum Linn.

A. cepa Linn.

A. ampeloprasum Linn.

A. ascalonicum Linn. A. leptophyllum Wall. A. macleanii Baker.

A. schoenoprasum Linn.

A. tuberosum Roxb.

Allium sativum is a scapigerous foetid perennial medicinal herb with underground compound bulbs covered over by outer white thin scales and with simple smooth, round stem, surrounded at the bottom by tubular leaf sheath. The leaves are simple, long, flat and linear. The flowers are small and white arranged in rounded umbels mixed with small bulbils. The entire umbel is enclosed in a tear-drop-shaped membranous spathe. Flowers are usually sterile (Warrier et al, 1993).

Agrotechnology: Garlic can be grown under a wide range of climatic conditions. It prefers moderate temperature in summer as well as in winter. Short days are very favourable for the formation of bulbs. Garlic requires well drained loamy soils rich in humus, with fairly good content of potash. Garlic is propagated by cloves or bulblets. In the hills, sowing is done in April and May. Types with bold and compact cloves and thick white covering sheath are preferred for planting. Ootty-1 garlic is an improved variety by clonal selection released from TNAU, Coimbatore. Garlic may be broadcast, planted in furrows or dibbled at the rate of 150-200kg cloves/ha. In furrow planting, cloves are dropped 7.5-10cm apart in furrows 15cm deep and covered lightly with loose soil. Cloves may be dibbled 5 to 7.5cm deep and 7.5cm apart in rows which are 15cm apart with their growing end upwards and then covered with loose soil. A basal dose of 60kg N and 50kg each of P2O5 and K2O are applied along with 25t/ha of FYM. 60kg N is given as topdressing 45 days after planting. First irrigation is given immediately after sowing and subsequent irrigations are given at 10-15 days interval depending upon the soil moisture availability. The last irrigation should be given 2-3 days before harvesting to facilitate easy harvest and minimum damage to bulbs. First weeding and hoeing is to be done at one mo nth after sowing followed by a second weeding one month after first interculture. Hoeing at about two and a half months from sowing loosens the soil and helps in setting of bigger and well-filled bulbs. Garlic is attacked by Thrips tabacii which causes withering of leaves. Application of methyl demeton 25EC or dimethoate 30EC at 1ml/l will check the pest incidence. Leaf spot caused by Alternaria solanii can be controlled by spraying Dithane M.45 at fortnightly intervals at 2.5g/l of water. Garlic is harvested when the tops turn yellowish or brownish and show signs of drying up. The plants are uprooted, tied into small bundles and kept in shade for 2-3 days for curing. Average yield of garlic is 6-8t/ha. (Kumar et al, 1997.)

Properties and activity: Garlic bulb is reported to contain volatile oil, alliin (S-allyl-L-cysteine sulfoxide), S-methyl-L-cysteine sulfoxide and allinase. It is rich in vitamins like thiamine, riboflavine and niacin. Volatile oil contains allicin (diallyl thiosulphinate), an active odour principle of garlic. Other major compounds present are diallyl disulphide, diallyl trisulphide, allyl methyl trisulphide and allyl methyl disulphide (Husain et al., 1992).

Garlic bulb is antirheumatic, stimulant, diaphoretic, expectorant, diuretic, antispasmodic, astringent, antiparalytic, antileprotic, aperient, febrifuge, carminative, stomachic, alterative and emmenagogue. The essential oil is hypocholestrolemic, hypotensive, antitumour and antidiabetic. Diallyl disulphide and diallyl trisulphide from essential oil have larvicidal action. Bulbs also have anti-bacterial, and anti-fungal activity.... garlic

(Linn.) Lam.

Habitat: Native to tropical America; cultivated throughout India for edible tubers.

English: Sweet potato.

Ayurvedic: Mukhaaluka, Rataalu, Raktaalu, Raktapindaka, Raktakan- da.

Siddha/Tamil: Sakkareivelleikulan- gu.

Unani: Shakarkand, Rataalu.

Action: Root—used in strangury, urinary discharges, burning sensation, thirst. Whole plant—used in low fever and skin diseases.

Cooked tubers contain reducing sugars 6.45, sucrose 2.23, maltose 864, dextrins 0.51 and polysaccharides 14-13%. Cooking increases the sweetness as a result of the hydrolysis of starch to maltose and dextrins through the action of beta-amylase.

Sweet potatoes are rich in starch content. During the storage a part of starch content is converted into reducing sugars and subsequently into sucrose. In a sample stored for 5 months, the starch content was reduced from 19.1% to 14.1% while the percentage of reducing sugars (as dextrose) and sucrose increased from 0.9 to 1.7 and 1.9 to 6.1% respectively.

Indian types with white flesh contain little or no carotene, while American types with pink flesh contain as high as 5.4-7.2 mg/100 g of carotene. Vitamins present in the tubers are : thiamine 0.09-0.14, riboflavin 0.05-0.10 and vitamin C 16-22 mg/100 g.

The hot aqueous extract of leaves exhibits significant inhibitory activity of rat lens aldose reductase (AR). Ellagic and 3,5-dicaffoylquinic acids have been isolated as potent inhibitors.

The leaves also contain polysaccha- rides which increase the platelet count in experimental animals due to enhanced production ofthrombopoietin.

From the stem and root, hexadecyl, octadecyl and eicosyl p-coumarates have been isolated.

The tubers show significant lectin activity and exhibit haemagglutinating activity in trypsinized rabbit erythro- cytes.... ipomoea batatas

Kola Nut Tea has been known for being effective in treating hunger pangs and boosting energy. The kola nut (cola) is native to the rainforests of Africa. The trees can reach up to 60 feet having 30 centimeters long leaves and star shaped fruits. The kola nut contains a huge amount of caffeine and it is used in many West African cultures to suppress hunger pangs. The kola nut is also used as a religious object being offered during prayers, weddings or funerals. It is used to flavor popular cola drinks such as Coca-Cola and Pepsi. The main constituents of kola nut are antioxidants, calcium, potassium, iron, beta-carotene, thiamine, riboflavin, niacin, sugar and vitamin C. How To Make Kola Nut tea To brew Kola Nut Tea, place 1-2 teaspoons of kola nut in 8 ounces of water. Boil the mix and then let it steep for about 3-5 minutes. When the time is up, pour the tea into your cup using a strainer to catch the kola nut herbs. Kola Nut Tea Benefits

• Boosts your mood.
• Fights depression.
• Improves male potency.
• Suppresses food appetite.
• Helps in the treatment of congestion problems such as asthma and whooping cough.

Kola Nut Tea Side Effects

• Because of its caffeine content, pregnant and breastfeeding women shouldn’t drink Kola Nut Tea.
• People with hypertension and heart disease should also avoid Kola Nut Tea.
• Do not drink Kola Nut Tea before bed, since its caffeine content may stop you from having a restful sleep.

Enjoy Kola Nut Tea and all its wonderful benefits. Just keep in mind that kola nut tea contains caffeine and try to avoid over consumption, in order to not experience its side effects!... kola nut tea

Linn.

Synonym: L. scariola Linn. var. sativa C.B. Clarke.

Family: Compositae; Asteraceae.

Habitat: Native to Southern and West Asia. Cultivated throughout India as a cold weather crop.

English: Garden Lettuce.

Unani: Kaahuu Bustaani, Salaad Pattaa, Salaad Baaghi.

Siddha/Tamil: Salattu.

Action: Plant—used in painful ulcers and burns.

The leaves contain calcium, phosphorus, iron, thiamine, riboflavin, niacin, carotine, iodine, fluorine. A. dietary allowance of 10 g of lettuce is adequate to meet the vitamin K requirement of the body.

Aqueous extract of roots gave a gua- iene-type sesquiterpene glycoside, lac- toside C, along with known glycosides, lactoside A and macro-cliniside A.... lactuca sativa

Mill.

Synonym: M. domestica Borkh. M. sylvestris Hort. non-Mill. Pyrus malus Linn. in part.

Family: Rosaceae.

Habitat: Native to Europe and West Asia; now cultivated in Himachal Pradesh., Kashmir, Kulu, Kumaon, Assam and in the Nilgiris.

English: Cultivated Apple.

Ayurvedic: Sinchitikaa.

Folk: Seb, Sev.

Action: Bark—anthelmintic, refrigerant, hypnotic, given in intermittent, remittent and bilious fevers. Leaves—inhibit the growth of a number of Gram-positive and Gram-negative bacteria.

The fruit contains malic (90-95% of the total acids), citric, lactic and succinic acids; (unripe fruit contains quinic acid, citric acid, succinic acid, lactic acid); caffeic acid derivatives, pectins, minerals and vitamins.

Edible portion of fresh apple contains thiamine 0.12, riboflavin 0.03, niacin 0.2 and ascorbic acid 2 mg/100 g. The ascorbic acid content varies widely and values up to 40 mg/100 g. Sugars constitute about 80% of the total carbohydrates of ripe fruits—fructose (60), glucose (25) and sucrose (15%). The pectin content of the edible portion varies from 0.14 to 0.96% (as calcium pectate). The uronic acid content of apple pectin varies from 0.5 to 15%.

The astringent principles of apple include tannins, tannin derivatives and colouring materials (flavones). The browning of apple slices on exposure to air is due to enzymic oxidation of tannin compounds.

Fresh juice contains 0.20-0.80 malic acid, 11.6 total sugars and 0.02100.080% tannin.

The seeds contain cyanogenic gly- coside, amygdalin (0.62-1.38%, HCN equivalent, 0.037-00.087%).... malus pumila

The natural food of all mammalia for a considerable period following their birth. It is practically the only form of animal food in which protein, fat, carbohydrate and salt are all represented in su?cient amount, and it therefore contains all the constituents of a standard diet. Milk is important in human nutrition because it contains ?rst-class animal protein of high biological value; because it is exceptionally rich in calcium; and because it is a good source of vitamin A, thiamine and ribo?avine. It also contains a variable amount of ascorbic acid (vitamin C) and of vitamin D – the amount of the latter being higher during the summer months than during the winter months. Raw milk yields 67 Calories (see CALORIE) per 100 millilitres, in which are present (in grams) 87·6 of water, 3·3 of protein, 3·6 of fat, 4·7 of carbohydrate, and 0·12 of calcium. Heat has no e?ect on the vitamin A or D content of milk, or on the ribo?avine content, but it causes a considerable reduction in the vitamin C and thiamine content.

Preparation of milk Milk may be prepared for food in various ways. Boiling destroys the bacteria, especially any Mycobacteria tuberculosis which the milk may contain. It also partly destroys vitamin C and thiamine, as does pasteurisation. Curdling of milk is e?ected by adding rennet, which carries out the initial stage of digestion and thus renders milk more suitable for people who could not otherwise tolerate it. Souring of milk is practised in many countries before milk is considered suitable for food; it is carried out by adding certain organisms such as the LACTIC ACID bacillus, the Bulgarian bacillus, and setting the milk in a warm place for several hours. Sterilisation, which prevents fermentation and decomposition, is usually carried out by raising the milk to boiling temperature (100 °C) for 15 minutes and then hermetically sealing it. Condensed, unsweetened milk – usually known as evaporated milk – is concentrated in vacuo at low temperature; the milk is then placed in tins, which are sealed, and is sterilised by heat at a temperature of 105 °C. This destroys 60 per cent of the vitamin C and 30–50 per cent of the thiamine. Sweetened condensed milk is not exposed to such a high temperature. The sugar, which prevents the growth of micro-organisms, is added before the condensing, and ?nally reaches a concentration of about 40 per cent.

Dried milk is prepared by evaporating all the ?uid so that the milk is reduced to the form of powder. Humanised milk is cow’s milk treated to render it closely similar to human milk.... milk

R. Br.

Synonym: Rorippa nasturtium- aquaticum (Linn.) Hayek.

Family: Cruciferae; Brassicaceae.

Habitat: Cultivated in Bengal, Orissa and Punjab.

English: Watercress.

Folk: Piriyaa-Haalim (Punjab), Latputiyaa (Maharashtra).

Action: Leaves—antiscorbutic, expectorant (used in catarrh of the respiratory organs), diuretic (used in kidney and bladder disorders), detoxifying. A lotion of leaves is applied to blotches, spots and blemishes. Fresh herb is used as a blood purifier.

Key application: For catarrh of respiratory tract. (German Commission E.)

Watercress contains vitamin A 4720 IU, ascorbic acid 77 mg/100 g, also thiamine, riboflavin, niacin and biotin; mineral matter 2.2%—calcium 290, phosphorus 140, iron 4.6 mg/100 g, also sulphur, iodine, manganese, zinc, arsenic and copper; proteins 2.9%, amino acid composition includes leucine, phenylalanine, valine, lysine, tyrosine, alanine, threonine, glutamic acid, serine, aspartic acid, cystine, methionine sulphoxide and proline.

The glucosinolate phenethyl isothio- cyanate, which is released upon chewing the leaf, is a chemopreventive agent against lung cancer. (cited in Expanded Commission E Monographs.)

Watercress is contraindicated in gastric and duodenal ulcers and inflammatory kidney diseases. (Francis Brinker.)... nasturtium officinale

Linn.

Family: Papaveraceae.

Habitat: Kashmir and throughout the plains of North India; cultivated in gardens.

English: Corn Poppy, Red Poppy.

Ayurvedic: Rakta Posta.

Siddha/Tamil: Sivappu, Kasakasa.

Folk: Laal Posta, Laal Kaskas.

Action: Latex from capsules— narcotic. Petal—expectorant, antitussive, sudorific. Used for diseases of the respiratory tract, for disturbed sleep and as a sedative for the relief of pain. (Included among unapproved herbs by German Commission E.)

The petals contain cyanidine derivatives. An alkaloid rhoeadine is present in leaves and flowers (0.031%), unripe capsules (0.035%) and in roots

Family: Papaveraceae.

Habitat: Native to Asia; now grown in Uttar Pradesh, Punjab, Rajasthan and Madhya Pradesh.

English: Opium Poppy.

Ayurvedic: Ahiphena, Aaphuuka. Post-daanaa (seed).

Unani: Afyum. Tukhm-e- khashkhaash (seed).

Siddha/Tamil: Kasakasa (seeds).

Action: Opium is obsolete as a drug. Narcotic, sedative, hypnotic, analgesic, sudorific, anodyne, antispasmodic. Crushed poppyheads were in use as a topical poultice for crippling pain in terminal diseases. Poppy seed—nutritive, demulcent, emollient, spasmolytic, devoid of narcotic properties. Specific against obstinate constipation, also used in catarrh of the bladder. Poppy seed oil is also free from narcotic properties. Used against diarrhoea, dysentery and scalds.

Opium contains isoquinoline alkaloids; the major one is morphine with narcotine, codeine, papaverine and thebaine. Poppy seeds, used in Indian medicine, do not contain alkaloids. The seeds contain thiamine 420, riboflavin 49, folic acid 30, pantothenic acid 2667 and niacin 1877 mcg/100 g. The seed oil (from Turkey) contains gamma-tocopherol 220, alpha-toco- pherol 40 and beta-tocopherol 20 mcg/ 100 g. Some low-molecular proteins (15% of total protein) have been isolated, along with cysteine, glutamic acid and arginine. The seeds yield a fatty oil (45%) containing palmitic, stearic, oleic, linoleic and linolenic acids.

The extract of seeds showed highly significant antisecretory (antidiarr- hoeal activity) against E. coli entero- toxin-induced secretory responses in experimental animals.

The triglycerides isolated from seeds showed anti-tumour activity against Ehrlichs ascites in mice.

The aqueous extract of seeds showed marked hypoglycaemic activity when administered to glucose-loaded and al- loxan diabetic rats.

The seeds were found to increase the activity of carcinogen detoxifying enzyme, glutathione-S-transferase by more than 78% in the stomach, liver and oesophagus in mice.

Following Papaver sp. are found in India:

P. argemone Linn. (indigenous to the Mediterranean region; commonly grown in gardens in India) contains 0.15% of alkaloids including rhoeadine, protopine, and anthocyanins. Petals are sudorific.

P dubium Linn. (North-western Himalaya form Kashmir to Garhwal; as a winter weed in North Indian plains) contains rhoeagenine as the principal alkaloid, besides rhoeadine, protopine. Petals contain cyanidin B and pelargonidin C. Petals are sudorific.

P. hybridum Linn. (gardens of Punjab and Uttar Pradesh) is diaphoretic (petals). Plant latex contains alkaloids including berberine, coptisine, pahybrine, papaverrubines A, B, D and E and sanguinarine. Plant also gave glaucine and glucamine.

P. nudicaule Linn. (Gulmarg, Kashmir, at altitudes of 3,300-3,600 m), known as Iceland Poppy, gave alkaloids including papaverrubines B and D; leave gave cyanogenic glycosides including dhurrin and triglochinin. The flower and fruit are mild diaphoretic.

P. orientale Linn. (indigenous to Mediterranean region; grown in Indian gardens), known as Oriental Poppy, contains 0.16% of alkaloids including thebaine, isothebane, protopine, glaucidine and oripavine. Latex from poppy capsule is narcotic.... papaver somniferum

Mill.

Synonym: P. gratissima Gaertn. f.

Family: Lauraceae.

Habitat: Native to Central America; introduced into India and grown for its fruit in Bangalore, Nandi Hills, Courtallam, Nagarcoil, Shevaroys, lower Palnis and the foothills of the Nilgiris; also in Pune.

English: Avocado, Alligator Pear, Butter Fruit.

Action: Fruit—hypocholestero- laemic. Leaf—bacteriostatic; potentially toxic to goats and sheep.

The fruit is highly nutritious. The fruit from Nilgiris contains 22.8% fat, 1.7% protein; also manganese, phosphorus, iron, potassium, vitamin E, vitamin C, beta-carotene, thiamine, ri- boflavin, nicotinic acid and foliate. It is relatively low in sodium and simple sugars.

American Avocado is rich in oil (1530 g/100 g fresh fruit) that is mainly monounsaturated and a good source of linoleic acid. Its high fiber content might be responsible for its cholesterol lowering effects.

Preliminary evidence suggests that unsaponifiable fractions of Avocado and soybean oils (combination) can inhibit cartilage degradation and promote cartilage repair in osteoarthritic chondrocytes. (Properties of Avocado cited in Natural Medicines Comprehensive Database, 2007.) Avocado oil is used in cosmetic preparations, soaps and pharmaceuticals. The peel of immature fruit contains antifungal compounds. The fruit pulp is used topically to promote hair growth.... persea americana

Linn.

Family: Palmae; Arecaceae.

Habitat: Cultivated in Punjab and Rajasthan.

English: Date Palm.

Ayurvedic: Kharjuura, Kharjuuraka, Kharjuurikaa. Pindakharjuurikaa. Chhuhaaraa (dry date). Pindakhar- juura is the fruit of Phoenix acaulis Roxb.

Unani: Khurmaa, Khajuur, Chhuharaa.

Siddha/Tamil: Perichchankay, Ita.

Action: Fruit pulp—antitussive, expectorant, demulcent, laxative, diuretic, restorative. Sap—cooling, laxative. Gum—used in diarrhoea and genitourinary diseases.

The fruit contains ascorbic acid (vitamin C), carotene (as vitamin A), nicotinic acid, riboflavin, thiamine, sugars (60-80%). Besides sucrose and invert sugars, rhamnose, xylose, ara- binose, ribose, galactose and galac- turonic acid have been identified in the fruit. Invert sugar predominates in the soft dates; sucrose in dry varieties. The dried date, used in Ayurvedic and Unani compositions, contains protein 2.5-3, fat 0.5, carbohydrates 75.882.9% and calcium 35.9, phosphorus 129.3 and iron 3.4 mg/100 g. Presence of sterols of ergosterol group, and esterone has been reported from dried date seeds.

Charged C-glycosylflavones and caf- feylshikimic acid, leucocyanidin are characteristically present in the plant. Flavonol glycosides are also common. Several uncharged C-glycosylflavones were also detected.

Dosage: Fresh fruit—10-50 g, dried fruit—10-15 g. (API, Vol. IV.)... phoenix dactylifera

Roxb.

Family: Palmae; Arecaceae.

Habitat: Andhra Pradesh, Karnata- ka and Madhya Pradesh.

English: Wild Date Palm.

Ayurvedic: Kharjuuri.

Siddha/Tamil: Periyaitcham, Icham.

Folk: Sulemaani Khajuur, Desi Khajuur.

Action: Fruits—restorative. Juice— cooling, gastric stimulant. Seeds— used in ague. Root—used for nervous debility.

Fresh, unfermented sap (Niraa) is a good source of ascorbic acid, nicotinic and isonicotinic acids, riboflavin, thiamine, sugars; crystine, leucine, isoleucine, lysine, phenylalanine, thre- onine, tyrosine.

The concentration of amino acids is much higher in palm jaggery than in sugar cane jaggery.

Fresh fruits contain protein 1.2, fat 0.4, calcium 0.022 and phosphorus 0.38%.

Dosage: Fruit—10-20 g paste. (CCRAS.)... phoenix sylvestris

Linn.

Habitat: Native to tropical America; grown in the hills and plains throughout India.

English: Cape Gooseberry.

Ayurvedic: Parpoti (var.).

Siddha/Tamil: Perungunni, Potti- pallam.

Folk: Rasbhari, Mako.

Action: Plant—diuretic. Leaf— anthelmintic, an infusion is used in abdominal disorders. Fruits— a good source of carotene and ascorbic acid; eaten as a table fruit.

The fruit contain carotene (as vitamin A) 2,380 IU, thiamine 0.05, ri- boflavin 0.02, nicotinic acid 0.3 and ascorbic acid 49 mg/100 g; mineral matter 0.8%; phytin phosphorus 18, iron 2.0, ionizable iron 0.9, sodium 0.9, potassium 320, copper 0.19, and sulphur 43 mg/100 g. The juice from the ripe fruits contain considerable quantity of pectin. The chief acid is citric acid, but malic and tartaric acids are also present.

The plant is a source of highly oxygenated ergostane-type of steroids— withanolides and related compounds.... physalis peruviana

Linn.

Family: Polygonaceae.

Habitat: Western Himalayas up to an altitude of 2,400 m.

English: French Sorrel.

Action: Plant—refrigerant, astringent; given in dysentery. Juice of leaves—antiscorbutic.

The roots contain oxymethyl an-

Action: Plant—astringent antiscorbutic, stomachic, diuretic, used for disorders of lymphatic and glandular system; for bronchitis, asthma; constipation, dyspepsia, diseases of liver and spleen; urinary and renal disorders; alcoholism. Seeds—antidysenteric.

Anthraquinone glucosides, emodin and chrysophanol, have been reported from leaves, root and seeds. The leaves contain large amounts of oxalate (21.8% on dry basis); vitamin C content is 12 mg and vitamin A 6,100 IU/100 g.

The leaves of Rumex species are eaten in salad or cooked like spinach. They contain protein, carbohydrates, potassium, magnesium, phosphorus, calcium, manganese, copper, zinc, (iodine, in some samples), ascorbic acid, beta-carotene and thiamine; also oxalic acid, potassium binoxalate and some tartaric acid.... rumex scutatus

Linn.

Family: Gramineae; Poaceae.

Habitat: Uttar Pradesh, Bihar and Punjab.

English: Sugarcane, Noble Cane.

Ayurvedic: Ikshu, Dirgha-chhada, Bhuurirasa, Morata, Asipatra, Madhutrna, Gudamuula, Trnarasa.

Unani: Gannaa, Naishakar.

Siddha/Tamil: Karumbu, Nanal.

Action: Cane Juice—restorative, cooling, laxative, demulcent, diuretic, antiseptic. Used in general debility, haemophilic conditions, jaundice and urinary diseases.

The Ayurvedic Pharmacopoeia ofIn- dia recommends the juice of the stem in haemorrhagic diseases and anuria; and the root in dysuria.

Sugarcane juice contains surcose (70-80% of soluble solids in the juice), glucose and fructose. Non-sugar constituents present in the cane juice are carbohydrates other than sugars. As- paragine and glutamine are prominent amino acids in the juice. Other amino acids include alanine, gamma- amino butyric acid, aspartic and glutamic acids, glycine, leucine, lysine, serine and tyrosine. The presence of phenylalanine, histidine, valine, proline, threonine and arginine, pipecolic acid, methionine and tryptophan has also been reported.

Aconitic acid constitutes about three-fourths of the total carboxylic acid present in the juice.

Vitamins present in the juice are: thiamine, riboflavin, niacin, pantothenic acid, biotin, and vitamin D; enzymes include diastase, invertase, lac- tase, peroxidase, tyrosinase.

Phenols in the cane juice are mainly polyphenols from tannin and antho- cyanin from the rind.

Cane juice contains glycolic acid which improves skin complexion as it has antiwrinkle effect, prevents scaly growth and increases natural collagen and elastin in the skin.

Enzymes present in the seeds include large quantities of diastase and invertase.

An ester, vanilloyl-l-O-beta-D-glu- coside, has been isolated from the bagasse.

The leaves contain alpha-amylase and glutathione-S-transferase.

Dosage: Stem—200-400 ml juice; rootstock—15-30 g for decoction. (API, Vol. IV.)... saccharum officinarum

Merrill.

Family: Euphorbiaceae.

Habitat: Sikkim, Khasi Hills and Western Ghats, and also grown in South India.

English: Star Goose Berry.

Siddha/Tamil: Thavasai Murungai.

Action: Plant—known as Multivitamin Green for its substantial vitamin content. Decoction is given in stricture of the bladder and in fevers; used as a diuretic.

The leaves contain protein 6.8; carbohydrates 11.6; mineral matter 3.4, Ca 0.57, phosphorus 0.20, iron 28.0 mg, carotene (as vitamin A), 9,510 IU, thiamine 0.48, riboflavin 0.32, nicotinic acid 2.6, and vitamin C 247 mg/100 g.... sauropus androgynus

Linn.

Synonym: S. orientale Linn.

Family: Pedaliaceae.

Habitat: Uttar Pradesh, Madhya Pradesh, Rajasthan, Orissa, Gujarat, Andhra Pradesh, Tamil Nadu, and Maharashtra.

English: Sesame, Gingelly.

Ayurvedic: Tila, Snehphala.

Unani: Kunjad, Til.

Siddha: Ellu (seed), Nallennai (oil).

Action: Seeds—an important source of protein; also rich in thiamine and niacine. Nourishing, lactagogue, diuretic, laxative, emollient. Powdered seeds—given internally in amenorrhoea and dysmenorrhoea. (Black seeds are preferred in Indian medicine.) Paste is applied to burns, scalds, piles. Leaves—used in affections of kidney and bladder. Bland mucilage is used in infantile diarrhoea, dysentery, catarrh and bladder troubles, acute cystitis and strangury.

Non-saponifiable fraction of the seed oil gave sterols, a lignans, sesamin and a nitrolactone, sesamolin. Sesamin and sesamolin are not found in any other vegetable oil. Sesamin is present in a concentration of 0.5 to 1.0%. The oil from the white seeds from West Bengal and Assam is reported to contain about 2.5% sesamin. Sesamol, a phenolic antioxidant, is present in traces.

The leaves gave a flavonoid, pedalin. Pinoresinol has also been reported from the plant.

The seed contains thiamine, niacin, riboflavin, nicotinic acid, pantothenic acid, folic acid, biotin, pyridoxine, in- ositol, choline, p-aminobenzoic acid, ascorbic acid, vitamin A, alpha-and beta-tocopherol. Sugars present are glucose, surcose, galactose, planteose, raffinose. Fatty acid in the seed are myristic, palmitic, stearic, arachidic, hexadecenoic, oleic, linoleic and lig- noceric.

Basic aroma compounds of the roasted seeds consisted of mainly dimethyl thiazole and substituted pyrozines.

Dosage: Seed—5-10 g powder. (API, Vol. IV.)... sesamum indicum

Roxb.

Family: Cucurbitaceae.

Habitat: Warmer regions of India, particularly in Uttar Pradesh. Bihar, West Bengal and Assam.

English: Patol, Pointed Gourd.

Ayurvedic: Patola, Kulaka, Raa- jiphala, Karkashchhada, Karkasha, Bijagarbha.

Unani: Parwal.

Siddha: Kommu Patolia.

Action: Aerial parts—hypogly- caemic. Fruits—juice of unripe fruits used in spermatorrhoea. Leaves—febrifuge; prescribed as a diet in enlargement of liver and spleen; piles and fistula. Root— cathartic, febrifuge.

The fruits contain free amino acids, nicotinic acid, riboflavin, vitamin C, thiamine, 5-hydroxytryptamine. Mature plant and root gave cucurbita-5, 24-dienol. Colocynthin, trichosan- thin, hentriacontane have been isolated from the root.

Fatty acids from the seeds comprise elaeostearic, linoleic, oleic and saturated acids.

The whole fruit and pulp produced significant hypocholesterolaemic, hy- potriglyceridaemic and hyper-phos- pholipidaemic effects in normal and midly diabetic human subjects.

Extracts of seeds exhibit haemagglu- nating activity.

Dosage: Leaf—10-2 ml juice. (CCRAS.)... trichosanthes dioica

(L.) Schott.

Family: Araceae.

Habitat: Peninsular India, and from Yamuna eastwards; also grown in South India.

Siddha/Tamil: Karu Karunai Kizhangu, Karunai Kizhangu.

Action: Tuber—applied as poultice on scirrhous tumours (fresh tuber is very acrid and a powerful stimulant). Eaten with bananas, the tubers relax the bowels and provide relief in haemorrhoids (tubers become innocuous on heating or drying).

The tubers contain carotene, folic acid, niacin, thiamine, sterols and beta- sitosterol.... typhonium trilobatum

 Bee Balm. Oswego tea. Monardo didyma L. Part used: herb.

Action: Antiseptic, Carminative, Expectorant.

Use s. Flatulence. Stomach cramp. Intestinal colic. Weak digestion. Nausea. Headache. menstruation.

Preparation. Tea. 1 teaspoon to each cup boiling water; infuse 5-10 minutes. Half-1 cup as necessary. Bergamot imparts the distinctive flavour to Earl Grey tea.

Aromatherapy. Diluted oil for shingles: 6 drops to 2 teaspoons Almond oil as a soothing lotion.

BERI BERI. A disease caused by a deficiency of thiamine (Vitamin B1) by eating polished rice from which the husk (in which the vitamin is found) is discarded. Others at risk from Vitamin B1 deficiency are alcoholics, hypothyroids, pregnant women and those with a high intake of refined sugar but a low intake of fresh fruits and vegetables. Heavy coffee drinkers suffer temporary wastage.

Symptoms: weight loss, poor appetite, loss of sensation in arms and legs. Polyneuritis, muscular atrophy. Mood changes.

Painful Of value. Slippery Elm. Dandelion. Alfalfa sprouts or tea. Psyllium husks.

Diet. Vitamin B1 is present in green vegetables, eggs, meat, nuts, yeast, natural unprocessed brown rice, cereal germ and husks, oatmeal, peas, beans, asparagus, brewer’s yeast, desiccated liver.

Supplements. Vitamin B-complex. Vitamins B1 and C. ... bergamot, red

An acute distressing symptom in elderly and very young people. ‘Lack of clarity in thinking.’ Mild brain failure. Temporary character-change and alteration in behaviour. Absence of classical symptoms of illness. Cannot formulate answers.

Diagnosis: dementia requires six months mental impairment, whereas acute confusional states may develop in a few days. Distinguish from Alzheimer’s disease.

Causes: Oxygen deficiency in the tissues (Vitamin E). Toxaemia (eliminatives). Delirium (nerve relaxants). Infections (Echinacea). Metabolism (Dandelion). Drugs (Ginseng). Hypothermia (Cayenne). Nutritional (Slippery Elm, thiamine).

Tea. Combine herbs, equal parts: Agrimony, Skullcap, Balm. 2 teaspoons to each cup boiling water; infuse 5-15 minutes. 1 cup freely.

Ginkgo: Favourable results reported.

Vitamins. B-complex. B12. Thiamine. E (1000iu daily). Minerals. Dolomite. Zinc. ... confusional state

Failure of contents of the large bowel to be evacuated due to inactivity, chemical laxatives, ignoring body signals that the body is full, obsession with bowel movements, piles, diverticulosis with small pockets from the colon, lack of exercise, spastic condition, low-fibre foods, poor eating habits, nervous stress. Waste products stagnate, changing behaviour of intestinal flora friendly to the body and necessary for breakdown of food. Toxins formed from reabsorption may be the cause of chronic disease.

Constipation is usually due to an underlying condition which requires primary treatment: i.e. anaemia.

The habit of taking purgatives lessens ability of the bowel to do its work. Gentler-acting remedies are advised: Isphagula (Psyllium seeds, light). In prescriptions, it is good practice to include a remedy for the liver (Barberry, Wahoo) and the digestive system (Dandelion, Liquorice). For constipation of pregnancy – see PREGNANCY.

Alternatives. Senna. 1-2 teaspoons leaves or 5-7 pods to cup cold water left to stand overnight. Combined tea. Equal parts: Senna leaves, Chamomile flowers, Fennel seeds. 1-2 teaspoons to each cup boiling water; infuse 15 minutes. 1 cup, evening.

Psyllium seeds (Ispaghula, pale) 1, 2, 3 or more teaspoons aided down with sips of water, morning or evening.

Decoctions. Any of the following: Black root, Blue Flag, Buckthorn, Cascara sag, Dandelion root, Turkey Rhubarb, Wahoo, Yellow Dock.

Tablets/capsules. Dandelion. Calamus. Blue Flag. Seaweed and Sarsaparilla. Turkey Rhubarb. Damiana. Senokot.

“Natural Herb Tablet”: Holy Thistle 60mg; Aloes BP 50mg; Fennel powder BPC 15mg; Myrrh powder BPC 15mg; Extract Skullcap 10mg; Powdered Valerian BPC 30mg; Powdered Lime flowers BPC 1949 30mg. Two or more tablets as necessary. Variations of this formula are on sale throughout Europe and the UK.

Powders. Combinations. Alternatives. (1) Turkey Rhubarb, with trace Cayenne. Use powder, or rubbed Rhubarb root with aid of kitchen grater.

(2) Equal parts: Barberry, Liquorice, Senna pods.

(3) Turkey Rhubarb 6; Slippery Elm 1; Liquorice 1. (4) Senna 70; Buckthorn 5; Fennel 10; Mate 5; Elder 5; Psyllium (pale) 5. Dose: 500-750mg (2-3 00 capsules or one-third-half a teaspoon) once or twice daily, as necessary.

Tinctures. Formulae: (1) Turkey Rhubarb, with trace of Capsicum. (2) Dandelion 2; Cascara sag, 2; Barberry 2; Liquorice 1; Tincture Ginger half. Half-2 teaspoons in hot water, evening.

Standard sales. A large number of preparations are on sale including Potter’s “Lion Cleansing Herbs”, Monastery herbs, Priory herbs. Fybogel Orange to increase bulk in colon. Regulan, for high fibre regimen. Enema or gravity douche: half an ounce Chamomile flowers to 2 pints boiling water allowed to cool. Inject warm; repeat twice weekly until normal function is established.

Diet. Milk-free diet often curative. Teaspoon powdered Agar Agar with meals once or twice daily. Prunes soaked overnight. Yoghurt. Crude black molasses. Increase fibre-foods. Dandelion coffee.

Hay Diet. Impressive results reported.

Supplementation. Cod Liver oil.

Vitamins: A. B-complex, Thiamine, Niacin, C. P (bioflavonoids). Minerals: Calcium. Potassium. Zinc. ... constipation

A persistent change of mood deeper than superficial sadness. Of symptoms, headache is the commonest presenting complaint (Feverfew, Skullcap). Release from symptoms may be obtained from teas, powders or liquid extracts of the following.

Liver causation: Dandelion (Coffee), Wild Yam, Goldenseal.

In the elderly: Skullcap, Sage.

With restlessness: Lemon balm, Californian Poppy.

With palpitations: Hawthorn, Motherwort.

From abuse of coffee: German Chamomile.

Unable to relax: Passion Flower.

Epileptic: Mistletoe. Vervain.

Parkinsonian: St John’s Wort, broad beans.

To correct hormone imbalance: Helonias, Raspberry leaves.

Pre-menstrual tension: Evening Primrose, St John’s Wort, Rosemary.

With painful menstruation: Black Cohosh.

Associated with glaucoma: Rutin tea.

The hidden alcoholic: Ginseng.

Pregnant depressive: Raspberry leaves.

Obese depressive: Cider vinegar.

Enuresis schoolchild: Liquorice.

With swollen prostate gland: Pulsatilla.

In heart cases, and to counter side effects of beta blockers: Hawthorn, Lily of the Valley.

Drug-induced: St John’s Wort, Californian Poppy, Ginseng.

General anti-depressives: Lemon balm, Celery, Chamomile, Borage, Ginkgo, Damiana, Kola, Mistletoe, Mugwort, Oats, Rosemary, Skullcap, Southernwood, Valerian, Vervain, Wormwood, St John’s Wort, Peppermint.

BHP (1983) combination: Kola nuts, Skullcap, Oats, Damiana.

Evening Primrose: 4 × 500mg capsules daily.

Temporary depression from physical and mental exhaustion: Life Drops (see entry). Pinch of Cayenne in cup of tea.

Old men. Low cholesterol levels are linked to depression among older men.

Practitioner: Persistent depression from shock: Tincture Arnica, 2-5 drops in water, thrice daily.

(Practice among German physicians.)

Aromatherapy. Inhalant: any one oil: Rose, Tangerine, Geranium.

Diet. Low caffeine. Oats: good for depression (oatmeal porridge, oatcakes, etc). Spinach for iron and calcium.

Supplementation. Vitamins: B-complex, B6, B12, C. Thiamine, Niacin. Minerals: Dolomite, Iron, Chromium, Iodine, Zinc.

Note: Depression may trigger mechanisms that introduce chronic disease by lowering immune response, hence need for conscientious patient compliance. ... depression

Mongolism. Trisomy 21. Not a disease but a defect in mental and physical development. In the normal human being there are 46 chromosomes; in Down’s there are 47 – one extra No 21 chromosome. The syndrome increases with the age of the mother after the age of 35. Over the age of 40 the chances of a mother having such a child are 1-2 per cent. Children with the defect have low levels of zinc.

Cases of Down’s have followed use of nonoxynol-9 (vaginal contraceptive device) such as the polyurethane sponge. The sponge. when left in situ for a long time, may cause Down’s to follow.

Certain physical characteristics are present. The most important feature is impaired mental development. Almost all are coeliacs.

Symptoms. Low IQ, short fingers, small flat head, flattened nose, low-set ears. May be subject to umbilical hernia, and heart disease. No treatment can cure, but certain herb teas rich in minerals (Alfalfa, Red Clover) together with Kelp (either in tablet or powder form) may help children, with possible improvements in IQ. Vitamin supplements – A, D, Thiamine, Riboflavin, B6, B12, C and E improve a child’s physical and mental health – as do also the minerals: Magnesium, Calcium, Zinc, Manganese, Copper, Iron and Iodine.

Children with Down’s syndrome run an increased risk of coeliac disease, due to disturbed immunity. A substantial evidence is held in America that links a low level of Selenium in the mother. Unnecessary X- rays should be avoided. Ensure fitness before conception by gentle exercise and nutrients: Folic Acid, Selenium and Zinc.

Children with the condition are noted for their happy disposition and warmth of feeling towards others. ... down’s syndrome

Inflammation or deterioration of a nerve, usually peripheral. Peripheral neuritis. When more than one nerve is involved it is known as polyneuritis which may occur in various parts of the body. Causes: injuries, bone fractures, alcoholism, viral infection, Vitamin B12 deficiency, diabetes. Nerves become inflamed when poisons are taken into the body in the form of lead, mercury, arsenic and other heavy metals. Gout, leukaemia, and infectious diseases generally, may leave a legacy of polyneuritis. The neuritis of beri-beri is due to lack of Vitamin B1 (thiamine). Neuritis of the optic nerve – Gelsemium. Symptoms. Swelling, redness and pain in affected area. When squeezed, muscles are tender. Knee-jerks and other reflexes may be lost. ‘Pins and needles’.

Treatment. Appropriate to all types. To enhance growth of new nerve fibres as well as to assuage pain. Alternatives. Catnep (inflammation), Chamomile, Cramp bark, Gelsemium, Ginseng, Fringe Tree bark, Ladyslipper, Hops, Oats, Valerian, Wild Yam.

Tea. Combine equal parts: Catnep, Skullcap, Chamomile. 1 heaped teaspoon to each cup boiling water; infuse 15 minutes. 1 cup freely.

Decoction. Combine equal parts: Cramp bark, Valerian. One heaped teaspoon to each cup water gently simmered 10-20 minutes. Half-1 cup thrice daily.

Tablets/capsules. Chamomile, Cramp bark, Ginseng, Skullcap, Valerian.

Powders. Combine, Cramp bark 1; Liquorice half; Valerian half; Wild Yam half. Dose: 500mg thrice daily.

Liquid extracts. Combine: Chamomile 1oz; Hops half an ounce; Skullcap 60 drops; Cramp bark 1oz; water to 8oz. Dose: 2 teaspoons in water after meals. (A. Barker)

Tinctures. Formula: Cramp bark 3; Chamomile 2; Hops 2; Peppermint 1. Dose: 2 teaspoons thrice daily. Practitioner. Tincture Gelsemium BPC (1973). Dose: 0.3ml (5 drops).

Topical. Oil of St John’s Wort. Cloves, Cajeput, Chamomile. Poultices. Chamomile, Yarrow.

Vitamins. B1, B2, B6, B12, B-complex.

Pantothenic acid.

Minerals. Magnesium. Dolomite. Manganese. ... neuritis

A wide variety of physical and mental disorders associated with heavy, prolonged consumption of alcohol.

High alcohol consumption increases the risk of cancers of the mouth, tongue, pharynx (throat), larynx (voice box), and oesophagus, especially if combined with smoking. Incidence of liver cancer, as well as the liver diseases alcoholic hepatitis and cirrhosis, is higher among alcoholics. High alcohol consumption increases the risk of cardiomyopathy, hypertension, and stroke. Alcohol irritates the digestive tract and may cause gastritis. Heavy drinking in pregnancy increases the risk of miscarriage and fetal alcohol syndrome. Alcoholics are more likely to suffer from anxiety and depression and to develop dementia.

Many alcoholics have a poor diet and are prone to diseases caused by nutritional deficiency, particularly of thiamine (see vitamin B complex). Severe thiamine deficiency, called beriberi, disturbs nerve function, causing cramps, numbness, and weakness in the legs and hands. Its effects on the brain can cause confusion, disturbances of speech and gait, and eventual coma (see Wernicke– Korsakoff syndrome). Severe thiamine deficiency can also cause heart failure.

A prolonged high level of alcohol in the blood and tissues can disturb body chemistry, resulting in hypoglycaemia (reduced glucose in the blood) and hyperlipidaemia (increased fat in the blood).

These may damage the heart, liver, blood vessels, and brain; irreversible damage may cause premature death.... alcohol-related disorders

A wide range of disorders can disrupt the heart’s action.

In general, genetic factors do not play a large part in causing heart disorders, however they do contribute to the hyperlipidaemias that predispose a person to atherosclerosis and coronary artery disease. Structural abnormalities in the heart are among the most common birth defects (see heart disease, congenital).

Infections after birth may result in endocarditis or myocarditis. Tumours arising from the heart tissues are rare. They include noncancerous myxomas and cancerous sarcomas.

The heart muscle may become thin and flabby from lack of protein and calories. Thiamine (vitamin B1) deficiency, common in alcoholics, causes beriberi with congestive heart failure. Alcohol poisoning over many years may cause a type of cardiomyopathy. Obesity is an important factor in heart disease, probably through its effect on other risk factors, such as hypertension, diabetes, and cholesterol.

The coronary arteries may become narrowed due to atherosclerosis, depriving areas of heart muscle of oxygen. The result may be angina pectoris or, eventually, a myocardial infarction.

Some drugs, such as the anticancer drug doxorubicin, tricyclic antidepressants, and even drugs used to treat heart disease, may disturb the heartbeat or damage the heart muscle.

Many common and serious heart disorders may be a complication of an underlying condition, such as cardiomyopathy or a congenital defect. Such disorders include cardiac arrhythmia, some cases of heart block, and heart failure. Cor pulmonale is a failure of the right side of the heart as a consequence of lung disease.... heart, disorders of

An uncommon brain disorder almost always related to malnutrition occurring in chronic alcohol dependence, but occasionally due to that which occurs in other conditions, such as cancer. Wernicke–Korsakoff syndrome is caused by deficiency of thiamine (see vitamin B complex), which affects the brain and nervous system.The disease consists of 2 stages: Wernicke’s encephalopathy and Korsakoff’s psychosis. Wernicke’s encephalopathy usually develops suddenly and produces nystagmus (abnormal, jerky eye movements), ataxia (difficulty in coordinating body movements), slowness, and confusion. Sufferers usually have signs of neuropathy, such as loss of sensation, pins-and-needles, or impaired reflexes. The level of consciousness falls progressively and may lead to coma and death unless treated. The condition is a medical emergency. Treatment with high doses of intravenous thiamine often reverses most of the symptoms, sometimes within a few hours.

Korsakoff’s psychosis may follow Wernicke’s encephalopathy if treatment is not begun promptly enough. Symptoms consist of severe amnesia, apathy, and disorientation. Korsakoff’s psychosis is usually irreversible.... wernicke–korsakoff syndrome

A group of watersoluble vitamins comprising thiamine (vitamin B1), riboflavin (vitamin B2), niacin, pantothenic acid, pyridoxine (vitamin B6), biotin (vitamin H), and folic acid. Vitamin B12 is discussed above.

Thiamine plays a role in the activities of various enzymes involved in the utilization of carbohydrates and thus in the functioning of nerves, muscles, and the heart. Sources include whole-grain cereals, wholemeal breads, brown rice, pasta, liver, kidney, pork, fish, beans, nuts, and eggs.

Those susceptible to deficiency include elderly people on a poor diet, and people who have hyperthyroidism, malabsorption, or severe alcohol dependence. Deficiency may also occur as a result of severe illness, surgery, or injury.

Mild deficiency may cause tiredness, irritability, and loss of appetite. Severe deficiency may cause abdominal pain, constipation, depression, memory impairment, and beriberi; in alcoholics, it may cause Wernicke–Korsakoff syndrome. Excessive intake is not known to cause harmful effects.

Riboflavin is necessary for the activities of various enzymes involved in the breakdown and utilization of carbohydrates, fats, and proteins; the production of energy in cells; the utilization of other B vitamins; and hormone production by the adrenal glands. Liver, whole grains, milk, eggs, and brewer’s yeast are good sources. People who are susceptible to riboflavin deficiency include those taking phenothiazine antipsychotic drugs, tricyclic antidepressant drugs, or oestrogen-containing oral contraceptives, and those with malabsorption or severe alcohol dependence. Riboflavin deficiency may also occur as a result of serious illness, surgery, or injury.

Prolonged deficiency may cause soreness of the tongue and the corners of the mouth, and eye disorders such as amblyopia and photophobia.

Excessive intake of riboflavin is not known to have any harmful effects.

Niacin plays an essential role in the activities of various enzymes involved in the metabolism of carbohydrates and fats, the functioning of the nervous and digestive systems, the manufacture of sex hormones, and the maintenance of healthy skin. The main dietary sources are liver, lean meat, fish, nuts, and dried beans. Niacin can be made in the body from tryptophan (an amino acid). Most cases of deficiency are due to malabsorption disorders or to severe alcohol dependence. Prolonged niacin deficiency causes pellagra. Excessive intake is not known to cause harmful effects.

Pantothenic acid is essential for the activities of various enzymes involved in the metabolism of carbohydrates and fats, the manufacture of corticosteroids and sex hormones, the utilization of other vitamins, the functioning of the nervous system and adrenal glands, and growth and development. It is present in almost all vegetables, cereals, and animal foods. Deficiency of pantothenic acid usually occurs as a result of malabsorption or alcoholism, but may also occur after severe illness, surgery, or injury. The effects include fatigue, headache, nausea, abdominal pain, numbness and tingling, muscle cramps, and susceptibility to respiratory infections. In severe cases, a peptic ulcer may develop. Excessive intake has no known harmful effects.Pyridoxine aids the activities of various enzymes and hormones involved in the utilization of carbohydrates, fats, and proteins, in the manufacture of red blood cells and antibodies, in the functioning of the digestive and nervous systems, and in the maintenance of healthy skin. Dietary sources are liver, chicken, pork, fish, whole grains, wheatgerm, bananas, potatoes, and dried beans. Pyridoxine is also manufactured by intestinal bacteria. People who are susceptible to pyridoxine deficiency include elderly people who have a poor diet, those with malabsorption or severe alcohol dependence, or those who are taking certain drugs (including penicillamine and isoniazid). Deficiency may cause weakness, irritability, depression, skin disorders, inflammation of the mouth and tongue, anaemia, and, in infants, seizures. In very large amounts, pyridoxine may cause neuritis.

Biotin is essential for the activities of various enzymes involved in the breakdown of fatty acids and carbohydrates and for the excretion of the waste products of protein breakdown. It is present in many foods, especially liver, peanuts, dried beans, egg yolk, mushrooms, bananas, grapefruit, and watermelon. Biotin is also manufactured by bacteria in the intestines. Deficiency may occur during prolonged treatment with antibiotics or sulphonamide drugs. Symptoms are weakness, tiredness, poor appetite, hair loss, depression, inflammation of the tongue, and eczema. Excessive intake has no known harmful effects.

Folic acid is vital for various enzymes involved in the manufacture of nucleic acids and consequently for growth and reproduction, the production of red blood cells, and the functioning of the nervous system. Sources include green vegetables, mushrooms, liver, nuts, dried beans, peas, egg yolk, and wholemeal bread. Mild deficiency is common, but can usually be corrected by increasing dietary intake. More severe deficiency may occur during pregnancy or breastfeeding, in premature or low-birthweight infants, in people undergoing dialysis, in people with certain blood disorders, psoriasis, malabsorption, or alcohol dependence, and in people taking certain drugs. The main effects include anaemia, sores around the mouth, and, in children, poor growth. Folic acid supplements taken just before conception, and for the first 12 weeks of pregnancy, have been shown to reduce the risk of a neural tube defect.... vitamin b complex