Linn.Family: Verbenaceae.
Habitat: Throughout India in the warmer zones; ascending to 900 m in the North-western Himalaya.
English: Five-leaved Chaste tree.Ayurvedic: Nirgundi, Shephaa- likaa, Sindhuka, Sindhuvaara, Suvahaa, Sugandhikaa. Nila, Nila- nirgundi, Shveta nirgundi (var.). White-flowered var. is known as Sinduvaara, blue-flowered as Nirgundi or Shephaali,Unani: Sambhaalu, Fanjankisht.Siddha/Tamil: Nochi, Nalla Nochi, Vellai Nochchi, Nirkundi.Action: Seeds—prescribed in spermatorrhoea, and for promoting spermiogenesis (in Unani medicine). Also given as a rejuvenating tonic for retarding old age and for retaining and promoting virility. (in Ayurvedic medicine). Leaf—anti-inflammatory, analgesic; removes foetid discharges and worms from ulcers. Flowers—astringent, febrifuge, antidiarrhoeic; prescribed in liver complaint. Oil— applied to sinus, scrofulous sores.
The Ayurvedic Pharmacopoeia of India recommends the leaf (also the root) in excessive vaginal discharges, oedema, skin diseases, pruritus, helmin- thiasis, rheumatism, and puerperal fever.A water extract of the leaves, when administered to rats, exhibited anti- inflammatory, analgesic, antihistami- nic and membrane stabilizing and an- tioxidant activities. (J. Ethnopharmo- col, 2003, (203), 199-206.) Methano- lic extract of leaves showed remarkable antihistaminic activity.The leaves contain iridoid glyco- sides, isomeric flavanones and flavo- noids, besides casticin and the gluco- sides, luteolin-7-glucoside and alpha- D-glucoside of a tetrahydroxy mono- methoxy flavone.Dried powder of roots contains hen- triacontane, beta-sitosterol and its aetat and stigmasterol. Alcoholic extract of the root showed 40-60% antiimplantation activity with no anti- ovulatory effect in rats.Flavone vitexicarpin (1), isolated from the leaves, exhibited broad cyto- toxicity in human cancer cell line panel. Two pentacyclic triterpenoids, betulin- ic acid and ursolic acid, along with an aliphatic alcohol, n-hentriacontanol, beta-sitosterol and p-hydroxybenzoic acid have been isolated from leaves.The seeds contain p-hydroxybenz- oic acid, 5-oxyisophthalic acid, glucose and the triterpene, vitextriter- pene. Several anti-inflammatory triter- penoids and flavonoids have also been isolated from the seeds. The flavanone, 5,7,3' trihydroxy-6, 8,4'-trimethoxy- flavone exhibited anti-androgenic activity in adult mice and dogs.Dosage: Leaf—10-15 ml juice (API, Vol. III); root—10-12 ml juice (API, Vol. IV.)
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