Prostaglandins play an important part in the production of PAIN, and it is now known that ASPIRIN relieves pain by virtue of the fact that it prevents, or antagonises, the formation of certain prostaglandins. In addition, they play some, although as yet incompletely de?ned, part in producing in?ammatory changes. (See INFLAMMATION; NON-STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS).)
Thus prostaglandins have potent biological effects, but their instability and rapid metabolism make them short-acting. They are produced but not stored by most living cells and act locally. The two most important prostaglandins are prostacycline and thromboxane: prostacycline is a vasodilator and an inhibitor of platelet aggregation; thromboxanes have the opposite effects and cause vasoconstriction and platelet aggregation. The NSAIDs act by blocking an ENZYME called cyclo-oxygenase which converts arachidonic acid to the precursors of the various prostaglandins. Despite their potent pharmacological properties, the role of prostaglandins in current therapeutics is limited and controversial. They have been used most successfully as an inhibitor of platelet aggregation in extra-corporeal haemoperfusion systems. The problems with the prostacyclines is that they have to be given intravenously as they are inactive by mouth, and continuous infusion is required because the drug is rapidly eliminated with a half-life of minutes. Side-effects tend to be severe because the drug is usually given at the highest dose the patient can tolerate. The hope for the future lies in the exploitation of the compound to generate, synthetically, stable orally active prostacycline analogues which will inhibit platelet aggregation and hence thrombotic events, and yet have minimal effects on the heart and blood vessels.... prostaglandins
Symptoms The condition is most commonly con?ned to the occurrence of ‘dead ?ngers’ – the ?ngers (or the toes, ears, or nose) becoming white, numb, and waxy-looking. This condition may last for some minutes, or may not pass o? for several hours, or even for a day or two.
Treatment People who are subject to these attacks should be careful in winter to protect the feet and hands from cold, and should always use warm water when washing the hands. In addition, the whole body should be kept warm, as spasm of the arterioles in the feet and hands may be induced by chilling of the body. Su?erers should not smoke. VASODILATORS are helpful, especially the calcium antagonists. In all patients who do not respond to such medical treatment, surgery should be considered in the form of sympathectomy: i.e. cutting of the sympathetic nerves to the affected part. This results in dilatation of the arterioles and hence an improved blood supply. This operation is more successful in the case of the feet than in the case of the hands.... raynaud’s disease
Vasodilator drugs include ACE inhibitors, alphablockers, calcium channel blockers, nitrate drugs, and sympatholytic drugs.
They are used to treat disorders in which abnormal narrowing of blood vessels reduces blood flow through tissues, impairing the supply of oxygen.
Such disorders include angina pectoris and peripheral vascular disease.
Vasodilators are also used to treat hypertension and heart failure.
All vasodilator drugs may cause flushing, headaches, dizziness, fainting, and swollen ankles.... vasodilator drugs
Atherosclerosis can be the forerunner of degenerative heart and kidney disease, with rise in blood pressure.
A study of Australian ’flu epidemic diseases revealed influenza as a major cause of cardiovascular disease and in particular, atherosclerosis.
Causes. Excessive smoking and alcohol, fatty foods, hereditary weakness, stress and emotional tension that release excessive adrenalin into the bloodstream. Toxic effects of environmental poisons (diesel fumes). Fevers.
Symptoms. Cold hands and feet, headache, giddiness. Diminished mental ability due to thickening of arteries in the brain. Pain on exertion, breathlessness and fatigue. Diagnosis of atheroma of main arteries: by placing stethoscope over second right intercostal space, half inch from the sternum, the second aortic sound will be pronounced.
Treatment. Surface vasodilators, Cardioactives. Anti-cholesterols.
Alternatives. Teas. To lower cholesterol levels and shrink hardened plaque: Alfalfa, Chamomile, Borage, Olive leaves, Mint, Nettles, Marigold, Garlic, Lime flowers, Yarrow, Horsetail, Hawthorn, Ginkgo, Orange Tree leaves, Meadowsweet, Eucalyptus leaves, Ispaghula, Bromelain. Rutin (Buckwheat tea).
Artichoke leaves. Spanish traditional. 2 teaspoons to each cup of water; simmer 2 minutes. Drink cold: 1 cup 2-3 times daily.
Mistletoe leaves. 1-2 teaspoons to each cup cold water steeped 8 hours (overnight). Half-1 cup thrice daily.
Tablets, or capsules. Garlic, Mistletoe, Poke root, Rutin, Hawthorn, Motherwort, Ginkgo, Bamboo gum. Liquid Extracts. Mix Hawthorn 2; Mistletoe 1; Barberry 1; Rutin 1; Poke root half. Dose: 30-60 drops thrice daily.
Tinctures. Mix: Hawthorn 2; Cactus flowers 2; Mistletoe 1; Capsicum half. Dose: 1-2 teaspoons thrice daily in water before meals.
Powders. Mix equal parts: Bamboo gum, Hawthorn, Mistletoe, Rutin, Ginger. Fill 00 capsules. Dose: 2-4 capsules, or quarter to half a teaspoon (375-750mg) thrice daily before meals.
Threatened stroke. Tincture Arnica BPC (1949): 3-5 drops in water morning and evening. Practitioner only.
Evening Primrose oil. Favourable results reported. (Maxepa)
Diet. Vegetarian. Low fat. Low salt. High fibre. Lecithin, polyunsaturated oils, artichokes, oily fish (see entry). Linseed on breakfast cereal. Garlic at meals, or Garlic tablets or capsules at night to reduce cholesterol.
Vitamins. A, B-complex, B6, B12, C (2g), E (400iu), daily.
Minerals. Chromium, Iodine, Potassium, Selenium, Magnesium, Manganese, Zinc.
“A man is as old as his arteries” – Thomas Sydenham, 17th century physician.
“A man’s arteries are as old as he makes them” – Robert Bell MD, 19th century physician. ... atherosclerosis
Treatment: frozen limbs should not be rubbed or manipulated, but thawed out in luke-warm water, a hand still remaining in the glove or foot in the boot. Vasodilators to equalise the circulation.
Teas. Boneset, Chamomile, Elderflowers, Feverfew, Hyssop, Lime flowers, Peppermint, Sage, Gotu Kola, Yarrow. Buckwheat.
Echinacea: tablets, liquid extract, tinctures.
Never give alcohol or use hot water bottles. Paint with Friar’s balsam followed by smoothing-in a little Olive oil. Abundant Vitamin C drinks. Life Drops in tea. Ginger, Capsicum. Horseradish.
Old Norwegian remedy: cold mashed onion poultice.
Supplements. Hourly: Vitamin C 1g; Vitamin E 500iu. ... frostbite
Left-sided heart failure may be caused by hypertension, anaemia, hyperthyroidism, a heart valve defect (such as aortic stenosis, aortic incompetence, or mitral incompetence), or a congenital heart defect (see heart disease, congenital). Other causes of left-sided heart failure include coronary artery disease, myocardial infarction, cardiac arrhythmias, and cardiomyopathy.
The left side of the heart fails to empty completely with each contraction, or has difficulty in accepting blood that has been returned from the lungs. The retained blood creates a back pressure that causes the lungs to become congested with blood. This condition leads to pulmonary oedema.
Right-sided heart failure most often results from pulmonary hypertension, which is itself caused by left-sided failure or by lung disease (such as chronic obstructive pulmonary disease (see pulmonary disease, chronic obstructive). Right-sided failure can also be due to a valve defect, such as tricuspid incompetence, or a congenital heart defect.
There is back pressure in the circulation from the heart into the venous system, causing swollen neck veins, enlargement of the liver, and oedema, especially of the legs and ankles. The intestines may become congested, causing discomfort.
Immediate treatment consists of bed rest, with the patient sitting up. Diuretic drugs are given, and digitalis drugs and vasodilators, especially ACE inhibitors, may also be administered. Morphine and oxygen may be given as emergency treatment in acute left-sided failure.... heart failure
Coronary thrombosis is more common in the West because of its preference for animal fats; whereas in the East fats usually take the form of vegetable oils – corn, sunflower seed, sesame, etc. Fatty deposits (atheroma) form in the wall of the coronary artery, obstructing blood-flow. Vessels narrowed by atheroma and by contact with calcium and other salts become hard and brittle (arterio-sclerosis) and are easily blocked. Robbed of oxygen and nutrients heart muscle dies and is replaced by inelastic fibrous (scar) tissue which robs the heart of its maximum performance.
Severe pain and collapse follow a blockage. Where only a small branch of the coronary arterial tree is affected recovery is possible. Cause of the pain is lack of oxygen (Vitamin E). Incidence is highest among women over 40 who smoke excessively and who take The Pill.
The first warning sign is breathlessness and anginal pain behind the breastbone which radiates to arms and neck. Sensation as if the chest is held in a vice. First-line agent to improve flow of blood – Cactus.
For cholesterol control target the liver. Coffee is a minor risk factor.
Measuring hair calcium levels is said to predict those at risk of coronary heart disease. Low hair concentrations may be linked with poor calcium metabolism, high aortic calcium build-up and the formation of plagues. (Dr Allan MacPherson, nutritionist, Scottish Agricultural College, Ayr, Scotland)
Evidence has been advanced that a diagonal ear lobe crease may be a predictor for coronary heart disease. (American Journal of Cardiology, Dec. 1992)
Tooth decay is linked to an increased risk of coronary heart disease and mortality, particularly in young men. (Dr Frank De Stefano, Marshfield Medical Research Foundation, Wisconsin, USA) Treatment. Urgency. Send for doctor or suitably qualified practitioner. Absolute bedrest for 3 weeks followed by 3 months convalescence. Thereafter: adapt lifestyle to slower tempo and avoid undue exertion. Stop smoking. Adequate exercise. Watch weight.
Cardiotonics: Motherwort, Hawthorn, Mistletoe, Rosemary. Ephedra, Lily of the Valley, Broom.
Cardiac vasodilators relax tension on the vessels by increasing capacity of the arteries to carry more blood. Others contain complex glycosides that stimulate or relax the heart at its work. Garlic is strongly recommended as a preventative of CHD.
Hawthorn, vasodilator and anti-hypertensive, is reputed to dissolve deposits in thickened and sclerotic arteries BHP (1983). It is believed to regulate the balance of lipids (body fats) one of which is cholesterol.
Serenity tea. Equal parts: Motherwort, Lemon Balm, Hawthorn leaves or flowers. 1 heaped teaspoon to each cup boiling water; infuse 5-15 minutes; 1 cup freely.
Decoction. Combine equal parts: Broom, Lily of the Valley, Hawthorn. 1-2 teaspoons to each cup water gently simmered 20 minutes. Half-1 cup freely.
Tablets/capsules. Hawthorn, Motherwort, Cactus, Mistletoe, Garlic.
Practitioner. Formula. Hawthorn 20ml; Lily of the Valley 10ml; Pulsatilla 5ml; Stone root 5ml; Barberry 5ml. Tincture Capsicum 1ml. Dose: Powders: 500mg (two 00 capsules or one-third teaspoon). Liquid extracts: 1 teaspoon. Tinctures: 2 teaspoons. Thrice daily in water or honey.
Prevention: Vitamin E – 400iu daily.
Diet. See: DIET – HEART AND CIRCULATION.
Supplements. Daily. Vitamin C, 2g. Vitamin E possesses anti-clotting properties, 400iu. Broad spectrum multivitamin and mineral including chromium, magnesium selenium, zinc, copper.
Acute condition. Strict bed-rest; regulate bowels; avoid excessive physical and mental exertion. Meditation and relaxation techniques dramatically reduce coronary risk. ... coronary heart disease
Causes: hormone deficiency (Agnus Castus) in females, where it may be associated with failing thyroid or ovarian function. In such cases, other agents include: Helonias, Motherwort, Black Haw bark. Other causes may be pregnancy, the menopause, or simply discontinuing The Pill. Certain skin diseases predispose: ringworm (Thuja), eczema (Yellow Dock), from thyroid disorder (Kelp, Blue Flag root).
Exposure to some cosmetics, excessive sunlight, strong chemicals and treatment of cancer with cytotoxic drugs may interfere with nutrition of the hair follicles. To ensure a healthy scalp a correct mineral balance is essential calling for supplementation of the diet with vitamins, selenium, zinc and silica. Yellow Dock is believed to counter toxicity of chemicals; Pleurisy root opens the pores to promote sweat and action of surface capillaries.
Baldness sometimes happens suddenly; eye-lashes or beard may be affected. Though emotional stress and a run-down condition is a frequent cause, most cases are not permanent, returning to normal with adequate treatment.
Baldness of the eyebrows alerts us to a lowered function of the thyroid gland, being an early outward sign of myxoedema. A pony-tail hair style or the wearing of a crash helmet may cause what is known as traction alopecia. Heavy coffee drinkers invariably lose hair lustre.
Soviet Research favours silica-rich plants internally and as a lotion: Horsetail, Burdock, Nettles, Bamboo gum.
Growth of hair is assisted by improving surface circulation of the scalp which is beneficial for conveying nutrients to the hair roots and facilitating drainage. Herbal vasodilators stimulate hair follicle nutrition and encourage growth: Cayenne, Pleurisy root, Black Cohosh and Prickly Ash, taken internally. A convenient way of taking Cayenne is the use of a pepper-shaker at table.
Topical. Hair rinse. 2-3 times weekly. Infusion: equal parts Yarrow, Sage and Rosemary. 1oz (30g) to 1 pint (500ml) water. Simmer gently five minutes. Allow to cool. Strain before use.
Cider vinegar – minimal success reported.
Day lotion. Liquid Extract Jaborandi half an ounce; Tincture Cantharides half an ounce; Oil Jojoba to 4oz. Shake well before use.
Oily lotion. Equal parts Olive and Eucalyptus oils.
Bay Rhum Lotion. Oil of Bay 50 drops; Olive oil half an ounce; Rum (Jamaica or other) to 4oz. Shake well before use.
Oil Rosemary: rub into hair roots.
Russian Traditional. Castor oil half an ounce; Almond oil 1oz; Oil Geranium 15 drops; Vodka to 6oz. Rub into hair roots.
Aromatherapy. To 1oz Castor oil and 1oz Olive oil add, 10 drops each – Oils Neroli, Lavender and Rosemary.
Gentian plant extract. Japanese scalp massage with extract from roots to thicken thinning hair. Some success reported.
Supplements. B-vitamins, Kelp, Silicea Biochemic salt. Zinc. Low levels of iron and zinc can cause the condition.
Note: Studies show that male occipital baldness confers a risk of heart disease, being associated with a higher total cholesterol and diastolic blood pressure than men with a full head of hair. Frontal baldness has not been found to be associated with increased risk of coronary heart disease and myocardial infarct. “It seems prudent for bald men to be specially vigorous in controlling risk factors for such conditions.” (S.M. Lesko, Journal of the American Medical Association, Feb 24, 1993, 269: 998-1003) ... hair loss
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