Uterosacral suspension Health Dictionary

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Uterosacral Suspension: From 1 Different Sources

(vaginal vault suspension) suturing the uterosacral ligament (attaching the cervix to the sacrum) to the apex of the vagina, which is performed vaginally, laparoscopically, or abdominally to prevent or treat *vault prolapse following hysterectomy.

Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Colloid

A type of suspension, for instance milk, in which insoluble particles are suspended in a ?uid. In medical parlance a colloid preparation is one containing PLASMA proteins and is used to treat patients in SHOCK. The follicles of the thyroid gland also contain a colloid substance.... colloid

Esr

The ESR or erythrocyte sedimentation rate is a test that measures the rate at which red blood cells settle out of suspension in blood PLASMA. In certain diseases, such as infection and malignancy, the amount of proteins in the plasma increases; the result is that red cells settle out more quickly and this test is used to show whether in?ammation is present and, to some extent, its severity.... esr

Balsamodendron Myrrha

Nees.

Synonym: Commiphora molmol Engl.

C. abyssinica (Berg.) Engl.

Family: Burseraceae.

Habitat: Arabia, Somaliland.

Ayurvedic: Bola, Hiraabola, Surasa, Barbara, Gandharasa.

Unani: Murmakki, Bol.

Siddha/Tamil: Vellaibolam.

Action: Oleo-gum-resin—em- menagogue (used for irregular menstruation and painful periods), anti-inflammatory (on pharyngitis and gingivitis), antiseptic, bacteriostatic, antiviral, astringent, stimulant, expectorant, stomachic, carminative (in dyspepsia), a leuco- cytogenic agent (increases number of white cells in the blood). Used externally for treating acne, boils and pressure sores, internally as a blood purifier.

Key application: In topical treatment of mild inflammations of the oral and pharyngeal mucosa. (German Commission E.) As a gargle or mouth rinse for the treatment of aphthous ulcers, tonsillitis, common cold and gingivitis. (The British Herbal Pharmacopoeia, ESCOP.)

The gum (30-60%) contains acidic polysaccharides, volatile oil (2-10%) including other constituents, heer- abolene, eugenol, furanosequiterpenes and monoterpenes.

Myrrh is taken as a powder or a tincture, rather than as an infusion; used generally externally or as a gargle.

Aqueous suspension of the gum resin decreased ethanol-induced and indomethacin-induced ulcer in rats. (JEthnopharmacol, 1997, Jan 55(2), 141150.)

Dosage: Gum-resin—3-5 g (CCRAS.)... balsamodendron myrrha

Butea Monosperma

(Lam.) Taub.

Synonym: B. frondosa Koenig ex Roxb.

Family: Papilionaceae; Fabaceae.

Habitat: Throughout India, up to 1,200 m except in very arid regions.

English: Flame of the Forest, Butea Gum, Bengal Kino.

Ayurvedic: Paalasha, Kimshuka, Raktapushpaka, Kshaarshreshtha, Brahmavriksha, Samidvar.

Unani: Dhaak, Samagh Dhaak, Kamarkas.

Siddha/Tamil: Palasam, Purasus.

Folk: Tesu.

Action: Bark—astringent, styptic (prescribed in bleeding piles, ulcers, haemorrhages, menstrual disorders), anthelmintic. Flowers— astringent, diuretic, emmenagogue (also given for leucorrhoea). A decoction of flowers is given in diarrhoea and haematuria, also to puerperal women. Seeds—clinical use of seeds as an anthelmintic drug is not considered safe in humans.

Leaves—antibacterial. Stem bark— antifungal.

An aqueous extract of flowers has shown hepatoprotective activity against CCl4-induced liver injury in albino rats.

Extracts of flowers have exhibited significant anti-oestrogenic activity in mice. The seed suspension, on oral administration to albino rats (175 and 350 mg/kg body weight), showed 38.46 and 68.75% cases, respectively, where pregnancy was not interrupted but foetus was malformed.

Alcoholic extract of the whole plant produced persistent vasodepression in cats.

The plant contains flavonoids and glucosides—butin, butrin, isobutrin and palastrin. Flowers contain butrin, coreopsin, monospermoside and their derivatives and sulphurein; also chal- cones.

Dosage: Stem bark—5-10 g powder (API Vol. II); flower—3-6 g powder; seed—3 g powder; gum—0.5-1.5 g (API Vol. IV.)... butea monosperma

Cucurbits

Cucurbitaceae

The family Cucurbitaceae includes a large group of plants which are medicinally valuable. The important genera belonging to the family are Trichosanthes, Lagenaria, Luffa, Benincasa, Momordica, Cucumis, Citrullus, Cucurbita, Bryonopsis and Corallocarpus. The medicinally valuable species of these genera are discussed below.

1. Trichosanthes dioica Roxb.

Eng: Wild Snake-gourd; San: Meki,Pargavi, Parvara, Patola;

Hin: Palval, Parvar

Ben: Potol;

Mal: Kattupatavalam, Patolam;

Tam: Kombuppudalai;

Tel: Kommupotta

Wild snake-gourd is a slender-stemmed, extensively climbing, more or less scabrous and woolly herb found throughout the plains of N. India, extending to Assam and W. Bengal. Tendrils are 2-4 fid. Leaves are 7.5x5cm in size, ovate-oblong, cordate, acute, sinuate- dentate, not lobed, rigid, rough on both surface and with a petiole of 2cm. Flowers are unisexual. Male flowers are not racemed but woolly outside. Calyx tube is 4.5cm long, narrow, teeth linear and erect. Anthers are free. Fruit is 5.9cm long, oblong or nearly spherical, acute, smooth and orange-red when ripe. Seeds are half-ellipsoid, compressed and corrugated on the margin (Kirtikar and Basu, 1988). The unripe fruit of this is generally used as a culinary vegetable and is considered very wholesome and specially suited for the convalescent. The tender shoots are given in decoction with sugar to assist digestion. The seeds are useful for disorders of the stomach. The leaf juice is rubbed over the chest in liver congestion and over the whole body in intermittent fevers (Nadkarni, 1998). The fruit is used as a remedy for spermatorrhoea. The fresh juice of the unripe fruit is often used as a cooling and laxative adjunct to some alterative medicines. In bilious fever, a decoction of patola leaves and coriander in equal parts is given. The fruit in combination with other drugs is prescribed in snakebite and scorpion sting (Kirtikar and Basu, 1988).

Fruits contain free amino acids and 5-hydroxy tryptamine. Fatty acids from seeds comprise elaeostearic, linoelic, oleic and saturated acids. The aerial part is hypoglycaemic. Leaf and root is febrifuge. Root is hydragogue, cathartic and tonic. Unripe leaf and fruit is laxative (Husain et al, 1992). The plant is alterative and tonic. Leaves are anthelmintic. Flower is tonic and aphrodisiac. The ripe fruit is sour to sweet, tonic, aphrodisiac, expectorant and removes blood impurities.

The other important species belonging to the genus Trichosanthes are as follows.

T. palmata Roxb. T. cordata Roxb. T. nervifolia Linn.

T. cucumerina Linn.

T. anguina Linn.

T. wallichiana Wight. syn. T. multiloba Clarke

2. Lagenaria vulgaris Ser. syn. Cucurbita Lagenaria Linn. ; Roxb.

Eng: Bottle gourd San: Alabu Hin: Lauki, Jangli-khaddu

Ben: Lau, Kodu

Mal: Katuchuram, Churakka

Tam: Soriai-kay

Tel: Surakkaya

Bottle gourd is a large softly pubescent climbing or trailing herb which is said to be indigenous in India, the Molucas and in Abyssinia. It has stout 5-angled stems with bifid tendrils. Leaves are ovate or orbiculate, cordate, dentate, 5-angular or 5-lobed, hairy on both surfaces. Flowers are large, white, solitary, unisexual or bisexual, the males long and females short peduncled. Ovary is oblong, softly pubescent with short style and many ovules. Fruits are large, usually bottle or dumb-bell-shaped, indehiscent and polymorphous. Seeds are many, white, horizontal, compressed, with a marginal groove and smooth. There are sweet fruited and bitter-fruited varieties (Kirtikar and Basu, 1988). The fruit contains a thick white pulp which, in the cultivated variety (kodu) is sweet and edible, while in the smaller wild variety (tamri) it is bitter and a powerful purgative. The seeds yield clear limpid oil which is cooling and is applied to relieve headache. The pulp of the cultivated forms is employed as and adjunct to purgatives and considered cool, diuretic and antibilious, useful in cough, and as an antidote to certain poisons. Externally it is applied as a poultice. The leaves are purgative and recommended to be taken in the form of decoction for jaundice (Nadkarni, 1998). In the case of sweet-fruited variety, the stem is laxative and sweet. The fruit is sweet oleagenous, cardiotonic, general tonic, aphrodisiac, laxative and cooling. In the case of bitter-fruited variety, the leaves are diuretic, antibilious; useful in leucorrhoea, vaginal and uterine complaints and earache. The fruit is bitter, hot, pungent, emetic, cooling, cardiotonic, antibilious; cures asthma, vata, bronchitis, inflammations ulcers and pains.

3. Luffa acutangula (Linn.) Roxb.

Eng: Ridged gourd; San: Dharmargavah, Svadukosataki;

Hin: Tori, Katitori;

Ben: Ghosha

Mal: Peechil, Peechinga;

Tam: Pikangai, Prikkangai;

Tel: Birakaya;

Kan: Kadupadagila

Ridged gourd or ribbed gourd is a large monoecious climber cultivated throughout India. It is with 5-angled glabrous stems and trifid tendrils. Leaves are orbicular-cordate, palmately 5-7 lobed, scabrous on both sides with prominent veins and veinlets. Flowers are yellow, males arranged in 12-20 flowered axillary racemes. Female flowers are solitary, arranged in the axils of the males. Ovary is strongly ribbed. Fruits are oblong-clavate with 10-sharp angles 15-30cm long, tapering towards the base. Seeds are black, ovoid-oblong, much compressed and not winged (Warrier et al, 1995). The leaves are used in haemorrhoids, leprosy, granular-conjunctivitis and ringworm. The seeds are useful in dermatopathy. The juice of the fresh leaves is dropped into the eyes of children in granular conjunctivitis, also to prevent the lids from adhering at night on account of excessive meihomian secretion (Nadkarni, 1998). Fruits are demulcent, diuretic, tonic, expectorant, laxative and nutritive. The seeds are bitter, emetic, cathartic, expectorant and purgative.

The other important species of the genus Luffa are:

L. aegyptiaca Mill.

L. acutangula var. amara Clarke

L. echinata Roxb.

4. Benincasa hispida (Thumb.) Cogn. syn. B. cerifera Savi.

Eng: Ash gourd, White gourd melon; San: Kusmandah;

Hin: Petha, Raksa;

Ben: Kumra

Mal: Kumpalam;

Tam: Pusanikkai;

Kan: Bile Kumbala;

Tel: Bodigummadi

Ash gourd or White gourd melon is a large trailing gourd climbing by means of tendrils which is widely cultivated in tropical Asia. Leaves are large and hispid beneath. Flowers are yellow, unisexual with male peduncle 7.5-10cm long and female peduncle shorter. Fruits are broadly cylindric, 30-45cm long, hairy throughout and ultimately covered with a waxy bloom. The fruits are useful in asthma, cough, diabetes, haemoptysis, hemorrhages from internal organs, epilepsy, fever and vitiated conditions of pitta. The seeds are useful in dry cough, fever, urethrorrhea, syphilis, hyperdipsia and vitiated conditions of pitta (Warrier et al,1993). It is a rejuvenative drug capable of improving intellect and physical strength. In Ayurveda, the fresh juice of the fruit is administered as a specific in haemoptysis and other haemorrhages from internal organs. The fruit is useful in insanity, epilepsy and other nervous diseases, burning sensation, diabetes, piles and dyspepsia. It is a good antidote for many kinds of vegetable, mercurial and alcoholic poisoning. It is also administered in cough, asthma or respiratory diseases, heart diseases and catarrah. Seeds are useful in expelling tapeworms and curing difficult urination and bladder stones. The important formulations using the drug are Kusmandarasayana, Himasagarataila, Dhatryadighrita, Vastyamantakaghrita, Mahaukusmandakaghrita, etc. (Sivarajan et al, 1994).

Fruits contain lupeol, -sitosterol, n-triacontanol, vitamin B, mannitol and amino acids. The fruit is alterative, laxative, diuretic, tonic, aphrodisiac and antiperiodic. Seed and oil from seed is anthelmintic (Husain et al, 1992).

5. Momordica charantia Linn.

Eng: Bitter gourd, Carilla fruit San: Karavellam

Hin: Karela, Kareli

Mal: Kaypa, Paval

Tam: Pavakkai, Paval, Pakar

Tel: Kakara

Bitter gourd or Carilla fruit is a branched climbing annual which is cultivated throughout India. It is a monoecious plant with angled and grooved stems and hairy or villous young parts. Tendrils are simple, slender and elongate. Leaves are simple, orbicular, cordate and deeply divided into 5-7 lobes. Flowers are unisexual, yellow and arranged on 5-10cm long peduncles. Fruits are 5-15cm long with 3-valved capsules, pendulous, fusiform, ribbed and beaked bearing numerous triangular tubercles. Seeds are many or few with shining sculptured surface. The roots are useful in coloptosis and ophthalmopathy. The leaves are useful in vitiated conditions of pita, helminthiasis, constipation, intermittent fever, burning sensation of the sole and nyctalopia. The fruits are useful in skin diseases, leprosy, ulcers, wounds, burning sensation, constipation, anorexia, flatulence, colic, helminthiasis, rheumatalgia, gout, diabetes, asthma, cough, dysmenorrhoea, impurity of breast milk, fever and debility. Seeds are useful in the treatment of ulcers, pharyngodynia, and obstructions of the liver and spleen. The leaves and fruits are used for external application in lumbago, ulceration and bone fractures and internally in leprosy, haemorrhoids and jaundice (Warrier et al, 1995). The drug improves digestion, calms down sexual urge, quells diseases due to pitta and kapha and cures anaemia, anorexia, leprosy, ulcers, jaundice, flatulence and piles. Fruit is useful in gout, rheumatism and complaints of liver and spleen (Nadkarni, 1954; Aiyer and Kolammal, 1966; Mooss, 1976; Kurup et al, 1979). Kaccoradi taila is an important preparation using the drug (Sivarajan et al, 1994).

The seeds give triterpene glycosides, named momordicosides A, B, C, D and E, which are glycosides of cucurbit-5-en-triol, tetraol or pentaol. Leaves and vines give tetracyclic triterpenes-momordicines I, II and III (bitter principles). Immature fruits give several non-bitter and 2 bitter cucurbitacin glycosides. Four of the non-bitter glycosides, momordicosides F1, F2, G and I and the bitter momordicosides; K and L have also been characterized. Fruits, seeds and tissue culture give a polypeptide which contained 17 types of amino acids and showed hypoglycaemic activity. Fruits also give 5-hydroxy tryptamine and a neutral compound charantin (a steroidal glucoside), diosgenin, cholesterol, lanosterol and -sitosterol. Leaf is emetic, purgative and antibilious. Fruit is stomachic, tonic, carminative, febrifuge, antirheumatic and hypoglycaemic. Root is astringent. Fruit and leaf is anti-leprotic. Fruit, leaf and root are abortifacient and anti-diabetic. Leaf and seed is anthelmintic. Seed oil possesses antifeeding and insecticidal properties. Unsaponifiable matter from seed oil exhibited pronounced inhibitory activity against gram negative bacteria. Seed and fruit are hypoglycaemic, cytotoxic and anti-feedant (Husain et al, 1992).

Other important species belonging to the genus Momordica are as follows.

M. dioica Roxb.

M. cochinchinensis Spreng.

M. tuberosa Cogn.

M. balsamina Linn.

6. Cucumis melo Linn. syn. C. melo Linn. var. cultis Kurz., C. pubescens

Willd., C. callosus (Rottl.) Cogn.

Eng: Sweet melon San,

Hin: Kharbuja

Ben: Kharmul

Mal: Mulam

Tam: Chukkari-kai, Thumatti-kai, Mulampazham

Tel: Kharbuja-doshavSweet melon is a creeping annual extensively cultivated throughout India, found wild in India, Baluchistan and tropical Africa. The stem is creeping, angular and scabrous. Leaves are orbicular-reniform in outline, 5-angled or lobed, scabrous on both surfaces and often with soft hairs. Lobes of leaves are not very deep nor acute and with 5cm long petiole. Female peduncle is 5cm. Fruit is spherical, ovoid, elongate or contorted, glabrous or somewhat hairy, not spinous nor tuberculate.

Cucumis melo includes two varieties, namely,

C. melo var. momordica syn. C. momordica Roxb.

C. melo var. utilissimus Duthie & Fuller. syn. C. utilissimus Roxb.

The fruit is eaten raw and cooked. Its pulp forms a nutritive, demulcent, diuretic and cooling drink. It is beneficial as a lotion in chronic and acute eczema as well as tan and freckles and internally in cases of dyspepsia. Pulp mixed with cumin seeds and sugar candy is a cool diet in hot season. Seeds yield sweet edible oil which is nutritive and diuretic, useful in painful discharge and suppression of urine. The whole fruit is useful in chronic eczema (Kirtikar & Basu, 1988).

Seeds contain fatty acids-myristic, palmitic, oleic, linoleic; asparagine, glutamine, citrulline, lysine, histidine, arginine, phenylalanine, valine, tyrosine, leucine, iso-leucine, methionine, proline, threonine, tryptophan and crystine. Seed is tonic, lachrymatory, diuretic and urease inhibitor. Fruit pulp is eczemic. Fruit is tonic, laxative, galactagogue, diuretic and diaphoretic. The rind is vulnerary (Husain et al, 1992).

7. Cucumic sativus Linn.

Eng: Cucumber, Common cucumber; San: Trapusah;

Hin,

Ben: Khira;

Mal: Vellari

Tam: Vellarikkai, Pippinkai;

Kan: Mullusavte;

Tel: Dosekaya

Cucumber is a climbing annual which is cultivated throughout India, found wild in the Himalayas from Kumaon to Sikkim. It is a hispidly hairy trailing or climbing annual. Leaves are simple, alternate, deeply cordate, 3-5 lobed with both surfaces hairy and denticulate margins. Flowers are yellow, males clustered, bearing cohering anthers, connective crusted or elevated above the cells. Females are solitary and thickly covered with very bulbous based hairs. Fruits are cylindrical pepo of varying sizes and forms. Seeds are cream or white with hard and smooth testa. The fruits are useful in vitiated conditions of pitta, hyperdipsia, burning sensation, thermoplegia, fever, insomnia, cephalgia, bronchitis, jaundice, haemorrhages, strangury and general debility. The seeds are useful in burning sensation, pitta, constipation, intermittent fevers, strangury, renal calculus, urodynia and general debility (Warrier et al, 1994). The leaves boiled and mixed with cumin seeds, roasted, powdered and administered in throat affections. Powdered and mixed with sugar, they are powerful diuretic (Nadkarni, 1998). The fruits and seeds are sweet, refrigerant, haemostatic, diuretic and tonic. Other important species belonging to the genus are:

C. trigonus Roxb. syn. C. pseudo-colocynthis

C. prophetarum Linn.

8. Citrullus colocynthis (Linn.) Schrader. syn. Cucumis colocynthis Linn.

Eng: Colocynth, Bitter apple; San: Visala, Mahendravaruni;

Hin: Badi indrayan, Makkal

Ben: Makhal;

Mal: Kattuvellari (Valutu), Valiya pekkummatti;

Tel: Etti-puchcha

Tam: Paitummatti, Petummatti;

Colocynth or Bitter apple is found, cultivated and wild, throughout India in warmer areas. It is an extensively trailing annual herb with bifid tendrils angular branching stems and wooly tender shoots. Leaves are deeply divided, lobes narrow thick, glabrous or somewhat hairy. Flowers are unisexual, yellow, both males and females solitary and with pale-yellow corolla. Fruit is a globose or oblong fleshy indehiscent berry, 5-7.5cm in diameter and variegated with green and white. Seeds are pale brown. The fruits are useful in tumours, ascites, leucoderma, ulcers, asthma, bronchitis, urethrorrhea, jaundice, dyspepsia, constipations, elephantiasis, tubercular glands of the neck and splenomegaly (Warrier et al, 1994). It is useful in abnormal presentations of the foetus and in atrophy of the foetus. In addition to the above properties, the root has a beneficial action in inflammation of the breasts, pain in the joints; externally it is used in ophthalmia and in uterine pains. The fruit and root, with or without is rubbed into a paste with water and applied to boils and pimples. In rheumatism, equal parts of the root and long pepper are given in pill. A paste of the root is applied to the enlarged abdomen of children (Kirtikar and Basu, 1988). The fruit is useful in ascites, biliousness, jaundice, cerebral congestion, colic, constipation dropsy, fever, worms and sciatica. Root is given in cases of abdominal enlargement, cough, asthma, inflammation of the breast, ulcers, urinary diseases and rheumatism. Oil from seeds is used for poisonous bites, bowel complaints, epilepsy and also for blackening the hair (Nadkarni, 1954; Dey, 1980). The important formulations using the root and fruit are Abhayarista, Mahatiktakam kasaya, Manasamitravatakam, Cavikasava, Madhuyastyadi taila, etc. (Sivarajan et al, 1994). The powder is often used as an insecticide. The extract should never be given without some aromatic to correct its griping tendency (Nadkarni, 1998).

Fruit contains a glycoside- colocynthin, its aglycone- -elaterin, citrulluin, citrullene and citrullic acid. Unripe fruit contains p-hydroxy benzyl methyl ester. Roots contain - elaterin and hentriacontane (Husain et al, 1992). Colocynth is, in moderate doses, drastic, hydrogogue, cathartic and diuretic. In large doses, it is emetic and gastro-intestinal irritant and in small doses, it is expectorant and alterative. Colocynthin is a cathartic and intensely bitter principle. It has a purgative action. All parts of the plant are very bitter. The fruit has been described as cathartic (Nadkarni, 1982).

9. Citrullus vulgaris Schrad. syn. C. lanatus (Thunb.) Mats. & Nakai.

Eng: Water melon; San: Tarambuja;

Hin: Tarbuj;

Ben: Tarbuz

Mal: Thannimathan;

Tam: Pitcha, Dharbusini

Watermelon is an extensively climbing annual which is largely cultivated throughout India and in all warm countries. It has thick angular branching stems. Tendrils are bifid, stout and pubescent. Leaves are long, deeply divided or moderately lobed, glabrous or somewhat hairy and hardly scabrous. Petiole is a little shorter than the limb and villous. Calyx-lobes are narrowly lanceolate, equalling the tube. Corolla is yellow within, greenish outside and villous. Lobes are ovate-oblong, obtuse and prominently 5-nerved. Fruit is sub-globose or ellipsoid, smooth, greenish or clouded, often with a glaucous waxy coating. Flesh is juicy, red or yellowish white. Seeds are usually margined. C. vulgaris var. fistulosus Duthie & Fuller. syn. C. fistulosus has its fruit about the size of small turnip, the seeds of which are used medicinally. The fruit is tasteless when unripe and sweet when ripe. The unripe fruit is used to cure jaundice. Ripe fruit cures kapha and vata and causes biliousness. It is good for sore eyes, scabies and itching. The seeds are tonic to the brain and used as a cooling medicine. An emulsion of the seeds is made into a poultice with the pounded leaves and applied hot in cases of intestinal inflammations (Kirtikar and Basu, 1988). Fruit juice is good in quenching thirst and it is used as an antiseptic in typhus fever with cumin and sugar. It is used as a cooling drink in strangury and affections of urinary organs such as gonorrhoea; in hepatic congestion and intestinal catarrh. The bitter watermelon of Sind is known as “Kirbut” and is used as a purgative.

Seeds yield a fixed oil and proteids; citrullin. Seeds are cooling, demulcent, diuretic, vermifuge and nutritive. Pulp is cooling and diuretic. Fruit-juice is cooling and refreshing (Nadkarni, 1982).

10. Curcurbita pepo Linn. syn. Pepo vulgaris et P. verrucosus Moench

Meth.

Eng: Pompion, Pumpkin, Vegetable Marrow; San: Karkaru, Kurkaru, Kushmandi

Hin,

Ben: Kadimah, Konda, Kumra, Safedkkadu;

Mal: Mathan, Matha

Tel: Budadegummadi, Pottigummadi

Pompion or Pumpkin is a climbing herb which is considered to be a native of America and cultivated in many parts of India. The stem and leaves are with a harsh prickly armature. Foliage is stiff, more or less rigid and erect. Leaves are with a broad triangular pointed outline and often with deep lobes. Corolla is mostly with erect or spreading (not drooping) pointed lobes, the tube narrowing towards the base. Peduncle is strongly 5-angled and little or much expanding near the fruit. The fruit is cooling and astringent to the bowels, increases appetite, cures leprosy, ‘kapha and vata’, thirst, fatigue and purifies the blood. The leaves are used to remove biliousness. Fruit is good for teeth, throat and eyes and allays thirst. Seeds cure sore chests, haemoptysis, bronchitis and fever. It is good for the kidney and brain. The leaves are used as an external application for burns. The seeds are considered anthelmintic. The seeds are largely used for flavouring certain preparations of Indian hemp, and the root for a nefarious purpose, viz., to make the preparation more potent. The seeds are taeniacide, diuretic and demulcent. The fruit is cooling, laxative and astringent. The leaves are digestible, haematinic and analgesic.

The other important species belonging to the genus Cucurbita is C. maxima Duchena, the seeds of which are a popular remedy for tape-worm and oil as a nervine tonic (Kirtikar & Basu, 1988).

11. Corallocarpus epigaeus Benth. ex Hook. f. syn. Bryonia epigaea Wight.

San: Katunahi;

Hin: Akasgaddah;

Mal: Kadamba, Kollankova

Tam: Akashagarudan, Gollankovai;

Tel: Murudonda, Nagadonda

Corallocarpus is a prostrate or climbing herb distributed in Punjab, Sind, Gujarat, Deccan, Karnataka and Sri Lanka. It is monoecious with large root which is turnip-shaped and slender stem which is grooved, zigzag and glabrous. Tendrils are simple, slender and glabrous. Leaves are sub-orbicular in outline, light green above and pale beneath, deeply cordate at the base, angled or more or less deeply 3-5 lobed. Petiole is long and glabrous. Male flowers are small and arranged at the tip of a straight stiff glabrous peduncle. Calyx is slightly hairy, long and rounded at the base. Corolla is long and greenish yellow. Female flowers are usually solitary with short, stout and glabrous peduncles. Fruit is stalked, long, ellipsoid or ovoid. Seeds are pyriform, turgid, brown and with a whitish corded margin. It is prescribed in later stages of dysentery and old veneral complaints. For external use in chronic rheumatism, it is made into a liniment with cumin seed, onion and castor oil. It is used in case of snakebite where it is administered internally and applied to the bitten part. The root is given in syphilitic rheumatism and later stages of dysentery. The plant is bitter, sweet, alexipharmic and emetic. The root is said to possess alterative and laxative properties (Kirtikar and Basu, 1988). Root contains a bitter principle like Breyonin (Chopra et al, 1980).

Agrotechnology: Cucurbits can be successfully grown during January-March and September- December. For the rainfed crop, sowing can also be started after the receipt of the first few showers.

Pits of 60cm diameter and 30-45cm depth are to be taken at the desired spacing. Well rotten FYM or vegetable mixture is to be mixed with topsoil in the pit and seeds are to be sown at 4-5/pit. Unhealthy plants are to be removed after 2 weeks and retained 2-3 plants/pit. FYM is to be applied at 20-25t/ha as basal dose along with half dose of N (35kg/ha) and full dose of P (25kg) and K (25kg). The remaining dose of N (35kg) can be applied in 2 equal split doses at fortnightly intervals. During the initial stages of growth, irrigation is to be given at an interval of 3-4 days and at alternate days during flowering and fruiting periods. For trailing cucumber, pumpkin and melon, dried twigs are to be spread on the ground. Bitter gourd, bottle gourd, snake gourd and ash gourd are to be trailed on Pandals. Weeding and raking of the soil are to be conducted at the time of fertilizer application. Earthing up may be done during rainy season. The most dreaded pest of cucurbits is fruit flies which can be controlled by using fruit traps, covering the fruits with polythene, cloth or paper bags, removal and destruction of affected fruits and lastly spraying with Carbaryl or Malathion 0. 2% suspension containing sugar or jaggery at 10g/l at fortnightly intervals after fruit set initiation. During rainy season, downy mildew and mosaic diseases are severe in cucurbits. The former can be checked by spraying Mancozeb 0.2%. The spread of mosaic can be checked by controlling the vectors using Dimethoate or Phosphamidon 0.05% and destruction of affected plants and collateral hosts. Harvesting to be done at least 10 days after insecticide or fungicide application (KAU,1996).... cucurbits

Hanging

Hanging is a form of death due to suspension of the body from the neck – either suddenly, as in judicial hanging (although not in the United Kingdom, as the death penalty is not used in the UK justice system), so as to damage the spinal column and cord, or in such a way as to constrict the AIR PASSAGES and the blood vessels to the brain. Death is, in any case, speedy, resulting in 2–3 minutes if not instantaneously. Apart from judicial hanging, and in the absence of any signs of a struggle, hanging is usually due to SUICIDE. The resuscitation of people found hanging is similar to that for drowning. (See APPENDIX 1: BASIC FIRST AID – Cardiac/respiratory arrest.)... hanging

Indian Bdellium

Commiphora mukul

Burseraceae

San: Gugulu, Mahisaksah, Koushikaha, Devadhupa

Hin: Gugal Mal:Gulgulu Tam,

Tel: Gukkulu

Kan: Guggul

Ben: Guggul

Importance: Indian bdellium is a small, armed, deciduous tree from the bark of which gets an aromatic gum resin, the ‘Guggul’ of commerce. It is a versatile indigenous drug claimed by ayurvedists to be highly effective in the treatment of rheumatism, obesity, neurological and urinary disorders, tonsillitis, arthritis and a few other diseases. The fumes from burning guggul are recommended in hay- fever, chronic bronchitis and phytises.

The price of guggulu gum has increased ten fold in ten years or so, indicating the increase in its use as well as decrease in natural plant stand. It has been listed as a threatened plant by Botanical Survey of India (Dalal, 1995) and is included in the Red Data Book (IUCN) and over exploited species in the country (Billare,1989).

Distribution: The center of origin of Commiphora spp. is believed to be Africa and Asia. It is a widely adapted plant well distributed in arid regions of Africa (Somalia, Kenya and Ethiopia in north east and Madagascar, Zimbabwe, Botswana, Zaire in south west Africa), Arabian peninsula (Yemen, Saudi Arabia and Oman). Different species of Commiphora are distributed in Rajasthan, Gujarat, Maharashtra and Karnataka states of India and Sind and Baluchistan provinces of Pakistan (Tajuddin et al, 1994). In India, the main commercial source of gum guggul is Rajasthan and Gujarat.

Botany: The genus Commiphora of family Burseraceae comprises about 185 species. Most of them occur in Africa, Saudi Arabia and adjoining countries. In India only four species have been reported. They are C. mukul(Hook. ex Stocks) Engl. syn. Balsamodendron mukul (Hook. ex Stocks), C. wightii (Arnott) Bhandari, C.stocksiana Engl., C. berryi and C.agallocha Engl.

In early studies about the flora of India, the ‘guggul’ plant was known as Commiphora mukul(Hook. ex Stocks) Engl. or Balsamodendron mukul (Hook. ex Stocks). It was renamed as C. roxburghii by Santapau in 1962. According to Bhandari the correct Latin name of the species is C. wightii(Arnott) Bhandari, since the specific name ‘wightii’ was published in 1839, prior to ‘roxburghi’ in 1848 (Dalal and Patel, 1995).

C. mukul is a small tree upto 3-4m height with spinescent branching. Stem is brownish or pale yellow with ash colored bark peeling off in flakes. Young parts are glandular and pubescent. Leaves are alternate, 1-3 foliate, obovate, leathery and serrate (sometimes only towards the apex). Lateral leaflets when present only less than half the size of the terminal ones. Flowers small, brownish red, with short pedicel seen in fascicles of 2-3. Calyx campanulate, glandular, hairy and 4-5 lobed. Corolla with brownish red, broadly linear petals reflexed at apex. Stamens 8-10, alternatively long and short. Ovary oblong, ovoid and stigma bifid. Fruit is a drupe and red when ripe, ovate in shape with 2-3 celled stones. The chromosome number 2n= 26 (Warrier et al, 1994; Tajuddin et al, 1994).

Agrotechnology: Guggal being a plant of arid zone thrives well in arid- subtropical to tropical climate.

The rainfall may average between 100mm and 500mm while air temperature may vary between 40 C in summer and 3 C during winter. Maximum relative humidity prevails during rainy season (83% in the morning and 48% in the evening).Wind velocity remains between 20-25 km/hour during the year is good. Though they prefer hard gypseous soil, they are found over sandy to silt loam soils, poor in organic matter but rich in several other minerals in arid tracks of western India (Tajuddin et al, 1994).

Plants are propagated both by vegetatively and seeds. Plants are best raised from stem cuttings from the semi woody (old) branch. For this purpose one metre long woody stem of 10mm thickness is selected and the cut end is treated with IBA or NAA and planted in a well manured nursery bed during June-July months; the beds should be given light irrigation periodically. The cuttings initiate sprouting in 10-15 days and grow into good green sprout in 10-12 months. These rooted plants are suitable for planting in the fields during the next rainy season. The cuttings give 80-94% sprouting usually. Air layering has also been successfully attempted and protocol for meristem culture is available in literature. Seed germination is very poor (5%) but seedling produce healthier plants which withstand high velocity winds.

The rooted cuttings are planted in a well laid-out fields during rainy season. Pits of size 0.5m cube are dug out at 3-4 m spacing in rows and given FYM and filler soil of the pit is treated with BHC (10%) or aldrin (5%) to protect the new plants from white ants damage. Fertilizer trials have shown little response except due to low level of N fertilization. Removal of side branches and low level of irrigation supports a good growth of these plants. The plantation does not require much weeding and hoeing. But the soil around the bushes be pulverised twice in a year to increase their growth and given urea or ammonium sulphate at 25- 50g per bush at a time and irrigated. Dalal et al (1989) reported that cercospora leaf spot was noticed on all the cultures. Bacterial leaf blight was also noticed to attack the cultures. A leaf eating caterpillar (Euproctis lanata Walker) attack guggal, though not seriously. White fly (Bemisia tabaci) is observed to suck sap of leaves and such leaves become yellowish and eventually drop. These can be effectively controlled by using suitable insecticide.

Stem or branch having maximum diameter of about 5cm at place of incision, irrespective of age is tapped. The necrotic patch on the bark is peeled off with a sharp knife and Bordeaux paste is applied to the exposed (peeled off) surface of the stem or branch. A prick chisel of about 3cm width is used to make bark- deep incisions and while incising the bark, the chisel is held at an acute angle so that scooped suspension present on the body of the chisel flows towards the blade of the chisel and a small quantity of suspension flows inside the incised bark. If tapping is successful, gum exudation ensures after about 15-20 days from the date of incision and continues for nearly 30-45 days. The exuded gum slides down the stem or branch, and eventually drops on the ground and gets soiled. A piece of polythene sheet can be pouched around the place of incision to collect gum. Alternatively, a polythene sheet can be spread on the ground to collect exuded gum. A maximum of about 500g of gum has been obtained from a plant (Dalal, 1995).

Post harvest technology: The best grade of guggul is collected from thick branches of tree. These lumps of guggul are translucent. Second grade guggul is usually mixed with bark, sand and is dull coloured guggul. Third grade guggul is usually collected from the ground which is mixed with sand, stones and other foreign matter. The final grading is done after getting cleansed material. Inferior grades are improved by sprinkling castor oil over the heaps of the guggul which impart it a shining appearance (Tajuddin et al, 1994).

Properties and activity: The gum resin contains guggul sterons Z and E, guggul sterols I-V, two diterpenoids- a terpene hydrocarbon named cembreneA and a diterpene alcohol- mukulol, -camphrone and cembrene, long chain aliphatic tetrols- octadecan-1,2,3,4-tetrol, eicosan-1,2,3,4-tetrol and nonadecan-1,2,3,4-tetrol. Major components from essential oil of gum resin are myrcene and dimyrcene. Plant without leaves, flowers and fruits contains myricyl alcohol, -sitosterol and fifteen aminoacids. Flowers contain quercetin and its glycosides as major flavonoid components, other constituents being ellagic acid and pelargonidin glucoside (Patil et al, 1972; Purushothaman and Chandrasekharan, 1976).

The gum resin is bitter, acrid, astringent, thermogenic, aromatic, expectorant, digestive, anthelmintic, antiinflammatory, anodyne, antiseptic, demulcent, carminative, emmenagogue, haematinic, diuretic, lithontriptic, rejuvenating and general tonic. Guggulipid is hypocholesteremic (Husain et al, 1992; Warrier et al, 1994).... indian bdellium

Long Pepper

Piper longum

Piperaceae: San: Pippali;

Hin, Ben, Pun: Piplamul; Kan, Mal:Thippali ;

Tam: Thippili; Mar: Pimpli;

Tel: Pipppaloo; Ass: Piplu.

Introduction: Long pepper is a slender aromatic climber whose spike is widely used in ayurvedic and unani systems of medicine particularly for diseases of respiratory tract. Pipalarishta, Pippalyasava, Panchakola, Pippalayadilauha, and Lavana bhaskar churan are common ayurvedic preparations made out of the dry spikes of female types. Ittrifal fauladi, Angaruya-i-kabir and Majun khadar are well known unani preparations of long pepper. Its roots also have several medicinal uses. The root is useful in bronchitis, stomach ache, diseases of spleen and tumours. Fruit is useful in vata and kapha, asthma, bronchitis, abdominal complaints, fever, leucoderma, urinary discharges, tumours, piles, insomnia and tuberculosis. Root and fruit are used in gout and lumbago. The infusion of root is prescribed after parturition to induce the expulsion of placenta. The root and fruit decoction are used in acute and chronic bronchitis and cough. It contains the alkaloid piperine which has diverse pharmacological activities, including nerve depressant and antagonistic effect on electro- shock and chemo -shock seizures as well as muscular incoordination.

Distribution: The plant is a native of Indo-Malaya region. It was very early introduced to Europe and was highly regarded as a flavour ingredient by the Romans. The Greek name “Peperi”, the Latin “Piper” and the English “Pepper” were derived from the Sanskrit name “Pippali”. It grows wild in the tropical rain forests of India, Nepal, Indonesia, Malaysia, Sri lanka, Rhio, Timor and the Philippines. In India, it is seen in Assam, West Bengal, Uttar Pradesh, Madhya Pradesh, Maharashtra, Kerala, Karnataka.and Tamil Nadu. It is also cultivated in Bengal, Chirapunchi area of Assam, Akola-Amravati region of Maharashtra, Anamalai hills of Tamil Nadu, Orissa, Uduppi and Mangalore regions of Karnataka. Bulk of Indian long pepper comes from its wild growth in Assam, Shillong and West Bengal, supplemented by imports from Sri Lanka and Indonesia (Viswanathan,1995)

Botany: Piper longum Linn. is a member of Piperaceae family. The plant is a glabrous perennial under-shrub with erect or sub-scandent nodose stem and slender branches, the latter are often creeping or trailing and rooting below or rarely scandent reaching a few metres height. Leaves are simple, alternate, stipulate, and petiolate or nearly sessile; lower ones broadly ovate, cordate; upper ones oblong, oval, all entire, smooth, thin with reticulate venation; veins raised beneath. It flowers nearly throughout the year. Inflorescence is spike with unisexual small achlamydeous densely packed flowers and form very close clusters of small greyish green or darker grey berries. Female spikes with short thick stalk varying from 1.5 to2.5 cm in length and 0.5 to 0.7 cm in thickness.

A number of geographical races are available in different agroclimatic regions of India; the most popular being Assam, West Bengal and Nepal races. Piper officinarum DC; syn. Chavica officinarum Miquel, Piper pepuloides and Piper chaba Hunter are the other related species of importance.

Agrotechnology: Long pepper is a tropical plant adapted to high rainfall areas with high humidity. An elevation of 100-1000 m is ideal. It needs partial shade to the tune of 20-30% for best growth. The natural habitat of the plant is on the borders of streams. It is successfully cultivated in well drained forest soils rich in organic matter. Laterite soils with high organic matter content and moisture holding capacity are also suitable for cultivation.

Long pepper is propagated by suckers or rooted vine cuttings.15-20 cm long 3-5 nodded rooted vine cuttings establishes very well in polybags. The best time for raising nursery is March-April. Normal irrigation is given on alternate days. The rooted cuttings will be ready for transplanting in 2 months time. With the onset of monsoon in June the field is ploughed well and brought to good tilth. 15-20 cm raised beds of convenient length and breadth are taken. On these beds, pits are dug at 60 x 60 cm spacing and well decomposed organic manure at 100 g/pit is applied and mixed with the soil. Rooted vine cuttings from polybags are transplanted to these pits. Gap filling can be done after one month of planting.The crop needs heavy manuring at the rate of 20 t FYM/ha every year. Application of heavy dose organic matter and mulching increase water retention in the soil and control weeds. Small doses of chemical fertilisers can also be used. The crop needs irrigation once a week. Sprinkler irrigation is ideal. With irrigation the crop continues to produce spikes and off-season produce will be available. However, it is reported that unirrigated crop after the onset of monsoon grows vigorously and shows much hardiness than the irrigated crop.

Crop losses can be heavy due to pests and diseases. Mealy bugs and root grubs, attack the plant particularly during summer. Infested plants show yellowing and stunted growth. Application of systemic insecticides like nuvacron or dimecron will control the pests. Adults and nymphs of Helopeltis theivora severely feeds on the foliage which can be controlled by 0.25% neem kernel suspension. Rotting of leaves and vines during monsoon season is caused by Colletotrichum glorosporiodes and necrotic lesions and blights on the leaves during summer is caused by Colletotrichum and Cercospora spp. These diseases can be controlled by spraying of 1% Bordeaux mixture repeatedly. A virus like disease characterised by yellowing and crinkling of leaves, stunted growth and production of spikes of smaller size and inferior quality was also recently reported.

The vines start flowering six months after planting and flowers are produced almost throughout the year. The spikes mature in 2 months time. The optimum stage of harvest is when the spikes are blackish green. The pungency is highest at this stage. Spikes are hand picked when they become mature and then dried. The yield of dry spike is 400 kg /ha during first year, increases to 1000kg during third year and thereafter it decreases. Therefore, after 3 years the whole plant is harvested. The stem is cut close to the ground and roots are dug up. Average yield is 500 kg dry roots/ha (Viswanathan,1995).

Piper longum can also be cultivated as an intercrop in plantations of coconut, subabul and eucalyptus.

Post harvest technology: The harvested spikes are dried in sun for 4-5 days until they are perfectly dry. The green to dry spike ratio is 10:1.5 by weight. The dried spikes have to be stored in moisture proof containers. Stem and roots are cleaned, cut into pieces of 2.5-5 cm length, dried in shade and marketed as piplamool. There are three grades of piplamool, based on the thickness. The commercial drug consists 0.5-2.5 cm long ,0.5-2.5 mm thick, cylindrical pieces dirty light brown in colour and peculiar odour with a pungent bitter taste, producing numbness to the tongue.

Properties and activity: The spike of long pepper contains 4-5% piperine, piplartin, piperolactam, N-isobutyl deca trans-2-trans-4-dienamide and piporadione alkaloides, besides 0.7 % essential oil. Roots gave the alkaloids piperine, piperlongumine (piplartine) and piperlonguminine; sesamine, methyl 3, 4, 5-trimethoxy cinnamate. Stem gave triacoutane 22, 23 - dihydrostigmasterol. Fruit essential oil contains piperidine, caryophyllene and sesquiterpene alcohol (Atal et al, 1975).

The root is plungent, hot, stomachic, laxative, anthelmintic and carminative. The fruit is sweetish, pungent, hot, stomachic, aphrodisiac, alterative, laxative, antidysenteric, emmenagogue, abortifacient, diuretic and tonic. The essential oil is antimicrobial and anthelmintic.

N-isobutyl-deca-trans-2-trans-4-dienamide is antitubercular.

Piperine is hypotensive, antipyretic, analeptic, and nerve stimulant (Warrier et al, 1995).... long pepper

Neem

Azadirachta indica

Meliaceae

San: Nimbah, Prabhadrah Hin,

Ben: Nim, Nim Mal: Aryaveppu

Tel: Vepa Ori: Nimba

Tam: Vembu, Veppu Pun: Bakam,Bukhain

Guj: Limba

Kan: Bevu Mar: Limbu

Importance: Neem or margose tree, also known as Indian lilac is a highly exploited medicinal plant of Indian origin, widely grown and cultivated throughout India. Every part of the tree, namely root, bark, wood, twig, leaf, flower, fruit, seed, kernel and oil has been in use from time immemorial in the Ayurvedic and Unani systems of medicine. Nimbarishta, nimbadi churna and nimbharidra khand are well known preparations. It is valuable as an antiseptic, used in the treatment of small pox. Small twigs are used as tooth brushes and as a prophylactic for mouth and teeth complaints. Extract from the leaves are useful for sores, eczema and skin diseases. Boiled and smashed leaves serve as excellent antiseptic. Decoction of leaves is used for purifying blood. Neem oil is used in soaps, toothpaste and as a hair tonic to kill lice. Seed is used in snake bite. The fruits and leaves being renewable, provide sustainable returns. Different parts of the fruit are separated into components and each one produces derivatives of varying chemical nature and utility. Neem derivatives are now used in agriculture, public health, human and veterinary medicines, toiletries, cosmetics and livestock production. Applications as pesticides, allied agrochemicals, plant nutrients and adjuvants for improving nitrogen use efficiency are of much importance. Neem kernel suspension (1%) is a house hold insecticide. Pesticide formulations containing azadirachtin are now commercially available in India, USA, Canada, Australia and Germany. Neem cake is rich in N, P, K, Ca and S. Neem Meliacins like epinimbin and nimbidin are commercially exploited for the preparation of slow and extended release of nutrients including nitrification inhibitors (Eg. Nimin). Extracts of neem seed oil and bark check the activity of male reproductive cells and prevents sperm production. Neem seed oil is more effective than the bark for birth control. Neem based commercial products are also available for diabetes treatment (Nimbola, JK-22), contraceptive effect (Sensal, Nim-76) and mosquito/ insect repelling (Srivastava, 1989; Tewari, 1992; Parmer and Katkar, 1993; Pushpangadan et al, 1993; Mariappan, 1995).

Distribution: Neem is a native of the Siwalik deccan parts of South India. It grows wild in the dry forests of Andra Pradesh, Tamil Nadu and Karnataka. It has spread to Pakistan, Bangladesh , Sri Lanka, Malaysia, Indonesia, Thailand, Middle East Sudan and Niger. It is now grown in Australia, Africa, Fiji, Mauritious, Central and South America, the Carribeans, Puerto Rico and Haiti. The largest known plantation of nearly 50,000 trees is at Arafat plains en route to Mecca in Saudi Arabia for providing shade to Haj pilgrims (Ahmed, 1988).

Botany: The genus Azadirachta of family Meliaceae comprises two species: A. indica A. Juss syn. Melia azadirachta Linn. and A. excelsa (Jack) Jacobs syn. A. integrifolia Mers., the latter being found in Philippines, Sumatra, Malaya, Borneo and New Guinea. Neem is a hardy medium to large, mostly evergreen tree attaining 20m height and 2.5m girth. It has a short bole with wide spreading branches and glabrous twigs forming a round to oval crown. The bark is thick, dark-gray with numerous longitudinal furrows and transverse cracks. Leaves are imparipinnately compound, alternate, exstipulate and 20-38cm long. Inflorescence is long, slender, axillary or terminal panicle. Flowers are white or pale yellow, small, bisexual, pentamerous and bracteate. Stamens 10; filaments unite to form a moniliform tube. Gynoecium is tricarpellary and syncarpous, ovary superior, trilocular. Each carpel bears two collateral ovules on parietal placentation. Fruit is one seeded drupe with woody endocarp, greenish yellow when ripe. Seed ellipsoid, cotyledons thick fleshy and oily. Neem has chromosome number 2n = 28. Neem trees tend to become deciduous for a brief period in dry ecology. Ecotypes, exhibiting morphological variation in root growth, leaf size, contents, bole length , canopy, inflorescence, fruit bearing, seed size, shape and quality exist in natural populations.

Agrotechnology: Neem grows in tropical arid regions with high temperatures, altitudes between 50m and 1000m, as little rainfall as 130mm/yr and long stretches of drought. Well drained sunny hill places are ideal. It grows on most kinds of soils including dry, stony, shallow, nutrient deficient soils with scanty vegetation, moderately saline and alkali soils, black cotton, compact clays and laterite crusts. However, silty flats, clayey depressions and land prone to inundation are not conducive for its growth (Chaturvedi, 1993). Soil pH of 5.0 to 10.0 is ideal. It brings surface soil to neutral pH by its leaf litter. It has extensive and deeply penetrating root system capable of extracting moisture and nutrients even from highly leached poor sandy soils.

Neem propagates easily by seed without any pretreatment, though it can be regenerated by vegetative means like root and shoot cuttings. Seeds are collected from June to August. These remain viable for 3-5 weeks only which necessitates sowing within this short time. Seeds may be depulped and soaked in water for 6 hours before sowing. Seeds are sown on nursery beds at 15x5cm spacing, covered with rotten straw and irrigated. Germination takes 15-30 days. Seedlings can be transplanted after two months of growth onwards either to polybags or to mainfield. Neem can be grown along with agricultural crops like groundnut, bean, millets, sorghum and wheat. It is also suitable for planting in roadsides, for afforestation of wastelands and under agroforestry system. For field planting, pits of size 50-75 cm cube are dug 5-6m apart, filled with top soil and well rotten manure, formed into a heap, and seedling is planted at the centre of the heap. FYM is applied at 10-20 kg/plant every year. Chemical fertilizers are not generally applied. Irrigation and weeding are required during the first year for quick establishment.

More than 38 insect pests are reported on Neem which may become serious at times. The important ones are seed and flower insect (Scirtothrips dorsalis Hood), defoliators (Boarmia variegata Moore and Eurema sp.), sap suckers (Helopeltes antonii Signoret and Pulvinaria maxima Green) , root feeders (Hototrichia consanguinea Blanchard), mealy bug (Pseudococus gilbertensis), scale insect (Parlatoria orientalis) and a leaf webber (Loboschiza Koenigiana)(Beeson, 1941, Bhasin et al, 1958, Parmar, 1995). They can be controlled by the application of 0.01-0.02% monocrotophos or dimethoate. No serious diseases are reported in Neem. Flowering starts after 5 years. In India flowering is during January-May and fruits mature from May-August. The leaves are shed during February- March and a full grown tree produces about 350 kg dry leaves and 40-50 kg berries per annum. Fresh fruits give 60% dry fruits which yield 10% kernel which contains 45% fixed oil, on an average. After 10 years of growth the wood can be cut and used as timber.

Properties and Activity: Dry Neem leaves contain carbohydrates 47-51%, crude protein 14-19%, crude fiber 11-24%, fat 2-7%, ash 7-9%, Ca 0.8-2.5% and P 0.1-0.2%. Leaves also contain the flavanoid quercetin, nimbosterol (-sitosterol), kaempferol and myricetin. Seed and oil contains desacetylnimbin, azadirachtin (C35H44O16), nimbidol, meliantriol ,tannic acid, S and amino acids. Neem cake contain the highest sulphur content of 1.07% among all the oil cakes. Trunk bark contains nimbin 0.04%, nimbinin 0.001%, nimbidin 0.4%, nimbosterol 0.03%, essential oil 0.02%, tannins 6.0 %, margosine and desacetylnimbin (Atal and Kapur, 1982; Thakur et al 1989).

Neem bark is bitter, astringent, acrid, refrigerant, depurative, antiperiodic, vulnerary, demulcent, insecticidal, liver tonic, expectorant and anthelmintic. Leaves are bitter, astringent, acrid, depurative, antiseptic, ophthalmic, anthelmintic, alexeteric, appetizer, insecticidal, demulcent and refrigerant. Seed and oil are bitter, acrid, thermogenic, purgative, emollient, anodyne, anthelmintic depurative, vulnerary, uterine stimulant, urinary astringent, pesticidal and antimicrobial (Warrier et al, 1993).... neem

Aerosol

n. a suspension of extremely small liquid or solid particles (about 0.001 mm diameter) in a gas. Drugs for inhalation are in aerosol form.... aerosol

Chyle

n. an alkaline milky liquid found within the *lacteals after a period of absorption. It consists of lymph with a suspension of minute droplets of digested fats (triglycerides), which have been absorbed from the small intestine. It is transported in the lymphatic system to the *thoracic duct. See also ascites.... chyle

Emblica Officinalis

Gaertn.

Synonym: Phyllanthus emblica Linn.

Family: Euphorbiaceae.

Habitat: Native to tropical Southeast Asia; distributed throughout India; also planted in public parks.

English: Emblic, Indian gooseberry.

Ayurvedic: Aaamalaki, Aaamalaka, Dhaatri, Kaayasthaa, Amoghaa, Amritaphala, Amla, Aaamalaa, Dhaatriphala, Vayasyaa, Vrshya, Shiva, Hattha.

Unani: Aamalaa, Amlaj.

Siddha/Tamil: Nellikkaai, Nelli.

Action: Fruit—antianaemic, anabolic, antiemetic, bechic, astringent, antihaemorrhagic, antidiarrhoeal, diuretic, antidiabetic, carminative, antioxidant. Used in jaundice, dyspepsia, bacillary dysentery, eye trouble and as a gastrointestinal tonic. Juice with turmeric powder and honey is prescribed in diabetes insipidus. Seed—antibilious, antiasthmatic. Used in bronchitis. Bark—astringent. Leaf—juice is given in vomiting.

A decoction of powdered pericarp is prescribed for paptic ulcer.

Key application: As an antacid. (Indian Herbal Pharmacopoeia.).

The fruit is an important source of vitamin C, minerals and amino acids. The edible fruit tissue contains protein concentration threefold and vitamin C (ascorbic acid) concentration 160-fold than those of apple. The fruit also contains considerably higher concentration of most minerals and amino acids than apple.

The fruit gave cytokinine-like substances identified as zeatin, zeatin ribo- side and zeatin nucleotide; suspension culture gave phyllembin. Phyllem- bin exhibits CNS depressant and spasmolytic activity, potentiates action of adrenaline and hypnotic action of Nembutal.

The leaves contain gallic acid (10.8 mg/g dry basis), besides ascorbic and music acid. The methanol extract of the leaves is found to be effective in rat paw inflammation.

The bark contains tannin identified as mixed type of proanthocyanidin.

The fruit contains superoxide dis- mutase 482.14 units/g fresh weight and exhibits antisenescent (anti-aging) activity. Fruit, juice, its sediment and residue are antioxidant due to gallic acid. EtOH (50%) extract—antiviral.

Aqueous extract of the fruit increases cardiac glycogen level and decreases serum GOT, GPT and LDH in rats having induced myocardial necrosis.

Preliminary evidence suggests that the fruit and its juice may lower serum cholesterol, LDL, triglycerides and phospholipids without affecting HDL levels and may have positive effect on atherosclerosis. (Eur J clin Nutr, 42, 1988, 939-944; PhytotherRes, 14, 2000, 592-595.)

An aqueous extract of the fruit has been reported to provide protection against radiation-induced chromosomal damage in both pre-and postirradiation treatment. The fruit is reported to enhance natural killer cell activity and antibody dependent cellular cytotoxicity in mice bearing Dalton's lymphoma ascites tumour. The extract of the fruit and ascorbic acid prevented hepatotoxic and nephrotoxic effects induced by lead and aluminium. The toxicity could be counteracted to a great extent by the fruit extract than by an amount of ascorbic acid alone equivalent to that contained in fruits. (The fruit can be used as a dietary supplement to counteract prolonged exposure to metals in population in industrial areas.)

The fruits are reported to activate trypsin (proteolytic enzyme) activity.

The fruits can be used as coagulant in the treatment of water and can purify low turbidity water.

The fruits can be consumed safely all round the year.

Dosage: Fresh fruit—10-20 g; pulp juice—5-10 ml. (API Vol. I.)... emblica officinalis

Ferula Jaeschkeana

Vatke.

Family: Umbelliferae; Apiaceae.

Habitat: Jammu and Kashmir and Himachal Pradesh from 2,000 to 4,000 m.

Ayurvedic: Hingupatri.

Action: Abortifacient, antiimplantation. Being investigated as a potential contraceptive. A related species, F. silphion, was used in ancient Rome as a contraceptive.

The oil extracted from the leaves possesses mycotoxic property against dermatophytes, Trichophyton sp.

The ethanolic extract of the aerial parts produced dilation and congestion and hypertrophy in liver in rats.

The roots contain sesquiterpenoids. A coumarin, ferujol, isolated from the rhizome, showed abortifacient and anti-implantation activity at a single dose of 0.6 mg/kg in rats by oral administration in a suspension of gum acacia. The essential oil shows antimy- cotic activity.

Action: Resin—less strong than asafoetida; used in the same way as asafoetida and galbanum. Used in Middle East for rheumatic affections and backache.... ferula jaeschkeana

Complement Fixation

the binding of *complement to the complex that is formed when an antibody reacts with a specific antigen. Because complement is taken up from the serum only when such a reaction has occurred, testing for the presence of complement after mixing a suspension of a known organism with a patient’s serum can give confirmation of infection with a suspected organism. The *Wassermann reaction for diagnosing syphilis is a complement-fixation test.... complement fixation

Culdoplasty

(McCall culdoplasty) n. a surgical procedure to correct a *vault prolapse after hysterectomy using sutures to suspend the vaginal vault at the origin of the uterosacral ligaments (which support the vagina) and to close off the *pouch of Douglas.... culdoplasty

Flocculation

n. a reaction in which normally invisible material leaves solution to form a coarse suspension or precipitate as a result of a change in physical or chemical conditions. See also agglutination.... flocculation

Gel

n. a colloidal suspension that has set to form a jelly. Some insoluble drugs are administered in the form of gels.... gel

Microbubbles

pl. n. (in radiology) an ultrasound *contrast medium consisting of suspensions of biocompatible gas-filled microspheres that are introduced into the vascular system or the Fallopian tubes in order to enhance ultrasound images.... microbubbles

Inhalants

Substances that can be inhaled into the body through the lungs. They may be delivered in traditional form dissolved in hot water and inhaled in the steam, or as an aerosol – a suspension of very small liquid or solid particles in the air. The latter are now usually delivered by devices in which the aerosol is kept under pressure in a small hand-held cylinder and delivered in required doses by a release mechanism.

Aerosols Asthmatic patients (see ASTHMA) ?nd aerosol devices to be of value in controlling their attacks. They provide an e?ective and convenient way of applying drugs directly to the bronchi, thus reducing the risks of unwanted effects accompanying SYSTEMIC therapy. BRONCHODILATOR aerosols contain either a beta-sympathomimetic agent or ipratropium bromide, which is an ANTICHOLINERGIC drug.

ISOPRENALINE was the ?rst compound to be widely used as an aerosol. It did however stimulate beta1 receptors in the heart as well as beta2 receptors in the bronchi, and so produced palpitations and even dangerous cardiac arrhythmias. Newer beta-adrenoceptor agonists are speci?c for the beta2 receptors and thus have a greater safety margin. They include SALBUTAMOL, TERBUTALINE, rimiterol, fenoterol and reproterol. Unwanted effects such as palpitations, tremor and restlessness are uncommon with these, more speci?c preparations. In patients who get insu?cient relief from the beta-adrenoreceptor agonist, the drug ipratropium bromide is worth adding. Salmeterol is a longer-acting choice for twice-daily administration: it is not intended for the relief of acute attacks, for which shorter-acting beta2 stimulants such as salbutamol should be used. Salmeterol should be added to existing corticosteroid therapy (see CORTICOSTEROIDS), rather than replacing it.

Patients must be taught carefully and observed while using their inhalers. It is important for them to realise that if the aerosol no longer gives more than slight transient relief, they should not increase the dose but seek medical help.... inhalants

Ocimum Sanctum

Linn.

Synonym: O. tenuiflorum Linn.

Family: Labiatae; Lamiaceae.

Habitat: Throughout India; grown in houses, gardens and temples.

English: Holy Basil, Sacred Basil.

Ayurvedic: Tulasi, Surasaa, Surasa, Bhuutaghni, Suravalli, Sulabhaa, Manjarikaa, Bahumanjari, Deva- dundubhi, Apet-raakshasi, Shuu- laghni, Graamya, Sulabhaa.

Unani: Tulasi.

Siddha/Tamil: Tulasi, Nalla-Tulasi.

Action: Leaf—carminative, stomachic, antispasmodic, antiasthmatic, antirheumatic, expectorant, stimulant, hepatoprotective, antiperiodic, antipyretic and diaphoretic. Seed— used in genitourinary diseases. Root—antimalarial. Plant—adap- togenic, antistress. Essential oil— antibacterial, antifungal.

The Ayurvedic Pharmacopoeia of India recommends the use of the leaf and seed in rhinitis and influenza; the seed in psychological disorders, including fear-psychosis and obsessions.

Major components of the essential oil are eugenol, carvacrol, nerol and eugenolmethylether. Leaves have been reported to contain ursolic acid, api- genin, luteolin, apigenin-7-O-glucu- ronide, luteolin-7-O-glucuronide, orientin and molludistin.

Ursolic acid, isolated from leaves, exhibited significant protection of mast cell membrane by preventing granulation and decreased histamine release. The ethanolic extract (50%) of fresh leaves, volatile oil from fresh leaves and fixed oil from seeds showed antiasth- matic activity and significantly protected guinea-pigs against histamine and dyspnoea. They also showed anti- inflammatory activity against carrage- enan-, serotonin-, histamine- and PGE-2-induced inflammation and inhibited hind paw oedema in rats.

The ethanol extract (90%) of the leaves showed hepatoprotective effect against paracetamol-induced liver damage.

The plant extract exhibited antiul- cerogenic property against experimental ulcers.

Oral administration of alcoholic extract of leaves lowers blood sugar level in normal, glucose-fed hyperglycaemic and streptozotocin-induced diabetic rats. The activity of the extract was 91.55 and 70.43% of that of tolbutamide in normal and diabetic rats respectively.

Administration of the juice of the plant affected a significant reduction in the size of urinary brushite crystals.

A study of methanol extract and aqueous suspension of the leaves showed immunostimulation of humoral immunologic response in albino rats indicating the adaptogenic action of the plant.

Dosage: Seed—1-2 g powder (API, Vol. IV); plant—50-10 ml infusion (CCRAS.).... ocimum sanctum

Mucilage

n. (in pharmacy) a thick aqueous solution of a gum used as a lubricant in skin preparations (see also glycerin), for the production of pills, and for the suspension of insoluble substances. The most important mucilages are of acacia, tragacanth, and starch.... mucilage

Small-bowel Meal

(barium follow-through) a technique for examining the small bowel, often used when small-bowel enema is not tolerated. The patient swallows dilute *barium sulphate suspension and then a series of abdominal radiographs are taken. A complete examination occurs when contrast reaches the first part of the large bowel (caecum). This technique is particularly useful for investigating small-bowel *Crohn’s disease.... small-bowel meal

Vault Prolapse

prolapse of the *fornix (vault) of the vagina, which occurs at the time of hysterectomy (vaginal or abdominal) when the superior vaginal support mechanism is disrupted. It can be surgically corrected (see sacrocolpopexy; uterosacral suspension).... vault prolapse

Transmission

Any mechanism by which a susceptible human host is exposed to an infectious or parasitic agent. These mechanism are:- 1. Direct transmission Direct and essentially immediate transfer of infectious agents (other than from an arthropod in which the organism has undergone essential multiplication or development) to a receptive portal of entry by which infection of humans may take place. This may be by touching, as in kissing, sexual intercourse or biting (direct contact); or by the direct projection of droplet spray onto the conjunctivae, or onto the mucous membranes of the nose or mouth during sneezing, coughing, spitting or talking (usually not possible over a distance greater than 3 ft) (droplet spread); or, as in the systemic mycoses, by direct exposure of susceptible tissue to soil, compost or decaying vegetable matter that contains the agent and where it normally leads a saprophytic existence. 2. Indirect transmission (a) Vehicle-borne Contaminated materials or inanimate objects such as toys, handkerchiefs, soiled clothes, bedding (fomites), surgical instruments or dressing (indirect contact); water, food, milk, biological products including serum and plasma, or anysubstance serving as an intermediate means by which an infectious agent is transported and introduced into a susceptible host through a suitable portal of entry. The agent may or may not have multiplied or developed in or on the vehicle before being introduced into man. (2) Vector-borne (i) Mechanical:- Includes simple mechanical carriage by a crawling or flying insect through soiling of its feet or proboscis, or by passage of organisms through its gastrointestinal tract. This does not require multiplication or development of the organism. (ii) Biological:- Propagation (multiplication), cyclic development, or a combination of them (cyclopropagation) is required before the arthropod can transmit the infective form of the agent to man. An incubation period (extrinsic) is required following infection before the arthropod becomes infective. Transmission may be by saliva during biting, or by regurgitation or deposition on the skin of agents capable of penetrating subsequently through the bite wound or through an area of trauma following scratching or biting. This is transmitted by an infected invertebrate host and must be differentiated for epidemiological purposes from simple mechanical carriage by a vector in the role of a vehicle. An arthropod in either role is termed a vector. (c) Air-borne The dissemination of microbial aerosols with carriage to suitable portal of entry, usually the respiratorytract. Microbial aerosols are suspensions in air of particles consisting partially or wholly of microorganisms. Particles in the 1 to 5 micron range are quite easily drawn into the lungs and retained there. They may remain suspended in the air for long periods of time, some retaining and others losing infectivity of virulence. Not considering as airborne are droplets and other large particles, which promptlysettle out; the following are airborne, their mode of transmission indirect: (i) Droplet nuclei: Usually the small residues which result from evaporation of droplets emitted by an infected host. Droplet nuclei also may be created purposely by a variety of atomising devices, or accidentally, in microbiology laboratories or in abattoirs, rendering plants, autopsy rooms, etc. They usuallyremain suspended in the air for long periods of time. (ii) Dust: The small particles of widely varying size which may arise from contaminated floors, clothes, beddings, other articles; or from soil (usually fungus spores separated from dry soil by wind or mechanical stirring). Note: Air conditioning and similar air circulating systems may play a significant role in air-borne transmission (e.g. Legionnaire’s disease).... transmission

Catalepsy

A medical curiosity occurring in some neurotic people who lose consciousness followed by muscular rigidity. Although rare, it may follow excessive stress. Suspension of heart beat, breathing. Other vital functions simulate death and are a cause for alarm. Rigidity may cause the body to assume a statue-like appearance. The subject should be carefully watched.

Treatment. Antispasmodics.

As swallowing is not possible, the gums should be rubbed with a little dilute Tincture or Liquid

Extract Lobelia, Eucalyptus, Thyme, Valerian or Wild Lettuce. When swallowing is possible, a cup of Chamomile, Lime blossom or Ephedra tea assists.

Practitioner: Ephedrine, 8-60mg by mouth, thrice daily. ... catalepsy

Public Interest Disclosure

1. the expression of concern about performance or competence that is privileged at law by virtue of the Public Interest Disclosure Act 1998. The statute provides that where an employee acts in good faith in questioning the behaviour or performance of another member of staff or an organization, he or she should be protected from such penalties as disciplinary procedures, suspension, or dismissal. See also whistle-blowing. 2. circumstances in which *confidentiality can be breached because there is a serious risk of physical harm to an identifiable individual or individuals. The basis on which confidentiality can be breached in the public interest were defined in the case of W v Egdell, in which the court held that the risk had to be of physical harm to identifiable person(s) and must not be merely ‘fanciful’. Where there is a serious risk of physical harm to a specific person, there is an entitlement but not a duty to breach confidentiality, and the *General Medical Council requires that doctors must be prepared to justify their decision either way.... public interest disclosure

Sacrocolpopexy

n. surgical treatment of *vault prolapse, which can be an abdominal or laparoscopic procedure. It involves suspending the prolapsed vaginal vault to the sacral promontory using a synthetic mesh or biological material; however, it is associated with a significant risk of haemorrhage and mesh erosion. Posterior intravaginal slingplasty (or infracoccygeal sacropexy) is a more recent technique in which a neo-uterosacral ligament (which supports the vagina) is formed. This helps to relocate the vaginal apex and restore the normal vaginal axis. The procedure appears to have similar efficacy to those currently in use but with minimal surgical morbidity.... sacrocolpopexy

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