Vincristine Health Dictionary

(L.) G. Don.

Synonym: Vinca rosea L. Lochnera rosea (L.) Reichub.

Family: Apocynaceae.

Habitat: Commonly grown in Indian gardens.

English: Madagascar Periwinkle (Vinca major L. Pich. and Vinca minor Linn. are known as Greater Periwinkle and Lesser Periwinkle respectively).

Folk: Sadaabahaar, Nayantaaraa, Nityakalyaani.

Action: The cytotoxic dimeric alkaloids, present in Madagascar Periwinkle, Catharanthus roseus L. Don, Vincea rosea L., and used for the treatment of certain type of cancer, have not been found in V. major.

Catharanthus roseus (Madagascar Periwinkle) : cytostatic, anti-neoplas- tic, slows down growth of cells by su- pressing immune response. Vinblas- tine and Vincristine are said to prolong remission of leukaemia to more than five years. These chemotherapeutic agents are toxic to the nervous system. Vinblastine is also used for breast cancer and Hodgkin's disease.

Vinca major L. Pich. (Greater Periwinkle): astringent, anti-haemorrha- gic; used for menorrhagia and leu- corrhoea. Contains indole alkaloids including reserpinine and serpentine; tannins.

Vinca minor Linn. (Lesser Periwinkle): astringent; circulatory stimulant. Leaves—stomachic and bitter. Root— hypotensive. Used for gastric catarrh, chronic dyspepsia, flatulence; also for headache, dizziness, behaviours disorders. A homoeopathic tincture is given for internal haemorrhages.... catharanthus roseus

Cytotoxic means destructive to living cells. Cytotoxic drugs possess anti-cancer properties but also have the potential to damage normal tissue. Their use is twofold: to eliminate a cancer and so prolong life; or to alleviate distressing symptoms, especially in patients whose prospects of a cure are poor. In many cases CHEMOTHERAPY with cytotoxic drugs is combined with surgery, RADIOTHERAPY or both. Chemotherapy may be used initially to reduce the size of the primary TUMOUR (a process called neoadjuvant therapy) before using radiotherapy or surgery to eliminate it. Cytotoxic drugs may also be used as adjuvant treatment to prevent or destroy secondary spread of the primary tumour that has either been removed by surgery or treated with radiotherapy. All chemotherapy causes side-effects: the ONCOLOGIST – a specialist in cancer treatment – has to strike a balance between hoped-for bene?ts and acceptable (for the patient) toxic effects, which include nausea and vomiting, BONE MARROW suppression, ALOPECIA (hair loss) and teratogenic effects (see TERATOGENESIS).

Cytotoxic drugs are used either singly or in combination, when an enhanced response is the aim. Chemotherapy of cancer is a complex process and should be supervised by an oncologist in co-operation with physicians, surgeons, radiotherapists and radiologists as appropriate.

The cytotoxic drugs include:

(1) The alkylating agents which act by damaging DNA, thus interfering with cell reproduction. Cyclophosphamide, ifosfamide, chlorambucil, kelphalan, busulphan, thiotepa and mustine are examples of alkylating agents.

(2) There are a number of cytotoxic antibiotics used in the treatment of cancer – doxorubicin, bleomycin, dactinomycin, mithramycin and amsacrine are examples. They are used primarily in the treatment of acute leukaemia and lymphomas.

(3) Antimetabolites – these drugs combine irreversibly with vital enzyme systems of the cell and hence prevent normal cell division. Methotrexate, cytarabine, ?uorouracil, mercaptopurine and azathioprine are examples.

(4) Another group of cytotoxic drugs are the vinca alkaloids such as vincristine, vinblastine and vindesima.

(5) Platinum compounds such as carboplatin, cisplatin and oxaliplatin are e?ective. All of them are given intravenously, but the latter two tend to have more unpleasant side-effects. Carboplatin and cisplatin are useful in the treatment of solid tumours. Carboplatin, a derivative of cisplatin, is given intravenously in ovarian cancer and in small-cell lung cancer. Better tolerated than cisplatin, the drug causes less nausea and vomiting, nephrotoxicity, neurotoxicity and ototoxicity. Where platinum-containing therapy has failed, intravenous treatment with paclitaxel may be tried. With only a limited success rate, it is relatively toxic and should be carefully supervised; responses, however, are sometimes prolonged.

Also of increasing importance in treating cancer are interferons. These are naturally occurring proteins with complex effects on immunity and cell function. Although toxic, with numerous adverse effects, they have shown some anti-tumour e?ect against certain lymphomas and solid tumours.... cytotoxic

Commonest form of cancer in women. Overall mortality remains about 50 per cent at five years. Appears to run in families. Strikes hard unmarried women. Married women who have no children. Those who do not nurse their babies, or who are infertile and have no child before thirty. Eight out of ten chest lumps are benign.

Symptoms. A small lump comes to light while washing, a discharge from the nipple, change in nipple size and colour, irregular contour of the breast surface. Though tissue change is likely to be a cyst, speedy diagnosis and treatment are necessary. Some hospital physicians and surgeons are known to view favourably supportive herbal aids, and do not always think in terms of radical mastectomy. Dr Finlay Ellingwood, Chicago physician (1916) cured a case by injection of one dram Echinacea root extract twice a week into the surrounding tissues.

The condition is believed to be due to a number of causes including suppression of ovulation and oestrogen secretion in pregnant and lactating women. A high fat diet is suspected of interference with the production of oestrogen. Some women are constitutionally disposed to the condition which may be triggered by trauma or emotional shock. Increase in incidence in older women has been linked with excessive sugar consumption. “Consumption overwhelms the pancreas which has to ‘push it out’ to all parts of the body (when broken down by the digestive process) whether they need it or not. The vital organs are rationed according to their requirements of nutrients from the diet. What is left over has to ‘go into store elsewhere’. And the breast is forced to take its share and store it. If it gets too much, for too long, it may rebel!” (Stephen Seely, Department of Bacteriology and Virology, Manchester)

“Women who nurse their babies less than one month are at an increased risk for breast cancer. The longer a woman breast-feeds – no matter what her age – the more the risk decreases. (Marion Tompson, co-founder, The La Leche League, in the American Journal of Epidemiology)

Lactation reduces the risk of pre-menopausal breast cancer. (Newcomb P.A. et al New England Journal of Medicine, 330 1994)

There is currently no treatment to cure metastatic breast cancer. In spite of chemotherapy, surgery and radiotherapy survival rate has not diminished. Herbs not only have a palliative effect but, through their action on hormone function offer a positive contribution towards overcoming the condition. Their activity has been widely recorded in medical literature. Unlike cytotoxic drugs, few have been known to cause alopecia, nausea, vomiting or inflammation of the stomach.

Treatment by a general medical practitioner or oncologist.

Special investigations. Low radiation X-ray mammography to confirm diagnosis. Test for detection of oestrogen receptor protein.

Treatment. Surgery may be necessary. Some patients may opt out from strong personal conviction, choosing a rigid self-disciplined approach – the Gentle Way. Every effort is made to build up the body’s natural defences (immune system).

An older generation of herbalists believed tissue change could follow a bruise on the breast, which should not be neglected but immediately painted with Tincture Arnica or Tincture Bellis perennis.

Vincristine, an alkaloid from Vinca rosea (Catharanthus roseus) is used by the medical profession as an anti-neoplastic and anti-mitotic agent to inhibit cell division.

Of possible therapeutic value. Blue Flag root, Burdock root, Chaparral, Clivers, Comfrey root, Echinacea, Figwort, Gotu Kola, Marshmallow root, Mistletoe, Myrrh, Prickly Ash bark, Red Clover, Thuja, Wild Violet, Yellow Dock.

Tea. Equal parts: Red Clover, Clivers, Gotu Kola, Wild Violet. 1 heaped teaspoon to each cup boiling water; infuse 5-15 minutes. 3 or more cups daily.

Decoctions. Echinacea, Blue Flag root, Queen’s Delight, Yellow Dock.

Tablets/capsules. Blue Flag root, Echinacea, Poke root, Mistletoe.

Formula. Echinacea 2; Gotu Kola 1; Poke root 1; Mistletoe 1; Vinca rosea 1. Mix. Dose: Powders: 500mg (two 00 capsules or one-third teaspoon). Liquid extracts: 1 teaspoon. Tinctures: 2 teaspoons. Thrice daily and at bedtime. According to progress of the disease, increase dosage as tolerated.

Maria Treben’s tea. Parts: Marigold (3), Yarrow 1; Nettles 1. Mix. 2 teaspoons to each cup boiling water. 1 cup as many times daily as tolerated.

William Boericke, M.D. recommends Houseleek. E.H. Ruddock M.D. favours Figwort.

Topical. Treatments believed to be of therapeutic value or for use as a soothing application.

(1) Cold poultice: Comfrey root.

(2) Poultice of fresh Marshmallow root pulped in juicer.

(3) Injection of Extract Greater Celandine (Chelidonium), locally, gained a reputation in the Eclectic school.

(4) The action of Blood root (Sanguinaria) is well known as a paint or injection.

(5) Ragwort poultice: 2oz Ragwort boiled in half a pint potato water for 15 minutes. See: POULTICE.

(6) Popular Russian traditional remedy: Badiaga (Spongilla fluviatilis), fresh water sponge gathered in the autumn; dried plant rubbed to a powder. Poultice.

(7) Maria Treben’s Poultice: Carefully washed fresh Plantain leaves, pulped, and applied direct to the lesion.

(8) If lymph glands are affected, apply Plantain poultice to glands.

(9) Dr Brandini’s treatment. Dr Brandini, Florence, used 4 grains Citric Acid (prepared from lemons) in 1oz (30ml) water for ulcerated cancer of the breast considered incurable. “The woman’s torments were so distressing that neither she nor other patients could get any rest. Applying lint soaked in the solution, relief was instantaneous. Repeated, it was successful.”

(10) Circuta leaves. Simmered till soft and mixed with Slippery Elm bark powder as a poultice morning and night.

(11) Decoction. Simmer gently Yellow Dock roots, fine cut or powdered, 1oz to 1 pint, 20 minutes. Saturate lint or suitable material and apply.

(12) Yellow Dock ointment. Half ounce Lobelia seed, half ounce Yellow Dock root powder. Baste into an ointment base. See: OINTMENT BASE.

(13) Infusion, for use as a wash. Equal parts: Horsetail, Red Clover, Raspberry leaves. 1oz to 1 pint boiling water infuse 15 minutes.

(14) Dr Christopher’s Ointment. Half an ounce White Oak, half an ounce Garden Sage, half an ounce Tormentil, half an ounce Horsetail, half an ounce Lemon Balm. Method: Boil gently half an hour in quart water, strain. Reduce to half a pint by simmering. Add half a pound honey. Bring to boil. Skim off scum. Allow cool. Apply: twice daily on sores.

(15) Dr Finlay Ellingwood. Poke root juice. “Fresh juice from the stems, leaves and roots applied directly to diseased tissue. Exercises a selective action; induces liquefaction and promotes removal, sometimes healing the open wound and encouraging scar formation. Masses of such tissue have been known to be destroyed in a few weeks with only a scar, with no other application but the fresh juice. Produces pain at first, but is otherwise harmless.”

(16) Lesion painted with Mandrake resin. (American Podophyllum)

(17) Dust affected parts with Comfrey powder. Mucilage from Comfrey powder or crushed root with the aid of a little milk. See: COMFREY.

(18) Dr Samuel Thomson’s Cancer Plaster. “Take heads of Red Clover and fill a kettle. Boil in water for one hour. Remove and fill kettle with fresh flower heads. Boil as before in the same liquor. Strain and press heads to express all the liquor. Simmer over a low fire till of the consistency of tar. It must not burn. Spread over a piece of suitable material.”

(19) Wipe affected area with cut Houseleek. (Dr Wm Boericke)

(20) Chinese Herbalism. Take 1-2 Liang pulverised liao-ko-wang (Wickstroemia indica), mix with cold boiled water or rice wine for local compress. Also good for mastitis.

(21) Italian women once used an old traditional remedy – Fenugreek tea.

(22) A clinical trial of Vitamin D provided encouraging results. Patients with locally advanced breast cancer were given a highly active Vitamin D analogue cream to rub on their tumours. “It was effective in one third of the tumours,” said Professor Charles Coombes, clinical oncologist, Charing Cross Hospital, London.

Diet. “A diet rich in cereal products (high in dietary fibre) and green leafy vegetables (antioxidants) would appear to offer women some protection against breast cancer due to the relation between fibre and oestrogen metabolism. Meat-free diet. In a study of 75 adolescent girls, vegetarians were found to have higher levels of a hormone that women suffering from breast cancer often lack. (Cancer Research) Supplements. Daily. Chromium. Selenium (600mcg). Zinc chelate (100mg morning and evening). Beta carotene. “Low levels of Selenium and Vitamins A and E are shown in breast cancer cases.” (British Journal of Cancer 49: 321-324, 1984).

Vitamins A and D inhibit virus penetration in healthy cell walls. Multivitamin combinations should not include Vitamin B12, production of which in the body is much increased in cancerous conditions. Vitamins B-complex and C especially required.

Note: A link between sugar consumption and breast cancer has been reported by some authorities who suggest that countries at the top of the mortality table are the highest also in sugar consumption; the operative factor believed to be insulin.

Screening. Breast screening should be annual from the age of forty.

General. Mothers are encouraged to breast-feed children for the protection it offers against mammary malignancy. (Am.J. Obstet. Gyn. 15/9/1984. 150.)

Avoidance of stress situations by singing, playing an instrument. Adopt relaxation techniques, spiritual healing and purposeful meditation to arouse the immune system; intensive visualisation. Avoid the carcinogens: smoking, alcohol.

Information. Breast Cancer Care. Free Help Line. UK Telephone: 0500 245345. ... cancer - breast

A group of substances derived from the periwinkle plant (VINCA ROSEA) that are used to treat leukaemias, lymphomas, and some solid tumours, such as breast cancer and lung cancer. All vinca alkaloids can cause neurological toxicity, which appears as neuropathy. Other side effects may include abdominal pain, constipation, and reversible alopecia. Common vinca alkaloids are vinblastine, vindesine, and vincristine.... vinca alkaloids

one of a group of *antimitotic drugs (see also cytotoxic drug) derived from the periwinkle (Vinca rosea). Vinca alkaloids are used especially to treat leukaemias and lymphomas; they include vinblastine, vincristine, and vindesine. Vinorelbine is used in the treatment of advanced breast cancer and *non-small-cell lung cancer. Vinflunine is given by intravenous infusion to treat *transitional cell carcinoma. Vinca alkaloids are highly toxic; side-effects include *myelosuppression, peripheral neuropathy, and severe irritation at the injection site.... vinca alkaloid

If you like herbal teas, there are lots of types you can try - one of them is periwinkle tea. Like most herbal teas, it has a slightly bitter taste, but it also has important health benefits. Read to find out more about periwinkle tea! About Periwinkle Tea Periwinkle tea is made from the vinca plant, an herbaceous plant which can be found in Europe, northwest Africa and southwest Asia. Vinca plant has long, trailing stems that grow near the ground, touching it. The branches can reach about half a meter in height. The leaves are evergreen and, opposite, the flowers are salverform, with 5 vilet (and sometimes white) petals connected together at the base. Two species of the plant are often cultivated as ornamental plants. However, in some parts of Australia, New Zealand, and the United States, it has spread too much, becoming an invasive plant. Interestingly, it is said that the plant protects you from voodoo magic. Periwinkle Tea constituents Vinca plants have lots of constituents which are transferred to periwinkle tea, as well. Periwinkle tea is rich in alkaloids that come from the vinca plant. It has at least 86 different alkaloids. Some of them are: vincamine, vinpocetine, vinblastine, vincristine, alstonine, ajmalicine, leurocristine, and reserpine. How to prepare Periwinkle Tea For a cup of periwinkle tea, you need a teaspoon of dried herbs. Pour boiling water into the cup and let it steep for 10-15 minutes. Once the steeping time is done, strain to remove the herbs and your cup of periwinkle tea is done. If the taste is too bitter for you, you can sweeten the tea by adding honey or fruit juice to your cup. Periwinkle Tea Benefits Thanks to the many constituents derived from the vinca plant, periwinkle tea has lots of important health benefits. Periwinkle tea plays an important role in the fight against cancer. It is often recommended in the treatment for leukemia, Hodgkin’s disease, malignant lymphomas, neuroblastoma, Wilm’s tumor and Kaposi’s sarcoma. Drinking periwinkle tea will help lower blood sugar levels and blood pressure, as well as improve blood circulation. You can drink periwinkle tea during menstruation if you’ve got an excessive blood flow. It should help in such situations. This tea is also useful in treating diarrhea, colitis and diabetes. You can use periwinkle tea to treat mouth sores and bleeding gums; it acts as a good mouth rinse. It can help you with headaches and memory loss problems and it enhances your memory. It also has calming effects, helping you with anxiety and nervousness. Periwinkle tea can be used topically, as well. You can wet a cloth with tea and use it to stop wounds from bleeding. You can also put it on the skin to treat wasp stings or on the eye if you’ve got an eye infection. Periwinkle Tea Side Effects With so many health benefits, periwinkle tea has to have a few side effects too. Here are some which you have to be careful with. If you’ve got kidney, liver or lung diseases, you should avoid drinking periwinkle tea. Also you should not drink it if you’ve got low blood pressure, or if you’re constipated. Pregnant women shouldn’t drinkperiwinkle tea, as it may lead to birth defects or even miscarriages. Also, it is best to stay away from this tea if you’re breast feeding; even in this case, it might affect the baby. It is best to stop drinking periwinkle tea before a surgery. It can lower blood pressure and it might lead to problems during and after the surgery. Check with your doctor and make sure you’re safe to drink periwinkle tea after a surgery. It is also recommended that you not drink more than 4 cups of periwinkle tea. Besides the usual symptoms (low blood pressure and constipation) you might also get other symptoms: headaches, loss of appetite, insomnia, dizziness, and irregular heartbeats. Drinking periwinkle tea can help you a lot, with its many health benefits. Don’t forget about the side effects, though. As long as you make sure it’s safe to drink periwinkle tea, you can happily drink it!... enjoy periwinkle tea

Linn.

Synonym: Catharanthus roseus (Linn.) G.Don.

Family: Apocynaceae.

Habitat: Native of West Indies; commonly grown in Indian gardens.

English: Madagascar Periwinkle.

Ayurvedic: Sadaapushpaa, Sadam- pushpa, Nityakalyaani, Sadaaba- haar.

Siddha: Nithiya kalyani, Sudukadu mallikai.

Action: Cytotoxic.

Over one hundred monomeric and bisindole alkaloids have been isolated.

The indole alkaloid, vincamine, is a vasodilator; the bisindole alkaloids vinblastine and vincristine proved to be highly effective as cancer chemothera- peutic agents.

Vinblastine and vincristine are clinically used in a number of thrombo- cytopenic disorders, such as refractory idiopathic thrombocytopenic purpurea and haemolytic anaemia.

Vinblastine in combination with other chemotherapeutic agents (cis- platin and bleomycin) is used for the treatment of metastatic testicular cancer; also against bladder cancer, breast cancer, non-small cell lung cancer and Hodgkin's lymphoma in combination with other drugs.

Vincristine, in various combinations, is highly effective in acute leukemia in children and lymphocytic leukemia; and pediatric tumours. (The Treatise on Indian Medicinal Plants.)... vinca rosea

The management of MALIGNANT disease – a major health problem since successful management requires close liaison between the patient, surgeons, physicians, oncologists, haematologists, paediatricians and other specialists. Diagnosis may involve various investigations and often requires a BIOPSY. Once a diagnosis has been established, treatment may involve surgery, radiotherapy or chemotherapy (or various combinations as required) – see below, and main dictionary entries.

Surgery may be most common, and is often the only treatment, for some gastrointestinal tumours, soft-tissue tumours, gynaecological tumours and advanced cancers of the head and neck.

Radiotherapy uses ionising radiation to kill tumour cells. Radiation is by naturally occurring isotopes (see ISOTOPE) or arti?cially produced X-RAYS. Germ-cell tumours (see SEMINOMA; TERATOMA) and malignant lymphomas (see LYMPHOMA) appear to be particularly sensitive to irradiation, and many head and neck tumours, gynaecological cancers, and localised cancers of the PROSTATE GLAND and URINARY BLADDER are curable with radiotherapy. It is also a valuable means of reducing pain from bone metastases (see METASTASIS). Unpleasant side-effects are common: chie?y lethargy, loss of appetite and dry, itchy skin symptoms.

Chemotherapy is also an important treatment in germ-cell tumours (see above); in some forms of LEUKAEMIA and lymphoma; in ovarian cancer (following surgery – see OVARIES, DISEASES OF); and in small-cell lung cancer (although most patients die within 18 months – see LUNGS, DISEASES OF). It is also used in some breast cancers (see BREASTS, DISEASES OF); advanced myeloma (see MYELOMATOSIS); sarcomas (see under CANCER); and some childhood cancers (such as WILMS’ TUMOUR).

More than 20 substances are in common use, the major classes being ALKYLATING AGENTS (e.g. cyclophosphamide, chlorambucil, busul fan); ANTIMETABOLITES (e.g. methotrexate); VINCA ALKALOIDS (e.g. vincristine, vinblastine); and antitumour ANTIBIOTICS (e.g. actinomycin D). Choice of agent and the appropriate regimen requires expert guidance. Common side-effects include nausea and vomiting, bone-marrow suppression and ALOPECIA, with each substance having its own spectrum of unwanted effects.

Good doctor-patient communication, with the sharing of information and bringing the patient into the decision-making process, is vital even if time-consuming and exhausting.

Equally imortant treatment is PALLIATIVE, for example to ensure e?ective pain or nausea control. Common sources of pain in cancer may involve bone, nerve compression, soft tissue, visceral, myofascial, constipation, muscle spasm, low-back pain, joint pain (e.g. capsulitis) and chronic post-operative pain. Patients may be suffering from more than one pain, all of which should be identi?ed. The aim should be to eliminate pain.

There are three rungs of the analgesic ladder; if one rung fails, the next one should be tried:

(1) non-opioid drugs – for example, aspirin, PARACETAMOL, NON-STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS); (2) weak opioids – for example, CODEINE, DIHYDROCODEINE, dextropropoxyphene; (3) strong opioids

– for example, MORPHINE, DIAMORPHINE, buprenorphine. Oral treatment is always preferable, unless prevented by severe vomiting. (See also CANCER; ONCOLOGIST; PAIN; PALLIATIVE CARE.)... oncology

The treatment of cancer with chemical drugs that are conveyed to all body tissues and attack the rapidly dividing cancer cells wherever they flourish. Unfortunately they also attack normal cells as in the alimentary canal, bone marrow and elsewhere reducing white blood cells, thus exposing the patient to infection.

Symptoms include: soreness of the mouth and throat, loss of appetite, etc.

For inoperable cancer chemotherapy is often deemed first choice of treatment. To some people this therapy is an endurance test. Many wear wigs because their hair has fallen out. Nausea and vomiting are common side-effects which may have an adverse effect upon moral and physical well-being. Often there is loss of quality of life.

Severity of the vomiting may be increased by defective function of kidneys, liver and pancreas; natural treatments are aimed at strengthening these organs with a possible improvement in a patient’s well-being and quality of life.

Teas. To rid the sickening taste, smell of sour brine and copper, and to dispel nausea: German Chamomile or Black Horehound. Anti-neoplasms – Vinca rosea herb or Violet leaves. 2 teaspoons to each cup boiling water; infuse 15 minutes. 1 cup freely.

Powders. Formula. Echinacea (to strengthen immune system) 2; Blue Flag root (anti-neoplasm) 1; Black Horehound (anti-emetic) 1; Ginkgo (anti-depressive) 2. Dose: 500mg (two 00 capsules or one-third teaspoon) every 3 hours with water or Violet leaf tea.

Liquid Extracts. Formula. Echinacea 2; Blue Flag root 1; Black Horehound 1; Ladyslipper 1. One 5ml teaspoon in water every 3 hours.

Vincristine. Dosage as on marked product.

External. For irritable skin rash: packs steeped in Castor oil, Aloe Vera gel or juice, or Houseleek juice. Note. Sips of Ginger ale have been known to relieve symptoms. ... chemotherapy

Catharanthus roseus

Apocynaceae

San: Nityakalyani;

Hin: Sadabahar, Baramassi;

Mal: Ushamalari, Nityakalyani

Tel: Billaganeru;

Tam: Sudukattu mallikai; Pun: Rattanjot;

Kan: Kasikanigale, Nitya Mallige

Importance: Periwinkle or Vinca is an erect handsome herbaceous perennial plant which is a chief source of patented cancer and hypotensive drugs. It is one of the very few medicinal plants which has a long history of uses as diuretic, antidysenteric, haemorrhagic and antiseptic. It is known for use in the treatment of diabetes in Jamaica and India. The alkaloids vinblastine and vincristine present in the leaves are recognized as anticancerous drugs. Vinblastine in the form of vinblastin sulphate is available in market under the trade name “VELBE” and Vincristine sulphate as “ONCOVIN” (Eli Lilly). Vinblastine is used in combination with other anticancer agents for the treatment of lymphocytic lymphoma, Hodgkin’s disease, testicular carcinoma and choriocarcinoma. Vincristine is used in acute leukemia, lymphosarcoma and Wilm’s tumour. Its roots are a major source of the alkaloids, raubasine (ajmalicine), reserpine and serpentine used in the preparation of antifibrillic and hypertension-relieving drugs. It is useful in the treatment of choriocarcinoma and Hodgkin’s disease-a cancer affecting lymph glands, spleen and liver. Its leaves are used for curing diabetes, menorrhagia and wasp stings. Root is tonic, stomachic, hypotensive, sedative and tranquilliser (Narayana and Dimri,1990).

Distribution: The plant is a native of Madagascar and hence the name Madagascar Periwinkle. It is distributed in West Indies, Mozambique, South Vi etnam, Sri Lanka , Philippines and Australia. It is well adapted to diverse agroclimatic situations prevalent in India and is commercially cultivated in the states of Tamil Nadu, Karnataka, Gujarat, Madhya Pradesh and Assam. USA, Hungary, West Germany, Italy, Netherlands and UK are the major consumers.

Botany: Catharanthus roseus (Linn.) G.Don.

syn. Vinca rosea Linn. belongs to the family Apocynaceae. It is an erect highly branched lactiferous perennial herb growing up to a height of one metre. Leaves are oblong or ovate, opposite, short-petioled, smooth with entire margin. Flowers are borne on axils in pairs. There are three flower colour types , pink, pink-eyed and white. Calyx with 5 sepal, green, linear, subulate. Corolla tube is cylindrical with 5 petals, rose-purple or white with rose-purple spot in the centre; throat of corolla tube hairy, forming a corona-like structure. The anthers are epipetalous borne on short filaments inside the bulging distal end of corolla tube converging conically above the stigma. Two characteristic secretary systems, namely a column like nectarium on both sides of pistil and a secretory cringulam circling the papillate stigma with a presumed role in pollination - fecundation process are present. Ovary bicarpellary, basally distinct with fused common style and stigma. The dehiscent fruit consists of a pair of follicles each measuring about 25 mm in length and 2.3 mm in diameter, containing up to thirty linearly arranged seeds with a thin black tegumen. On maturity, the follicles split along the length dehiscing the seeds.

Agrotechnology: Periwinkle grows well under tropical and subtropical climate. A well distributed rainfall of 1000 mm or more is ideal. In north India the low winter temperatures adversely affect the crop growth. It can grow on any type of soil ,except those which are highly saline, alkaline or waterlogged. Light soils, rich in humus are preferable for large scale cultivation since harvesting of the roots become easy.

Catharanthus is propagated by seeds. Fresh seeds should be used since they are short-viable. Seeds can be either sown directly in the field or in a nursery and then transplanted. Seed rate is 2.5 kg/ha for direct sowing and the seeds are drilled in rows 45 cm apart or broadcasted. For transplanted crop the seed rate is 500gm/ha. Seeds are sown in nursery and transplanted at 45x 30cm spacing after 60 days when the seedlings attain a height of 15-20cm Nursery is prepared two months in advance so that transplanting coincides with the on set of monsoons. Application of FYM at the rate of 15 t/ha is recommended. An alternate approach is to grow leguminous green manure crops and incorporate the same into the soil at flowering stage. Fertilisers are recommended at 80:40:40 kg N:P2O5:K2O/ha for irrigated crop and 60:30:30 kg/ha for rainfed crop. N is applied in three equal splits at planting and at 45 and 90 days after planting. 4 or 5 irrigations will be needed to optimise yield when rainfall is restricted. Fortnightly irrigations support good crop growth when the crop is grown exclusively as an irrigated crop. Weeding is carried out before each topdressing. Alternatively, use of fluchloraline at 0.75 kg a.i. /ha pre-plant or alachlor at 1.0 kg a.i. per ha as pre-emergence to weeds provides effective control of a wide range of weeds in periwinkle crop. Detopping of plants by 2cm at 50% flowering stage improves root yield and alkaloid contents. No major pests, other than Oleander hawk moth, have been reported in this crop. Fungal diseases like twig blight (top rot or dieback) caused by Phytophthora nicotianae., Pythium debaryanum, P. butleri and P. aphanidermatum; leaf spot due to Alternaria tenuissima, A. alternata, Rhizoctonia solani and Ophiobolus catharanthicola and foot-rot and wilt by Sclerotium rolfsii and Fusarium solani have been reported. However, the damage to the crop is not very serious. Three virus diseases causing different types of mosaic symptoms and a phyllody or little leaf disease due to mycoplasma -like organisms have also been reported; the spread of which could be checked by uprooting and destroying the affected plants.

The crop allows 3-4 clippings of foliage beginning from 6 months. The flowering stage is ideal for collection of roots with high alkaloid content. The crop is cut about 7 cm above the ground and dried for stem, leaf and seed. The field is irrigated, ploughed and roots are collected. The average yields of leaf, stem and root are 3.6, 1.5and 1.5 t/ha, respectively under irrigated conditions and 2.0, 1.0 and 0.75t/ha, respectively under rainfed conditions on air dry basis. The harvested stem and roots loose 80% and 70% of their weight, respectively. The crop comes up well as an undercrop in eucalyptus plantation in north India. In north western India a two year crop sequence of periwinkle-senna-mustard or periwinkle-senna- coriander are recommended for higher net returns and productivity (Krishnan,1995).

Properties and activity: More than 100 alkaloids and related compounds have so far been isolated and characterised from the plant. The alkaloid contents in different parts show large variations as roots 0.14-1.34%, stem 0.074-0.48%, leaves 0.32-1.16%, flowers 0.005-0.84%, fruits 0.40%, seeds 0.18% and pericarp 1.14% (Krishnan et al, 1983). These alkaloids includes monomeric indole alkaloids, 2-acyl indoles, oxindole, -methylene indolines, dihydroindoles, bisindole and others. Dry leaves contain vinblastine (vincaleucoblastine or VLB) 0.00013-0.00063%, and vincristine (leurocristine or LC) 0.0000003-0.0000153% which have anticancerous activity (Virmani et al, 1978). Other alkaloids reported are vincoside, isovincoside (strictosidine), catharanthine, vindolinine, lochrovicine, vincolidine, ajmalicine (raubasine), reserpine, serpentine, leurosine, lochnerine, tetrahydroalstonine, vindoline, pericalline, perivine, periformyline, perividine, carosine, leurosivine, leurosidine and rovidine. The different alkaloids possessed anticancerous, antidiabetic, diuretic, antihypertensive, antimicrobial, antidysenteric, haemorrhagic, antifibrillic, tonic, stomachic, sedative and tranquillising activities.... periwinkle

a malignant disease of lymphatic tissue – a form of *lymphoma – usually characterized by painless enlargement of one or more groups of lymph nodes in the neck, axillae (armpits), groin, chest, or abdomen; the spleen, liver, bone marrow, and bones may also be involved. Apart from the enlarging nodes, there may also be weight loss, fever, profuse sweating at night, and itching (known as B symptoms). Hodgkin’s disease is distinguished from other forms of lymphoma by the presence of large binucleate cells (Reed–Sternberg cells) in the affected lymph nodes. Treatment depends on the extent of disease and may include surgery, radiotherapy, drug therapy, or a combination of these. Drugs used in the treatment of the disease include vincristine, procarbazine, prednisolone, chlorambucil, and vinblastine. Many patients can be cured; in the early stages of the disease this may be in the order of 90% or more. [T. Hodgkin (1798–1866), British physician]... hodgkin’s disease

n. cancer of the lymph nodes, including *Hodgkin’s disease and non-Hodgkin’s lymphomas. There is a broad spectrum of malignancy, with prognosis ranging from a few months to many years. The patient usually shows evidence of multiple enlarged lymph nodes and may have constitutional symptoms such as weight loss, fever, and sweating (the so-called ‘B symptoms’). Disease may be widespread, but in some cases is confined to a single area, which may be extranodal (such as the tonsil). Treatment is with drugs such as chlorambucil or combinations of cyclophosphamide, vincristine, and prednisolone, sometimes with the addition of doxorubicin and/or bleomycin; response to these drugs is often dramatic. New *targeted agents are used depending on the expression of cell surface molecules, particularly *rituximab against CD20 in diffuse B-cell lymphoma. Localized disease may be treated with radiotherapy followed by drugs. Patients with non-Hodgkin’s lymphoma who do not respond to chemotherapy may be considered for a bone-marrow transplant.... lymphoma

(osteogenic sarcoma) n. a highly malignant tumour arising from within a bone, usually in the *metaphysis of the long bones of the body and especially around the knee and the proximal end of the humerus. It is usually seen in children and adolescents but can occur in adults of all ages, occasionally in association with *Paget’s disease of bone. In children the usual site for the tumour is the leg, particularly the femur. Secondary growths (metastases) are common, most frequently in the lungs (though other sites, such as the liver, may also be involved). The symptoms are usually pain and swelling at the site of the tumour and there is often a history of preceding trauma, although it is doubtful whether this contributes to the cause. Treatment of disease localized to the primary site was traditionally by amputation of the limb; limb-sparing surgery is now possible after *neoadjuvant chemotherapy, with replacement of the diseased bone by a metal prosthesis. Many centres also give *adjuvant therapy in an attempt to kill any microscopic tumour that might have already spread. The drugs used include doxorubicin, cisplatin, vincristine, cyclophosphamide, and methotrexate.... osteosarcoma

n. a rare malignant tumour, usually of childhood, originating in, or showing the characteristics of, striated muscle. Pleomorphic rhabdomyosarcoma occurs in late middle age, in the muscles of the limbs. Embryonal rhabdomyosarcomas, affecting infants, children, and young adults, are classified as botryoid (in the vagina (see sarcoma botryoides), bladder, ear, etc.), embryonal (most common in the head and neck, particularly the orbit); and alveolar (at the base of the thumb). The pleomorphic and alveolar types respond poorly to treatment; botryoid tumours are treated with a combination of radiotherapy, surgery, and drugs. The embryonal type, if treated at an early stage, can often be cured with a combination of radiotherapy and drugs (including vincristine, dactinomycin, and cyclophosphamide).... rhabdomyosarcoma