Cat’s claw (Uncaria tomentosa).Plant Part Used: Inner bark, stem, root.Dominican Medicinal Uses: Bark, root, stem: infusion or multi-herb tincture, orally, for arthritis, cancer, diabetes, kidney disorders, leukemia, obesity and women’s health.Safety: No toxicity shown in clinical and animal studies; long-term use may affect hormone levels.Contraindications: Pregnancy, lactation; autoimmune disorders or implanted organs (immune stimulating properties).Drug Interactions: Anticoagulants, antiplatelet and thrombolytic agents and low molecular weight heparins (potential risk of excessive bleeding); immunosuppressants (may interfere with drug); P450 3A4-metabolyzed drugs (potential inhibition).Clinical Data: Clinical: DNA repair, immune enhancement, immunostimulant, rheumatoid arthritis treatment (bark extract).Laboratory & Preclinical Data: In vivo: anti-amnesic (alkaloids), anti-inflammatory, antioxidant, antimutagenic, antinociceptive, DNA repair, immune enhancement, immunomodulatory (plant extracts).In vitro: anticancer, anti-inflammatory, antimutagenic, antioxidant, antitumor, antiviral, cytoprotective, immunomodulatory (bark or leaf extracts).* See entry for Uña de gato in “Part 3: Dominican Medicinal Plant Profiles” of this book for more information, including references.