Linn.Family: Urticaceae.
Habitat: North-western Himalaya from Kashmir to Simla at 2,4003,600 m.
English: Stinging Nettle.Ayurvedic: Vrishchhiyaa-shaaka (related species).Unani: Anjuraa.Folk: Shisuun (Kumaon).Action: Plant—diuretic, astringent, antihaemorrhagic; eliminates uric acid from the body, detoxifies the blood. Externally, astringent and haemostatic.
Used internally for the treatment of nephritis, haemoptysis and other haemorrhages.Key application: Above ground parts—as a supportive therapy for rheumatic ailments (internally and externally). Internally, in irrigation therapy for inflammatory diseases of the lower urinary tract and prevention and treatment of kidney gravel. (German Commission E, ESCOP, The British Herbal Compendium, The British Herbal Pharmacopoeia.) Root—in symptomatic treatment of micturition disorders (dysuria, pol- lakiuria, nocturia, urine retention) in benign prostatic hyperplasia at stages I and II. (German Commission E, ESCOP, WHO, The British Herbal Pharmacopoeia.)Clinical experiments have confirmed the utility of the herb as a haemostatic in uterine haemorrhage and bleeding from nose. The herb is also used in sciatica, rheumatism and palsy. The treatment for paralysis comprises slapping the patient with a bundle of twigs. Alcoholic extract of Russian sp. is used in the cholecystitis and habitual constipation.The root exhibits an antiprolifera- tive effect on prostatic epithelial and stromal cells. It may also lessen the effects of androgenic hormones by competitively blocking acess to human sex hormone binding globulin. (Planta Med, 63, 1997; ibid, 66, 2000. Also, ESCOP monograph; Altern Complem Ther, 1998; Simon Mills; Natural Medicines Comprehensive Database, 2007.)In Europe, the juice of the leaves or roots, mixed with honey or sugar, was prescribed forbronchial asthma. In the USA, a freeze-dried preparation of the herb (300 mg gelatin capsules) has been found to improve condition of allergic rhinitis patients. The powdered seeds were considered a cure for goitre. (M. Grieve.)The urticating properties of the hairs are attributed to the presence of acetyl- choline, histamine and 5-hydroxytryp- tamine (5-HT). A histamine-liberating enzyme is also present.Acetylcholine is present in the leaves, rootlets, rhizomes and cortex in the ascending order of concentration. Histamine is not present in the underground parts of the plant. Its concentration in the leaves is about four times than that in the stem-cortex. Betaine and choline are present in the leaves.The leaves gave flavonoids (including rutin), sterols, carotenoids, vitamins (including C, B group, K), minerals, plant phenolic acids. The coumarin scopoletin has been isolated from the flowers and the root.A polysaccharide fraction obtained from aqueous extract showed anti- inflammatory activity in carrageenan- induced rat paw oedema and lymphocyte transformation test. A lectin was found to stimulate proliferation of human lymphocytes. (Planta Med, 55, 1989.)The leaf and root is contraindicat- ed in kidney disease and pregnancy. 5-hydroxytryptamine is a uterotropic constituent. (Francis Brinker.)
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